David A Eastmond

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint The use of genetically modified mice in cancer risk assessment: challenges and limitations
    David A Eastmond
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    Crit Rev Toxicol 43:611-31. 2013
  2. ncbi request reprint Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene
    David A Eastmond
    Environmental Toxicology Graduate Program, 5429 Boyce Hall, University of California, Riverside, CA 92521, USA
    Chem Biol Interact 153:207-16. 2005
  3. doi request reprint Evaluating genotoxicity data to identify a mode of action and its application in estimating cancer risk at low doses: A case study involving carbon tetrachloride
    David A Eastmond
    Environmental Toxicology Graduate Program, Department of Cell Biology and Neuroscience, University of California, Riverside, California 92506, USA
    Environ Mol Mutagen 49:132-41. 2008
  4. ncbi request reprint Evaluation of hyperdiploidy in the bladder epithelial cells of male F344 rats treated with ortho-phenylphenol
    S Balakrishnan
    Environmental Toxicology Graduate Program, University of California, 5429 Alfred M Boyce Hall, Riverside, CA 92521 0314, USA
    Mutat Res 537:11-20. 2003
  5. doi request reprint Trivalent chromium: assessing the genotoxic risk of an essential trace element and widely used human and animal nutritional supplement
    David A Eastmond
    Environmental Toxicology Graduate Program, 2109 Biological Sciences Bldg, University of California, Riverside, CA 92506, USA
    Crit Rev Toxicol 38:173-90. 2008
  6. doi request reprint A comparative study of the cytotoxic and genotoxic effects of ICRF-154 and bimolane, two catalytic inhibitors of topoisomerase II
    Minh C Vuong
    Environmental Toxicology Graduate Program and Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    Mutat Res 750:63-71. 2013
  7. doi request reprint Bimolane induces multiple types of chromosomal aberrations in human lymphocytes in vitro
    Shambhu K Roy
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    Mutat Res 726:181-7. 2011
  8. doi request reprint Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms
    Luoping Zhang
    School of Public Health, 50 University Hall, University of California, Berkeley, CA 94720 7356, USA
    Mutat Res 681:150-68. 2009
  9. ncbi request reprint Differential cell cycle-specificity for chromosomal damage induced by merbarone and etoposide in V79 cells
    Ling Wang
    Environmental Toxicology Graduate Program, 2109 Biological Sciences Building, University of California, Riverside, CA 92521, USA
    Mutat Res 616:70-82. 2007
  10. ncbi request reprint Detection of micronuclei, cell proliferation and hyperdiploidy in bladder epithelial cells of rats treated with o-phenylphenol
    S Balakrishnan
    Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, USA
    Mutagenesis 17:89-93. 2002

Collaborators

Detail Information

Publications25

  1. doi request reprint The use of genetically modified mice in cancer risk assessment: challenges and limitations
    David A Eastmond
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    Crit Rev Toxicol 43:611-31. 2013
    ..Hence, caution should be exercised when using GM mouse models to assess the carcinogenic risks of chemicals...
  2. ncbi request reprint Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene
    David A Eastmond
    Environmental Toxicology Graduate Program, 5429 Boyce Hall, University of California, Riverside, CA 92521, USA
    Chem Biol Interact 153:207-16. 2005
    ..Current evidence indicates that multiple mechanisms are likely to contribute to benzene-induced leukemias, and that inhibition of topo II could represent an important step in the development of certain leukemia subtypes...
  3. doi request reprint Evaluating genotoxicity data to identify a mode of action and its application in estimating cancer risk at low doses: A case study involving carbon tetrachloride
    David A Eastmond
    Environmental Toxicology Graduate Program, Department of Cell Biology and Neuroscience, University of California, Riverside, California 92506, USA
    Environ Mol Mutagen 49:132-41. 2008
    ..This conclusion is consistent with rodent cancer bioassay results in which steep nonlinear dose responses have been seen...
  4. ncbi request reprint Evaluation of hyperdiploidy in the bladder epithelial cells of male F344 rats treated with ortho-phenylphenol
    S Balakrishnan
    Environmental Toxicology Graduate Program, University of California, 5429 Alfred M Boyce Hall, Riverside, CA 92521 0314, USA
    Mutat Res 537:11-20. 2003
    ....
  5. doi request reprint Trivalent chromium: assessing the genotoxic risk of an essential trace element and widely used human and animal nutritional supplement
    David A Eastmond
    Environmental Toxicology Graduate Program, 2109 Biological Sciences Bldg, University of California, Riverside, CA 92506, USA
    Crit Rev Toxicol 38:173-90. 2008
    ....
  6. doi request reprint A comparative study of the cytotoxic and genotoxic effects of ICRF-154 and bimolane, two catalytic inhibitors of topoisomerase II
    Minh C Vuong
    Environmental Toxicology Graduate Program and Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    Mutat Res 750:63-71. 2013
    ....
  7. doi request reprint Bimolane induces multiple types of chromosomal aberrations in human lymphocytes in vitro
    Shambhu K Roy
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    Mutat Res 726:181-7. 2011
    ....
  8. doi request reprint Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms
    Luoping Zhang
    School of Public Health, 50 University Hall, University of California, Berkeley, CA 94720 7356, USA
    Mutat Res 681:150-68. 2009
    ..To test these hypotheses, we recommend that future studies apply biomarkers validated for other chemical leukemogens to the study of formaldehyde...
  9. ncbi request reprint Differential cell cycle-specificity for chromosomal damage induced by merbarone and etoposide in V79 cells
    Ling Wang
    Environmental Toxicology Graduate Program, 2109 Biological Sciences Building, University of California, Riverside, CA 92521, USA
    Mutat Res 616:70-82. 2007
    ....
  10. ncbi request reprint Detection of micronuclei, cell proliferation and hyperdiploidy in bladder epithelial cells of rats treated with o-phenylphenol
    S Balakrishnan
    Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, USA
    Mutagenesis 17:89-93. 2002
    ..These results also indicate that at high concentrations the sodium salt can enhance chromosomal damage in the rat urothelium...
  11. ncbi request reprint Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme
    David A Eastmond
    University of California, Riverside, USA
    Mutagenesis 24:341-9. 2009
    ..The approach presented in this paper focuses on the identification of mutagens and genotoxic carcinogens. Selection of appropriate in vitro and in vivo tests as well as a strategy for germ cell testing are described...
  12. ncbi request reprint Concordance of transcriptional and apical benchmark dose levels for conazole-induced liver effects in mice
    Virunya S Bhat
    Environmental Toxicology Graduate Program, University of California, Riverside, California 92521
    Toxicol Sci 136:205-15. 2013
    ..These results support the utility of measuring short-term gene expression changes to inform quantitative risk assessments from long-term exposures...
  13. doi request reprint Topoisomerase II inhibition by the bioactivated benzene metabolite hydroquinone involves multiple mechanisms
    Scott Mondrala
    Environmental Toxicology Graduate Program and Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, United States
    Chem Biol Interact 184:259-68. 2010
    ....
  14. ncbi request reprint Elevated levels of tetraploid cervical cells in human papillomavirus-positive Papanicolaou smears diagnosed as atypical squamous cells of undetermined significance
    Andrew J Olaharski
    Environmental Toxicology Graduate Program, Department of Cell Biology and Neuroscience, University of California, Riverside, California, USA
    Cancer 102:192-9. 2004
    ..The identification of elevated levels of numerical chromosomal aberrations in women diagnosed with ASCUS Pap smears, therefore, may be of prognostic value...
  15. ncbi request reprint Enhancing the in vitro and in vivo detection of aneuploidy by fluorescence in situ hybridization with the use of bromodeoxyuridine as a proliferation marker
    S Balakrishnan
    Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, USA
    Mutat Res 521:81-9. 2002
    ..The combination of BrdU-labeling and FISH allows the scoring of hyperdiploidy to be focused on the actively replicating cells, thereby increasing the sensitivity of the FISH technique...
  16. ncbi request reprint Tetraploidy and chromosomal instability are early events during cervical carcinogenesis
    Andrew J Olaharski
    Environmental Toxicology Graduate Program, Department of Cell Biology and Neuroscience, 5429 Boyce Hall, University of California, Riverside, CA 92521, USA
    Carcinogenesis 27:337-43. 2006
    ....
  17. ncbi request reprint The nature of chromosomal aberrations detected in humans exposed to benzene
    Luoping Zhang
    School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley 94720 7360, USA
    Crit Rev Toxicol 32:1-42. 2002
    ..Leukemia cases associated with benzene exposure are, however, more likely to contain clonal chromosome aberrations then those arising de novo in the general population...
  18. ncbi request reprint Chromosome breakage is primarily responsible for the micronuclei induced by 1,4-dioxane in the bone marrow and liver of young CD-1 mice
    S K Roy
    Environmental Toxicology Graduate Program, 5429 Boyce Hall, University of California, Riverside, CA 92521, USA
    Mutat Res 586:28-37. 2005
    ....
  19. ncbi request reprint Micronuclei and cell proliferation as early biological markers of ortho-phenylphenol-induced changes in the bladder of male F344 rats
    S Balakrishnan
    Environmental Toxicology Graduate Program, University of California, 5429 Boyce Hall, Riverside, CA 92521, USA
    Food Chem Toxicol 44:1340-7. 2006
    ..These results also indicate that micronucleus formation and cell proliferation can detect early OPP-induced changes in the rat bladder and may be useful as biomarkers for bladder carcinogens...
  20. ncbi request reprint Catalytic inhibitors of topoisomerase II are DNA-damaging agents: induction of chromosomal damage by merbarone and ICRF-187
    Ling Wang
    Environmental Toxicology Graduate Program, Department of Cell Biology and Neuroscience, University of California, Riverside, California 92521, USA
    Environ Mol Mutagen 39:348-56. 2002
    ....
  21. ncbi request reprint Noscapine hydrochloride-induced numerical aberrations in cultured human lymphocytes: a comparison of FISH detection methods and multiple end-points
    M Schuler
    Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, USA
    Mutagenesis 18:235-42. 2003
    ..These studies indicate that FISH in combination with CYB or BrdU immunfluorescent staining can be sensitive tools for the identification of aneuploidy-inducing agents...
  22. ncbi request reprint Postulated carbon tetrachloride mode of action: a review
    Mary K Manibusan
    Office of Pesticide Programs, U S Environmental Protection Agency, Washington, DC 20460, United States
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 25:185-209. 2007
    ..To fulfill the mode of action framework, additional research may be necessary to determine alternative mode(s) of action for liver tumors formed via carbon tetrachloride exposure...
  23. ncbi request reprint Induction of cell proliferation, micronuclei and hyperdiploidy/polyploidy in the mammary cells of DDT- and DMBA-treated pubertal rats
    Padma T Uppala
    Department of Environmental and Occupational Health, School of Public Health, Loma Linda University, Loma Linda, CA 92350, USA
    Environ Mol Mutagen 46:43-52. 2005
    ..These initial studies indicate that DDT and DMBA can induce cellular and chromosomal alterations in the rat mammary gland, which is consistent with the hypothesis that these agents can induce early events in mammary carcinogenesis...
  24. ncbi request reprint Non-disjunction events induced by albendazole in human cells
    Tzutzuy Ramirez
    Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas Instituto Nacional de Cancerología, Mexico, D F, Mexico
    Mutat Res 626:191-5. 2007
    ..Significant increase in non-disjunction events that involved either chromosome were observed in cells treated with ABZ or ABZSO. Both ABZ and ABZSO induced non-disjunction at lower concentrations than those at which MN were observed...
  25. ncbi request reprint Childhood acute lymphocytic leukemia and perspectives on risk assessment of early-life stage exposures
    Andrea S Kim
    National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, 1200 Pennsylvania Avenue MC 8623D, Washington, DC 20460, USA
    Mutat Res 613:138-60. 2006
    ....