JEFFREY EDBERG

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Cell type-specific glycoforms of Fc gamma RIIIa (CD16): differential ligand binding
    J C Edberg
    Department of Medicine, University of Alabama at Birmingham 35294, USA
    J Immunol 159:3849-57. 1997
  2. ncbi request reprint Differential regulation of human neutrophil FcgammaRIIa (CD32) and FcgammaRIIIb (CD16)-induced Ca2+ transients
    J C Edberg
    Division of Clinical Immunology and Rheumatology, Departments of Medicine and Microbiology, University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 273:8071-9. 1998
  3. ncbi request reprint The cytoplasmic domain of human FcgammaRIa alters the functional properties of the FcgammaRI.gamma-chain receptor complex
    J C Edberg
    Departments of Medicine and Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35209, USA
    J Biol Chem 274:30328-33. 1999
  4. ncbi request reprint The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosis
    Jeffrey C Edberg
    Departments of Medicine and Microbiology, The University of Alabama at Birmingham, 1530 3rd Avenue S, THT433A, Birmingham, AL 35294, USA
    J Biol Chem 277:41287-93. 2002
  5. ncbi request reprint Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus
    Jeffrey C Edberg
    University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Arthritis Rheum 46:2132-40. 2002
  6. doi request reprint Genetic variation in the CRP promoter: association with systemic lupus erythematosus
    Jeffrey C Edberg
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Hum Mol Genet 17:1147-55. 2008
  7. ncbi request reprint A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling
    Xiaoli Li
    University of Alabama at Birmingham, AL 35294 0006, USA
    Arthritis Rheum 48:3242-52. 2003
  8. ncbi request reprint Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients
    Ji Yih Chen
    Department of Medicine, Chang Gung Memorial Hospital, Taiwan, Republic of China
    Arthritis Rheum 54:3908-17. 2006
  9. pmc Variations in CCL3L gene cluster sequence and non-specific gene copy numbers
    Sadeep Shrestha
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, 1665 University Blvd, RPHB Room 217L, Birmingham, Alabama 35294 0022, USA
    BMC Res Notes 3:74. 2010
  10. pmc Time to renal disease and end-stage renal disease in PROFILE: a multiethnic lupus cohort
    Graciela S Alarcon
    Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Med 3:e396. 2006

Research Grants

  1. Genetic Polymorphisms in Wegener's Granulomatosis
    JEFFREY EDBERG; Fiscal Year: 2003

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Cell type-specific glycoforms of Fc gamma RIIIa (CD16): differential ligand binding
    J C Edberg
    Department of Medicine, University of Alabama at Birmingham 35294, USA
    J Immunol 159:3849-57. 1997
    ....
  2. ncbi request reprint Differential regulation of human neutrophil FcgammaRIIa (CD32) and FcgammaRIIIb (CD16)-induced Ca2+ transients
    J C Edberg
    Division of Clinical Immunology and Rheumatology, Departments of Medicine and Microbiology, University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 273:8071-9. 1998
    ..These data provide a mechanism for the functional differences between these two receptors and suggest the possibility that they can be differentially modulated...
  3. ncbi request reprint The cytoplasmic domain of human FcgammaRIa alters the functional properties of the FcgammaRI.gamma-chain receptor complex
    J C Edberg
    Departments of Medicine and Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35209, USA
    J Biol Chem 274:30328-33. 1999
    ..These results demonstrate a functional role for the CY of FcgammaRIa and provide a general model for understanding how multiple receptors that utilize the gamma-chain can generate diversity in function...
  4. ncbi request reprint The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosis
    Jeffrey C Edberg
    Departments of Medicine and Microbiology, The University of Alabama at Birmingham, 1530 3rd Avenue S, THT433A, Birmingham, AL 35294, USA
    J Biol Chem 277:41287-93. 2002
    ....
  5. ncbi request reprint Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus
    Jeffrey C Edberg
    University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Arthritis Rheum 46:2132-40. 2002
    ....
  6. doi request reprint Genetic variation in the CRP promoter: association with systemic lupus erythematosus
    Jeffrey C Edberg
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Hum Mol Genet 17:1147-55. 2008
    ..These data demonstrate that rs3093061 at the -707 site within the CRP gene is an SLE susceptibility locus...
  7. ncbi request reprint A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling
    Xiaoli Li
    University of Alabama at Birmingham, AL 35294 0006, USA
    Arthritis Rheum 48:3242-52. 2003
    ..The transmembrane domain of FcgammaRIIb may also contribute to receptor signaling. Therefore, we investigated the biologic significance of single-nucleotide polymorphisms (SNPs) throughout the coding region...
  8. ncbi request reprint Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients
    Ji Yih Chen
    Department of Medicine, Chang Gung Memorial Hospital, Taiwan, Republic of China
    Arthritis Rheum 54:3908-17. 2006
    ....
  9. pmc Variations in CCL3L gene cluster sequence and non-specific gene copy numbers
    Sadeep Shrestha
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, 1665 University Blvd, RPHB Room 217L, Birmingham, Alabama 35294 0022, USA
    BMC Res Notes 3:74. 2010
    ..These genes are involved in host defense and inflammatory processes. Several CNV assays have been developed for the CCL3L1 gene...
  10. pmc Time to renal disease and end-stage renal disease in PROFILE: a multiethnic lupus cohort
    Graciela S Alarcon
    Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Med 3:e396. 2006
    ..The purpose of this study was to determine the factors predicting the development of renal involvement and its progression to ESRD in a multi-ethnic SLE cohort (PROFILE)...
  11. pmc A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia
    Chandrika J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer 117:957-63. 2011
    ....
  12. ncbi request reprint Diversity and duplicity: human FCgamma receptors in host defense and autoimmunity
    Robert P Kimberly
    Department of Medicine and Microbiology, The University of Alabama at Birmingham, 35294 0006, USA
    Immunol Res 26:177-89. 2002
  13. ncbi request reprint A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus
    Kaihong Su
    Division of Clinical Immunology and Rheumatology, Departments of Medicine and Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 172:7186-91. 2004
    ..72; p = 0.0083). These results suggest that an expression variant of FCGR2B is a risk factor for human lupus and implicate FCGR2B in disease pathogenesis...
  14. ncbi request reprint Fc receptor genes and the systemic lupus erythematosus diathesis
    Elizabeth E Brown
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
    Autoimmunity 40:567-81. 2007
    ....
  15. pmc Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus
    Kaihong Su
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 178:3272-80. 2007
    ..Our studies demonstrate the constitutive regulation of FcgammaRIIb by natural gene polymorphisms and the acquired dysregulation in SLE autoimmunity, which may identify opportunities for using this receptor as a therapeutic target...
  16. ncbi request reprint A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expre
    Kaihong Su
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 172:7192-9. 2004
    ....
  17. pmc Pathways: Strategies for susceptibility genes in SLE
    James M Kelley
    Comprehensive Arthritis, Musculoskeletal, and Autoimmunity Center, Department of Medicine, University of Alabama at Birmingham, USA
    Autoimmun Rev 9:473-6. 2010
    ....
  18. pmc Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion
    Xinrui Li
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:1012-8. 2008
    ..These results provide a mechanism by which Fcgamma receptors can elevate circulating BLyS levels and promote autoantibody production in immune complex-mediated autoimmune diseases...
  19. ncbi request reprint A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patients
    Jianming Wu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294 0006, USA
    J Immunol 170:132-8. 2003
    ..This functionally significant SNP demonstrates the potential importance of SNPs in regulatory regions and suggests that differences in the regulation of FasL expression may contribute to the development of the autoimmune phenotype...
  20. ncbi request reprint FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA
    Jianming Wu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 1825 University Boulevard, Birmingham, AL 35294, USA
    J Immunol 178:3973-82. 2007
    ....
  21. ncbi request reprint Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain
    Hongwei Qin
    Department of Medicine, University of Alabama at Birmingham, 1900 University Boulevard, Birmingham, AL 35294 0006, USA
    J Immunol 173:6211-9. 2004
    ....
  22. pmc An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans
    James M Kelley
    University of Alabama at Birmingham, Birmingham, AL, USA
    PLoS Genet 5:e1000424. 2009
    ..An African ancestry-specific genetic variant of CTLA4 appears to be associated with protection from RA in African Americans. This finding may explain, in part, the relatively low prevalence of RA in black African populations...
  23. ncbi request reprint Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects
    James Kelley
    The University of Alabama at Birmingham, AL 35294, USA
    Arthritis Rheum 56:3375-8. 2007
    ....
  24. pmc Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort
    Sergio Durán
    University of Alabama at Birmingham, AL, USA
    Arthritis Rheum 59:1332-40. 2008
    ..To examine the clinical and genetic correlates of hemolytic anemia and its impact on damage accrual and mortality in systemic lupus erythematosus (SLE) patients...
  25. pmc Wegener's granulomatosis: a model of auto-antibodies in mucosal autoimmunity
    James M Kelley
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, USA
    Clin Immunol 134:104-12. 2010
    ..Given discrepancies in associating ANCA levels with disease activity, future work should determine if IgA ANCAs are present in WG patients and examine the biology underlying the ANCAs' signaling partners--the FcRs...
  26. ncbi request reprint Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins
    Sumiaki Tanaka
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 171:6090-6. 2003
    ..The greater activity of the FcgammaRIIIB-NA1 genotype may also explain the greater severity of disease and its flare-ups in patients with this allele...
  27. pmc Clinical and genetic risk factors for pneumonia in systemic lupus erythematosus
    Brent W Kinder
    Division of Rheumatology, University of California San Francisco, 374 Parnassus Avenue, San Francisco, CA 94143, USA
    Arthritis Rheum 56:2679-86. 2007
    ....
  28. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  29. ncbi request reprint The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA
    Arthritis Rheum 50:2750-6. 2004
    ..To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA)...

Research Grants5

  1. Genetic Polymorphisms in Wegener's Granulomatosis
    JEFFREY EDBERG; Fiscal Year: 2003
    ....