Research Topics
Species | JEFFREY EDBERGSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Detail Information
Publications
Cell type-specific glycoforms of Fc gamma RIIIa (CD16): differential ligand bindingJ C Edberg
Department of Medicine, University of Alabama at Birmingham 35294, USA
J Immunol 159:3849-57. 1997....- Differential regulation of human neutrophil FcgammaRIIa (CD32) and FcgammaRIIIb (CD16)-induced Ca2+ transientsJ C Edberg
Division of Clinical Immunology and Rheumatology, Departments of Medicine and Microbiology, University of Alabama, Birmingham, Alabama 35294, USA
J Biol Chem 273:8071-9. 1998..These data provide a mechanism for the functional differences between these two receptors and suggest the possibility that they can be differentially modulated... - The cytoplasmic domain of human FcgammaRIa alters the functional properties of the FcgammaRI.gamma-chain receptor complexJ C Edberg
Departments of Medicine and Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35209, USA
J Biol Chem 274:30328-33. 1999..These results demonstrate a functional role for the CY of FcgammaRIa and provide a general model for understanding how multiple receptors that utilize the gamma-chain can generate diversity in function... - The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosisJeffrey C Edberg
Departments of Medicine and Microbiology, The University of Alabama at Birmingham, 1530 3rd Avenue S, THT433A, Birmingham, AL 35294, USA
J Biol Chem 277:41287-93. 2002.... - Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosusJeffrey C Edberg
University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
Arthritis Rheum 46:2132-40. 2002.... 
Genetic variation in the CRP promoter: association with systemic lupus erythematosusJeffrey C Edberg
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
Hum Mol Genet 17:1147-55. 2008..These data demonstrate that rs3093061 at the -707 site within the CRP gene is an SLE susceptibility locus...- A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signalingXiaoli Li
University of Alabama at Birmingham, AL 35294 0006, USA
Arthritis Rheum 48:3242-52. 2003..The transmembrane domain of FcgammaRIIb may also contribute to receptor signaling. Therefore, we investigated the biologic significance of single-nucleotide polymorphisms (SNPs) throughout the coding region... - Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patientsJi Yih Chen
Department of Medicine, Chang Gung Memorial Hospital, Taiwan, Republic of China
Arthritis Rheum 54:3908-17. 2006.... 
Variations in CCL3L gene cluster sequence and non-specific gene copy numbersSadeep Shrestha
Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, 1665 University Blvd, RPHB Room 217L, Birmingham, Alabama 35294 0022, USA
BMC Res Notes 3:74. 2010..These genes are involved in host defense and inflammatory processes. Several CNV assays have been developed for the CCL3L1 gene...- Time to renal disease and end-stage renal disease in PROFILE: a multiethnic lupus cohortGraciela S Alarcon
Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS Med 3:e396. 2006..The purpose of this study was to determine the factors predicting the development of renal involvement and its progression to ESRD in a multi-ethnic SLE cohort (PROFILE)... - A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasiaChandrika J Piyathilake
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Cancer 117:957-63. 2011.... - Diversity and duplicity: human FCgamma receptors in host defense and autoimmunityRobert P Kimberly
Department of Medicine and Microbiology, The University of Alabama at Birmingham, 35294-0006, USA
Immunol Res 26:177-89. 2002 - A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosusKaihong Su
Division of Clinical Immunology and Rheumatology, Departments of Medicine and Microbiology, University of Alabama, Birmingham, AL 35294, USA
J Immunol 172:7186-91. 2004..72; p = 0.0083). These results suggest that an expression variant of FCGR2B is a risk factor for human lupus and implicate FCGR2B in disease pathogenesis... - Fc receptor genes and the systemic lupus erythematosus diathesisElizabeth E Brown
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
Autoimmunity 40:567-81. 2007.... - Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosusKaihong Su
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 178:3272-80. 2007..Our studies demonstrate the constitutive regulation of FcgammaRIIb by natural gene polymorphisms and the acquired dysregulation in SLE autoimmunity, which may identify opportunities for using this receptor as a therapeutic target... - A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expreKaihong Su
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
J Immunol 172:7192-9. 2004.... - Pathways: Strategies for susceptibility genes in SLEJames M Kelley
Comprehensive Arthritis, Musculoskeletal, and Autoimmunity Center, Department of Medicine, University of Alabama at Birmingham, USA
Autoimmun Rev 9:473-6. 2010.... - Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashionXinrui Li
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 181:1012-8. 2008..These results provide a mechanism by which Fcgamma receptors can elevate circulating BLyS levels and promote autoantibody production in immune complex-mediated autoimmune diseases... - A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patientsJianming Wu
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294 0006, USA
J Immunol 170:132-8. 2003..This functionally significant SNP demonstrates the potential importance of SNPs in regulatory regions and suggests that differences in the regulation of FasL expression may contribute to the development of the autoimmune phenotype... - FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgAJianming Wu
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 1825 University Boulevard, Birmingham, AL 35294, USA
J Immunol 178:3973-82. 2007.... - Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chainHongwei Qin
Department of Medicine, University of Alabama at Birmingham, 1900 University Boulevard, Birmingham, AL 35294 0006, USA
J Immunol 173:6211-9. 2004.... - An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African AmericansJames M Kelley
University of Alabama at Birmingham, Birmingham, AL, USA
PLoS Genet 5:e1000424. 2009..An African ancestry-specific genetic variant of CTLA4 appears to be associated with protection from RA in African Americans. This finding may explain, in part, the relatively low prevalence of RA in black African populations... - Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjectsJames Kelley
The University of Alabama at Birmingham, AL 35294, USA
Arthritis Rheum 56:3375-8. 2007.... - Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohortSergio Durán
University of Alabama at Birmingham, AL, USA
Arthritis Rheum 59:1332-40. 2008..To examine the clinical and genetic correlates of hemolytic anemia and its impact on damage accrual and mortality in systemic lupus erythematosus (SLE) patients... - Wegener's granulomatosis: a model of auto-antibodies in mucosal autoimmunityJames M Kelley
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, USA
Clin Immunol 134:104-12. 2010..Given discrepancies in associating ANCA levels with disease activity, future work should determine if IgA ANCAs are present in WG patients and examine the biology underlying the ANCAs' signaling partners--the FcRs... - Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxinsSumiaki Tanaka
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
J Immunol 171:6090-6. 2003..The greater activity of the FcgammaRIIIB-NA1 genotype may also explain the greater severity of disease and its flare-ups in patients with this allele... - Clinical and genetic risk factors for pneumonia in systemic lupus erythematosusBrent W Kinder
Division of Rheumatology, University of California San Francisco, 374 Parnassus Avenue, San Francisco, CA 94143, USA
Arthritis Rheum 56:2679-86. 2007.... - Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other lociJohn B Harley
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
Nat Genet 40:204-10. 2008..Our results show that numerous genes, some with known immune-related functions, predispose to SLE... - The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanerceptLindsey A Criswell
Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA
Arthritis Rheum 50:2750-6. 2004..To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA)...
Research Grants
- Genetic Polymorphisms in Wegener's GranulomatosisJEFFREY EDBERG; Fiscal Year: 2003....