Research Topics
Genomes and Genes | D P EdwardsSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
The role of coactivators and corepressors in the biology and mechanism of action of steroid hormone receptorsD P Edwards
University of Colorado Health Sciences Center, Department of Pathology, Denver 80262, USA
J Mammary Gland Biol Neoplasia 5:307-24. 2000....- Rapid extranuclear signaling by the estrogen receptor (ER): MNAR couples ER and Src to the MAP kinase signaling pathwayDean P Edwards
Department of Pathology and Program in Molecular Biology, University of Colorado Health Sciences Center Denver, CO 80262, USA
Mol Interv 3:12-5. 2003..e., Src) and the mitogen-activated protein kinase (MAPK) cascade. The MNAR-ER complex also appears to positively influence ER-mediated gene expression... - Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathwaysDean P Edwards
Program in Molecular Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B216 Denver, CO 80262, USA
J Steroid Biochem Mol Biol 83:173-86. 2002..This interaction mediates rapid progesterone activation of Src/MAP K signaling pathways and defines a molecular mechanism for some of the rapid non-genomic actions of progesterone... - Regulation of signal transduction pathways by estrogen and progesteroneDean P Edwards
University of Colorado Health Sciences Center, Department of Pathology and Program in Molecular Biology, Aurora, Colorado 80045, USA
Annu Rev Physiol 67:335-76. 2005.... 
Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivatorSuzanne E Wardell
Program in Molecular Biology, Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Mol Cell Biol 22:5451-66. 2002..JDP-2 has preferential activity on PR among the nuclear receptors tested and is expressed in progesterone target cells and tissues, suggesting that it has a physiological role in PR function...- Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinasesV Boonyaratanakornkit
University of Colorado School of Medicine, Pathology Department and Molecular Biology Program, Denver, CO 80262, USA
Mol Cell 8:269-80. 2001.... - High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cellsV Boonyaratanakornkit
Department of Pathology and Molecular Biology Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Mol Cell Biol 18:4471-87. 1998.... - The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptorsC A Beck
Department of Pathology, University of Colorado Health Sciences Center, Denver 80262
Endocrinology 133:728-40. 1993..As an antiprogestin, RU486 action is exerted predominantly at a post-DNA-binding step... - The role of the C-terminal extension (CTE) of the estrogen receptor alpha and beta DNA binding domain in DNA binding and interaction with HMGBVida Senkus Melvin
Molecular Biology Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 279:14763-71. 2004..The CTE of both ER subtypes was also shown to be required for interaction with ERE half-sites. These studies reveal the importance of the CTE and HMGB-1/-2 for ERalpha and ERbeta interaction with their cognate target DNAs... - Progesterone receptor transcription and non-transcription signaling mechanismsSusan A Leonhardt
Department of Pathology B216, School of Medicine University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box B216, Denver, CO 80262, USA
Steroids 68:761-70. 2003..This paper also reviews recent results on the mechanism of the extra-nuclear action of PR and the potential biological roles and implications of this novel PR signaling pathway... - A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domainKrista K Hill
Molecular Biology Program, School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
J Biol Chem 284:24415-24. 2009..These studies provide insights into the role and functional importance of the CTE for co-activator interactions... - Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanismSuzanne E Wardell
Molecular Biology Program, University of Colorado Health Sciences Center, Aurora, USA
Mol Cell Biol 25:8792-808. 2005.... - Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodiesP A Estes
Department of Pathology, University of Colorado Health Sciences Center, Denver 80262
Biochemistry 26:6250-62. 1987..These new MAbs are valuable reagents for further studies of human receptor structure and function and for clinical immunodetection of PR in breast tumors... - Mechanisms controlling agonist and antagonist potential of selective progesterone receptor modulators (SPRMs)Suzanne E Wardell
Molecular Biology Program, University of Colorado Health Sciences Center, Denver, Colorado, USA
Semin Reprod Med 23:9-21. 2005..We also describe newly developed SPRMs that mediate subsets of agonist and/or antagonist activities, and discuss the clinical potential of these compounds... - Receptor mechanisms of rapid extranuclear signalling initiated by steroid hormonesViroj Boonyaratanakornkit
Department of Pathology, School of Medicine and Program in Molecular Biology, University of Colorado Health Sciences Center, Denver, CO 80218, U.S.A
Essays Biochem 40:105-20. 2004.... - Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cellsAdam C Buser
Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
Mol Endocrinol 21:106-25. 2007..These results define a negative cross talk between PR and Stat5a/GR that may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene in the mammary gland during pregnancy... - Mechanism of high-mobility group protein B enhancement of progesterone receptor sequence-specific DNA bindingSarah C Roemer
Program in Molecular Biology, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA
Nucleic Acids Res 36:3655-66. 2008..We conclude that a transient HMGB-CTE interaction alters a repressive conformation of the flexible CTE enabling it to bind to preferred sequences flanking the PRE... - Progesterone regulates proliferation of endothelial cellsF Vazquez
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 274:2185-92. 1999..These results have important implications to our current knowledge of the effect of steroids on endothelial cell function and to the overall contribution of progesterone to vascular repair... - Mechanism of action of progesterone antagonistsSusan A Leonhardt
University of Colorado Health Sciences Center, Department of Pathology, Denver, Colorado 80262, USA
Exp Biol Med (Maywood) 227:969-80. 2002..We also discuss steroidal and nonsteroidal antagonist selectivity for PR versus other steroid hormone receptors and suggest that it may be possible to develop tissue/cell specific modulators of PR... - The C-terminal extension (CTE) of the nuclear hormone receptor DNA binding domain determines interactions and functional response to the HMGB-1/-2 co-regulatory proteinsVida Senkus Melvin
Program in Molecular Biology and the Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA
J Biol Chem 277:25115-24. 2002..These results reveal the importance of the steroid receptor CTE for DNA binding affinity and functional response to HMGB-1/-2... - Comparison of different antibodies for detection of progesterone receptor in breast cancerMichael Press
Department of Pathology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA
Steroids 67:799-813. 2002..These results indicate that PgR636 and PgR1294 are optimal antibodies for IHC detection of PR in routine paraffin tissue blocks... - Structure of the progesterone receptor-deoxyribonucleic acid complex: novel interactions required for binding to half-site response elementsSarah C Roemer
Program in Molecular Biology, Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
Mol Endocrinol 20:3042-52. 2006..These results, taken together, support the notion that sequences outside of the HREs influence the DNA binding affinity and specificity of steroid receptors... 
The role and mechanism of progesterone receptor activation of extra-nuclear signaling pathways in regulating gene transcription and cell cycle progressionViroj Boonyaratanakornkit
Department of Molecular and Cellular Biology and Pathology, Baylor College of Medicine, Houston, TX 77030, USA
Steroids 73:922-8. 2008..These results demonstrate the importance of PR activation of extra-nuclear signaling pathways in regulating selected target genes and cell cycle progression...- Receptor mechanisms mediating non-genomic actions of sex steroidsViroj Boonyaratanakornkit
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Semin Reprod Med 25:139-53. 2007..A better definition of receptor mechanisms involved in mediating activation of non-genomic signaling pathways is important to our overall understanding of the biology of steroid hormones... - Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinaseJames G Greger
Women s Health and Musculoskeletal Biology, Wyeth Research, Nuclear Receptors, 500 Arcola Road, Collegeville, PA 19426, USA
Mol Cell Biol 27:1904-13. 2007..These results provide new and important insights into the molecular mechanisms of E2-induced regulation of cell proliferation and apoptosis... - The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycleViroj Boonyaratanakornkit
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 21:359-75. 2007..These results highlight the importance of PR activation of the Src/MAPK signaling pathway for progesterone-induced transcription of select target genes and cell cycle progression... - Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivatorRamesh Narayanan
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Biol 25:264-77. 2005.... - Human progesterone receptor displays cell cycle-dependent changes in transcriptional activityRamesh Narayanan
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Biol 25:2885-98. 2005.... - Ligand-specific dynamics of the progesterone receptor in living cells and during chromatin remodeling in vitroGeetha V Rayasam
Laboratory of Receptor Biology and Gene Expression, Building 41, B602, National Cancer Institute, National Institutes of Health, 41 Library Dr, Bethesda, MD 20892 5055, USA
Mol Cell Biol 25:2406-18. 2005.... - Differential modulation of DNA conformation by estrogen receptors alpha and betaJennifer R Schultz
Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
J Biol Chem 277:8702-7. 2002.... - A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer riskIrina U Agoulnik
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Endocrinol Metab 89:6340-7. 2004..This is of special interest, because only a few genetic markers are available for the majority of women diagnosed with sporadic ovarian cancer... - Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxinToshio M Igarashi
Women's Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Fertil Steril 84:67-74. 2005.... - Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathwaysRomina P Carnevale
Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires C1428ADN, Argentina
Mol Endocrinol 21:1335-58. 2007..Our present findings provide mechanistic support to the design of a novel therapeutic intervention in PR-positive breast tumors involving blockage of PR capacity to activate cytoplasmic signaling... - Progestins reinitiate cell cycle progression in antiestrogen-arrested breast cancer cells through the B-isoform of progesterone receptorEileen M McGowan
Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Cancer Res 67:8942-51. 2007.... - Progesterone receptor isoforms A and B differentially regulate MUC1 expression in uterine epithelial cellsMelissa J Brayman
Department of Biological Sciences, University of Delaware, 118C Wolf Hall, Newark, Delaware 19713, USA
Mol Endocrinol 20:2278-91. 2006..The differential MUC1 response to P in these two species may be due to dissimilar expression of the two PR isoforms in the uterine epithelium...