Affiliation: University of Texas Medical Branch
- Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the proteinT D Eaves-Pyles
Divisions of Critical Care Medicine, and Infectious Diseases, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
J Immunol 167:7009-16. 2001..5 pg/ml) and 6HIS flag (987 pg/ml). The potent proinflammatory activity of flagellin, therefore, resides in the highly conserved N and C D1 and D2 regions...
- Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanismTonyia Eaves-Pyles
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America
PLoS ONE 6:e24869. 2011....
- Outer membrane protein A of Escherichia coli O157:H7 stimulates dendritic cell activationAlfredo G Torres
Department of Microbiology and Immunology, 301 University Blvd, University of Texas Medical Branch, Galveston, Texas 77555 1070, USA
Infect Immun 74:2676-85. 2006..While OmpA was required for bacterial binding to polarized Caco-2 cells, it was not needed for the induction of cytokine production by Caco-2 cells or for human DC migration across polarized cells...
- Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cellsTonyia Eaves-Pyles
Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1070, USA
Int J Med Microbiol 298:397-409. 2008..These findings demonstrate that E. coli O83:H1 possesses the characteristics of the AIEC LF82 strain that may contribute to the low-grade, chronic inflammation observed in Crohn's disease...
- Levofloxacin rescues mice from lethal intra-nasal infections with virulent Francisella tularensis and induces immunity and production of protective antibodyGary R Klimpel
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
Vaccine 26:6874-82. 2008..tularensis...
- Role of primary human alveolar epithelial cells in host defense against Francisella tularensis infectionMegan Gentry
Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1070, USA
Infect Immun 75:3969-78. 2007..These data indicate a crucial role for ATII cells in the innate immune response to F. tularensis...
- Protection Afforded by Fluoroquinolones in Animal Models of Respiratory Infections with Bacillus anthracis, Yersinia pestis, and Francisella tularensisJohnny W Peterson
Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd Galveston, Texas 77555 0610
Open Microbiol J 4:34-46. 2010..These results provide effective antibiotic dosages in mice, guinea pigs, and rabbits and lay the foundation for the development and evaluation of combinational treatment modalities...
- Heat shock inhibits activation of NF-kappaB in the absence of heat shock factor-1Vivek Malhotra
Division of Critical Care Medicine, Children's Hospital Medical Center and Children's Hospital Research Foundation, Cincinnati, Ohio 45229-3039, USA
Biochem Biophys Res Commun 291:453-7. 2002..These data demonstrate that heat shock inhibits activation of the NF-kappaB/IkappaBalpha pathway and NF-kappaB-dependent gene expression in the absence of an intact heat shock response...
- Burkholderia mallei and Burkholderia pseudomallei stimulate differential inflammatory responses from human alveolar type II cells (ATII) and macrophagesRichard Lu
Department of Microbiology and Immunology, University of Texas Medical Branch Galveston, TX, USA
Front Cell Infect Microbiol 2:165. 2012....
- Critical role for serum opsonins and complement receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in phagocytosis of Francisella tularensis by human dendritic cells (DC): uptake of Francisella leads to activation of immature DC and intracellular survival ofAbdelhakim Ben Nasr
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA
J Leukoc Biol 80:774-86. 2006..These results suggest that the simultaneous production of an activating (IL-12, IL-1beta, and TNF-alpha) and a suppressing (IL-10) cytokine profile could contribute to the immunopathogenesis of tularemia...
- Mechanistic study of flagellin-induced inflammationTonyia Eaves Pyles; Fiscal Year: 2004..These studies will provide insights into bacterial and host cells interactions that are critical for establishing disease and will offer new avenues for the development of treatment. ..
- Franciscella Tularensis: Characterizing Lung Innate ImmunityTonyia Eaves Pyles; Fiscal Year: 2007..tularensis. This funding of this proposal will provide crucial insight into the effective and ineffective innate immune responses to help find future vaccines and therapeutic development. ..