David Eckmann

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Variations in epidural catheter manufacture: implications for bending and stiffness
    David M Eckmann
    Department of Anesthesia, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
    Reg Anesth Pain Med 28:37-42. 2003
  2. pmc Air bubble contact with endothelial cells causes a calcium-independent loss in mitochondrial membrane potential
    Peter Sobolewski
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e47254. 2012
  3. pmc Hyaluronan and dextran modified tubes resist cellular activation with blood contact
    David M Eckmann
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    Colloids Surf B Biointerfaces 108:44-51. 2013
  4. pmc Dynamic factors controlling targeting nanocarriers to vascular endothelium
    Vladimir R Muzykantov
    University of Pennsylvania, Philadelphia, PA 19104 4215, USA
    Curr Drug Metab 13:70-81. 2012
  5. pmc Polidocanol for endovenous microfoam sclerosant therapy
    David M Eckmann
    University of Pennsylvania, 331 John Morgan Building 6112, 3620 Hamilton Walk, Philadelphia, PA 19104 4215, USA
    Expert Opin Investig Drugs 18:1919-27. 2009
  6. ncbi request reprint Gas embolism and surfactant-based intervention: implications for long-duration space-based activity
    David M Eckmann
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 1077:256-69. 2006
  7. ncbi request reprint Influence of endothelial glycocalyx degradation and surfactants on air embolism adhesion
    David M Eckmann
    Department of Anesthesiology and Critical Care, Institute for Medicine and Engineering, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 105:1220-7. 2006
  8. ncbi request reprint Surfactants reduce platelet-bubble and platelet-platelet binding induced by in vitro air embolism
    David M Eckmann
    Department of Anesthesiology and Critical Care and Institute for Medicine and Engineering, The University of Pennsylvania, 3400 Spruce Street, HUP, Philadelphia, PA 19104, USA
    Anesthesiology 103:1204-10. 2005
  9. ncbi request reprint Microvascular embolization following polidocanol microfoam sclerosant administration
    David M Eckmann
    Department of Anestthesia, The University of Pennsylvania, PA 19104, USA
    Dermatol Surg 31:636-43. 2005
  10. ncbi request reprint Surfactants attenuate gas embolism-induced thrombin production
    David M Eckmann
    Department of Anesthesia and the Institute for Medicine and Engineering, University of Pennsylvania, Philadephia, 19104, USA
    Anesthesiology 100:77-84. 2004

Research Grants

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Variations in epidural catheter manufacture: implications for bending and stiffness
    David M Eckmann
    Department of Anesthesia, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
    Reg Anesth Pain Med 28:37-42. 2003
    ..We analyzed catheter bending stiffness to determine the range of stiffness of catheters commonly used. We hypothesized that catheter material has a greater influence on stiffness than does cross-sectional shape...
  2. pmc Air bubble contact with endothelial cells causes a calcium-independent loss in mitochondrial membrane potential
    Peter Sobolewski
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e47254. 2012
    ..Here, we investigate the mitochondrial consequences of air bubble contact with endothelial cells...
  3. pmc Hyaluronan and dextran modified tubes resist cellular activation with blood contact
    David M Eckmann
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    Colloids Surf B Biointerfaces 108:44-51. 2013
    ..Based on our findings, we suggest that surface coating with hyaluronic acid or dextran acts as a potent shield from blood cellular activation during forms of extracorporeal circulation...
  4. pmc Dynamic factors controlling targeting nanocarriers to vascular endothelium
    Vladimir R Muzykantov
    University of Pennsylvania, Philadelphia, PA 19104 4215, USA
    Curr Drug Metab 13:70-81. 2012
    ..This article reviews experimental and computational approaches for analysis of factors modulating targeting nanocarriers to the endothelial cells...
  5. pmc Polidocanol for endovenous microfoam sclerosant therapy
    David M Eckmann
    University of Pennsylvania, 331 John Morgan Building 6112, 3620 Hamilton Walk, Philadelphia, PA 19104 4215, USA
    Expert Opin Investig Drugs 18:1919-27. 2009
    ..Polidocanol is a liquid surfactant having endothelial cell lytic properties. In the form of a controlled, dispensed microfoam it is administered endovenously as a sclerosing agent in the treatment of varicose veins...
  6. ncbi request reprint Gas embolism and surfactant-based intervention: implications for long-duration space-based activity
    David M Eckmann
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 1077:256-69. 2006
    ..Special consideration is given to modeling the transport and hydrodynamic interactions associated with surfactant-based intervention...
  7. ncbi request reprint Influence of endothelial glycocalyx degradation and surfactants on air embolism adhesion
    David M Eckmann
    Department of Anesthesiology and Critical Care, Institute for Medicine and Engineering, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 105:1220-7. 2006
    ..The authors tested the hypothesis that exogenous surfactants delivered intravascularly have differential effects on the rate of restoration of blood flow after heparinase-induced degradation of the endothelial glycocalyx...
  8. ncbi request reprint Surfactants reduce platelet-bubble and platelet-platelet binding induced by in vitro air embolism
    David M Eckmann
    Department of Anesthesiology and Critical Care and Institute for Medicine and Engineering, The University of Pennsylvania, 3400 Spruce Street, HUP, Philadelphia, PA 19104, USA
    Anesthesiology 103:1204-10. 2005
    ..The effect of gas bubbles on platelet behavior is poorly characterized. The authors assessed platelet-bubble and platelet-platelet binding in platelet-rich plasma in the presence and absence of bubbles and three surface-active compounds...
  9. ncbi request reprint Microvascular embolization following polidocanol microfoam sclerosant administration
    David M Eckmann
    Department of Anestthesia, The University of Pennsylvania, PA 19104, USA
    Dermatol Surg 31:636-43. 2005
    ..Intravenous microfoam sclerotherapy solutions can potentially cause cerebrovascular arterial embolization...
  10. ncbi request reprint Surfactants attenuate gas embolism-induced thrombin production
    David M Eckmann
    Department of Anesthesia and the Institute for Medicine and Engineering, University of Pennsylvania, Philadephia, 19104, USA
    Anesthesiology 100:77-84. 2004
    ..The authors conducted experiments to measure thrombin production in sheared whole blood in the presence and absence of bubbles and three surface-active compounds...
  11. ncbi request reprint Microvascular gas embolization clearance following perfluorocarbon administration
    David M Eckmann
    Department of Anesthesia and Institute for Medicine and Engineering, The University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    J Appl Physiol (1985) 94:860-8. 2003
    ..These dynamic events did not occur if embolization preceded fluorocarbon administration...
  12. ncbi request reprint Accelerated arteriolar gas embolism reabsorption by an exogenous surfactant
    Annette B Branger
    Department of Anesthesia and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 96:971-9. 2002
    ....
  13. ncbi request reprint Numerical modeling of the transport to an intravascular bubble in a tube with a soluble/insoluble surfactant
    Portonovo S Ayyaswamy
    Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104 6315, USA
    Ann N Y Acad Sci 1077:270-87. 2006
    ..For identical surface concentrations of the surfactant, the effect of the presence of a soluble surfactant is more severe on the retardation of the bubble motion than that of an insoluble surfactant...
  14. pmc Imaging macromolecular interactions at an interface
    Joshua W Lampe
    Center for Resuscitation Science, Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Langmuir 26:2452-9. 2010
    ....
  15. pmc Creating biomimetic polymeric surfaces by photochemical attachment and patterning of dextran
    M Carme Coll Ferrer
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6202, USA
    Langmuir 26:14126-34. 2010
    ..The antifouling properties of dextran functionalized surfaces were verified by the selective adsorption of FITC-labeled human albumin only on the nondextranized regions of the patterned polyurethane and polystyrene substrates...
  16. ncbi request reprint Clinical application of acoustic reflectometry in predicting the difficult airway
    E Andrew Ochroch
    Department of Anesthesiology, University of Pennsylvania Health System, 416C Ravdin Court, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Anesth Analg 95:645-9, table of contents. 2002
    ..2 mL) would predict absolute inability to intubate. We conclude that by use of acoustic reflectometry, there was no relationship between inability to intubate, poor glottic visualization, and multiple laryngoscopies with airway volume...
  17. ncbi request reprint A quantitative and selective chromatography method for determining coverages of multiple proteins on surfaces
    Michela Ombelli
    Department of Anesthesia, University of Pennsylvania, 319B John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 826:198-205. 2005
    ..Relative to silicon, the dextranized surfaces were found to strongly inhibit protein adsorption, decreasing BSA and Fg coverages by 76 and 60%, respectively...
  18. pmc Finite-sized gas bubble motion in a blood vessel: non-Newtonian effects
    Karthik Mukundakrishnan
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 78:036303. 2008
    ....
  19. pmc Numerical study of wall effects on buoyant gas-bubble rise in a liquid-filled finite cylinder
    Karthik Mukundakrishnan
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 76:036308. 2007
    ..The paper includes figures of bubble shape regimes for various values of R*, Eo, Mo, and ReT. Our predictions agree with existing results reported in the literature...
  20. ncbi request reprint Dextran functionalized surfaces via reductive amination: morphology, wetting, and adhesion
    Davide Miksa
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, 19104, USA
    Biomacromolecules 7:557-64. 2006
    ..Overall, film morphology and wetting behavior were relatively invariant with grafting density, confirming the method's robustness for preparing biomimetic coatings with consistent properties...
  21. ncbi request reprint Model predictions of gas embolism growth and reabsorption during xenon anesthesia
    Naomi Sta Maria
    Department of Biomedical Engineering, Univeristy of Pennsylvania, Philadelphia, 19104, USA
    Anesthesiology 99:638-45. 2003
    ..The authors used a computational model based on the physics of gas exchange to predict cerebrovascular embolism behavior during xenon anesthesia...
  22. ncbi request reprint A guest molecule-host cavity fitting algorithm to mine PDB for small molecule targets
    William C Byrem
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Biochim Biophys Acta 1764:1320-4. 2006
    ..Proteins with large numbers of such cavities are more likely to be functionally altered by halothane...
  23. pmc Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments
    Jin Liu
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:16530-5. 2010
    ..Hence, our computational protocol represents a quantitative and predictive approach for model-driven design and optimization of functionalized nanocarriers in targeted vascular drug delivery...
  24. pmc Bubble motion through a generalized power-law fluid flowing in a vertical tube
    Karthik Mukundakrishnan
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann N Y Acad Sci 1161:256-67. 2009
    ..Results show that at low shear rates, for a given pressure gradient the residence time for a non-Newtonian flow is higher than that for a Newtonian flow...
  25. pmc Mechanotransductional basis of endothelial cell response to intravascular bubbles
    Alexandra L Klinger
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    Integr Biol (Camb) 3:1033-42. 2011
    ....
  26. pmc Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores
    Peter Sobolewski
    Dept of Anesthesiology and Critical Care, Univ of Pennsylvania, Philadelphia, 19104 4283, USA
    Am J Physiol Cell Physiol 301:C679-86. 2011
    ....
  27. ncbi request reprint Regarding "Stroke after varicose vein foam injection sclerotherapy"
    David M Eckmann
    J Vasc Surg 44:225; author reply 225-6. 2006
  28. ncbi request reprint Dose- and time-dependent liquid sclerosant effects on endothelial cell death
    Shunji Kobayashi
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Dermatol Surg 32:1444-52. 2006
    ..Intravenous sclerotherapy solutions can induce endothelial cell death...
  29. ncbi request reprint Embolism bubble adhesion force in excised perfused microvessels
    Akira Suzuki
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Anesthesiology 99:400-8. 2003
    ..The authors conducted experiments to measure the adhesion force of bubbles contacting the vessel wall...
  30. ncbi request reprint Surfactant reduction in embolism bubble adhesion and endothelial damage
    Akira Suzuki
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Anesthesiology 101:97-103. 2004
    ..The authors measured bubble adhesion force using excised microvessels. They assessed endothelial damage by measuring vessel reactivity and with microscopy...
  31. ncbi request reprint Air bubble growth in water
    David M Eckmann
    Anesthesiology 105:1059; author reply 1059-60. 2006

Research Grants23

  1. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 1999
    ..By examining the fundamental effects of gas embolism bubbles, the proposed experiments will direct us to new clinical strategies for treatment or prevention of gas embolism. ..
  2. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2006
    ..The only clinical alternative is hyperbaric therapy, which requires patient transport to a chamber for postembolism treatment, and is therefore generally used only in catastrophic cases. ..
  3. Activation of clotting & cell adhesion: gas embolism
    David Eckmann; Fiscal Year: 2009
    ..This work is the basis for neuroprotection in gas embolism-induced stroke, a persistent, growing health threat without treatment. ..
  4. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2009
    ..The development of biomimetic surface coatings is a powerful method to increase medical device biocompatibility. ..
  5. Targeted microcarrier design and optimization
    David Eckmann; Fiscal Year: 2009
    ..This work to characterize quantitatively and predict computationally the binding mechanics and dynamics for nanocarrier binding to endothelial cells will lead to improvements in therapeutics for many diseases. ..
  6. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David M Eckmann; Fiscal Year: 2010
    ..The development of biomimetic surface coatings is a powerful method to increase medical device biocompatibility. ..
  7. Targeted microcarrier design and optimization
    David M Eckmann; Fiscal Year: 2010
    ..This work to characterize quantitatively and predict computationally the binding mechanics and dynamics for nanocarrier binding to endothelial cells will lead to improvements in therapeutics for many diseases. ..
  8. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2005
    ..The only clinical alternative is hyperbaric therapy, which requires patient transport to a chamber for postembolism treatment, and is therefore generally used only in catastrophic cases. ..
  9. Activation of Clotting & cell adhesion : gas embolism
    David Eckmann; Fiscal Year: 2005
    ..abstract_text> ..
  10. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2004
    ..The only clinical alternative is hyperbaric therapy, which requires patient transport to a chamber for postembolism treatment, and is therefore generally used only in catastrophic cases. ..
  11. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2000
    ..By examining the fundamental effects of gas embolism bubbles, the proposed experiments will direct us to new clinical strategies for treatment or prevention of gas embolism. ..
  12. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2001
    ..By examining the fundamental effects of gas embolism bubbles, the proposed experiments will direct us to new clinical strategies for treatment or prevention of gas embolism. ..
  13. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2000
    ..By examining the fundamental effects of gas embolism bubbles, the proposed experiments will direct us to new clinical strategies for treatment or prevention of gas embolism. ..
  14. Activation of Clotting & cell adhesion : gas embolism
    David Eckmann; Fiscal Year: 2002
    ..abstract_text> ..
  15. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2002
    ..By examining the fundamental effects of gas embolism bubbles, the proposed experiments will direct us to new clinical strategies for treatment or prevention of gas embolism. ..
  16. Activation of Clotting & cell adhesion : gas embolism
    David Eckmann; Fiscal Year: 2002
    ..abstract_text> ..
  17. Activation of Clotting & cell adhesion : gas embolism
    David Eckmann; Fiscal Year: 2003
    ..abstract_text> ..
  18. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2003
    ..The only clinical alternative is hyperbaric therapy, which requires patient transport to a chamber for postembolism treatment, and is therefore generally used only in catastrophic cases. ..
  19. Activation of Clotting & cell adhesion : gas embolism
    David Eckmann; Fiscal Year: 2004
    ..abstract_text> ..
  20. Activation of clotting & cell adhesion: gas embolism
    David M Eckmann; Fiscal Year: 2010
    ..This work is the basis for neuroprotection in gas embolism-induced stroke, a persistent, growing health threat without treatment. ..