M Ebadi

Summary

Affiliation: University of North Dakota
Country: USA

Publications

  1. ncbi Metallothionein provides ubiquinone-mediated neuroprotection in Parkinson's disease
    Manuchair Ebadi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, P O Box 9037, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Proc West Pharmacol Soc 45:36-8. 2002
  2. pmc Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease
    Manuchair Ebadi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Brain Res Mol Brain Res 134:67-75. 2005
  3. ncbi Coenzyme Q10 inhibits mitochondrial complex-1 down-regulation and nuclear factor-kappa B activation
    M Ebadi
    Center of Excellence For Neurosciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA
    J Cell Mol Med 8:213-22. 2004
  4. ncbi Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease
    Manuchair Ebadi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Antioxid Redox Signal 5:319-35. 2003
  5. ncbi Metallothioneins 1 and 2 attenuate peroxynitrite-induced oxidative stress in Parkinson disease
    Manuchair Ebadi
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Exp Biol Med (Maywood) 231:1576-83. 2006
  6. ncbi Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases
    Manuchair Ebadi
    Department of Pharmacology, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Curr Drug Targets 7:1513-29. 2006
  7. ncbi Neuroprotective actions of selegiline
    M Ebadi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA
    J Neurosci Res 67:285-9. 2002
  8. ncbi Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease
    M Ebadi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, N Dak 58203 2817, USA
    Biol Signals Recept 10:224-53. 2001
  9. ncbi Introduction. Oxidative stress in mitochondria disorders of aging
    M Ebadi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Biol Signals Recept 10:5-13. 2001
  10. ncbi Complex-1 activity and 18F-DOPA uptake in genetically engineered mouse model of Parkinson's disease and the neuroprotective role of coenzyme Q10
    Sushil K Sharma
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, United States
    Brain Res Bull 70:22-32. 2006

Research Grants

Collaborators

Detail Information

Publications54

  1. ncbi Metallothionein provides ubiquinone-mediated neuroprotection in Parkinson's disease
    Manuchair Ebadi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, P O Box 9037, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Proc West Pharmacol Soc 45:36-8. 2002
  2. pmc Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease
    Manuchair Ebadi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Brain Res Mol Brain Res 134:67-75. 2005
    ..These data are interpreted to suggest that peroxynitrite ions are involved in the etiopathogenesis of Parkinson's disease, and metallothionein-mediated coenzyme Q10 synthesis may provide neuroprotection...
  3. ncbi Coenzyme Q10 inhibits mitochondrial complex-1 down-regulation and nuclear factor-kappa B activation
    M Ebadi
    Center of Excellence For Neurosciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA
    J Cell Mol Med 8:213-22. 2004
    ....
  4. ncbi Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease
    Manuchair Ebadi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Antioxid Redox Signal 5:319-35. 2003
    ..As apoptosis is critical to the progression of neurodegenerative disease, including PD, selegiline or selegiline-like compounds to be discovered in the future may be efficacious in treating PD...
  5. ncbi Metallothioneins 1 and 2 attenuate peroxynitrite-induced oxidative stress in Parkinson disease
    Manuchair Ebadi
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Exp Biol Med (Maywood) 231:1576-83. 2006
    ..These observations provide further evidence that nitric oxide synthase activation and ONOO- synthesis may be involved in the etiopathogenesis of PD, and that metallothionein gene induction may provide neuroprotection...
  6. ncbi Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases
    Manuchair Ebadi
    Department of Pharmacology, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Curr Drug Targets 7:1513-29. 2006
    ..Its therapeutic efficacy in Alzheimer's disease remains uncertain. In Alzheimer's disease, short term studies of selegiline suggest a beneficial effect; whereas long term studies are less convincing...
  7. ncbi Neuroprotective actions of selegiline
    M Ebadi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA
    J Neurosci Res 67:285-9. 2002
    ..Most of the aforementioned properties occur independently of selegiline's efficacy to inhibit MAO-B...
  8. ncbi Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease
    M Ebadi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, N Dak 58203 2817, USA
    Biol Signals Recept 10:224-53. 2001
    ..Although the serum levels of CoQ10 is normal in patients with Parkinson's disease, CoQ10 is able to attenuate the MPTP-induced loss of striatal dopaminergic neurons...
  9. ncbi Introduction. Oxidative stress in mitochondria disorders of aging
    M Ebadi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Biol Signals Recept 10:5-13. 2001
    ....
  10. ncbi Complex-1 activity and 18F-DOPA uptake in genetically engineered mouse model of Parkinson's disease and the neuroprotective role of coenzyme Q10
    Sushil K Sharma
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, United States
    Brain Res Bull 70:22-32. 2006
    ..Therefore, metallothionein-induced coenzyme Q10 synthesis may provide neuroprotection by augmenting mitochondrial complex-1 activity in Parkinson's disease...
  11. ncbi Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons
    Sushil K Sharma
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Antioxid Redox Signal 5:251-64. 2003
    ....
  12. ncbi 1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells
    Shaik Shavali
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58203, USA
    J Neurosci Res 76:563-71. 2004
    ..Taken together, these results suggest that alpha-syn up-regulation and oxidative stress are contributing factors in 1BnTIQ-induced neurotoxicity in dopaminergic neurons in PD...
  13. ncbi Neuroprotective actions of coenzyme Q10 in Parkinson's disease
    S Sharma
    School of Medicine and Health Sciences, University of North Dakota, Grand Forks 58203, USA
    Methods Enzymol 382:488-509. 2004
  14. ncbi Insulin-like growth factor I (IGF-1) supplementation prevents diabetes-induced alterations in coenzymes Q9 and Q10
    L E Wold
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, USA
    Acta Diabetol 40:85-90. 2003
    ..These data suggest that IGF-1 antagonizes the diabetes-induced alterations in endogenous antioxidants including coenzyme Q(10), and hence may have a therapeutic role in diabetes...
  15. ncbi Deferoxamine attenuates iron-induced oxidative stress and prevents mitochondrial aggregation and alpha-synuclein translocation in SK-N-SH cells in culture
    P Sangchot
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, N D 58203, USA
    Dev Neurosci 24:143-53. 2002
    ..However, in the absence of excess iron, DFO itself may have deleterious effects on the morphology and hence integrity of dopaminergic neurons...
  16. ncbi Salsolinol, a dopamine-derived tetrahydroisoquinoline, induces cell death by causing oxidative stress in dopaminergic SH-SY5Y cells, and the said effect is attenuated by metallothionein
    Sawitri Wanpen
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58202, USA
    Brain Res 1005:67-76. 2004
    ..Furthermore, MT overexpression may protect dopaminergic neurons against salsolinol-induced neurotoxicity, most probably by the inhibition of oxidative stress and apoptotic pathways including caspase-3 activation...
  17. ncbi Reactive macrophages increase oxidative stress and alpha-synuclein nitration during death of dopaminergic neuronal cells in co-culture: relevance to Parkinson's disease
    Shaik Shavali
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Neurochem Res 31:85-94. 2006
    ..These results suggest that reactive microglias could induce oxidative stress in dopaminergic neurons and such oxidative stress may finally lead to nitration of alpha-synuclein and death of dopaminergic neurons in PD...
  18. ncbi Metallothionein provides zinc-mediated protective effects against methamphetamine toxicity in SK-N-SH cells
    Amornpan Ajjimaporn
    Department of Pharmacology, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Brain Res Bull 67:466-75. 2005
    ..In conclusion, our study suggests that MT, a potent scavenger of free radicals is neuroprotective against dopaminergic toxicity in conditions such as drug of abuse and in Parkinson's disease...
  19. ncbi Pineal opioid receptors and analgesic action of melatonin
    M Ebadi
    Department of Pharmacology, University of Nebraska College of Medicine, Omaha 68198 6260, USA
    J Pineal Res 24:193-200. 1998
    ..Therefore, future research may synthesize highly efficacious melatonin analogues capable of providing maximum analgesia and hopefully being devoid of addiction liability now associated with currently available narcotics...
  20. ncbi Peroxynitrite in the pathogenesis of Parkinson's disease and the neuroprotective role of metallothioneins
    Manuchair Ebadi
    School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202 9037, USA
    Methods Enzymol 396:276-98. 2005
    ..These studies provide evidence that nitric oxide synthase activation and peroxynitrite ion overproduction may be involved in the etiopathogenesis of PD, and that metallothionein gene induction may provide neuroprotection...
  21. ncbi Mechanism of 1-methyl-4-phenylpyridinium-induced dopamine release from PC12 cells
    Jaturaporn Chagkutip
    Departments of Pharmacology and of Neurosciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, 58202, USA
    Neurochem Res 30:633-9. 2005
    ..These effects of MPP+ result in the generation of ROS, which may be involved in neuronal degeneration seen in Parkinson's disease...
  22. ncbi Radiation safety and quality control in the cyclotron laboratory
    Sushil Sharma
    Positron Imaging Research Laboratory, Center of Excellence in Neurosciences, University of North Dakota, School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Radiat Prot Dosimetry 118:431-9. 2006
    ....
  23. ncbi Attenuation of cocaine and methamphetamine neurotoxicity by coenzyme Q10
    Sirirat Klongpanichapak
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Grand Forks, ND, 58203, USA
    Neurochem Res 31:303-11. 2006
    ..CoQ10 treatment attenuated cocaine and METH-induced inhibition in the striatal 18F-DOPA uptake as determined by high-resolution microPET neuroimaging. Hence exogenous administration of CoQ10 may provide neuroprotection in drug addiction...
  24. ncbi SPECT neuroimaging in translational research of CNS disorders
    Sushil Sharma
    Cyclotron and Positron Imaging Research Laboratory, Center of Excellence in Neurosciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Neurochem Int 52:352-62. 2008
    ..It is envisaged that high-resolution SPECT imaging system will further improve in vivo non-invasive translational research on CNS disorders of unknown etiopathogenesis and their treatment in future...
  25. pmc Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells
    Shaik Shavali
    Department of Pathology, University of North Dakota, School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58202, USA
    Neurosci Lett 439:125-8. 2008
    ..This study has implications to the pathogenesis of familial PD where alpha-syn overexpression is mainly involved...
  26. ncbi Dopamine agonist 3-PPP fails to protect against MPTP-induced toxicity
    Dhanasekaran Muralikrishnan
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA
    Neurochem Res 29:379-84. 2004
    ..3-PPP had no effect on the SH-SY5Y neuronal cell growth in culture and did not block the MPP(+)-induced cytotoxicity. This study shows that the dopamine agonist 3-PPP failed to protect against MPTP-induced dopaminergic neurotoxicity...
  27. ncbi The multiple actions of selegiline
    Manuchair Ebadi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, P O Box 9037, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Proc West Pharmacol Soc 45:39-41. 2002
  28. ncbi An improved method for analyzing coenzyme Q homologues and multiple detection of rare biological samples
    Sushil K Sharma
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA
    J Neurosci Methods 137:1-8. 2004
    ..It is envisaged that in addition to coenzyme Q homologues, the improved method could be utilized for the multiple analyses of DNA, RNA and proteins from clinically significant biopsy and autopsy samples...
  29. ncbi Effect of MPTP on Dopamine metabolism in Ames dwarf mice
    Dhanasekaran Muralikrishnan
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA
    Neurochem Res 27:457-64. 2002
    ..This study shows that the MAO activity and the coenzyme content of dwarf mice are similar to those of their wild-type controls and hence susceptible to MPTP-induced toxicity...
  30. ncbi Neuroprotective actions of Selegiline in inhibiting 1-methyl, 4-phenyl, pyridinium ion (MPP+)-induced apoptosis in SK-N-SH neurons
    Sushil K Sharma
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, North Dakota, USA
    J Neurocytol 32:329-43. 2003
    ....
  31. ncbi Identification of dopamine transporter in bovine pineal gland using [3H]GBR 12935
    P Govitrapong
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58203, USA
    J Pineal Res 35:16-23. 2003
    ..These results indicate that a high affinity dopamine transporter exists in the bovine pineal, which may exhibit circadian periodicity, and whose physiological functions need to be delineated and characterized in future investigations...
  32. pmc TRPC1 protects human SH-SY5Y cells against salsolinol-induced cytotoxicity by inhibiting apoptosis
    Sunitha Bollimuntha
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, 58201, USA
    Brain Res 1099:141-9. 2006
    ..Furthermore, overexpression of TRPC1 could inhibit apoptotic complex thereby increasing neuronal cell survivability in Parkinson's disease...
  33. ncbi Salsolinol, an endogenous neurotoxin, activates JNK and NF-kappaB signaling pathways in human neuroblastoma cells
    Sawitri Wanpen
    Department of Pharmacology, School of Medicine and Health Sciences, University of North Dakota, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Neurochem Res 32:443-50. 2007
    ..These results partly suggest that salsolinol-induced JNK and NF-kappaB signaling pathways may be involved in induction of apoptosis in human dopaminergic neurons, as seen in Parkinson's disease...
  34. ncbi 1-Methyl-4-phenylpyridinium-induced down-regulation of dopamine transporter function correlates with a reduction in dopamine transporter cell surface expression
    Jaturaporn Chagkutip
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58202, USA
    Biochem Biophys Res Commun 311:49-54. 2003
    ....
  35. pmc TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells
    Sunitha Bollimuntha
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58203, USA
    J Biol Chem 280:2132-40. 2005
    ..Furthermore, TRPC1 may inhibit degenerative apoptotic signaling to provide neuroprotection against Parkinson's disease-inducing agents...
  36. ncbi Distribution of coenzyme Q homologues in brain
    C B Albano
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58203, USA
    Neurochem Res 27:359-68. 2002
    ....
  37. ncbi Distribution kinetics of 18F-DOPA in weaver mutant mice
    Sushil K Sharma
    Center of Excellence in Neuroscience, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Brain Res Mol Brain Res 139:23-30. 2005
    ..Furthermore, this unique and noninvasive approach may expedite quality control and drug development for human applications...
  38. ncbi Salsolinol causing parkinsonism activates endoplasmic reticulum-stress signaling pathways in human dopaminergic SK-N-SH cells
    Mohsen Kheradpezhouh
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, N Dakota 58202, USA
    Neurosignals 12:315-24. 2003
    ..These findings suggest a widespread involvement of ER stress and unfolded protein response in the pathophysiology of Parkinson's disease...
  39. ncbi Free radical scavenging actions of hippocampal metallothionein isoforms and of antimetallothioneins: an electron spin resonance spectroscopic study
    M V Kumari
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58203, USA
    Cell Mol Biol (Noisy-le-grand) 46:627-36. 2000
    ..Moreover, antibodies formed against MT isoform retain some, but not all, free radical scavenging actions exhibited by MT-1 and MT-2...
  40. pmc The 27-kDa heat shock protein confers cytoprotective effects through a beta 2-adrenergic receptor agonist-initiated complex with beta-arrestin
    Lalida Rojanathammanee
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, Grand Forks, ND 58202 9037, USA
    Mol Pharmacol 75:855-65. 2009
    ..As a result, these studies represent the first description of an agonist-dependent relationship between a small heat shock protein and beta-arrestin to form a previously unknown antiapoptotic "signalosome."..
  41. ncbi 1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, induces dopaminergic cell death through apoptosis
    Shaik Shavali
    Department of Pharmacology, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, 58202, Grand Forks, ND, USA
    Neurotoxicology 24:417-24. 2003
    ..These results strongly suggest that 1BnTIQ induces dopaminergic cell death by apoptosis and dopamine receptor agonists may be useful neuroprotective agents against 1BnTIQ toxicity...
  42. ncbi Insulin-like growth factor-1 protects human dopaminergic SH-SY5Y cells from salsolinol-induced toxicity
    Shaik Shavali
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Neurosci Lett 340:79-82. 2003
    ..These results suggest that IGF-1 may be a useful growth factor in the treatment of PD...
  43. ncbi The presence of delta and mu-, but not kappa or ORL(1) receptors in bovine pinealocytes
    Piyarat Govitrapong
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, P O Box 9037, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Brain Res 951:23-30. 2002
    ..These opioid receptors, by stimulating the activity of N-acetyltransferase, enhance the synthesis of melatonin...
  44. ncbi Zinc protects SK-N-SH cells from methamphetamine-induced alpha-synuclein expression
    Amornpan Ajjimaporn
    Neuro Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, Salaya, Nakornpathom 73170, Thailand
    Neurosci Lett 419:59-63. 2007
    ..Pretreatment with ZnCl(2) (50microM) reversed this stimulatory effect. We propose that zinc mediates this neuroprotective response via the production of metallothionein...
  45. doi Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK-N-SH cells
    Sirirat Klongpanichapak
    Neuro Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, Salaya, Nakornpathom, Thailand
    Neurosci Lett 436:309-13. 2008
    ..Further studies are needed to explore the mechanism by which alpha-synuclein contributes to TH-pSer40 dephosphorylation and the mechanism by which melatonin contributes to this interaction...
  46. ncbi Melatonin protects SK-N-SH neuroblastoma cells from amphetamine-induced neurotoxicity
    Sirirat Klongpanichapak
    Neuro Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, Salaya, Nakornpathom, Thailand
    J Pineal Res 43:65-73. 2007
    ..These results suggest that the antioxidant properties of melatonin may provide a protective mechanism against AMPH-induced neuronal degeneration...
  47. ncbi Role of lipoamide dehydrogenase and metallothionein on 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced neurotoxicity
    Muralikrishnan Dhanasekaran
    Division of Pharmacology and Toxicology, Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA
    Neurochem Res 33:980-4. 2008
    ....
  48. ncbi Ebselen effects on MPTP-induced neurotoxicity
    Muralikrishnan Dhanasekaran
    Department of Pharmacal Sciences, Division of Pharmacology and Toxicology, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA
    Brain Res 1118:251-4. 2006
    ..Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum...
  49. ncbi EGb761 pretreatment reduces monoamine oxidase activity in mouse corpus striatum during 1-methyl-4-phenylpyridinium neurotoxicity
    Patricia Rojas
    Laboratory of Neurotoxicology, Instituto Nacional de Neurologia y Neurocirugia, Manuel Velasco Suarez, Mexico, DF, Mexico
    Neurochem Res 29:1417-23. 2004
    ..Results suggest that EGb761 supplements may be effective in reducing MAO activity as well as enhancement in dopamine metabolism, thereby preventing MPP+-neurotoxicity...
  50. ncbi Reduction of zinc-positive terminal fields in striatum of mouse after 1-methyl-4-phenylpyridinium neurotoxicity
    Patricia Rojas
    Laboratory of Neurotoxicology, Instituto Nacional de Neurologia y Neurocirugia, Manuel Velasco Suarez, SS, Av Insurgentes Sur No 3877, C P 14269 México D F, Mexico
    Neurotoxicology 26:959-68. 2005
    ..The decrease of zinc-positive neuronal terminal fields in the striatum after MPP+ administration is most likely due to a neuronal release of vesicular zinc in response to its dopaminergic neurotoxicity...
  51. ncbi Phytoestrogen alpha-zearalanol antagonizes homocysteine-induced imbalance of nitric oxide/endothelin-1 and apoptosis in human umbilical vein endothelial cells
    Jinhong Duan
    University of North Dakota School of Medicine, Grand Forks, ND Chinese Academy of Medical Sciences, Beijing, P R China
    Cell Biochem Biophys 45:137-45. 2006
    ..In summary, these results suggested that alpha-ZAL may effectively preserve Hcy-induced decrease in NO, increase in ET-1/NO ratio and apoptosis, which contributes to protective effects of phytoestrogens on endothelial function...
  52. ncbi Effects of D1- and D2-dopamine receptor activation on melatonin synthesis in bovine pinealocytes
    Chorthip Santanavanich
    Institute of Science and Technology for Research and Development, Mahidol University, Salaya, Nakornpathom, Thailand
    J Pineal Res 35:169-76. 2003
    ..The precise mechanism whereby activation of dopamine receptors altered the NAT activity and melatonin level needs to be further delineated...
  53. ncbi The neuroprotective effect of melatonin against the induction of c-Jun phosphorylation by 6-hydroxydopamine on SK-N-SH cells
    Banthit Chetsawang
    Neuro Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, Salaya, Nakornpathom 73170, Thailand
    Neurosci Lett 371:205-8. 2004
    ..These results demonstrate some protective properties of melatonin against neuronal cell degeneration and its action on the inhibition of c-Jun-N terminal kinase signaling cascade...
  54. ncbi Differential mechanisms of nitric oxide- and peroxynitrite-induced cell death
    Johanna T A Meij
    Department of Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Avenue, OH 45267 0521, USA
    Mol Pharmacol 66:1043-53. 2004
    ..Moreover, post-treatment with insulin inhibited caspase-3 activation and loss of cell viability in NONOate- but not in SIN-1-exposed cells. These findings suggest that NO is a potent toxin independent of peroxynitrite formation...

Research Grants13

  1. PINEAL OPIOID RECEPTORS & ANALGESIC ACTION OF MELATONIN
    Manuchair Ebadi; Fiscal Year: 2002
    ..Therefore, future research must synthesize highly efficacious melatonin analogues capable of providing maximum analgesia and hopefully being devoid of addiction liability now associated with currently available narcotics. ..
  2. UBIQUINONE AND MITOCHONDRIAL OXIDATIVE DISORDERS OF AGIN
    Manuchair Ebadi; Fiscal Year: 2003
    ..The completion of these studies will undoubtedly provide additional items of information on reactive oxygen species-induced damage of mitochondrial DNA and the protective effects of coenzyme Q10(ubiquinol) to minimize it. ..