M Edgerton

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Histatin 5 resistance of Candida glabrata can be reversed by insertion of Candida albicans polyamine transporter-encoding genes DUR3 and DUR31
    Swetha Tati
    Department of Oral Biology, University at Buffalo, Buffalo, New York, USA
    PLoS ONE 8:e61480. 2013
  2. pmc Uptake of the antifungal cationic peptide Histatin 5 by Candida albicans Ssa2p requires binding to non-conventional sites within the ATPase domain
    Jianing N Sun
    Department of Oral Biology, School of Dental Medicine, Public Health and Health Professions and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA
    Mol Microbiol 70:1246-60. 2008
  3. pmc Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans
    Woong Sik Jang
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Mol Microbiol 77:354-70. 2010
  4. pmc Host cell invasion and virulence mediated by Candida albicans Ssa1
    Jianing N Sun
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, New York, United States of America
    PLoS Pathog 6:e1001181. 2010
  5. pmc Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis
    Sumant Puri
    Department of Oral Biology, University at Buffalo, Buffalo, New York, USA
    PLoS ONE 7:e46020. 2012
  6. pmc The role of released ATP in killing Candida albicans and other extracellular microbial pathogens by cationic peptides
    Slavena Vylkova
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY, 14214, USA
    Purinergic Signal 3:91-7. 2007
  7. ncbi request reprint Salivary histatin 5 and its similarities to the other antimicrobial proteins in human saliva
    M Edgerton
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, 14214, USA
    Adv Dent Res 14:16-21. 2000
  8. ncbi request reprint Calcium blocks fungicidal activity of human salivary histatin 5 through disruption of binding with Candida albicans
    J Dong
    Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA
    J Dent Res 82:748-52. 2003
  9. pmc Salivary histatin 5 and human neutrophil defensin 1 kill Candida albicans via shared pathways
    M Edgerton
    Departments of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Antimicrob Agents Chemother 44:3310-6. 2000
  10. ncbi request reprint Candidacidal activity of salivary histatins. Identification of a histatin 5-binding protein on Candida albicans
    M Edgerton
    Department of Oral Biology, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 273:20438-47. 1998

Research Grants

  1. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2000
  2. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2009
  3. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2009
  4. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2007
  5. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2006
  6. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2005
  7. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2004
  8. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2003
  9. HISTATIN RECEPTORS AS DRUG TARGETS FOR ORAL CANDIDIASIS
    Mira Edgerton; Fiscal Year: 2003
  10. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2002

Collaborators

  • Anna Dongari-Bagtzoglou
  • X Li
  • Scott G Filler
  • S L Gaffen
  • S M Holland
  • Jing Fei Dong
  • Slavena Vylkova
  • Jianing N Sun
  • Woong Sik Jang
  • Didi Baev
  • Swetha Tati
  • Sumant Puri
  • Wansheng Li
  • Namrata Nayyar
  • Rohitashw Kumar
  • H R Conti
  • David Wunder
  • Alberto Rivetta
  • Clifford L Slayman
  • Rui Li
  • Sonia Chadha
  • Heather R Conti
  • D Baev
  • Paul J Cullen
  • Bernhard Hube
  • R A Li
  • A F Freeman
  • O Baker
  • W S Jang
  • Angela Thompson
  • Norma V Solis
  • Jashanjot Singh Bajwa
  • Helena Kashleva
  • Quynh T Phan
  • Jashanjot S Bajwa
  • Yaoping Liu
  • Mark D Sutton
  • Jennifer C Berner
  • Ge Fei Zeng
  • Esther Bashi
  • P A Raj
  • Peter Keng
  • E Marcus

Detail Information

Publications23

  1. pmc Histatin 5 resistance of Candida glabrata can be reversed by insertion of Candida albicans polyamine transporter-encoding genes DUR3 and DUR31
    Swetha Tati
    Department of Oral Biology, University at Buffalo, Buffalo, New York, USA
    PLoS ONE 8:e61480. 2013
    ..Thus, neither C. glabrata cell surface or biofilm matrix β-1,3-glucan levels affected Hst 5 toxicity; rather the crucial rate limiting step is reduced uptake that can be overcome by expression of C. albicans Dur proteins in C. glabrata...
  2. pmc Uptake of the antifungal cationic peptide Histatin 5 by Candida albicans Ssa2p requires binding to non-conventional sites within the ATPase domain
    Jianing N Sun
    Department of Oral Biology, School of Dental Medicine, Public Health and Health Professions and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA
    Mol Microbiol 70:1246-60. 2008
    ..Thus, C. albicans Ssa2p binds Hst 5 at a surface-localized epitope in a subunit of the ATPase domain; and this region is required for intracellular translocation and killing functions of Hst 5...
  3. pmc Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans
    Woong Sik Jang
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Mol Microbiol 77:354-70. 2010
    ..Thus, Hst 5 is capable of heterogeneous intracellular entry routes, but only direct cytosolic translocation causes cell death as a result of ionic efflux...
  4. pmc Host cell invasion and virulence mediated by Candida albicans Ssa1
    Jianing N Sun
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, New York, United States of America
    PLoS Pathog 6:e1001181. 2010
    ..albicans to cause maximal damage to host cells and induce disseminated and oropharyngeal disease...
  5. pmc Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis
    Sumant Puri
    Department of Oral Biology, University at Buffalo, Buffalo, New York, USA
    PLoS ONE 7:e46020. 2012
    ..Inhibition of Msb2 processing at the level of Saps may provide a means of attenuating MAPK signaling and reducing C. albicans virulence...
  6. pmc The role of released ATP in killing Candida albicans and other extracellular microbial pathogens by cationic peptides
    Slavena Vylkova
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY, 14214, USA
    Purinergic Signal 3:91-7. 2007
    ....
  7. ncbi request reprint Salivary histatin 5 and its similarities to the other antimicrobial proteins in human saliva
    M Edgerton
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, 14214, USA
    Adv Dent Res 14:16-21. 2000
    ..This mechanism for fungal cytotoxicity may be shared by other antimicrobial cationic proteins. Microbicidal domains of salivary and host innate proteins should be considered as potential therapeutic agents in the oral cavity...
  8. ncbi request reprint Calcium blocks fungicidal activity of human salivary histatin 5 through disruption of binding with Candida albicans
    J Dong
    Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA
    J Dent Res 82:748-52. 2003
    ..albicans cells. Calcium is a potent inhibitor of Hst 5 candidacidal activity at physiological concentrations and may be the primary salivary ion responsible for the masking effect of saliva...
  9. pmc Salivary histatin 5 and human neutrophil defensin 1 kill Candida albicans via shared pathways
    M Edgerton
    Departments of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Antimicrob Agents Chemother 44:3310-6. 2000
    ....
  10. ncbi request reprint Candidacidal activity of salivary histatins. Identification of a histatin 5-binding protein on Candida albicans
    M Edgerton
    Department of Oral Biology, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 273:20438-47. 1998
    ..albicans Hst 5-binding protein provides further insight into the potential mechanism of yeast killing and suggests a basis for differential activity between yeast killing and the nontoxic nature of Hsts to humans...
  11. ncbi request reprint Genetically engineered human salivary histatin genes are functional in Candida albicans: development of a new system for studying histatin candidacidal activity
    D Baev
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo Main Street Campus, 3435 Main Street, Buffalo, NY 14214, USA
    Microbiology 147:3323-34. 2001
    ..By employing a codon-optimization strategy it was shown that expression of heterologous sequences in C. albicans can be a useful tool for functional studies...
  12. pmc New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome
    H R Conti
    Department of Oral Biology, University at Buffalo, SUNY, Buffalo, New York, USA
    Mucosal Immunol 4:448-55. 2011
    ..This is the first demonstration that HIES is associated with defective salivary activity, and provides a mechanism for the severe susceptibility of these patients to OPC...
  13. ncbi request reprint Delineation of an active fragment and poly(L-proline) II conformation for candidacidal activity of bactenecin 5
    P A Raj
    Department of Oral Biology, State University of New York at Buffalo, 14214, USA
    Biochemistry 35:4314-25. 1996
    ..Our results suggest that poly(L-proline) type II structure may, indeed, be the biologically active conformation for candidacidal activity of bactenecin peptides...
  14. ncbi request reprint Candida albicans cell wall ssa proteins bind and facilitate import of salivary histatin 5 required for toxicity
    Xuewei S Li
    Department of Oral Biology and Restorative Dentistry, School of Dental Medicine, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 281:22453-63. 2006
    ..Thus, C. albicans Ssa2p facilitates fungicidal activity of Hst 5 in binding and intracellular translocation, whereas Ssa1p appears to have a lesser functional role in Hst 5 toxicity...
  15. pmc Human salivary histatin 5 causes disordered volume regulation and cell cycle arrest in Candida albicans
    Didi Baev
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, 14214, USA
    Infect Immun 70:4777-84. 2002
    ..This novel process of fungicidal activity by a human salivary protein has highlighted potential interactions of Hst 5 with volume regulatory mechanisms and the process of yeast cell cycle control...
  16. pmc Killing of Candida albicans by human salivary histatin 5 is modulated, but not determined, by the potassium channel TOK1
    Didi Baev
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, 14214, USA
    Infect Immun 71:3251-60. 2003
    ....
  17. ncbi request reprint Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5
    Xuewei S Li
    Department of Oral Biology and Restorative Dentistry, School of Dental Medicine, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 278:28553-61. 2003
    ..This study provides evidence for a novel function for yeast Ssa1/2 proteins as cell envelope binding receptors for Hst 5 that mediate fungicidal activity...
  18. pmc Human salivary histatin 5 fungicidal action does not induce programmed cell death pathways in Candida albicans
    David Wunder
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Antimicrob Agents Chemother 48:110-5. 2004
    ..We conclude that ROS may not play a direct role in fungicidal activity and that Hst 5 does not initiate apoptosis or programmed cell death pathways...
  19. ncbi request reprint The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5
    Didi Baev
    Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, NY 14214, USA
    J Biol Chem 279:55060-72. 2004
    ..albicans...
  20. pmc Human beta-defensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruption
    Slavena Vylkova
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Antimicrob Agents Chemother 51:154-61. 2007
    ....
  21. pmc The P-113 fragment of histatin 5 requires a specific peptide sequence for intracellular translocation in Candida albicans, which is independent of cell wall binding
    Woong Sik Jang
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Antimicrob Agents Chemother 52:497-504. 2008
    ....
  22. pmc Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway
    Slavena Vylkova
    Department of Oral Biology, SUNY at Buffalo Main Street Campus, Buffalo, NY 14214, USA
    Eukaryot Cell 6:1876-88. 2007
    ..The HOG stress response pathway likely represents a significant and effective challenge to physiological levels of Hst 5 and other toxic peptides in fungal cells...
  23. pmc Distinct antifungal mechanisms: beta-defensins require Candida albicans Ssa1 protein, while Trk1p mediates activity of cysteine-free cationic peptides
    Slavena Vylkova
    Department of Oral Biology, School of Dental Medicine, 310 Foster Hall, State University of New York at Buffalo, Main Street Campus, 3435 Main Street, Buffalo, New York 14214, USA
    Antimicrob Agents Chemother 50:324-31. 2006
    ..These results demonstrate that (i) Trk1p mediates candidacidal activities of cysteine-free peptides, but not of defensins, and (ii) hBD-2 and hBD-3, but not HNP-1, require Ssa1/2p for antifungal activity...

Research Grants15

  1. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2000
    ..These studies will contribute to characterization of novel intracellular pathways utilized by Hst to cause yeast cell death and lead to further understanding of the role of ATP efflux as a cell regulatory or signaling process. ..
  2. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2009
    ..albicans. The proposed experiments will be accomplished during the final year of the parent grant and accelerate the tempo of our research by generating new data for additional publications and a new research project. ..
  3. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2009
    ..Objectives of this proposal are to design salt-insensitive peptides that selectively target yeast cells as oral therapeutic agents for candidiasis. ..
  4. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2007
    ..albicans microarray analysis. An understanding of the mechanism of Hst 5-induced killing and the nature of its specificity for yeast cells over human cells will contribute to future development of improved antifungal drugs. ..
  5. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2006
    ..albicans microarray analysis. An understanding of the mechanism of Hst 5-induced killing and the nature of its specificity for yeast cells over human cells will contribute to future development of improved antifungal drugs. ..
  6. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2005
    ..albicans microarray analysis. An understanding of the mechanism of Hst 5-induced killing and the nature of its specificity for yeast cells over human cells will contribute to future development of improved antifungal drugs. ..
  7. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2004
    ..albicans microarray analysis. An understanding of the mechanism of Hst 5-induced killing and the nature of its specificity for yeast cells over human cells will contribute to future development of improved antifungal drugs. ..
  8. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2003
    ..These studies will contribute to characterization of novel intracellular pathways utilized by Hst to cause yeast cell death and lead to further understanding of the role of ATP efflux as a cell regulatory or signaling process. ..
  9. HISTATIN RECEPTORS AS DRUG TARGETS FOR ORAL CANDIDIASIS
    Mira Edgerton; Fiscal Year: 2003
    ..This award would provide her the opportunity to extend her background in yeast biology to the molecular level and apply this new expertise to studies of virulence and pathogenesis of oral and systemic candidiasis. ..
  10. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2002
    ..These studies will contribute to characterization of novel intracellular pathways utilized by Hst to cause yeast cell death and lead to further understanding of the role of ATP efflux as a cell regulatory or signaling process. ..
  11. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2001
    ..These studies will contribute to characterization of novel intracellular pathways utilized by Hst to cause yeast cell death and lead to further understanding of the role of ATP efflux as a cell regulatory or signaling process. ..
  12. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2001
    ..These studies will contribute to characterization of novel intracellular pathways utilized by Hst to cause yeast cell death and lead to further understanding of the role of ATP efflux as a cell regulatory or signaling process. ..
  13. Supplements to Support Candida DNA Microarray Facilities
    Mira Edgerton; Fiscal Year: 2000
    ..These studies will contribute to characterization of novel intracellular pathways utilized by Hst to cause yeast cell death and lead to further understanding of the role of ATP efflux as a cell regulatory or signaling process. ..
  14. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2010
    ..Objectives of this proposal are to design salt-insensitive peptides that selectively target yeast cells as oral therapeutic agents for candidiasis. ..