A Eddy

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy
    Guoqiang Zhang
    Children s Hospital and Regional Medical Center, Division of Nephrology, University of Washington, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    J Am Soc Nephrol 14:1234-53. 2003
  2. ncbi request reprint Interstitial fibrosis in hypercholesterolemic rats: role of oxidation, matrix synthesis, and proteolytic cascades
    A A Eddy
    Hospital for Sick Children, Toronto, Ontario, Canada
    Kidney Int 53:1182-9. 1998
  3. ncbi request reprint Interstitial fibrosis in mice with overload proteinuria: deficiency of TIMP-1 is not protective
    A A Eddy
    the Children s Hospital and Regional Medical Center, University of Washington, Seattle 98105, USA
    Kidney Int 58:618-28. 2000
  4. ncbi request reprint Molecular basis of renal fibrosis
    A A Eddy
    Children s Hospital and Regional Medical Center, Division of Nephrology, University of Washington, CH 46, 4800 Sand Point Way, NE, Seattle, WA 98105 0371, USA
    Pediatr Nephrol 15:290-301. 2000
  5. ncbi request reprint Role of cellular infiltrates in response to proteinuria
    A Eddy
    Children s Hospital and Regional Medical Center, University of Washington, Seattle, WA, USA
    Am J Kidney Dis 37:S25-9. 2001
  6. pmc An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes
    L Zhang
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 15:6961-70. 1995
  7. ncbi request reprint Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice
    Shunya Matsuo
    Children s Hospital and Regional Medical Center and Department of Pediatrics, University of Washington, Seattle, Washington 98105, USA
    Kidney Int 67:2221-38. 2005
  8. ncbi request reprint Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals
    Guoqiang Zhang
    Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Division of Nephrology, Mail Stop M1 5, Seattle, WA 98105, USA
    J Am Soc Nephrol 18:846-59. 2007
  9. ncbi request reprint Endogenous urokinase lacks antifibrotic activity during progressive renal injury
    Ikuyo Yamaguchi
    Department of Pediatrics, Children s Hospital and Regional Medical Center, University of Washington, Seattle, WA 98105 0371, USA
    Am J Physiol Renal Physiol 293:F12-9. 2007
  10. ncbi request reprint Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury
    Daryl M Okamura
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, 4800 Sand Point Way NE, Seattle WA 98015, USA
    Am J Physiol Renal Physiol 293:F575-85. 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy
    Guoqiang Zhang
    Children s Hospital and Regional Medical Center, Division of Nephrology, University of Washington, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    J Am Soc Nephrol 14:1234-53. 2003
    ....
  2. ncbi request reprint Interstitial fibrosis in hypercholesterolemic rats: role of oxidation, matrix synthesis, and proteolytic cascades
    A A Eddy
    Hospital for Sick Children, Toronto, Ontario, Canada
    Kidney Int 53:1182-9. 1998
    ..Based on changes in renal gene expression at the mRNA level, impaired matrix protein synthesis and increased intrarenal activity of the metalloproteinases and uPA/plasmin may play a role in the attenuation of fibrosis...
  3. ncbi request reprint Interstitial fibrosis in mice with overload proteinuria: deficiency of TIMP-1 is not protective
    A A Eddy
    the Children s Hospital and Regional Medical Center, University of Washington, Seattle 98105, USA
    Kidney Int 58:618-28. 2000
    ....
  4. ncbi request reprint Molecular basis of renal fibrosis
    A A Eddy
    Children s Hospital and Regional Medical Center, Division of Nephrology, University of Washington, CH 46, 4800 Sand Point Way, NE, Seattle, WA 98105 0371, USA
    Pediatr Nephrol 15:290-301. 2000
    ..During this time the tubules and peritubular capillaries are obliterated. The number of intact nephrons progressively declines resulting in a continuous reduction in glomerular filtration...
  5. ncbi request reprint Role of cellular infiltrates in response to proteinuria
    A Eddy
    Children s Hospital and Regional Medical Center, University of Washington, Seattle, WA, USA
    Am J Kidney Dis 37:S25-9. 2001
    ..It is predicted that therapeutic interventions that dampen the interstitial inflammatory response will attenuate the renal fibrogenic response, preserving normal renal architecture and function...
  6. pmc An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes
    L Zhang
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 15:6961-70. 1995
    ..Thus, H-2Kk-Fli-1 transgenic mice may serve as a murine model for autoimmune disease in humans, such as systemic lupus erythematosus...
  7. ncbi request reprint Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice
    Shunya Matsuo
    Children s Hospital and Regional Medical Center and Department of Pediatrics, University of Washington, Seattle, Washington 98105, USA
    Kidney Int 67:2221-38. 2005
    ..PAI-1 is a multifunctional protein and the mechanisms that account for its profibrotic effects have not been fully elucidated...
  8. ncbi request reprint Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals
    Guoqiang Zhang
    Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Division of Nephrology, Mail Stop M1 5, Seattle, WA 98105, USA
    J Am Soc Nephrol 18:846-59. 2007
    ..Plasmin-induced ERK phosphorylation was enhanced in PAR-1-overexpressing tubular cells. These findings support important profibrotic roles for plasmin that include PAR-1-dependent ERK signaling and EMT induction...
  9. ncbi request reprint Endogenous urokinase lacks antifibrotic activity during progressive renal injury
    Ikuyo Yamaguchi
    Department of Pediatrics, Children s Hospital and Regional Medical Center, University of Washington, Seattle, WA 98105 0371, USA
    Am J Physiol Renal Physiol 293:F12-9. 2007
    ..Finally, these results highlight a significant organ-specific difference in basic fibrogenic pathways, as enhanced uPA activity has been reported to attenuate pulmonary and hepatic fibrosis...
  10. ncbi request reprint Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury
    Daryl M Okamura
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, 4800 Sand Point Way NE, Seattle WA 98015, USA
    Am J Physiol Renal Physiol 293:F575-85. 2007
    ..01). Strong tubular expression suggests that in addition to inflammatory interstitial cells, renal tubular scavenger receptors may help to orchestrate the inflammatory and fibrogenic pathways that are activated by oxLDL...
  11. ncbi request reprint Exogenous bone morphogenetic protein-7 fails to attenuate renal fibrosis in rats with overload proteinuria
    Yukiko Ikeda
    Children s Hospital and Regional Medical Center, University of Washington, Seattle, Wash 98105, USA
    Nephron Exp Nephrol 97:e123-35. 2004
    ..The present study was designed to investigate the effect of BMP-7 on interstitial fibrosis in the rat protein-overloaded model...
  12. ncbi request reprint Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy
    Guoqiang Zhang
    Division of Nephrology, University of Washington, Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    J Am Soc Nephrol 14:1254-71. 2003
    ..These data suggest that renal uPAR attenuates the fibrogenic response to renal injury, an outcome that is mediated in part by urokinase-dependent but plasminogen-independent functions...
  13. ncbi request reprint Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: actions of an alternative urokinase receptor and LDL receptor-related protein
    Guoqiang Zhang
    University of Washington, Children s Hospital and Regional Medical Center, Division of Nephrology, Seattle, WA 98105, USA
    J Am Soc Nephrol 15:2090-102. 2004
    ..Enhanced proliferation of uPAR-/- fibroblasts seems to be mediated by uPA-dependent ERK signaling via an alternative urokinase receptor...
  14. ncbi request reprint Plasminogen activator inhibitor-1 and the kidney
    Allison A Eddy
    Children s Hospital and Regional Medical Center, University of Washington, Seattle, Washington 98105, USA
    Am J Physiol Renal Physiol 283:F209-20. 2002
    ..An active area of present research interest, untold stories are likely to be uncovered soon...
  15. ncbi request reprint Plasminogen activator inhibitor-1 in chronic kidney disease: evidence and mechanisms of action
    Allison A Eddy
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, WA 98105, USA
    J Am Soc Nephrol 17:2999-3012. 2006
  16. ncbi request reprint Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice
    Sarah J Collins
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Wash, USA
    Nephron Exp Nephrol 104:e23-34. 2006
    ..Although increased intrarenal expression of PAI-1 is also a feature of diabetic nephropathy, evidence that PAI-1 plays a primary pathogenetic role in the renal pathology is lacking...
  17. ncbi request reprint Ramping up endogenous defences against chronic kidney disease
    Allison A Eddy
    Nephrol Dial Transplant 21:1174-7. 2006
  18. ncbi request reprint Progression in chronic kidney disease
    Allison A Eddy
    Division of Nephrology, University of Washington and Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Adv Chronic Kidney Dis 12:353-65. 2005
    ..Development of new therapeutic agents for CKD looks promising, but several agents that target different components of the fibrogenic cascade will almost certainly be necessary...
  19. ncbi request reprint Can renal fibrosis be reversed?
    Allison A Eddy
    Pediatr Nephrol 20:1369-75. 2005
    ..A powerful new molecular tool-box is at our disposal that can be used to begin to translate recent discoveries into the clinical research arena with the goal of reversing renal fibrosis in a functionally meaningful way...
  20. ncbi request reprint Proteinuria and interstitial injury
    Allison A Eddy
    Nephrol Dial Transplant 19:277-81. 2004
  21. pmc Urokinase and its receptors in chronic kidney disease
    Guoqiang Zhang
    University of Washington and Children s Hospital and Regional Medical Center, Division of Nephrology, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Front Biosci 13:5462-78. 2008
    ..Vitronectin and high molecular weight kininogen are alternate uPAR ligands, and receptors in addition to uPAR may also bind directly to uPA and activate cell signaling pathways...