James H Eberwine

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases
    Anup Sharma
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e9002. 2010
  2. pmc Serotonergic neuron regulation informed by in vivo single-cell transcriptomics
    Jennifer M Spaethling
    2University of Pennsylvania, 37 John Morgan Bldg, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    FASEB J 28:771-80. 2014
  3. pmc Quantitative biology of single neurons
    James Eberwine
    Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    J R Soc Interface 9:3165-83. 2012
  4. ncbi request reprint Methodological considerations regarding single-cell gene expression profiling for brain injury
    Jason E Davis
    The Head Injury Center, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Neurochem Res 29:1113-21. 2004
  5. pmc Intron retention facilitates splice variant diversity in calcium-activated big potassium channel populations
    Thomas J Bell
    Department of Pharmacology, Penn Genome Frontiers Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:21152-7. 2010
  6. pmc Transcriptome transfer provides a model for understanding the phenotype of cardiomyocytes
    Tae Kyung Kim
    Department of Pharmacology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:11918-23. 2011
  7. doi request reprint Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma
    Jacqueline F Morris
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Pathol 44:766-76. 2013
  8. ncbi request reprint Neuron-specific mRNA complexity responses during hippocampal apoptosis after traumatic brain injury
    Paolo G Marciano
    Departments of Neuroscience, Center for Bioinformatics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:2866-76. 2004
  9. ncbi request reprint Single-cell antisense RNA amplification and microarray analysis as a tool for studying neurological degeneration and restoration
    Max B Kelz
    Department of Pharmacology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Sci Aging Knowledge Environ 2002:re1. 2002
  10. ncbi request reprint Region-directed phototransfection reveals the functional significance of a dendritically synthesized transcription factor
    Lindy E Barrett
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Methods 3:455-60. 2006

Collaborators

Detail Information

Publications19

  1. pmc A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases
    Anup Sharma
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e9002. 2010
    ..These results suggest a molecular link between the presence of inclusions and neuronal loss that is shared across a spectrum of neurodegenerative disease...
  2. pmc Serotonergic neuron regulation informed by in vivo single-cell transcriptomics
    Jennifer M Spaethling
    2University of Pennsylvania, 37 John Morgan Bldg, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    FASEB J 28:771-80. 2014
    ..This study illustrates that unbiased single-cell transcriptomics coupled with functional analyses provides novel insights into how neurons and neuronal systems are regulated...
  3. pmc Quantitative biology of single neurons
    James Eberwine
    Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    J R Soc Interface 9:3165-83. 2012
    ..With the application of new highly sensitive molecular and genomic technologies, the quantitative biochemistry of single cells is now accessible...
  4. ncbi request reprint Methodological considerations regarding single-cell gene expression profiling for brain injury
    Jason E Davis
    The Head Injury Center, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Neurochem Res 29:1113-21. 2004
    ..In this review, we will discuss the application of these techniques to experimental, clinically relevant models of traumatic brain injury...
  5. pmc Intron retention facilitates splice variant diversity in calcium-activated big potassium channel populations
    Thomas J Bell
    Department of Pharmacology, Penn Genome Frontiers Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:21152-7. 2010
    ..Collectively, these data show that STREX splice variant regulation via cytoplasmic splicing and intron retention helps generate STREX-dependent BKCa current diversity in hippocampal neurons...
  6. pmc Transcriptome transfer provides a model for understanding the phenotype of cardiomyocytes
    Tae Kyung Kim
    Department of Pharmacology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:11918-23. 2011
    ..The transcriptome-induced phenotype remodeling-generated tCardiomyocyte has significant implications for understanding and modulating cardiac disease development...
  7. doi request reprint Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma
    Jacqueline F Morris
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Pathol 44:766-76. 2013
    ..This nuclear localization and correlation with tumor differentiation in adenocarcinoma suggests a potentially important transcriptional and biochemical role of this phosphorylation site in carcinogenesis of this tumor type...
  8. ncbi request reprint Neuron-specific mRNA complexity responses during hippocampal apoptosis after traumatic brain injury
    Paolo G Marciano
    Departments of Neuroscience, Center for Bioinformatics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:2866-76. 2004
    ....
  9. ncbi request reprint Single-cell antisense RNA amplification and microarray analysis as a tool for studying neurological degeneration and restoration
    Max B Kelz
    Department of Pharmacology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Sci Aging Knowledge Environ 2002:re1. 2002
    ..We also review some new work with neural stem cells and their application to restorative neurobiology. Finally, we discuss the use of cell-specific molecular profiles to better understand the basics of neuronal cell biology...
  10. ncbi request reprint Region-directed phototransfection reveals the functional significance of a dendritically synthesized transcription factor
    Lindy E Barrett
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Methods 3:455-60. 2006
    ....
  11. ncbi request reprint Expression profile analysis of neurodegenerative disease: advances in specificity and resolution
    Jason G Glanzer
    Department of Pharmacology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Neurochem Res 29:1161-8. 2004
    ..Expression profile studies from several neuropathological states are presented, with emphasis placed on those studies using small samples of cellular material and those using specialized methods of cell isolation and RNA amplification...
  12. ncbi request reprint Single-cell transcriptomics for drug target discovery
    Jennifer M Spaethling
    Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Curr Opin Pharmacol 13:786-90. 2013
    ....
  13. pmc Identification of a circadian output circuit for rest:activity rhythms in Drosophila
    Daniel J Cavanaugh
    Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell 157:689-701. 2014
    ..Notably, selective activation or ablation of just six DH44+ PI cells causes arrhythmicity. These findings delineate a circuit through which clock cells can modulate locomotor rhythms...
  14. pmc mRNA for the EAAC1 subtype of glutamate transporter is present in neuronal dendrites in vitro and dramatically increases in vivo after a seizure
    John R Ross
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4318, USA
    Neurochem Int 58:366-75. 2011
    ..These studies provide the first evidence that EAAC1 mRNA localizes to dendrites and suggest that dendritic targeting of EAAC1 mRNA is increased by seizure activity and may be regulated by neuronal activity/depolarization...
  15. pmc Mammalian cell transfection: the present and the future
    Tae Kyung Kim
    Department of Pharmacology, University of Pennsylvania Medical School Pharmacology, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    Anal Bioanal Chem 397:3173-8. 2010
    ..However, each method has its own advantages and disadvantages so the optimum method depends on experimental design and objective...
  16. ncbi request reprint Single-cell molecular biology: implications for diagnosis and treatment of neurologic disease
    David A Hinkle
    Department of Pharmacology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Biol Psychiatry 54:413-7. 2003
    ..These technologies promise to accelerate our understanding of both normal and abnormal molecular processes within neurons, and they have the potential for direct application to the study of human neurologic disease...
  17. ncbi request reprint Mechanisms of translational control in dendrites
    Jason G Glanzer
    Department of Pharmacology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Neurobiol Aging 24:1105-11. 2003
    ..This review will cover several suggested pathways for regulation of dendritic translation and propose a correlation between deregulated dendritic translation and disease...
  18. pmc Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers
    Mark D Levin
    Penn Cardiovascular Institute and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:3420-36. 2009
    ..These data suggest that dysfunction of melanocyte-like cells in the atrium and pulmonary veins may contribute to atrial arrhythmias...