Robert Eckel

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Skeletal muscle munc18c and syntaxin 4 in human obesity
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Aurora, CO, USA
    Nutr Metab (Lond) 5:21. 2008
  2. ncbi The metabolic syndrome
    Robert H Eckel
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    Lancet 365:1415-28. 2005
  3. ncbi Preventive cardiology by lifestyle intervention: opportunity and/or challenge? Presidential address at the 2005 American Heart Association Scientific Sessions
    Robert H Eckel
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
    Circulation 113:2657-61. 2006
  4. ncbi Carbohydrate balance predicts weight and fat gain in adults
    Robert H Eckel
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    Am J Clin Nutr 83:803-8. 2006
  5. ncbi Obesity research in the next decade
    R H Eckel
    Department of Physiology and Biophysics, University of Colorado Denver, Aurora, CO 80045, USA
    Int J Obes (Lond) 32:S143-51. 2008
  6. ncbi Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on the pathophysiology of obesity-associated cardiovascular disease
    Robert H Eckel
    University of Colorado Health Sciences Center, Denver, USA
    Circulation 105:2923-8. 2002
  7. ncbi Clinical practice. Nonsurgical management of obesity in adults
    Robert H Eckel
    Division of Endocrinology, Metabolism, and Diabetes and the Division of Cardiology, University of Colorado Denver, Aurora, CO 80045, USA
    N Engl J Med 358:1941-50. 2008
  8. ncbi Obesity
    Robert H Eckel
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver, Health Sciences Center, Denver, CO, USA
    Circulation 111:e257-9. 2005
  9. ncbi Mechanisms of the components of the metabolic syndrome that predispose to diabetes and atherosclerotic CVD
    Robert H Eckel
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS8106, Aurora, Colorado 80045, USA
    Proc Nutr Soc 66:82-95. 2007
  10. ncbi Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women
    Marc-Andre Cornier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Obes Res 13:703-9. 2005

Research Grants

  1. NUTRITION, LIPOPROTEIN LIPASE AND BODY WEIGHT REGULATION
    Robert Eckel; Fiscal Year: 1992
  2. TISSUE SPECIFIC REGULATION OF LIPOPROTEIN LIPASE
    Robert Eckel; Fiscal Year: 2001
  3. TISSUE SPECIFIC REGULATION OF LIPOPROTEIN LIPASE
    Robert Eckel; Fiscal Year: 2004
  4. Kern Aspen Lipid Conference 2002
    Robert Eckel; Fiscal Year: 2002
  5. LIPOPROTEIN LIPASE, NUTRITION AND NERVE MYELINATION
    Robert Eckel; Fiscal Year: 2003
  6. Mechanisms Defending Fat Mass in Human after Lipectomy
    Robert Eckel; Fiscal Year: 2007
  7. TISSUE SPECIFIC REGULATION OF LIPOPROTEIN LIPASE
    Robert Eckel; Fiscal Year: 1993
  8. HORMONAL CONTROL OF ADIPOSE TISSUE LIPOPROTEIN LIPASE
    Robert Eckel; Fiscal Year: 1990

Detail Information

Publications81

  1. ncbi Skeletal muscle munc18c and syntaxin 4 in human obesity
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Aurora, CO, USA
    Nutr Metab (Lond) 5:21. 2008
    ..Animal and cell culture data suggest a critical role for Munc18c and Syntaxin 4 proteins in insulin mediated glucose transport in skeletal muscle, but no studies have been published in humans...
  2. ncbi The metabolic syndrome
    Robert H Eckel
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    Lancet 365:1415-28. 2005
    ..The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction...
  3. ncbi Preventive cardiology by lifestyle intervention: opportunity and/or challenge? Presidential address at the 2005 American Heart Association Scientific Sessions
    Robert H Eckel
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
    Circulation 113:2657-61. 2006
  4. ncbi Carbohydrate balance predicts weight and fat gain in adults
    Robert H Eckel
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    Am J Clin Nutr 83:803-8. 2006
    ..The prevention and treatment of obesity is a public health challenge...
  5. ncbi Obesity research in the next decade
    R H Eckel
    Department of Physiology and Biophysics, University of Colorado Denver, Aurora, CO 80045, USA
    Int J Obes (Lond) 32:S143-51. 2008
    ..Communication between scientists and physicians at the far end of the spectrum needs new and ongoing emphasis...
  6. ncbi Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on the pathophysiology of obesity-associated cardiovascular disease
    Robert H Eckel
    University of Colorado Health Sciences Center, Denver, USA
    Circulation 105:2923-8. 2002
  7. ncbi Clinical practice. Nonsurgical management of obesity in adults
    Robert H Eckel
    Division of Endocrinology, Metabolism, and Diabetes and the Division of Cardiology, University of Colorado Denver, Aurora, CO 80045, USA
    N Engl J Med 358:1941-50. 2008
  8. ncbi Obesity
    Robert H Eckel
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver, Health Sciences Center, Denver, CO, USA
    Circulation 111:e257-9. 2005
  9. ncbi Mechanisms of the components of the metabolic syndrome that predispose to diabetes and atherosclerotic CVD
    Robert H Eckel
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS8106, Aurora, Colorado 80045, USA
    Proc Nutr Soc 66:82-95. 2007
    ..In general, the greater the number of metabolic syndrome components, the greater the risk for these outcomes. The cytokines and pro-thrombotic factors also appear to contribute...
  10. ncbi Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women
    Marc-Andre Cornier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Obes Res 13:703-9. 2005
    ..For maximal benefit, the macronutrient composition of a hypocaloric diet may need to be adjusted to correspond to the state of Si...
  11. ncbi Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues
    Hong Wang
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA
    Diabetes 58:116-24. 2009
    ..Skeletal muscle-specific LPL knockout mouse (SMLPL(-/-)) were created to study the systemic impact of reduced lipoprotein lipid delivery in skeletal muscle on insulin sensitivity, body weight, and composition...
  12. ncbi Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet
    Teri L Hernandez
    University of Colorado, Aurora, CO, USA
    Am J Clin Nutr 91:578-85. 2010
    ..Little is known about the comparative effect of weight-loss diets on metabolic profiles during dieting...
  13. ncbi Intramuscular lipid metabolism in the insulin resistance of smoking
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Diabetes 58:2220-7. 2009
    ..We hypothesized smokers would have increased intramuscular triglyceride (IMTG) and diacylglycerol (DAG) concentration and decreased fractional synthesis rate (FSR) compared with nonsmokers...
  14. ncbi Impact of diet-induced weight loss on the cardiac autonomic nervous system in severe obesity
    Paul Poirier
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Obes Res 11:1040-7. 2003
    ....
  15. ncbi Lipoprotein subfraction cholesterol distribution is proatherogenic in women with type 1 diabetes and insulin resistance
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 59:1771-9. 2010
    ..We investigated differences in lipoprotein subfraction cholesterol distribution and insulin resistance between subjects with and without type 1 diabetes to better understand the etiology of increased CVD risk...
  16. ncbi Total energy expenditure and carbohydrate oxidation are increased in the human immunodeficiency virus lipodystrophy syndrome
    Lisa A Kosmiski
    Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Metabolism 52:620-5. 2003
    ..The increase in TEE appears to be due to increases in REE. The pathogenesis of elevated EE in HIV lipodystrophy and other forms of lipodystrophy remains to be determined...
  17. ncbi Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    J Appl Physiol 108:1134-41. 2010
    ..Increased synthesis rates are not due to recovery from exercise and are likely adaptations to chronic endurance exercise training...
  18. ncbi Plasma alpha-melanocyte-stimulating hormone: sex differences and correlations with obesity
    William T Donahoo
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Denver, P O Box 6511, Aurora, CO 80045, USA
    Metabolism 58:16-21. 2009
    ..The lack of correlation between peripheral alpha-MSH and parameters of adiposity suggests that endogenous plasma alpha-MSH levels are not a metric for body composition per se...
  19. ncbi Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle
    Leslie K Pulawa
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA
    J Lipid Res 48:145-51. 2007
    ..Furthermore, the decrease of LPL activity in the heart, along with the inhibitory effects of excess apoC-II, may contribute to the hypertriglyceridemia observed in apoC-II transgenic mice...
  20. ncbi Increased expression of the SNARE accessory protein Munc18c in lipid-mediated insulin resistance
    Isabel R Schlaepfer
    Department of Medicine, Division of Endocrinology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Lipid Res 44:1174-81. 2003
    ..Together, these data are the first to implicate in vivo increases in Munc18c as a potential contributing mechanism to fatty acid-induced insulin resistance...
  21. ncbi CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice
    Jill M Schroeder-Gloeckler
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    J Biol Chem 282:15717-29. 2007
    ..These data provide novel evidence linking C/EBPbeta expression to lipogenesis and energy balance with important implications for the treatment of obesity and fatty liver disease...
  22. ncbi Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association
    Robert H Eckel
    Department of Physiology and Biophysics, University of Colorado Health Science Center, Aurora, USA
    Diabetes Care 29:1697-9. 2006
  23. ncbi Awareness and treatment of dyslipidemia in young adults with type 1 diabetes
    R Paul Wadwa
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B140, Denver, CO 80262, USA
    Diabetes Care 28:1051-6. 2005
    ..In this report, we describe the prevalence of dyslipidemia and adequacy of pharmacological treatment in patients with type 1 diabetes and comparable nondiabetic subjects...
  24. ncbi Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of prediabetes?
    Leigh Perreault
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 295:E428-35. 2008
    ..Together, these data indicate that IFG/IGT may be a distinct prediabetic syndrome rather than progression from IFG...
  25. ncbi Effects of maintained weight loss on sleep dynamics and neck morphology in severely obese adults
    Teri L Hernandez
    Division of Endocrinology, University of Colorado Denver, Aurora, Colorado, USA
    Obesity (Silver Spring) 17:84-91. 2009
    ..1 +/- 1.4 at baseline, to 17.1 +/- 3.0 after weight loss; F = 18.13, P = 0.001). In severely obese patients, even moderate weight loss (approximately 10%) boasts substantial benefit in terms of the severity of SDB and sleep dynamics...
  26. ncbi Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?
    Dalan R Jensen
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado at Denver, Aurora, CO, USA
    J Lipid Res 49:870-9. 2008
    ....
  27. ncbi Determinants of serum adiponectin in persons with and without type 1 diabetes
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Epidemiol 166:731-40. 2007
    ..Although some of the difference can be explained, further study is needed to better understand the relation between elevated adiponectin levels and patient outcomes, including coronary heart disease...
  28. ncbi Severe hypertriglyceridemia with a history of treatment failure
    Warren H Capell
    Division of Endocrinology, Metabolism, and Diabetes at the University of Colorado at Denver and Health Sciences Center, CO, USA
    Nat Clin Pract Endocrinol Metab 1:53-8; quiz 59. 2005
    ..Once serum triglycerides were controlled, attention was turned to lowering LDL-cholesterol concentration according to The National Cholesterol Education Program, Adult Treatment Panel III guidelines...
  29. ncbi Fasting decreases free fatty acid turnover in mice overexpressing skeletal muscle lipoprotein lipase
    Bryan C Bergman
    University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO 80045, USA
    Metabolism 55:1481-7. 2006
    ..These data suggest increased skeletal muscle LPL expression decreases dependence on plasma FFA during prolonged fasting in mice...
  30. ncbi Time course of C-reactive protein reduction with simvastatin therapy in patients with type 2 diabetes mellitus
    Teri L Hernandez
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
    Am J Cardiol 98:1656-9. 2006
    ..In conclusion, in patients with type 2 diabetes mellitus, simvastatin reduced hs-CRP within 7 days. However, this potentially beneficial effect was lost within 28 days...
  31. ncbi Longitudinal lipid screening and use of lipid-lowering medications in pediatric type 1 diabetes
    David M Maahs
    Barbara Davis Center for Childhood Diabetes and the Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Pediatr 150:146-50, 150.e1-2. 2007
    ..Because cardiovascular disease (CVD) is the leading cause of death in patients with type 1 diabetes (T1D) and dyslipidemia is an important CVD risk factor, we investigated dyslipidemia and its treatment in children with T1D...
  32. ncbi Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis
    Adam Kretowski
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
    Diabetes 56:863-71. 2007
    ....
  33. ncbi Low plasma adiponectin levels predict progression of coronary artery calcification
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Circulation 111:747-53. 2005
    ..However, it is not known whether low adiponectin levels predict development of atherosclerosis independently of other cardiovascular risk factors...
  34. ncbi Short-term triglyceride lowering with fenofibrate improves vasodilator function in subjects with hypertriglyceridemia
    Warren H Capell
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Arterioscler Thromb Vasc Biol 23:307-13. 2003
    ....
  35. ncbi Overexpression of muscle lipoprotein lipase and insulin sensitivity
    Leslie K Pulawa
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Curr Opin Clin Nutr Metab Care 5:569-74. 2002
    ..Insulin resistance, a common feature of both conditions, has come under intense investigation. This review focuses on our current understanding of the insulin signaling cascade and potential mechanisms of regulation...
  36. ncbi Evaluating changes in coronary artery calcium: an analytic method that accounts for interscan variability
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, 4200 E Ninth Ave, B 119, Denver, CO 80262, USA
    AJR Am J Roentgenol 182:1327-32. 2004
    ..The transformation that stabilized the variation in calcium volume scores was applied to progression of calcium volume scores in 109 subjects with diabetes...
  37. ncbi Simvastatin lowers C-reactive protein within 14 days: an effect independent of low-density lipoprotein cholesterol reduction
    Julie K Plenge
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Circulation 106:1447-52. 2002
    ..CONCLUSIONS: Simvastatin lowers hsCRP by 14 days, independent of its effect on LDL cholesterol. This rapid impact of a statin on hsCRP has potential implications in the management of acute coronary syndromes...
  38. ncbi Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study
    Dana Dabelea
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes 52:2833-9. 2003
    ..In conclusion, gender differences in insulin resistance-associated fat distribution may explain why type 1 diabetes increases coronary calcification in women relatively more than in men...
  39. ncbi Fatty acids increase glucose uptake and metabolism in C2C12 myoblasts stably transfected with human lipoprotein lipase
    Warren H Capell
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Am J Physiol Endocrinol Metab 299:E576-83. 2010
    ..Our results suggest that LPL overexpression in these cells leads to chronic metabolic adaptations that alter glucose uptake and retention...
  40. ncbi Retinoid X receptor gamma-deficient mice have increased skeletal muscle lipoprotein lipase activity and less weight gain when fed a high-fat diet
    Bryan R Haugen
    Division of Endocrinology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Endocrinology 145:3679-85. 2004
    ..An understanding of the mechanisms governing the role of RXR in TG disposal and metabolism may lead to the rational design of RXR-selective agonists and antagonists that may be useful in common disorders such as dyslipidemia and obesity...
  41. ncbi Effects of the hepatic lipase gene and physical activity on coronary heart disease risk
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Epidemiol 158:836-43. 2003
    ..Thus, in this prospective cohort study, the LIPC-480 TT genotype increased susceptibility to CHD only in those subjects with normal levels of physical activity, not in those with the high-risk genotype who were vigorously active...
  42. ncbi A common promoter polymorphism in the hepatic lipase gene (LIPC-480C>T) is associated with an increase in coronary calcification in type 1 diabetes
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes 51:1208-13. 2002
    ..In conclusion, the LIPC-480C>T polymorphism was associated with subclinical CHD in type 1 diabetes. This genetic variant may identify subjects in which early intervention to prevent CHD may be appropriate...
  43. ncbi Progression of coronary artery calcification in type 1 diabetes: the importance of glycemic control
    Janet K Snell-Bergeon
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes Care 26:2923-8. 2003
    ....
  44. ncbi Hypertension prevalence, awareness, treatment, and control in an adult type 1 diabetes population and a comparable general population
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave, Denver, CO 80262, USA
    Diabetes Care 28:301-6. 2005
    ..To compare the prevalence, awareness, treatment, and control of hypertension in a population-representative sample of adults with type 1 diabetes and comparable nondiabetic control subjects...
  45. ncbi Insulin resistance during puberty and future fat accumulation
    Sharon H Travers
    Division of Endocrinology, Department of Pediatrics, The Children s Hospital, Denver, Colorado 80218, USA
    J Clin Endocrinol Metab 87:3814-8. 2002
    ..These results suggest that during puberty, children who are more insulin resistant have decreased sc fat gain...
  46. ncbi Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin
    Joseph A Sennello
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Endocrinology 146:2157-64. 2005
    ..In conclusion, although leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNF alpha-induced death...
  47. ncbi Approach to the patient who is intolerant of statin therapy
    Robert H Eckel
    University of Colorado Denver, Anschutz Medical Campus, Mail Stop 8106, 12801 East 17th Avenue, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 95:2015-22. 2010
    ..At present, the superiority of one approach has not been demonstrated, and the need for clinical trials in well-characterized patients with statin intolerance cannot be dismissed...
  48. ncbi Americans' awareness, knowledge, and behaviors regarding fats: 2006-2007
    Robert H Eckel
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado, Denver, CO, USA
    J Am Diet Assoc 109:288-96. 2009
    ..The positive change in consumer awareness about trans fats is likely attributable to the wide range of messages available to them, including the AHA "Face the Fats" national consumer education campaign...
  49. ncbi Lipoprotein lipase: from gene to obesity
    Hong Wang
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Am J Physiol Endocrinol Metab 297:E271-88. 2009
    ....
  50. ncbi Lipoprotein lipase: genetics, lipid uptake, and regulation
    Martin Merkel
    Department of Medicine, University of Hamburg, Hamburg, Germany. Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    J Lipid Res 43:1997-2006. 2002
    ..2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake. 3) LPL gene regulation: the LPL promoter and its regulatory elements are described...
  51. ncbi Understanding the complexity of trans fatty acid reduction in the American diet: American Heart Association Trans Fat Conference 2006: report of the Trans Fat Conference Planning Group
    Robert H Eckel
    University of Colorado at Denver and Health Sciences Center, USA
    Circulation 115:2231-46. 2007
    ..The conference demonstrated the value of collaboration between the food industry and health and nutrition professionals, and this conference model should be used to address other food development, processing, and/or technology issues...
  52. ncbi Adipocyte-derived hormone levels in HIV lipodystrophy
    Lisa Kosmiski
    Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, Col, USA
    Antivir Ther 8:9-15. 2003
    ..We examined the relationships of plasma leptin and adiponectin levels to fat distribution and insulin sensitivity in the HIV lipodystrophy syndrome...
  53. ncbi Lipoprotein lipase is expressed in rat sciatic nerve and regulated in response to crush injury
    Patricia Uelmen Huey
    Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    J Lipid Res 43:19-25. 2002
    ..These data suggest a role for LPL in the response of peripheral nerves to crush injury, possibly in order to facilitate reutilization of lipids from degenerating myelin...
  54. ncbi A patient outreach program between visits improves diabetes care: a pilot study
    Thomas D Denberg
    Division of General Internal Medicine, B180, 12631 East 17th Avenue, Aurora, CO 80045, USA
    Int J Qual Health Care 21:130-6. 2009
    ..We evaluated this intervention in terms of operational feasibility, provider and patient acceptance and effects on process of care measures...
  55. ncbi The metabolic syndrome
    Marc Andre Cornier
    University of Colorado Denver, Division of Endocrinology, Metabolism, and Diabetes, Mail Stop 8106, 12801 East 17 Avenue, Room 7103, Aurora, Colorado 80045, USA
    Endocr Rev 29:777-822. 2008
    ..Finally, in 2008 the MetS is an evolving concept that continues to be data driven and evidence based with revisions forthcoming...
  56. ncbi T cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alpha
    Alison M Morris
    Division of Endocrinology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Metabolism 55:555-9. 2006
    ..These findings indicate that inflammation-induced TNF-alpha is a critical mediator of adipose-tissue-derived adiponectin in vivo...
  57. ncbi Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1
    Hubert C Chen
    Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, California 94141 9100, USA
    J Clin Invest 109:1049-55. 2002
    ..Our results suggest that inhibition of DGAT1 may be useful in treating insulin resistance and leptin resistance in human obesity...
  58. ncbi Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes
    Robert H Eckel
    Circulation 105:e138-43. 2002
  59. ncbi Egg consumption in relation to cardiovascular disease and mortality: the story gets more complex
    Robert H Eckel
    Am J Clin Nutr 87:799-800. 2008
  60. ncbi Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Found
    Samuel Klein
    Circulation 110:2952-67. 2004
    ..The data demonstrate that weight loss and physical activity can prevent and treat obesity-related coronary heart disease risk factors and should be considered a primary therapy for obese patients with cardiovascular disease...
  61. ncbi Assessing dietary fat intake in cardiac rehabilitation
    Coni C Francis
    J Cardiopulm Rehabil 22:168-9. 2002
  62. ncbi AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. American Heart Association Scien
    Thomas A Pearson
    Circulation 106:388-91. 2002
  63. ncbi Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults
    Glen E Duncan
    Department of Medicine, University of Florida, Gainesville, Florida 32610 0226, USA
    Diabetes Care 26:557-62. 2003
    ..To determine the effects of exercise, without weight loss, on insulin sensitivity (S(I)), postheparin plasma lipase activity (PHPL), intravenous fat clearance rate (K(2)), and fasting lipids in sedentary adults...
  64. ncbi Prevention Conference VII: Obesity, a worldwide epidemic related to heart disease and stroke: executive summary
    Robert H Eckel
    Circulation 110:2968-75. 2004
  65. ncbi America's children: a critical time for prevention
    Robert H Eckel
    Circulation 111:1866-8. 2005
  66. ncbi Overweight in children and adolescents: pathophysiology, consequences, prevention, and treatment
    Stephen R Daniels
    Circulation 111:1999-2012. 2005
    ..In addition, treatment approaches are presented, including behavioral, pharmacological, and surgical treatment. Childhood and adolescent overweight is one of the most important current public health concerns...
  67. ncbi Obesity and metabolic syndrome in circadian Clock mutant mice
    Fred W Turek
    Department of Neurology, Northwestern University, Evanston, IL 60208, USA
    Science 308:1043-5. 2005
    ..These results suggest that the circadian clock gene network plays an important role in mammalian energy balance...
  68. ncbi Diabetes and dietary macronutrients: is carbohydrate all that bad?
    Robert H Eckel
    Am J Clin Nutr 80:537-8. 2004
  69. ncbi Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical
    Paul Poirier
    Circulation 113:898-918. 2006
    ..In this statement, we review the available evidence of the impact of obesity on CVD with emphasis on the evaluation of cardiac structure and function in obese patients and the effect of weight loss on the cardiovascular system...
  70. ncbi The utilization of cardiac imaging
    Raymond J Gibbons
    Circulation 113:1715-6. 2006
  71. ncbi Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss
    Paul Poirier
    Quebec Heart and Lung Institute, Sainte Foy, Canada
    Arterioscler Thromb Vasc Biol 26:968-76. 2006
    ..As a whole, overweight/obesity predispose or is associated with numerous cardiac complications such as coronary heart disease, heart failure, and sudden death through its impact on the cardiovascular system...
  72. ncbi Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary
    Scott M Grundy
    Cardiol Rev 13:322-7. 2005
  73. ncbi Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
    ..In addition, rIL-18 reversed hyperglycemia in Il18-/- mice through activation of STAT3 phosphorylation. These findings indicate a new role of IL-18 in the homeostasis of energy intake and insulin sensitivity...
  74. ncbi Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association
    Robert H Eckel
    Circulation 113:2943-6. 2006
  75. ncbi Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston Mass 02111, USA
    Arterioscler Thromb Vasc Biol 24:1092-7. 2004
    ....
  76. ncbi A new look at dietary protein in diabetes
    Robert H Eckel
    Am J Clin Nutr 78:671-2. 2003
  77. ncbi Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle
    Masayoshi Yokoyama
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Lipid Res 48:646-55. 2007
    ..Thus, pathways affecting cholesterol balance in heart and skeletal muscle differ...
  78. ncbi Obesity and cardiovascular disease
    Paul Poirier
    Institut Universitaire de Cardiologie et de Pneumologie, , 2725 Chemin Sainte-Foy, Sainte-Foy, , Canada
    Curr Atheroscler Rep 4:448-53. 2002
    ....
  79. ncbi Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1
    Hubert C Chen
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Clin Invest 111:1715-22. 2003
    ..Our results highlight the importance of the endocrine function of WAT and suggest that an alteration in this function contributes to the increased energy expenditure and insulin sensitivity in DGAT1-deficient mice...
  80. ncbi Diet, obesity, and cardiovascular risk
    Robert O Bonow
    Northwestern University Feinberg School of Medicine, Chicago, USA
    N Engl J Med 348:2057-8. 2003
  81. ncbi Evaluating and managing cardiovascular disease in women: understanding a woman's heart
    Alice K Jacobs
    Circulation 111:383-4. 2005

Research Grants38

  1. NUTRITION, LIPOPROTEIN LIPASE AND BODY WEIGHT REGULATION
    Robert Eckel; Fiscal Year: 1992
    ..These studies should provide exciting new insights into the role of LPL in the regulation of body weight...
  2. TISSUE SPECIFIC REGULATION OF LIPOPROTEIN LIPASE
    Robert Eckel; Fiscal Year: 2001
    ..Overall, these studies should provide important and new insights into tissue-specific lipid fuel metabolism which may result in targeted gene-based therapies to alter nutrient fuel partitioning, and ultimately body weight. ..
  3. TISSUE SPECIFIC REGULATION OF LIPOPROTEIN LIPASE
    Robert Eckel; Fiscal Year: 2004
    ..abstract_text> ..
  4. Kern Aspen Lipid Conference 2002
    Robert Eckel; Fiscal Year: 2002
    ..The Co-Chairs will be Drs. Robert Eckel (UCHSC), and Gerald Shulman (Yale University)...
  5. LIPOPROTEIN LIPASE, NUTRITION AND NERVE MYELINATION
    Robert Eckel; Fiscal Year: 2003
    ..Overall, these studies should provide a comprehensive understanding of the role of LPL in the peripheral nerve. Moreover, we are hopeful that new insights into the treatment of peripheral neuropathies will also ensue. ..
  6. Mechanisms Defending Fat Mass in Human after Lipectomy
    Robert Eckel; Fiscal Year: 2007
    ..abstract_text> ..
  7. TISSUE SPECIFIC REGULATION OF LIPOPROTEIN LIPASE
    Robert Eckel; Fiscal Year: 1993
    ..Overall, these studies should provide new insights into tissue-specific fuel metabolism which may ultimately result in novel strategies to prevent obesity or sustain the reduced-obese state...
  8. HORMONAL CONTROL OF ADIPOSE TISSUE LIPOPROTEIN LIPASE
    Robert Eckel; Fiscal Year: 1990
    ..Overall, these studies will combine an in vivo approach to establish a deeper understanding of the relevance of LPL regulation in the adipocyte and in adipose tissue to human physiology and diseases such as obesity and diabetes mellitus...