DANIEL EBERL

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Anatomical and molecular design of the Drosophila antenna as a flagellar auditory organ
    Sokol V Todi
    Interdisciplinary Graduate Program in Neuroscience, The University of Iowa, Iowa City, Iowa 52242, USA
    Microsc Res Tech 63:388-99. 2004
  2. ncbi request reprint Feeling the vibes: chordotonal mechanisms in insect hearing
    D F Eberl
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa, 52242 1324, USA
    Curr Opin Neurobiol 9:389-93. 1999
  3. pmc Development of Johnston's organ in Drosophila
    Daniel F Eberl
    Department of Biology, University of Iowa, Iowa City, IA 52242 1324, USA
    Int J Dev Biol 51:679-87. 2007
  4. pmc The role of bHLH genes in ear development and evolution: revisiting a 10-year-old hypothesis
    Bernd Fritzsch
    Department of Biology, College of Liberal Arts and Sciences, University of Iowa, 143 BB, Iowa City, IA 52242, USA
    Cell Mol Life Sci 67:3089-99. 2010
  5. pmc Towards a molecular understanding of Drosophila hearing
    Jason C Caldwell
    Department of Biological Sciences, The University of Iowa, Iowa City, Iowa, 52242 1324, USA
    J Neurobiol 53:172-89. 2002
  6. pmc Synaptic ultrastructure of Drosophila Johnston's organ axon terminals as revealed by an enhancer trap
    Elena Sivan-Loukianova
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242 1324, USA
    J Comp Neurol 491:46-55. 2005
  7. doi request reprint Meeting report: genes, neurons, circuits, and behaviors: highlights of cold spring harbor meeting on Drosophila neurobiology, October 3-7, 2007
    Daniel F Eberl
    Department of Biology, University of Iowa, Iowa City, Iowa, USA
    J Neurogenet 22:3-13. 2008
  8. pmc reduced ocelli encodes the leucine rich repeat protein Pray For Elves in Drosophila melanogaster
    Jason C Caldwell
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Fly (Austin) 1:146-52. 2007
  9. pmc Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development
    Sokol V Todi
    Neuroscience Graduate Program, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 3:e2115. 2008
  10. pmc TRPA channels distinguish gravity sensing from hearing in Johnston's organ
    Yishan Sun
    Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:13606-11. 2009

Collaborators

  • Daniel P Kiehart
  • Grace Boekhoff-Falk
  • Bernd Fritzsch
  • Y Ben-Shahar
  • David Soll
  • Maurice Kernan
  • Sokol V Todi
  • Jason C Caldwell
  • Elena Sivan-Loukianova
  • Julie S Jacobs
  • Ryan G Kavlie
  • Yishan Sun
  • Yashoda Sharma
  • Robin E Williamson
  • Saurabh Prakash
  • Ritu Sarpal
  • P D Si Dong
  • Michael J Welsh
  • Lei Liu
  • Richard L Maas
  • Cynthia C Morton
  • Keith N Darrow
  • M Charles Liberman
  • Sarah K Fineberg
  • Marilyn C Jones
  • Sebastien Michaud
  • Thomas R Clandinin
  • Josef D Franke
  • Susan Wing
  • James W Erickson
  • Seema Shirolikar
  • Elizabeth C Raff
  • Krishanu Ray
  • Narayan Subramanian
  • Matthew M Miller
  • Una Cheung
  • Ellen W Larsen

Detail Information

Publications18

  1. pmc Anatomical and molecular design of the Drosophila antenna as a flagellar auditory organ
    Sokol V Todi
    Interdisciplinary Graduate Program in Neuroscience, The University of Iowa, Iowa City, Iowa 52242, USA
    Microsc Res Tech 63:388-99. 2004
    ..Based on evidence gathered from these studies, we propose a speculative model for how the chordotonal organ might function...
  2. ncbi request reprint Feeling the vibes: chordotonal mechanisms in insect hearing
    D F Eberl
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa, 52242 1324, USA
    Curr Opin Neurobiol 9:389-93. 1999
    ..Identification of these elusive molecules will settle this issue...
  3. pmc Development of Johnston's organ in Drosophila
    Daniel F Eberl
    Department of Biology, University of Iowa, Iowa City, IA 52242 1324, USA
    Int J Dev Biol 51:679-87. 2007
    ..Finally, we discuss further research directions that would probe remaining questions in understanding Johnston's organ development, function and evolution...
  4. pmc The role of bHLH genes in ear development and evolution: revisiting a 10-year-old hypothesis
    Bernd Fritzsch
    Department of Biology, College of Liberal Arts and Sciences, University of Iowa, 143 BB, Iowa City, IA 52242, USA
    Cell Mol Life Sci 67:3089-99. 2010
    ..This sequence of expression changes was accompanied by modification of the E-box binding sites of these genes to regulate different downstream genes and to form inhibitory loops among each other, thus fine-tuning expression transitions...
  5. pmc Towards a molecular understanding of Drosophila hearing
    Jason C Caldwell
    Department of Biological Sciences, The University of Iowa, Iowa City, Iowa, 52242 1324, USA
    J Neurobiol 53:172-89. 2002
    ..The identification and analysis of mutations that affect auditory function are summarized here, and prospects for the role of the Drosophila auditory system in understanding both insect and vertebrate hearing are discussed...
  6. pmc Synaptic ultrastructure of Drosophila Johnston's organ axon terminals as revealed by an enhancer trap
    Elena Sivan-Loukianova
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242 1324, USA
    J Comp Neurol 491:46-55. 2005
    ..The ultrastructure of JO fibers and synapses may indicate an ability to process temporally discretized acoustic information...
  7. doi request reprint Meeting report: genes, neurons, circuits, and behaviors: highlights of cold spring harbor meeting on Drosophila neurobiology, October 3-7, 2007
    Daniel F Eberl
    Department of Biology, University of Iowa, Iowa City, Iowa, USA
    J Neurogenet 22:3-13. 2008
  8. pmc reduced ocelli encodes the leucine rich repeat protein Pray For Elves in Drosophila melanogaster
    Jason C Caldwell
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Fly (Austin) 1:146-52. 2007
    ..Our identification and initial characterization of the rdo locus will contribute to the understanding of neurogenesis and neural development in the simple photoreceptors of the Drosophila visual system...
  9. pmc Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development
    Sokol V Todi
    Neuroscience Graduate Program, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 3:e2115. 2008
    ..ck/MyoVIIA mutations result in apical detachment of auditory transduction units (scolopidia) from the cuticle that transmits antennal vibrations as mechanical stimuli to JO...
  10. pmc TRPA channels distinguish gravity sensing from hearing in Johnston's organ
    Yishan Sun
    Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:13606-11. 2009
    ..The results also distinguish between different mechanosensory modalities and set the stage for understanding how TRP channels contribute to mechanosensation...
  11. pmc Dynamic analysis of larval locomotion in Drosophila chordotonal organ mutants
    Jason C Caldwell
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 100:16053-8. 2003
    ..Thus, cho sensilla are major proprioceptive components that underlie touch sensitivity, locomotion, and peristaltic contraction by providing sensory feedback to the locomotor CPG circuit in larvae...
  12. pmc PPTGAL, a convenient Gal4 P-element vector for testing expression of enhancer fragments in drosophila
    Yashoda Sharma
    Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242, USA
    Genesis 34:115-8. 2002
  13. pmc Hearing in Drosophila requires TilB, a conserved protein associated with ciliary motility
    Ryan G Kavlie
    Interdisciplinary Graduate Program in Genetics and Department of Biology, University of Iowa, Iowa City, IA 52242, USA
    Genetics 185:177-88. 2010
    ..Further elucidation of tilB functional mechanisms will provide greater understanding of cilia function and will facilitate understanding ciliary diseases...
  14. pmc Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila
    Sokol V Todi
    Neuroscience Graduate Program, Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242, USA
    Curr Biol 15:862-8. 2005
    ....
  15. ncbi request reprint Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis
    Robin E Williamson
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet A 143:1630-9. 2007
    ..A knockout mouse model for MTAP deficiency was also created and no significant hearing loss was detected in heterozygotes for Mtap. Homozygous Mtap-deficient mice were embryonic lethal...
  16. pmc Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targets
    Saurabh Prakash
    Department of Neurobiology, 299 W Campus Drive, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 8:443-50. 2005
    ..We propose that N-cadherin mediates a homophilic, attractive interaction between photoreceptor growth cones and their targets that precedes synaptic partner choice...
  17. ncbi request reprint Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails
    Ritu Sarpal
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Curr Biol 13:1687-96. 2003
    ..Kinesin associated protein (KAP) is identified as the non-motor accessory subunit of Kinesin II, but its role in the corresponding motor function is not understood...
  18. pmc Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes
    P D Si Dong
    Department of Anatomy, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:10293-8. 2003
    ..Electrophysiological analyses confirm that spalt/spalt-related mutant flies are deaf. These commonalities suggest that there is functional conservation for spalt genes between vertebrates and insects...

Research Grants11

  1. Drosophila deafness genes: analysis of chordotonal organ functions
    DANIEL EBERL; Fiscal Year: 2007
    ..Overall, these studies will inform future research on the developmental and functional biology of the mammalian inner ear, and accelerate our understanding of human auditory disorders. ..
  2. Drosophila Deafness Genes: Analysis of Chordotonal Organ
    DANIEL EBERL; Fiscal Year: 2005
    ..Identifying auditory genes by any of these approaches and elucidating the molecular roles of their products will provide very important insight into the fundamental but poorly understood process of mechanosensation. ..
  3. Drosophila deafness genes: analysis of chordotonal organ functions
    Daniel F Eberl; Fiscal Year: 2010
    ..Overall, these studies will inform future research on the developmental and functional biology of the mammalian inner ear, and accelerate our understanding of human auditory disorders. ..