David R Edwards

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi Catalytic proficiency: the extreme case of S-O cleaving sulfatases
    David R Edwards
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Am Chem Soc 134:525-31. 2012
  2. pmc Proton-in-flight mechanism for the spontaneous hydrolysis of N-methyl O-phenyl sulfamate: implications for the design of steroid sulfatase inhibitors
    David R Edwards
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Org Chem 77:4450-3. 2012
  3. pmc Hydrolysis of N-alkyl sulfamates and the catalytic efficiency of an S-N cleaving sulfamidase
    Danielle C Lohman
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Org Chem 77:2907-10. 2012
  4. pmc Catalysis by a de novo zinc-mediated protein interface: implications for natural enzyme evolution and rational enzyme engineering
    Bryan S Der
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599 7260, USA
    Biochemistry 51:3933-40. 2012

Collaborators

  • Bryan S Der
  • Danielle C Lohman
  • Brian Kuhlman
  • Richard Wolfenden

Detail Information

Publications4

  1. doi Catalytic proficiency: the extreme case of S-O cleaving sulfatases
    David R Edwards
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Am Chem Soc 134:525-31. 2012
    ..The hydrolytic rates of phosphate and sulfate monoesters are compared directly, and the misleading impression that the two classes of ester are of similar reactivity is dispelled...
  2. pmc Proton-in-flight mechanism for the spontaneous hydrolysis of N-methyl O-phenyl sulfamate: implications for the design of steroid sulfatase inhibitors
    David R Edwards
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Org Chem 77:4450-3. 2012
    ..Rate constants for hydrolysis of a wide range of sulfuryl esters, ArOSO(2)X(-), are shown to be correlated by a two-parameter equation based on pK(a)(ArOH) and pK(a)(ArOSO2XH)...
  3. pmc Hydrolysis of N-alkyl sulfamates and the catalytic efficiency of an S-N cleaving sulfamidase
    Danielle C Lohman
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Org Chem 77:2907-10. 2012
    ..heparinum is approximately 10(16)-fold, which is somewhat larger than those generated by most hydrolytic enzymes but considerably smaller than those generated by S-O cleaving sulfatases...
  4. pmc Catalysis by a de novo zinc-mediated protein interface: implications for natural enzyme evolution and rational enzyme engineering
    Bryan S Der
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599 7260, USA
    Biochemistry 51:3933-40. 2012
    ....