V Reggie Edgerton

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Effect of chronic unloading and rehabilitation on human Achilles tendon properties: a velocity-encoded phase-contrast MRI study
    Dongsuk Shin
    Muscle Imaging and Modeling Laboratory, Department of Radiology, RIL, School of Medicine, University of California San Diego, 3510 Dunhill Street, San Diego, CA 92121 0852, USA
    J Appl Physiol (1985) 105:1179-86. 2008
  2. pmc Accommodation of the spinal cat to a tripping perturbation
    Hui Zhong
    Departments of Integrative Biology and Physiology, University of California Los Angeles Los Angeles, CA, USA
    Front Physiol 3:112. 2012
  3. pmc Novel and direct access to the human locomotor spinal circuitry
    Yury Gerasimenko
    Pavlov Institute of Physiology, St Petersburg 199034, Russia
    J Neurosci 30:3700-8. 2010
  4. pmc Propriospinal bypass of the serotonergic system that can facilitate stepping
    Yury Gerasimenko
    Pavlov Institute of Physiology, St Petersburg 199034, Russia
    J Neurosci 29:5681-9. 2009
  5. ncbi request reprint Sub-threshold spinal cord stimulation facilitates spontaneous motor activity in spinal rats
    Parag Gad
    Department of Integrative Biology and Physiology, University of California, Los Angeles, Terasaki Life Sciences Building, 610 Charles E, Young Drive East, Los Angeles, CA 90095 7239, USA
    J Neuroeng Rehabil 10:108. 2013
  6. ncbi request reprint A new age for rehabilitation
    V R Edgerton
    Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA
    Eur J Phys Rehabil Med 48:99-109. 2012
  7. pmc Activity-dependent plasticity of spinal locomotion: implications for sensory processing
    V Reggie Edgerton
    Department of Physiological Science, Brain Research Institute, University of California, Los Angeles, 90095, USA
    Exerc Sport Sci Rev 37:171-8. 2009
  8. pmc Training locomotor networks
    V Reggie Edgerton
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Brain Res Rev 57:241-54. 2008
  9. ncbi request reprint Paralysis recovery in humans and model systems
    V Reggie Edgerton
    Brain Research Institute, University of California, Los Angeles Brain Research Institute, 695 Charles E Young Drive, South Los Angeles 90095 1761, USA
    Curr Opin Neurobiol 12:658-67. 2002
  10. ncbi request reprint Plasticity of the spinal neural circuitry after injury
    V Reggie Edgerton
    Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Annu Rev Neurosci 27:145-67. 2004

Detail Information

Publications100

  1. pmc Effect of chronic unloading and rehabilitation on human Achilles tendon properties: a velocity-encoded phase-contrast MRI study
    Dongsuk Shin
    Muscle Imaging and Modeling Laboratory, Department of Radiology, RIL, School of Medicine, University of California San Diego, 3510 Dunhill Street, San Diego, CA 92121 0852, USA
    J Appl Physiol (1985) 105:1179-86. 2008
    ..The increase in the transition point following chronic unloading as measured by the VE-PC-MRI technique has not been previously reported and offers new insights into the biomechanical changes that may occur in the tendon crimp structure...
  2. pmc Accommodation of the spinal cat to a tripping perturbation
    Hui Zhong
    Departments of Integrative Biology and Physiology, University of California Los Angeles Los Angeles, CA, USA
    Front Physiol 3:112. 2012
    ..Furthermore, these adaptations remained evident for a number of steps after removal of the mechanosensory stimulation...
  3. pmc Novel and direct access to the human locomotor spinal circuitry
    Yury Gerasimenko
    Pavlov Institute of Physiology, St Petersburg 199034, Russia
    J Neurosci 30:3700-8. 2010
    ..The present results suggest that SEMS could be an effective noninvasive clinical tool to determine the potential of an individual to recover locomotion after a spinal cord injury, as well as being an effective rehabilitation tool itself...
  4. pmc Propriospinal bypass of the serotonergic system that can facilitate stepping
    Yury Gerasimenko
    Pavlov Institute of Physiology, St Petersburg 199034, Russia
    J Neurosci 29:5681-9. 2009
    ..Thus, different neurotransmitter receptor systems can be used to mediate the same type of sensory event, i.e., locomotor-like proprioception to facilitate the same motor task, i.e., hindlimb stepping...
  5. ncbi request reprint Sub-threshold spinal cord stimulation facilitates spontaneous motor activity in spinal rats
    Parag Gad
    Department of Integrative Biology and Physiology, University of California, Los Angeles, Terasaki Life Sciences Building, 610 Charles E, Young Drive East, Los Angeles, CA 90095 7239, USA
    J Neuroeng Rehabil 10:108. 2013
    ..Herein we have studied the effects of eEmc using a sub-threshold intensity of stimulation combined with spontaneous load-bearing proprioception to facilitate hindlimb stepping and standing during daily cage activity in paralyzed rats...
  6. ncbi request reprint A new age for rehabilitation
    V R Edgerton
    Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA
    Eur J Phys Rehabil Med 48:99-109. 2012
    ..Fortunately the extensive conservation of neural mechanisms of motor control has provided a window for gaining considerable insight into the mechanisms of recovery of motor function in humans...
  7. pmc Activity-dependent plasticity of spinal locomotion: implications for sensory processing
    V Reggie Edgerton
    Department of Physiological Science, Brain Research Institute, University of California, Los Angeles, 90095, USA
    Exerc Sport Sci Rev 37:171-8. 2009
    ....
  8. pmc Training locomotor networks
    V Reggie Edgerton
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Brain Res Rev 57:241-54. 2008
    ....
  9. ncbi request reprint Paralysis recovery in humans and model systems
    V Reggie Edgerton
    Brain Research Institute, University of California, Los Angeles Brain Research Institute, 695 Charles E Young Drive, South Los Angeles 90095 1761, USA
    Curr Opin Neurobiol 12:658-67. 2002
    ..Advances are being made with robotic devices for mice, rats and humans...
  10. ncbi request reprint Plasticity of the spinal neural circuitry after injury
    V Reggie Edgerton
    Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Annu Rev Neurosci 27:145-67. 2004
    ..Rehabilitative efforts combining locomotor training pharmacological means and/or spinal cord electrical stimulation paradigms will most likely result in more effective methods of recovery than using only one intervention...
  11. ncbi request reprint Invited review: gravitational biology of the neuromotor systems: a perspective to the next era
    V R Edgerton
    Brain Research Institute, University of California, Los Angeles, California 90095, USA
    J Appl Physiol (1985) 89:1224-31. 2000
    ..Disorders associated with energy support and delivery systems and how these functions are altered by sedentary life styles at 1 G and by space travel in a microgravity environment are also discussed...
  12. pmc Robotic training and spinal cord plasticity
    V Reggie Edgerton
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    Brain Res Bull 78:4-12. 2009
    ..These types of robotic devices have the potential to aid therapists in the clinical setting and to enhance the ability of spinal cord injured individuals to regain the maximum locomotor ability possible...
  13. pmc Retraining the injured spinal cord
    V R Edgerton
    Brain Research Institute and Departments of Physiological Science and Neurobiology, University of California, Los Angeles, CA 90095, USA
    J Physiol 533:15-22. 2001
    ..These concepts and observations demonstrate that (a) the spinal cord can interpret complex afferent information and generate the appropriate motor task; and (b) motor ability can be defined to a large degree by training...
  14. ncbi request reprint Sensorimotor adaptations to microgravity in humans
    V R Edgerton
    Brain Research Institute, Department of Physiological Science University of California, Los Angeles, CA 90095 1527, USA
    J Exp Biol 204:3217-24. 2001
    ....
  15. ncbi request reprint Rehabilitative therapies after spinal cord injury
    V Reggie Edgerton
    Brain Research Institute, University of California, Los Angeles, Los Angeles, California, USA
    J Neurotrauma 23:560-70. 2006
    ....
  16. ncbi request reprint Neural and neuroendocrine adaptations to microgravity and ground-based models of microgravity
    V R Edgerton
    Brain Research Institute and Department of Physiological Science, University of California, Los Angeles, CA, USA
    J Gravit Physiol 7:45-52. 2000
    ..These results suggest a unique neuroendocrine control system and demonstrate its sensitivity to chronic patterns of proprioceptive input associated with load-bearing locomotion...
  17. pmc Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey
    Yvette S Nout
    California State Polytechnic University, Pomona, CA, USA
    Neurorehabil Neural Repair 26:556-69. 2012
    ..Reliable outcome measures are essential for preclinical modeling of spinal cord injury (SCI) in primates...
  18. ncbi request reprint Performance of locomotion and foot grasping following a unilateral thoracic corticospinal tract lesion in monkeys (Macaca mulatta)
    Gregoire Courtine
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1527, USA
    Brain 128:2338-58. 2005
    ....
  19. ncbi request reprint Epidural spinal cord stimulation plus quipazine administration enable stepping in complete spinal adult rats
    Yury P Gerasimenko
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    J Neurophysiol 98:2525-36. 2007
    ..Quipazine potentiated the amplitude of these responses. The data suggest that there are fundamental differences in the circuitry that generates flexion and extension during locomotion...
  20. pmc Use of quadrupedal step training to re-engage spinal interneuronal networks and improve locomotor function after spinal cord injury
    Prithvi K Shah
    1 Departments of Integrative Biology and Physiology, University of California, Los Angeles, California 90095, USA
    Brain 136:3362-77. 2013
    ....
  21. pmc Electromechanical modulation of catabolic and anabolic pathways in chronically inactive, but neurally intact, muscles
    Jung A Kim
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, California 90095, USA
    Muscle Nerve 42:410-21. 2010
    ..These data suggest that regulatory mechanisms for maintaining muscle mass previously shown in acute states of atrophy differ substantially from those observed in chronic states...
  22. pmc Axon regeneration can facilitate or suppress hindlimb function after olfactory ensheathing glia transplantation
    Aya Takeoka
    Department of Integrative Biology and Physiology, UCLA, Los Angeles, California 90095, USA
    J Neurosci 31:4298-310. 2011
    ..These novel findings demonstrate that OEG promote regeneration of mature axons across a complete transection and reorganization of spinal circuitry, both of which contribute to sensorimotor function...
  23. ncbi request reprint Locomotor ability in spinal rats is dependent on the amount of activity imposed on the hindlimbs during treadmill training
    John Cha
    Department of Biological Science, California State University, Los Angeles, California 90032 8162, USA
    J Neurotrauma 24:1000-12. 2007
    ....
  24. pmc Facilitation of stepping with epidural stimulation in spinal rats: role of sensory input
    Igor Lavrov
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, California 90095 1527, USA
    J Neurosci 28:7774-80. 2008
    ..These data suggest that facilitation of stepping with epidural stimulation is mediated primarily through ipsilateral afferents that project to the locomotor networks...
  25. pmc Local and remote growth factor effects after primate spinal cord injury
    John H Brock
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 30:9728-37. 2010
    ..Remote cortical effects of spinally administered growth factors could "prime" the neuron to respond to experimental therapies that promote axonal plasticity or regeneration...
  26. pmc Gene expression during inactivity-induced muscle atrophy: effects of brief bouts of a forceful contraction countermeasure
    Soo J Kim
    Brain Research Institute, University of California Los Angeles, CA 90095 1761, USA
    J Appl Physiol (1985) 105:1246-54. 2008
    ..Although the protein anabolic pathway (IGF-1/PI3K/Akt) appears to play a minor role in regulating mass in the SI model, increased translational capacity may have contributed to mass preservation in response to isometric contractions...
  27. pmc Dose dependence of the 5-HT agonist quipazine in facilitating spinal stepping in the rat with epidural stimulation
    Ronaldo M Ichiyama
    Department of Physiological Science, University of California, Los Angeles, CA 90095, United States
    Neurosci Lett 438:281-5. 2008
    ....
  28. pmc Changes in GABA(A) receptor subunit gamma 2 in extensor and flexor motoneurons and astrocytes after spinal cord transection and motor training
    Windyanne Khristy
    Department of Physiological Science, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Brain Res 1273:9-17. 2009
    ..Since the gamma2 subunit is involved with GABA(A) receptor trafficking and synaptic clustering, it appears that this subunit could be an important component of the activity-dependent response of the spinal cord after a spinal injury...
  29. ncbi request reprint Electromechanical stimulation ameliorates inactivity-induced adaptations in the medial gastrocnemius of adult rats
    Soo J Kim
    Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095 1761, USA
    J Appl Physiol 103:195-205. 2007
    ....
  30. pmc Development of a multi-electrode array for spinal cord epidural stimulation to facilitate stepping and standing after a complete spinal cord injury in adult rats
    Parag Gad
    Biomedical Engineering IDP, University of California, Los Angeles, CA 90095, USA
    J Neuroeng Rehabil 10:2. 2013
    ....
  31. pmc OEG implantation and step training enhance hindlimb-stepping ability in adult spinal transected rats
    Marc D Kubasak
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
    Brain 131:264-76. 2008
    ..These data demonstrate that olfactory bulb-derived OEG transplantation improves hindlimb stepping in paraplegic rats and further suggest that task-specific training may enhance this OEG effect...
  32. pmc Distribution and localization of 5-HT(1A) receptors in the rat lumbar spinal cord after transection and deafferentation
    Chad K Otoshi
    Department of Physiological Science, University of California Los Angeles, Los Angeles, California 90095 1606, USA
    J Neurotrauma 26:575-84. 2009
    ..Combined, these data demonstrate that the upregulation in 5-HT(1A)R that occurs with spinal cord transection alone is dependent on the presence of sensory input...
  33. pmc Further evidence of olfactory ensheathing glia facilitating axonal regeneration after a complete spinal cord transection
    Matthias D Ziegler
    Department of Integrative Biology and Physiology, University of California Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Exp Neurol 229:109-19. 2011
    ..This article is part of a Special Issue entitled: Understanding olfactory ensheathing glia and their prospect for nervous system repair...
  34. pmc Phase-dependent modulation of percutaneously elicited multisegmental muscle responses after spinal cord injury
    Christine J Dy
    Department of Physiological Science, University of California, LosAngeles, Los Angeles, California, USA
    J Neurophysiol 103:2808-20. 2010
    ....
  35. ncbi request reprint Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injury
    Zhe Ying
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA Division of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, CA 90095 1527, USA
    Exp Neurol 193:411-9. 2005
    ..These results are consistent with the concept that synaptic pathways under the regulatory role of BDNF induced by exercise can play a role in facilitating recovery of locomotion following spinal cord injury...
  36. pmc Epidural stimulation induced modulation of spinal locomotor networks in adult spinal rats
    Igor Lavrov
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 28:6022-9. 2008
    ..The long-latency responses to epidural stimulation are correlated with the recovery of weight-bearing bipedal locomotion and may reflect activation of interneuronal central pattern-generating circuits...
  37. pmc Forelimb EMG-based trigger to control an electronic spinal bridge to enable hindlimb stepping after a complete spinal cord lesion in rats
    Parag Gad
    Biomedical Engineering IDP, University of California, Los Angeles, CA 90095, USA
    J Neuroeng Rehabil 9:38. 2012
    ..The objective of this study was to develop an electronic bridge across the lesion of the spinal cord to facilitate hindlimb stepping after a complete mid-thoracic spinal cord injury in adult rats...
  38. ncbi request reprint Afferent input modulates neurotrophins and synaptic plasticity in the spinal cord
    Fernando Gomez-Pinilla
    Department of Physiological Science, UCLA Brain Injury Research Center, Los Angeles, California 90095, USA
    J Neurophysiol 92:3423-32. 2004
    ..Combined, these results indicate that the level of supraspinal and muscle afferent input plays an important role in modulating the levels of BDNF and NT-3 in the spinal cord...
  39. pmc Why variability facilitates spinal learning
    Matthias D Ziegler
    Department of Integrative Biology and Physiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:10720-6. 2010
    ..These data suggest that some critical level of variation in the specific circuitry activated and the resulting kinematics reflect a fundamental feature of the neural control mechanisms even in a highly repetitive motor task...
  40. ncbi request reprint Activity-independent neural influences on cat soleus motor unit phenotypes
    Hui Zhong
    Brain Research Institute, University of California at Los Angeles, 1320 Gonda Neuroscience and Genetics Building, Box 951761, Los Angeles, California 90095 1761, USA
    Muscle Nerve 26:252-64. 2002
    ..The predominance of fibers containing both fast and slow MHC and SERCA isoforms in 2 motor units demonstrates a strong motoneuronal influence on the muscle-fiber phenotype even when the motoneurons are silent...
  41. ncbi request reprint Plasticity of spinal cord reflexes after a complete transection in adult rats: relationship to stepping ability
    Igor Lavrov
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1527, USA
    J Neurophysiol 96:1699-710. 2006
    ..Combined, these findings support the view that restoration of polysynaptic spinal cord reflexes induced epidurally may provide a measure of functional restoration of spinal cord locomotor networks after ST...
  42. pmc Neuromodulation of motor-evoked potentials during stepping in spinal rats
    Parag Gad
    Biomedical Engineering IDP, University of California, Los Angeles, California
    J Neurophysiol 110:1311-22. 2013
    ..These data suggest that LRs facilitated electrically and/or pharmacologically are not time-locked to the stimulation pulse but are highly correlated to the stepping patterns of spinal rats. ..
  43. pmc Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury
    Yvette S Nout
    Department of Animal and Veterinary Sciences, College of Agriculture, California State Polytechnic University, Pomona, CA, USA
    Neurotherapeutics 9:380-92. 2012
    ....
  44. pmc Recovery of control of posture and locomotion after a spinal cord injury: solutions staring us in the face
    Andy J Fong
    Division of Engineering, Bioengineering, California Institute of Technology, Pasadena, CA, USA
    Prog Brain Res 175:393-418. 2009
    ..Much work remains, but we already have the capability, and more importantly, the responsibility, to help spinal cord injury patients now...
  45. ncbi request reprint Soleus aponeurosis strain distribution following chronic unloading in humans: an in vivo MR phase-contrast study
    Hae Dong Lee
    Department of Radiological Sciences, University of California, Los Angeles, CA, USA
    J Appl Physiol 100:2004-11. 2006
    ....
  46. pmc Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury
    Gregoire Courtine
    Department of Physiological Sciences, University of California, Los Angeles, California 90095 1763, USA
    Nat Med 14:69-74. 2008
    ..Targeting interventions toward augmenting the remodeling of relay connections may provide new therapeutic strategies to bypass lesions and restore function after SCI and in other conditions such as stroke and multiple sclerosis...
  47. ncbi request reprint Activity-unrelated neural control of myogenic factors in a slow muscle
    Jon Philippe K Hyatt
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1761, USA
    Muscle Nerve 33:49-60. 2006
    ..These activity-independent modulatory influences, however, are less in the slow soleus than previously observed in fast muscles...
  48. ncbi request reprint Hindlimb loading determines stepping quantity and quality following spinal cord transection
    Wojciech K Timoszyk
    Department of Mechanical and Aerospace Engineering, 4200 Engineering Gateway EG3225, University of California, Irvine, CA 92697 3975, USA
    Brain Res 1050:180-9. 2005
    ..Finally, load-bearing failure point can be a quantitative measure of locomotor recovery following spinal cord injury, especially for severely impaired animals that cannot step unassisted...
  49. ncbi request reprint Spinal cord reflexes induced by epidural spinal cord stimulation in normal awake rats
    Yury P Gerasimenko
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    J Neurosci Methods 157:253-63. 2006
    ..These data demonstrate the feasibility of using epidural stimulation for examining monosynaptic and polysynaptic pathways to motor pools associated with multiple muscles during movement and over a prolonged period...
  50. ncbi request reprint Using robotics to teach the spinal cord to walk
    Ray D de Leon
    Department of Kinesiology and Nutritional Science, California State University, 5151 State University Drive, Los Angeles, CA 90032, USA
    Brain Res Brain Res Rev 40:267-73. 2002
    ..These results suggest that critical elements for successful training of hindlimb stepping in spinal cord injured rats can be implemented rigorously and evaluated using the rat stepper...
  51. pmc Epidural stimulation: comparison of the spinal circuits that generate and control locomotion in rats, cats and humans
    Yury Gerasimenko
    Department of Physiological Science, University of California Los Angeles, Los Angeles, CA 90095, USA
    Exp Neurol 209:417-25. 2008
    ..g., serotonergic agonists, and/or chronic step training also are described. Finally, a major point emphasized in this review is the striking similarity of the lumbosacral circuitry controlling locomotion in the rat and in the human...
  52. ncbi request reprint Use-dependent modulation of inhibitory capacity in the feline lumbar spinal cord
    Niranjala J K Tillakaratne
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    J Neurosci 22:3130-43. 2002
    ..This modulation is specific to the motor task that is performed repetitively and is closely linked to the ability of the animal to perform a specific motor task...
  53. ncbi request reprint Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus)
    Gregoire Courtine
    Dept of Physiological Science, University of California, Los Angeles, 405 Hilgard Ave, Los Angeles, CA 90095 1527, USA
    J Neurophysiol 93:3127-45. 2005
    ..We suggest that such adaptive changes may have facilitated evolution toward bipedal locomotion...
  54. ncbi request reprint Muscle kinematics during isometric contraction: development of phase contrast and spin tag techniques to study healthy and atrophied muscles
    Shantanu Sinha
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 900095 1721, USA
    J Magn Reson Imaging 20:1008-19. 2004
    ....
  55. ncbi request reprint Rat alpha- and gamma-motoneuron soma size and succinate dehydrogenase activity are independent of neuromuscular activity level
    Roland R Roy
    Brain Research Institute, 1320 Gonda Neuroscience and Genetics Building, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    Muscle Nerve 36:234-41. 2007
    ....
  56. ncbi request reprint Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury
    Hong Yang
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Neurosci 26:2157-66. 2006
    ..Thus, cell replacement is an extensive natural compensatory response to injury in the primate spinal cord that contributes to neural repair and is a potential target for therapeutic enhancement...
  57. pmc Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury
    Ephron S Rosenzweig
    Department of Neurosciences, University of California San Diego, La Jolla, California, USA
    Nat Neurosci 13:1505-10. 2010
    ..These findings identify what may be the most extensive natural recovery of mammalian axonal projections after nervous system injury observed to date, highlighting an important role for primate models in translational disease research...
  58. ncbi request reprint Does daily activity level determine muscle phenotype?
    John A Hodgson
    Brain Research Institute, University of California Los Angeles, 90095 1761, USA
    J Exp Biol 208:3761-70. 2005
    ....
  59. ncbi request reprint Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training
    Andy J Fong
    Biomedical Engineering Interdepartmental Program, University of California, Los Angeles, California 90095, USA
    J Neurosci 25:11738-47. 2005
    ..When administered intermittently during an extended period of robotic training, quipazine revealed training-induced stepping improvements that were masked in the absence of the pharmacological treatment...
  60. pmc Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning
    M Selvan Joseph
    Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e41288. 2012
    ....
  61. ncbi request reprint Effects of inactivity on fiber size and myonuclear number in rat soleus muscle
    Hui Zhong
    Brain Research Institute, University of California, Los Angeles, 90095 1761, USA
    J Appl Physiol 99:1494-9. 2005
    ..The results also indicate that a loss of myonuclei is not a prerequisite for sustained muscle fiber atrophy...
  62. pmc Persistence of motor unit and muscle fiber types in the presence of inactivity
    Roland R Roy
    Brain Research Institute, University of California, Los Angeles, CA 90024 1761, USA
    J Exp Biol 211:1041-9. 2008
    ..Although neuromuscular activity level influences fiber phenotype, the present results demonstrate that activity-independent mechanisms remain important sources of the control of phenotype establishment in the near absence of activity...
  63. ncbi request reprint Influence of structure on the tissue dynamics of the human soleus muscle observed in MRI studies during isometric contractions
    John A Hodgson
    Department of Physiological Sciences, University of California, Los Angeles, California 90095 1527, USA
    J Morphol 267:584-601. 2006
    ....
  64. ncbi request reprint Activity-dependent influences are greater for fibers in rat medial gastrocnemius than tibialis anterior muscle
    Roland R Roy
    Brain Research Institute, University of California, Los Angeles, CA 951761, USA
    Muscle Nerve 32:473-82. 2005
    ..The smaller myonuclear domains after a period of chronic inactivity suggest the presence of intrinsic mechanisms operating to maintain the genetic material necessary to recover from atrophic conditions...
  65. pmc Application of a rat hindlimb model: a prediction of force spaces reachable through stimulation of nerve fascicles
    Will L Johnson
    Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, CA 90024, USA
    IEEE Trans Biomed Eng 58:3328-38. 2011
    ..This novel, neuroanatomically derived reduction in input dimension emphasizes the potential to simplify controllers for functional electrical stimulation to improve functional recovery after a neuromuscular injury...
  66. ncbi request reprint Muscle synergism during isometric plantarflexion in achilles tendon rupture patients and in normal subjects revealed by velocity-encoded cine phase-contrast MRI
    Taija Finni
    Department of Radiological, University of California, Los Angeles, 90095 1527, USA
    Clin Biomech (Bristol, Avon) 21:67-74. 2006
    ..The triceps surae muscle is often considered to be the sole contributor to the plantarflexion torque although the deeper plantarflexor muscles may also be activated in the plantarflexion task...
  67. ncbi request reprint Mechanical properties of rat soleus after long-term spinal cord transection
    Robert J Talmadge
    Department of Biological Sciences, California State Polytechnic University, Pomona 91768, California, USA
    J Appl Physiol (1985) 93:1487-97. 2002
    ..Thus some specific functional properties of the rat soleus related to contractile force, speed, and fatigue adapted independently after ST...
  68. pmc Transcriptional regulation of the myosin heavy chain IIb gene in inactive rat soleus
    Gary E McCall
    Department of Physiology, University of California, Irvine, California, USA
    Muscle Nerve 40:411-9. 2009
    ....
  69. ncbi request reprint Mapping of movement in the isometrically contracting human soleus muscle reveals details of its structural and functional complexity
    Taija Finni
    Department of Radiological Sciences, University of California, Los Angeles, California 90095 1527, USA
    J Appl Physiol 95:2128-33. 2003
    ..These are located on the anterior and posterior surfaces of the muscle. The lowest velocities overlay the aponeuroses connected to the origin of the muscle and are generally located intramuscularly...
  70. pmc Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys
    Ephron S Rosenzweig
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Comp Neurol 513:151-63. 2009
    ..Thus, augmentation of sprouting of these extensive bilateral CST projections may provide a novel target for enhancing recovery after spinal cord injury...
  71. ncbi request reprint Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth
    Christie Engesser-Cesar
    Institute for Brain Aging and Dementia, University of California, Irvine, USA
    Eur J Neurosci 25:1931-9. 2007
    ..These observations suggest that improvement in function may be related to changes in serotonin fibers immediately caudal to the injury epicenter...
  72. doi request reprint Quantitative metrics of spinal cord injury recovery in the rat using motion capture, electromyography and ground reaction force measurement
    Will L Johnson
    Mechanical and Aerospace Engineering Department, UCLA, Los Angeles, CA, USA
    J Neurosci Methods 206:65-72. 2012
    ..The results demonstrate the discriminative potential of these physiologically based measures in quantifying the progressive recovery of gait performance after a lateral spinal cord hemisection...
  73. ncbi request reprint Use of robotics in assessing the adaptive capacity of the rat lumbar spinal cord
    Ray D de Leon
    Department of Kinesiology and Nutritional Science, California State University, Los Angeles, CA 90032 8162, USA
    Prog Brain Res 137:141-9. 2002
    ....
  74. pmc Transgenic mice with enhanced neuronal major histocompatibility complex class I expression recover locomotor function better after spinal cord injury
    M Selvan Joseph
    Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, USA
    J Neurosci Res 89:365-72. 2011
    ....
  75. ncbi request reprint Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord
    Zhe Ying
    Department of Physiological Science, UCLA, 621 Charles E Young Dr, Los Angeles, CA 90095, USA
    Brain Res 987:93-9. 2003
    ....
  76. ncbi request reprint Reinnervation of the rat levator ani muscle after neonatal denervation
    Jane L Lubischer
    Program in Neuroscience, Brain Research Institute, University of California, Los Angeles, California 90024, USA
    J Neurobiol 63:188-98. 2005
    ..These data suggest that motoneurons that survived injury on P14 innervated more muscle fibers than normal and exhibited a similar ability to functionally reinnervate the target muscle as those motoneurons that survived injury on P21...
  77. ncbi request reprint Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity
    Fernando Gomez-Pinilla
    Department of Physiological Science, Los Angeles, California 90095, USA
    J Neurophysiol 88:2187-95. 2002
    ..These results indicate that basal levels of neuromuscular activity are required to maintain normal levels of BDNF in the neuromuscular system and the potential for neuroplasticity...
  78. ncbi request reprint Influences of electromechanical events in defining skeletal muscle properties
    Roland R Roy
    Brain Research Institute, University of California at Los Angeles, 1320 Gonda Neuroscience and Genetics Building, Box 951761, Los Angeles, California 90095 1761, USA
    Muscle Nerve 26:238-51. 2002
    ..The clinical implications of these findings for rehabilitation strategies are discussed...
  79. pmc Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?
    Gregoire Courtine
    Department of Physiological Science and Neurobiology, and Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Nat Med 13:561-6. 2007
  80. ncbi request reprint Nonuniform strain of human soleus aponeurosis-tendon complex during submaximal voluntary contractions in vivo
    Taija Finni
    Brain Research Institute, University of California, Los Angeles, CA 90095 1527, USA
    J Appl Physiol (1985) 95:829-37. 2003
    ..Force transmission along intrasoleus connective tissue may also be a significant source of nonuniform strain in the aponeurosis...
  81. pmc Toward an implantable functional electrical stimulation device to correct strabismus
    Federico G Velez
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, California 90095, USA
    J AAPOS 13:229-35.e1. 2009
    ..To investigate the feasibility of electrically stimulating the lateral rectus muscle to recover its physiologic abduction ability in cases of complete sixth cranial (abducens) nerve palsy...
  82. ncbi request reprint In vivo diffusion tensor imaging of the human calf muscle
    Shantanu Sinha
    Department of Radiology, UCSD School of Medicine, University of California San Diego, San Diego, California, USA
    J Magn Reson Imaging 24:182-90. 2006
    ..To demonstrate the feasibility of in vivo calf muscle fiber tracking in human subjects...
  83. ncbi request reprint Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei
    Jon Philippe K Hyatt
    Department of Physiological Science, University of California Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Am J Physiol Cell Physiol 285:C1161-73. 2003
    ..These results demonstrate a neural effect independent of electrical activity that 1) helps preserve muscle mass, 2) regulates muscle-specific genes, and 3) potentially spares the satellite cell pool in inactive muscles...
  84. ncbi request reprint Ultrastructural synaptic features differ between alpha- and gamma-motoneurons innervating the tibialis anterior muscle in the rat
    Ronaldo M Ichiyama
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    J Comp Neurol 499:306-15. 2006
    ....
  85. pmc Enhanced motor function by training in spinal cord contused rats following radiation therapy
    Ronaldo Ichiyama
    Departments of Physiological Science and Neurobiology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 4:e6862. 2009
    ..Further, for restoring beneficial motor function following radiotherapy, training seems to be crucial...
  86. ncbi request reprint The role of neural and mechanical influences in maintaining normal fast and slow muscle properties
    Yoshinobu Ohira
    Graduate School of Medicine, Osaka University, Osaka, Japan
    Cells Tissues Organs 182:129-42. 2006
    ....
  87. ncbi request reprint Motoneuron and sensory neuron plasticity to varying neuromuscular activity levels
    Akihiko Ishihara
    Laboratory of Neurochemistry, Faculty of Integrated Human Studies, Kyoto University, Japan
    Exerc Sport Sci Rev 30:152-8. 2002
    ..When subjected to chronic decreases or increases in neuromuscular activity, however, the adaptations in these properties are much more limited in the neural compared with the muscular elements...
  88. ncbi request reprint Fiber size, type, and myosin heavy chain content in rhesus hindlimb muscles after 2 weeks at 2 G
    Morteza Tavakol
    Department of Physiological Science, University of California, Los Angeles 90095 1761, USA
    Aviat Space Environ Med 73:551-7. 2002
    ..Fiber atrophy and an increase in the percentage of fast fibers have been observed in Rhesus leg muscles after spaceflight. Hypothesis: Hypergravity will result in muscle fiber hypertrophy and an increase in the percentage of slow fibers...
  89. ncbi request reprint How selective is the reinnervation of skeletal muscle fibers?
    V Reggie Edgerton
    U CA, Los Angeles
    Muscle Nerve 25:765-7. 2002
  90. ncbi request reprint A robotic device for studying rodent locomotion after spinal cord injury
    Jeff A Nessler
    Rehabilitation Institute of Chicago, IL 60610, USA
    IEEE Trans Neural Syst Rehabil Eng 13:497-506. 2005
    ..This paper provides a detailed description of the device design and a characterization of its robotic performance capabilities...
  91. ncbi request reprint New fiber formation in the interstitial spaces of rat skeletal muscle during postnatal growth
    Tetsuro Tamaki
    Department of Physiology, Division of Human Structure and Function, Tokai University University School of Medicine, Kanagawa, Japan
    J Histochem Cytochem 50:1097-111. 2002
    ..Furthermore, these data suggest that the new fibers may be formed from myogenic cells in the interstitial spaces of skeletal muscle and may express CD34 that is distinct from satellite cells...
  92. ncbi request reprint Motoneuron and sensory neuron plasticity to varying neuromuscular activity levels
    Akihiko Ishihara
    Laboratory of Neurochemistry, Faculty of Integrated Human Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Exerc Sport Sci Rev 31:51-7. 2003
    ..When subjected to chronic decreases or increases in neuromuscular activity, however, the adaptations in these properties are much more limited in the neural compared with the muscular elements...
  93. ncbi request reprint Changes in motoneuron properties and synaptic inputs related to step training after spinal cord transection in rats
    Jeffrey C Petruska
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794 5230, USA
    J Neurosci 27:4460-71. 2007
    ....
  94. ncbi request reprint Myosin heavy chain isoform mRNA and protein levels after long-term paralysis
    Robert J Talmadge
    Biological Sciences, California State Polytechnic University, Pomona, CA 91768, USA
    Biochem Biophys Res Commun 325:296-301. 2004
    ..The relative lack of adaptation to ST by the MG suggests that the reduced activity and load bearing encountered by the MG were insufficient to induce a change in muscle phenotype...
  95. ncbi request reprint Succinate dehydrogenase activity in rat dorsolateral ventral horn motoneurons at L6 after spaceflight and recovery
    Akihiko Ishihara
    Laboratory of Neurochemistry, Faculty of Integrated Human Studies, Kyoto University, Kyoto, Japan
    J Gravit Physiol 9:39-48. 2002
    ..These data indicate that moderate-sized motoneurons, most likely innervating fibers in high-oxidative muscles, are responsive to the microgravity environment...
  96. ncbi request reprint Adaptations in metabolic capacity of rat soleus after paralysis
    Jeffrey S Otis
    Muscle Function Laboratory, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    J Appl Physiol 96:584-96. 2004
    ....
  97. doi request reprint Step training reinforces specific spinal locomotor circuitry in adult spinal rats
    Ronaldo M Ichiyama
    Institute of Membrane and Systems Biology, University of Leeds, Leeds, United Kingdom
    J Neurosci 28:7370-5. 2008
    ..These results suggest that training reinforces the efficacy of specific sensorimotor pathways, resulting in a more selective and stable network of neurons that controls locomotion...
  98. ncbi request reprint Implications of assist-as-needed robotic step training after a complete spinal cord injury on intrinsic strategies of motor learning
    Lance L Cai
    Division of Bioengineering, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 26:10564-8. 2006
    ....
  99. ncbi request reprint Dynamics of myosin heavy chain gene regulation in slow skeletal muscle: role of natural antisense RNA
    Clay E Pandorf
    Department of Physiology and Biophysics, University of California Irvine, CA 92697, USA
    J Biol Chem 281:38330-42. 2006
    ..In conclusion, NATs may mediate cross-talk between adjacent genes, which may be essential to the coordinated regulation of the skeletal muscle MHC genes during dynamic phenotype shifts...
  100. pmc Does elimination of afferent input modify the changes in rat motoneurone properties that occur following chronic spinal cord transection?
    Duane C Button
    Spinal Cord Research Centre, Department of Physiology, University of Manitoba, 730 William Avenue, 436 BMSB, Winnipeg, Manitoba, Canada R3E 3J7
    J Physiol 586:529-44. 2008
    ..This study is the first to demonstrate that intact ascending and afferent input does not modify the effects of spinal transection on basic and rhythmic firing properties of rat hindlimb motoneurones...

Research Grants22

  1. Serotonergic facilitation of spinal stepping by epidural stimulation: mechanisms
    REGGIE EDGERTON; Fiscal Year: 2010
    ....
  2. Robotically Generated Locomotion in Rodents
    V Edgerton; Fiscal Year: 2002
    ..These data will also provide insight into development of body weight support control and manual (or robotic) intervention for human locomotor training. ..
  3. Combined OEG transplantation and step training promote regeneration in adult SCI
    V Edgerton; Fiscal Year: 2009
    ..Our long term goal is to regain voluntary control of hindlimb stepping after a complete midthoracic spinal cord injury in an adult animal. ..
  4. Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCI
    V Edgerton; Fiscal Year: 2009
    ..We hypothesize that the combination of stimulation of the spinal cord and either stand or step training will allow individuals with a spinal cord injury to regain these functions. ..
  5. Serotonergic facilitation of spinal stepping by epidural stimulation: mechanisms
    V Edgerton; Fiscal Year: 2009
    ....
  6. Combined OEG transplantation and step training promote regeneration in adult SCI
    V Edgerton; Fiscal Year: 2009
    ..Our long term goal is to regain voluntary control of hindlimb stepping after a complete midthoracic spinal cord injury in an adult animal. ..
  7. Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCI
    REGGIE EDGERTON; Fiscal Year: 2010
    ..We hypothesize that the combination of stimulation of the spinal cord and either stand or step training will allow individuals with a spinal cord injury to regain these functions. ..
  8. Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCI
    V Edgerton; Fiscal Year: 2009
    ..We hypothesize that the combination of stimulation of the spinal cord and either stand or step training will allow individuals with a spinal cord injury to regain these functions. ..
  9. Serotonergic Facilitation & Robotics in Spinal Learning
    V Edgerton; Fiscal Year: 2007
    ..The results from these studies are expected to demonstrate a new paradigm for optimizing the recovery of motor function in mice that can be readily translated to humans with neuromotor disorder such as spinal cord injury and stroke. ..
  10. Combined OEG transplantation and step training promote regeneration in adult SCI
    V Edgerton; Fiscal Year: 2007
    ..Our long term goal is to regain voluntary control of hindlimb stepping after a complete midthoracic spinal cord injury in an adult animal. ..
  11. Serotonergic Facilitation & Robotics in Spinal Learning
    V Edgerton; Fiscal Year: 2003
    ..The results from these studies are expected to demonstrate a new paradigm for optimizing the recovery of motor function in mice that can be readily translated to humans with neuromotor disorder such as spinal cord injury and stroke. ..
  12. Serotonergic Facilitation & Robotics in Spinal Learning
    V Edgerton; Fiscal Year: 2004
    ..The results from these studies are expected to demonstrate a new paradigm for optimizing the recovery of motor function in mice that can be readily translated to humans with neuromotor disorder such as spinal cord injury and stroke. ..
  13. Serotonergic Facilitation & Robotics in Spinal Learning
    V Edgerton; Fiscal Year: 2005
    ..The results from these studies are expected to demonstrate a new paradigm for optimizing the recovery of motor function in mice that can be readily translated to humans with neuromotor disorder such as spinal cord injury and stroke. ..
  14. Combined OEG transplantation and step training promote regeneration in adult SCI
    V Edgerton; Fiscal Year: 2006
    ..Our long term goal is to regain voluntary control of hindlimb stepping after a complete midthoracic spinal cord injury in an adult animal. ..
  15. Serotonergic Facilitation & Robotics in Spinal Learning
    V Edgerton; Fiscal Year: 2006
    ..The results from these studies are expected to demonstrate a new paradigm for optimizing the recovery of motor function in mice that can be readily translated to humans with neuromotor disorder such as spinal cord injury and stroke. ..
  16. Serotonergic facilitation of spinal stepping by epidural stimulation: mechanisms
    REGGIE EDGERTON; Fiscal Year: 2010
    ....