Scott T Eblen

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes
    Scott T Eblen
    Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 22:6023-33. 2002
  2. pmc Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion
    Scott T Eblen
    Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 24:2308-17. 2004
  3. pmc PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation
    Jill K Slack-Davis
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Cell Biol 162:281-91. 2003
  4. ncbi request reprint Identifying specific kinase substrates through engineered kinases and ATP analogs
    N Vinay Kumar
    Department of Microbiology and Cancer Center, University of Virginia, Health Science Center, Charlottesville, VA 22908, USA
    Methods 32:389-97. 2004
  5. ncbi request reprint MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling
    Charu Sharma
    Department of Microbiology and Cancer Center, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biochem 94:708-19. 2005
  6. ncbi request reprint Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs
    Scott T Eblen
    Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:14926-35. 2003
  7. ncbi request reprint Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization
    Daniel Gioeli
    Department of Microbiology, P O Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 20:503-15. 2006
  8. pmc Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion
    Yuying Liu
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Nucleic Acids Res 41:4949-62. 2013
  9. pmc MEK1 activation by PAK: a novel mechanism
    Electa R Park
    Department of Biochemistry, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Cell Signal 19:1488-96. 2007

Collaborators

Detail Information

Publications9

  1. pmc Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes
    Scott T Eblen
    Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 22:6023-33. 2002
    ..These findings reveal a novel mechanism by which adhesion and growth factor signals are integrated during ERK activation...
  2. pmc Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion
    Scott T Eblen
    Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 24:2308-17. 2004
    ..We propose that activation of ERK during adhesion creates a feedback system in which ERK phosphorylates MEK1 on T292, and this in turn blocks additional S298 phosphorylation in response to integrin signaling...
  3. pmc PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation
    Jill K Slack-Davis
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Cell Biol 162:281-91. 2003
    ....
  4. ncbi request reprint Identifying specific kinase substrates through engineered kinases and ATP analogs
    N Vinay Kumar
    Department of Microbiology and Cancer Center, University of Virginia, Health Science Center, Charlottesville, VA 22908, USA
    Methods 32:389-97. 2004
    ..We also describe the direct labeling of ERK2 substrates in cell lysates. These methodologies can be adapted for use with other protein kinases to increase the understanding of intracellular signal transduction...
  5. ncbi request reprint MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling
    Charu Sharma
    Department of Microbiology and Cancer Center, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biochem 94:708-19. 2005
    ..These results support the concept that MP1 functions as a regulator of MAP kinase signaling by binding to MEK1 and regulating its association with a larger signaling complex that may sequentially service multiple molecules of ERK...
  6. ncbi request reprint Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs
    Scott T Eblen
    Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:14926-35. 2003
    ..These results not only identify two novel ERK2 substrates but also provide a framework for the future identification of numerous cellular targets of this important signaling cascade...
  7. ncbi request reprint Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization
    Daniel Gioeli
    Department of Microbiology, P O Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 20:503-15. 2006
    ..Our data suggest that stress kinase signaling and nuclear export regulate AR transcriptional activity...
  8. pmc Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion
    Yuying Liu
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Nucleic Acids Res 41:4949-62. 2013
    ..Our results demonstrate for the first time that SPF45 overexpression enhances cell migration and invasion, dependent on biochemical regulation by Clk1...
  9. pmc MEK1 activation by PAK: a novel mechanism
    Electa R Park
    Department of Biochemistry, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Cell Signal 19:1488-96. 2007
    ....