David R Edwards

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi Catalytic proficiency: the extreme case of S-O cleaving sulfatases
    David R Edwards
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Am Chem Soc 134:525-31. 2012
  2. pmc Proton-in-flight mechanism for the spontaneous hydrolysis of N-methyl O-phenyl sulfamate: implications for the design of steroid sulfatase inhibitors
    David R Edwards
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Org Chem 77:4450-3. 2012
  3. doi Catalysis by desolvation: the catalytic prowess of SAM-dependent halide-alkylating enzymes
    Danielle C Lohman
    Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, United States
    J Am Chem Soc 135:14473-5. 2013
  4. pmc Hydrolysis of N-alkyl sulfamates and the catalytic efficiency of an S-N cleaving sulfamidase
    Danielle C Lohman
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Org Chem 77:2907-10. 2012
  5. pmc Catalysis by a de novo zinc-mediated protein interface: implications for natural enzyme evolution and rational enzyme engineering
    Bryan S Der
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599 7260, USA
    Biochemistry 51:3933-40. 2012

Collaborators

  • Danielle C Lohman
  • Richard Wolfenden
  • Bryan S Der
  • Brian Kuhlman

Detail Information

Publications5

  1. doi Catalytic proficiency: the extreme case of S-O cleaving sulfatases
    David R Edwards
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Am Chem Soc 134:525-31. 2012
    ..The hydrolytic rates of phosphate and sulfate monoesters are compared directly, and the misleading impression that the two classes of ester are of similar reactivity is dispelled...
  2. pmc Proton-in-flight mechanism for the spontaneous hydrolysis of N-methyl O-phenyl sulfamate: implications for the design of steroid sulfatase inhibitors
    David R Edwards
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Org Chem 77:4450-3. 2012
    ..Rate constants for hydrolysis of a wide range of sulfuryl esters, ArOSO(2)X(-), are shown to be correlated by a two-parameter equation based on pK(a)(ArOH) and pK(a)(ArOSO2XH)...
  3. doi Catalysis by desolvation: the catalytic prowess of SAM-dependent halide-alkylating enzymes
    Danielle C Lohman
    Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, United States
    J Am Chem Soc 135:14473-5. 2013
    ..These rate enhancements, achieved without the assistance of cofactors, metal ions, or general acid-base catalysis, are the largest that have been reported for an enzyme that acts on two substrates...
  4. pmc Hydrolysis of N-alkyl sulfamates and the catalytic efficiency of an S-N cleaving sulfamidase
    Danielle C Lohman
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Org Chem 77:2907-10. 2012
    ..heparinum is approximately 10(16)-fold, which is somewhat larger than those generated by most hydrolytic enzymes but considerably smaller than those generated by S-O cleaving sulfatases...
  5. pmc Catalysis by a de novo zinc-mediated protein interface: implications for natural enzyme evolution and rational enzyme engineering
    Bryan S Der
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599 7260, USA
    Biochemistry 51:3933-40. 2012
    ....