Affiliation: University of Iowa
- Anatomical and molecular design of the Drosophila antenna as a flagellar auditory organSokol V Todi
Interdisciplinary Graduate Program in Neuroscience, The University of Iowa, Iowa City, Iowa 52242, USA
Microsc Res Tech 63:388-99. 2004..Based on evidence gathered from these studies, we propose a speculative model for how the chordotonal organ might function...
- Feeling the vibes: chordotonal mechanisms in insect hearingD F Eberl
Department of Biological Sciences, University of Iowa, Iowa City, Iowa, 52242 1324, USA
Curr Opin Neurobiol 9:389-93. 1999..Identification of these elusive molecules will settle this issue...
- Development of Johnston's organ in DrosophilaDaniel F Eberl
Department of Biology, University of Iowa, Iowa City, IA 52242 1324, USA
Int J Dev Biol 51:679-87. 2007..Finally, we discuss further research directions that would probe remaining questions in understanding Johnston's organ development, function and evolution...
- The role of bHLH genes in ear development and evolution: revisiting a 10-year-old hypothesisBernd Fritzsch
Department of Biology, College of Liberal Arts and Sciences, University of Iowa, 143 BB, Iowa City, IA 52242, USA
Cell Mol Life Sci 67:3089-99. 2010..This sequence of expression changes was accompanied by modification of the E-box binding sites of these genes to regulate different downstream genes and to form inhibitory loops among each other, thus fine-tuning expression transitions...
- Towards a molecular understanding of Drosophila hearingJason C Caldwell
Department of Biological Sciences, The University of Iowa, Iowa City, Iowa, 52242-1324, USA
J Neurobiol 53:172-89. 2002..The identification and analysis of mutations that affect auditory function are summarized here, and prospects for the role of the Drosophila auditory system in understanding both insect and vertebrate hearing are discussed...
- Synaptic ultrastructure of Drosophila Johnston's organ axon terminals as revealed by an enhancer trapElena Sivan-Loukianova
Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242-1324, USA
J Comp Neurol 491:46-55. 2005..The ultrastructure of JO fibers and synapses may indicate an ability to process temporally discretized acoustic information...
- Meeting report: genes, neurons, circuits, and behaviors: highlights of cold spring harbor meeting on Drosophila neurobiology, October 3-7, 2007Daniel F Eberl
Department of Biology, University of Iowa, Iowa City, Iowa, USA
J Neurogenet 22:3-13. 2008
- reduced ocelli encodes the leucine rich repeat protein Pray For Elves in Drosophila melanogasterJason C Caldwell
Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242 1324, USA
Fly (Austin) 1:146-52. 2007..Our identification and initial characterization of the rdo locus will contribute to the understanding of neurogenesis and neural development in the simple photoreceptors of the Drosophila visual system...
- Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ developmentSokol V Todi
Neuroscience Graduate Program, The University of Iowa, Iowa City, Iowa, United States of America
PLoS ONE 3:e2115. 2008..ck/MyoVIIA mutations result in apical detachment of auditory transduction units (scolopidia) from the cuticle that transmits antennal vibrations as mechanical stimuli to JO...
- TRPA channels distinguish gravity sensing from hearing in Johnston's organYishan Sun
Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 106:13606-11. 2009..The results also distinguish between different mechanosensory modalities and set the stage for understanding how TRP channels contribute to mechanosensation...
- Dynamic analysis of larval locomotion in Drosophila chordotonal organ mutantsJason C Caldwell
Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 100:16053-8. 2003..Thus, cho sensilla are major proprioceptive components that underlie touch sensitivity, locomotion, and peristaltic contraction by providing sensory feedback to the locomotor CPG circuit in larvae...
- PPTGAL, a convenient Gal4 P-element vector for testing expression of enhancer fragments in drosophilaYashoda Sharma
Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242, USA
Genesis 34:115-8. 2002
- Hearing in Drosophila requires TilB, a conserved protein associated with ciliary motilityRyan G Kavlie
Interdisciplinary Graduate Program in Genetics and Department of Biology, University of Iowa, Iowa City, IA 52242, USA
Genetics 185:177-88. 2010..Further elucidation of tilB functional mechanisms will provide greater understanding of cilia function and will facilitate understanding ciliary diseases...
- Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in DrosophilaSokol V Todi
Neuroscience Graduate Program, Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242, USA
Curr Biol 15:862-8. 2005....
- Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysisRobin E Williamson
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Am J Med Genet A 143:1630-9. 2007..A knockout mouse model for MTAP deficiency was also created and no significant hearing loss was detected in heterozygotes for Mtap. Homozygous Mtap-deficient mice were embryonic lethal...
- Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targetsSaurabh Prakash
Department of Neurobiology, 299 W Campus Drive, Stanford University, Stanford, California 94305, USA
Nat Neurosci 8:443-50. 2005..We propose that N-cadherin mediates a homophilic, attractive interaction between photoreceptor growth cones and their targets that precedes synaptic partner choice...
- Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tailsRitu Sarpal
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
Curr Biol 13:1687-96. 2003..Kinesin associated protein (KAP) is identified as the non-motor accessory subunit of Kinesin II, but its role in the corresponding motor function is not understood...
- Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypesP D Si Dong
Department of Anatomy, University of Wisconsin, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 100:10293-8. 2003..Electrophysiological analyses confirm that spalt/spalt-related mutant flies are deaf. These commonalities suggest that there is functional conservation for spalt genes between vertebrates and insects...
- Drosophila deafness genes: analysis of chordotonal organ functionsDANIEL EBERL; Fiscal Year: 2007..Overall, these studies will inform future research on the developmental and functional biology of the mammalian inner ear, and accelerate our understanding of human auditory disorders. ..
- Drosophila Deafness Genes: Analysis of Chordotonal OrganDANIEL EBERL; Fiscal Year: 2005..Identifying auditory genes by any of these approaches and elucidating the molecular roles of their products will provide very important insight into the fundamental but poorly understood process of mechanosensation. ..
- Drosophila deafness genes: analysis of chordotonal organ functionsDaniel F Eberl; Fiscal Year: 2010..Overall, these studies will inform future research on the developmental and functional biology of the mammalian inner ear, and accelerate our understanding of human auditory disorders. ..