Robert Andrew Edwards

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability
    Yumay Chen
    Department of Medicine, Division of Endocrinology, University of California at Irvine, 1130 Gross Hall, Irvine, CA 92697, USA
    Mol Cancer 10:5. 2011
  2. ncbi Defective arachidonate release and PGE2 production in Gi alpha2-deficient intestinal and colonic subepithelial myofibroblasts
    Robert Andrew Edwards
    Department of Pathology, University of California Irvine, Irvine, California 92697 4800, USA
    Inflamm Bowel Dis 12:153-65. 2006
  3. ncbi Role for epithelial dysregulation in early-onset colitis-associated colon cancer in Gi2-alpha-/- mice
    Robert A Edwards
    Department of Pathology, University of California, Irvine, Irvine, California 92697 4800, USA
    Inflamm Bowel Dis 14:898-907. 2008
  4. ncbi Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer
    Robert A Edwards
    Department of Pathology, University of California Irvine, Irvine, California 92697 4800, USA
    Cancer Res 69:6423-9. 2009
  5. ncbi Comparison of healing after cystotomy and repair with fibrin glue and sutured closure in the porcine model
    James F Borin
    Department of Urology, University of California Irvine, 101 The City Drive, Orange, CA 92612, USA
    J Endourol 22:145-50. 2008
  6. ncbi Bovine serum albumin glutaraldehyde for completely sutureless laparoscopic heminephrectomy in a survival porcine model
    Michael K Louie
    Department of Urology, University of California Irvine, Orange, California 92868, USA
    J Endourol 24:451-5. 2010
  7. ncbi Evaluation of the outcomes of electrosurgical induced bowel injury treated with tissue glue/sealant versus sutured repair in a rabbit model
    Geoffrey N Box
    Department of Urology, University of California, Irvine, Orange, California 92868, USA
    J Endourol 23:535-40. 2009
  8. ncbi Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts
    Brian Hoang
    Dept of Pathology, D449 Med Sci I, Univ of California Irvine, Irvine, CA 92697 4800, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1511-9. 2007
  9. ncbi NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer
    Shaheen S Sikandar
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, California, USA
    Cancer Res 70:1469-78. 2010
  10. ncbi Comparative study of in vivo lymphatic sealing capability of the porcine thoracic duct using laparoscopic dissection devices
    Geoffrey N Box
    Department of Urology, University of California Irvine, Orange, California, USA
    J Urol 181:387-91. 2009

Research Grants

  1. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2006
  2. Protanoids, Colitis, and Colon Cancer in Gia2-KO mice
    Robert Edwards; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. ncbi Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability
    Yumay Chen
    Department of Medicine, Division of Endocrinology, University of California at Irvine, 1130 Gross Hall, Irvine, CA 92697, USA
    Mol Cancer 10:5. 2011
    ..NEK1-deficient cells also fail to activate the checkpoint kinases CHK1 and CHK2, and fail to arrest properly at G1/S or G2/M-phase checkpoints after DNA damage...
  2. ncbi Defective arachidonate release and PGE2 production in Gi alpha2-deficient intestinal and colonic subepithelial myofibroblasts
    Robert Andrew Edwards
    Department of Pathology, University of California Irvine, Irvine, California 92697 4800, USA
    Inflamm Bowel Dis 12:153-65. 2006
    ..In the gut, arachidonate-derived prostaglandin E2 (PGE2) modulates intestinal immune responses and epithelial restitution and is derived largely from subepithelial myofibroblasts...
  3. ncbi Role for epithelial dysregulation in early-onset colitis-associated colon cancer in Gi2-alpha-/- mice
    Robert A Edwards
    Department of Pathology, University of California, Irvine, Irvine, California 92697 4800, USA
    Inflamm Bowel Dis 14:898-907. 2008
    ..They are predominantly right-sided, multifocal, mucinous, and arise from areas of flat dysplasia...
  4. ncbi Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer
    Robert A Edwards
    Department of Pathology, University of California Irvine, Irvine, California 92697 4800, USA
    Cancer Res 69:6423-9. 2009
    ..These data link chronic hypoxic inflammation, epigenetic MMR protein down-regulation, development of MMR-deficient colorectal cancer, and the firstmouse model of somatically acquired MMR-deficient colorectal cancer...
  5. ncbi Comparison of healing after cystotomy and repair with fibrin glue and sutured closure in the porcine model
    James F Borin
    Department of Urology, University of California Irvine, 101 The City Drive, Orange, CA 92612, USA
    J Endourol 22:145-50. 2008
    ..We compared healing after laparoscopic cystotomy using fibrin glue, sutures, or a combination to determine whether fibrin glue can obviate the need for sutures and whether there is any detriment when glue is used in the presence of sutures...
  6. ncbi Bovine serum albumin glutaraldehyde for completely sutureless laparoscopic heminephrectomy in a survival porcine model
    Michael K Louie
    Department of Urology, University of California Irvine, Orange, California 92868, USA
    J Endourol 24:451-5. 2010
    ..We evaluated the use of BSAG as the sole agent for parenchymal and collecting system closure during LPN in a survival porcine model...
  7. ncbi Evaluation of the outcomes of electrosurgical induced bowel injury treated with tissue glue/sealant versus sutured repair in a rabbit model
    Geoffrey N Box
    Department of Urology, University of California, Irvine, Orange, California 92868, USA
    J Endourol 23:535-40. 2009
    ..Questions have been raised about the possible use of a tissue adhesive to repair injured bowel. We compared glued repair and sutured repair of both large bowel (LB) and small bowel (SB) electrosurgical injuries in a rabbit model...
  8. ncbi Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts
    Brian Hoang
    Dept of Pathology, D449 Med Sci I, Univ of California Irvine, Irvine, CA 92697 4800, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1511-9. 2007
    ..These data suggest a physiological role for prostaglandins, MAPK signaling, and cAMP signaling for the production of myofibroblast-derived IL-11 in the mouse intestinal mucosa...
  9. ncbi NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer
    Shaheen S Sikandar
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, California, USA
    Cancer Res 70:1469-78. 2010
    ..Our findings describe a novel human cell system to study NOTCH signaling in CRC tumor initiation and suggest that inhibition of NOTCH signaling may improve CRC chemoprevention and chemotherapy...
  10. ncbi Comparative study of in vivo lymphatic sealing capability of the porcine thoracic duct using laparoscopic dissection devices
    Geoffrey N Box
    Department of Urology, University of California Irvine, Orange, California, USA
    J Urol 181:387-91. 2009
    ..To our knowledge we compared for the first time the quality of lymphatic sealing by each of 4 commonly used laparoscopic dissection devices...
  11. ncbi Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS
    Linda N Stiles
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Eur J Immunol 36:613-22. 2006
    ..Therefore, CXCR3 signaling has a non-redundant role in T cell subset trafficking in response to viral infection...

Research Grants3

  1. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2006
    ..This application has the support of outstanding mentors at two institutions, and funding of this application will foster Dr Edwards' continued development as a physician-scientist. ..
  2. Protanoids, Colitis, and Colon Cancer in Gia2-KO mice
    Robert Edwards; Fiscal Year: 2007
    ..Importantly, these animals also provide a useful in vivo model for addressing whether NSAID chemoprevention via COX inhibition is due to suppression of prostanoid production or elevation of mucosal free arachidonate levels. ..