Affiliation: University of Michigan
- Probiotic Lactobacillus reuteri ameliorates disease due to enterohemorrhagic Escherichia coli in germfree miceKathryn A Eaton
Unit for Laboratory Animal Medicine, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0614, USA
Infect Immun 79:185-91. 2011..reuteri prior to treatment. The twice-daily administration of L. reuteri appeared more effective than every-other-day administration. These data indicated that L. reuteri partially protects mice from disease manifestations of EHEC...
- Ulcerative typhlocolitis associated with Helicobacter mastomyrinus in telomerase-deficient miceK A Eaton
University of Michigan Medical School, Ann Arbor, MI 48109, USA
Vet Pathol 48:713-25. 2011..Telomerase-deficient mice are susceptible to helicobacter-associated typhlocolitis. H mastomyrinus causes severe disease in susceptible mouse strains...
- Pathogenesis of renal disease due to enterohemorrhagic Escherichia coli in germ-free miceKathryn A Eaton
Unit for Laboratory Animal Medicine, 018 Animal Research Facility, University of Michigan, Ann Arbor, MI 48109 0614, USA
Infect Immun 76:3054-63. 2008..The disease in mice was Stx2 and bacterial strain dependent. This animal model should be a useful tool for studying the pathogenesis of renal disease secondary to EHEC infection...
- A reproducible scoring system for quantification of histologic lesions of inflammatory disease in mouse gastric epitheliumKathryn A Eaton
Ohio State University, Columbus, USA
Comp Med 57:57-65. 2007..We propose that this system may be useful in standardizing the morphologic evaluation of rodent models of H. pylori and that a similar system could be devised for evaluation of other animal models of enteric disease...
- Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in miceKathryn A Eaton
University of Michigan, Ann Arbor, Michigan 48109, USA
Infect Immun 74:4673-84. 2006..pylori-infected recipient SCID mice. This indicates that Th1-independent mechanisms can cause gastric inflammation and disease due to H. pylori...
- Adoptive transfer of splenocytes in SCID mice implicates CD4+ T cells in apoptosis and epithelial proliferation associated with Helicobacter pylori-induced gastritisRichard A Peterson
The Ohio State University, College of Veterinary Medicine, Department of Veterinary Biosciences, Columbus, Ohio 43210, USA
Comp Med 53:498-509. 2003..Influx of CD4 cells and gastritis are correlated with epithelial proliferation and apoptosis, and suggest that CD4-dependent H. pylori gastritis leads to epithelial damage with attendant proliferative and metaplastic responses...
- In vivo complementation of ureB restores the ability of Helicobacter pylori to colonizeKathryn A Eaton
Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
Infect Immun 70:771-8. 2002..Finally, our results suggest that total urease activity and colonization density do not contribute to gastritis due to H. pylori...
- Helicobacter spp. in wild mice (Peromyscus leucopus) found in laboratory animal facilitiesMelissa C Dyson
Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA
J Am Assoc Lab Anim Sci 48:754-6. 2009..At this time, wild mice found in our animal facilities do not appear to be a significant source of common laboratory mouse viral pathogens. However, they are a potential source of Helicobacter infections...
- Helicobacter pylori-pulsed dendritic cells induce H. pylori-specific immunity in miceMin Zhang
Department of Internal Medicine Gastroenterology Division, University of Michigan, Ann Arbor, Michigan 48109, USA
Helicobacter 13:200-8. 2008..The growing concern over the emergence of antibiotic-resistant Helicobacter pylori infection is propelling the development of an efficacious vaccine to control this highly adaptive organism...
- Gangrenous Clostridium perfringens infection and subsequent wound management in a rhesus macaque (Macaca mulatta)Thomas R Meier
Unit for Laboratory Animal Medicine, Jobst Vascular Research Laboratories, University of Michigan Medical Center, Ann Arbor, MI, USA
J Am Assoc Lab Anim Sci 46:68-73. 2007..This case study is the first report of Clostridium perfringens myonecrosis in a laboratory nonhuman primate. We discuss various methodologies for the diagnosis and treatment of necrotizing clostridial infections...
- Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defenseJohn Y Kao
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0682, USA
Am J Physiol Gastrointest Liver Physiol 291:G73-81. 2006..lwoffi. Our findings suggest that dendritic cells participate in the host immune response against H. pylori and that their suppression by H. pylori may explain why infected hosts fail to prevent bacterial colonization...
- The Entner-Doudoroff pathway has little effect on Helicobacter pylori colonization of miceAmy E Wanken
Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
Infect Immun 71:2920-3. 2003..In spite of better colonization, however, wild-type strains did not displace the mutant in cocolonization experiments. Loss of 6PGD diminishes the fitness of H. pylori in vivo, but the pathway is nonessential for colonization...
- Interleukin-1beta promotes gastric atrophy through suppression of Sonic HedgehogMeghna Waghray
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Gastroenterology 138:562-72, 572.e1-2. 2010..Sonic Hedgehog (Shh) is highly expressed in the gastric corpus and its loss correlates with gastric atrophy. Therefore, we tested the hypothesis that proinflammatory cytokines induce gastric atrophy by inhibiting Shh expression...
- E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infectionDavid M Aronoff
Divisions of Infectious Diseases, University of Michigan Health System, Ann Arbor, MI 48109, USA
J Immunol 183:2642-9. 2009..Pharmacological targeting of the PGE(2)-EP3 axis represents a novel area warranting greater investigative interest in the prevention and/or treatment of infectious diseases...
- Uropathogenic Escherichia coli Suppresses the host inflammatory response via pathogenicity island genes sisA and sisBAmanda L Lloyd
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Infect Immun 77:5322-33. 2009....
- Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic miceLymari Lopez-Diaz
Department of Molecular and Integrative Physiology, University of Michigan, 7761 Medical Science II Building, Ann Arbor, MI 48109, USA
Am J Physiol Gastrointest Liver Physiol 290:G970-9. 2006..High Ctox in parietal cells can also induce progressive changes in the cellular architecture of the gastric glands, corresponding to the development of anti-parietal cell antibodies and autoimmune gastritis...
- Vaccination with proteus toxic agglutinin, a hemolysin-independent cytotoxin in vivo, protects against Proteus mirabilis urinary tract infectionPraveen Alamuri
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
Infect Immun 77:632-41. 2009..The serum immunoglobulin G levels correlated with protection (P = 0.03). This is the first report describing the in vivo cytotoxicity and antigenicity of an autotransporter in P. mirabilis and its use in vaccine development...
- Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinomaYana Zavros
Department of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0650, USA
Oncogene 24:2354-66. 2005..Moreover, neoplastic transformation of the antral gastric mucosa does not require gastrin...
- Response to "eradication of Helicobacter pylori and resolution of gastritis in the gastric mucosa of IL-10-deficient mice"Kathryn A Eaton
Helicobacter 11:135-6. 2006
- Helicobacter acinonychis: genetic and rodent infection studies of a Helicobacter pylori-like gastric pathogen of cheetahs and other big catsDaiva Dailidiene
Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri 63110, USA
J Bacteriol 186:356-65. 2004..pylori, its ability to infect mice, and its ability to coexist and recombine with certain H. pylori strains in vivo should be useful in studies of Helicobacter infection and virulence mechanisms and studies of genome evolution...
- Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticusJason S Pratt
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
Infect Immun 74:4496-504. 2006..hepaticus. These results suggest that CDT plays a key immunomodulatory role that allows persistence of H. hepaticus and that in IL-10-/- mice this alteration of the host immune response results in the development of colitis...
- Host and Bacterial Factors in Disease due to H. pyloriKATHRYN EATON; Fiscal Year: 2007..Successful completion of these aims will lead to improved understanding of the pathogenesis of H. pylori associated disease and provide a foundation for development of novel therapies. ..
- Recombinant murine IL-10 produced in situ by H. pyloriKATHRYN EATON; Fiscal Year: 2005..pylori, but will also establish a model in which the roles of other cytokines and mediators can be determined, and host and bacterial interactions can be directly evaluated in vivo. ..
- Host and Bacterial Factors in Disease due to H. pyloriKathryn A Eaton; Fiscal Year: 2010..This will allow us to hire additional staff to ensure rapid completion of the remaining experiments. With these changes we fully expect to complete these experiments in 2 years. ..