Thomas D Dziubla

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint The Role of Carrier Geometry in Overcoming Biological Barriers to Drug Delivery
    Carolyn Jordan
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506 0046
    Curr Pharm Des 22:1259-73. 2016
  2. pmc Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies
    Thomas D Dziubla
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, 1 John Morgan Building, 36th Street and Hamilton Walk, Philadelphia, PA 19104 6068, USA
    Biomaterials 29:215-27. 2008
  3. pmc Loading PEG-catalase into filamentous and spherical polymer nanocarriers
    ERIC A SIMONE
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pharm Res 26:250-60. 2009
  4. doi request reprint Suppressing iron oxide nanoparticle toxicity by vascular targeted antioxidant polymer nanoparticles
    David B Cochran
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40508, USA
    Biomaterials 34:9615-22. 2013
  5. doi request reprint Optimization of the lyophilization process for long-term stability of solid-lipid nanoparticles
    Melissa D Howard
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506 0046, USA
    Drug Dev Ind Pharm 38:1270-9. 2012
  6. pmc Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase
    ERIC A SIMONE
    Department of Bioengineering, Institute for Translational Medicine and Therapeutics, and Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biomacromolecules 10:1324-30. 2009
  7. pmc Bioerodible system for sequential release of multiple drugs
    Sharath C Sundararaj
    Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506 0070, USA
    Acta Biomater 10:115-25. 2014
  8. doi request reprint Carboxylesterase-triggered hydrolysis of nanoparticle PEGylating agents
    Melissa D Howard
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0596, United States
    Langmuir 28:12030-7. 2012
  9. doi request reprint Synthesis and characterization of poly(antioxidant β-amino esters) for controlled release of polyphenolic antioxidants
    Paritosh P Wattamwar
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, 40506, USA
    Acta Biomater 8:2529-37. 2012
  10. pmc Bioerodible calcium sulfate/poly(β-amino ester) hydrogel composites
    Bryan R Orellana
    Center for Biomedical Engineering, Wenner Gren Research Lab, University of Kentucky, Lexington, KY 40506 0070, USA
    J Mech Behav Biomed Mater 26:43-53. 2013

Collaborators

Detail Information

Publications31

  1. ncbi request reprint The Role of Carrier Geometry in Overcoming Biological Barriers to Drug Delivery
    Carolyn Jordan
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506 0046
    Curr Pharm Des 22:1259-73. 2016
    ..In this review, we present a summary of some approaches used to control carrier shape and the impact these geometries have upon drug transport across biological barriers. ..
  2. pmc Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies
    Thomas D Dziubla
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, 1 John Morgan Building, 36th Street and Hamilton Walk, Philadelphia, PA 19104 6068, USA
    Biomaterials 29:215-27. 2008
    ..Vascular targeting of PNC-loaded detoxifying enzymes may find wide medical applications including management of oxidative stress and other toxicities...
  3. pmc Loading PEG-catalase into filamentous and spherical polymer nanocarriers
    ERIC A SIMONE
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pharm Res 26:250-60. 2009
    ..Based on a unique phase alignment that occurs during formulation, we postulated that PEG-ylation of the cargo enzyme would enhance its encapsulation within diblock copolymer nanocarriers and thus resistance to proteases...
  4. doi request reprint Suppressing iron oxide nanoparticle toxicity by vascular targeted antioxidant polymer nanoparticles
    David B Cochran
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40508, USA
    Biomaterials 34:9615-22. 2013
    ..These results indicate the potential of using poly(trolox ester) as a means of mitigating iron oxide toxicity, potentially expanding the clinical use and relevance of these exciting systems...
  5. doi request reprint Optimization of the lyophilization process for long-term stability of solid-lipid nanoparticles
    Melissa D Howard
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506 0046, USA
    Drug Dev Ind Pharm 38:1270-9. 2012
    ..To optimize a lyophilization protocol for solid-lipid nanoparticles (SLNs) loaded with dexamethasone palmitate (Dex-P) and to compare the long-term stability of lyophilized SLNs and aqueous SLN suspensions at two storage conditions...
  6. pmc Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase
    ERIC A SIMONE
    Department of Bioengineering, Institute for Translational Medicine and Therapeutics, and Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biomacromolecules 10:1324-30. 2009
    ..Thus, we report here for the first time f-PNC that encapsulate an active enzyme with polymer MW-tunable flexibility, offering several potential therapeutic applications...
  7. pmc Bioerodible system for sequential release of multiple drugs
    Sharath C Sundararaj
    Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506 0070, USA
    Acta Biomater 10:115-25. 2014
    ....
  8. doi request reprint Carboxylesterase-triggered hydrolysis of nanoparticle PEGylating agents
    Melissa D Howard
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0596, United States
    Langmuir 28:12030-7. 2012
    ..These studies reveal the importance of confirming the stability of PEG surface coatings prior to undertaking in vivo experiments in small animal models, which can have considerably higher plasma esterase activity than humans...
  9. doi request reprint Synthesis and characterization of poly(antioxidant β-amino esters) for controlled release of polyphenolic antioxidants
    Paritosh P Wattamwar
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, 40506, USA
    Acta Biomater 8:2529-37. 2012
    ..Treatment of endothelial cells with PAβAE degradation products protected cells from hydrogen-peroxide-induced oxidative stress...
  10. pmc Bioerodible calcium sulfate/poly(β-amino ester) hydrogel composites
    Bryan R Orellana
    Center for Biomedical Engineering, Wenner Gren Research Lab, University of Kentucky, Lexington, KY 40506 0070, USA
    J Mech Behav Biomed Mater 26:43-53. 2013
    ....
  11. pmc Polymeric carriers: role of geometry in drug delivery
    ERIC A SIMONE
    University of Pennsylvania, Department of Bioengineering, 3620 Hamilton Walk, 1 John Morgan Building, Philadelphia, PA 19104, USA
    Expert Opin Drug Deliv 5:1283-300. 2008
    ..This article reviews drug delivery aspects of non-spherical drug delivery systems, including material selection and formulation, drug loading and release, biocompatibility, circulation behavior, targeting and subcellular addressing...
  12. doi request reprint Tuning of the pro-oxidant and antioxidant activity of trolox through the controlled release from biodegradable poly(trolox ester) polymers
    Paritosh P Wattamwar
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky 40506, USA
    J Biomed Mater Res A 99:184-91. 2011
    ..This polymer delivery form possessed a unique ability to suppress protein oxidation, a feature not seen in the free drug form, emphasizing the advantage of the delivery/dosage formulation has upon regulating cellular response...
  13. pmc Design of a multiple drug delivery system directed at periodontitis
    Sharath C Sundararaj
    Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506 0070, USA
    Biomaterials 34:8835-42. 2013
    ..The multilayered CAPP delivery system offers a versatile approach for releasing different drugs based on the pathogenesis of periodontitis and other conditions. ..
  14. ncbi request reprint Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers
    ERIC A SIMONE
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biomacromolecules 8:3914-21. 2007
    ..PNC morphology also greatly influenced its degradation, offering a new means of controlled delivery...
  15. ncbi request reprint Synthetic carriers for vascular delivery of protein therapeutics
    Thomas D Dziubla
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biotechnol Genet Eng Rev 22:267-98. 2006
  16. pmc Synthetic oral mucin mimic from polymer micelle networks
    Sundar P Authimoolam
    Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, Kentucky 40506, United States
    Biomacromolecules 15:3099-111. 2014
    ..The synthetic networks provide an excellent, yet simple, means of independently characterizing mucin network properties (e.g., surface chemistry, stiffness, and pore size). ..
  17. doi request reprint Local delivery of imiquimod in hamsters using mucoadhesive films and their residence time in human patients
    Sandeep K Ramineni
    Department of Biomedical Engineering, University of Kentucky, Lexington, KY, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol 118:665-73. 2014
    ..To investigate the ability of mucoadhesive films to locally deliver an immune response modifier (imiquimod) to oral mucosa...
  18. doi request reprint Synthesis and characterization of an antibacterial hydrogel containing covalently bound vancomycin
    Andrew L Lakes
    Department of Chemical and Materials Engineering and Department of Biomedical Engineering, College of Engineering, University of Kentucky, Lexington, Kentucky 40506, United States
    Biomacromolecules 15:3009-18. 2014
    ..Bioactivity of released vancomycin was also confirmed alongside the resulting antimicrobial activity of the reacted vancomycin releasate. ..
  19. doi request reprint Block copolymers for the rational design of self-forming postsurgical adhesion barriers
    John M Medley
    Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY 40506 0046, USA
    Acta Biomater 6:72-82. 2010
    ..Energy dissipation analysis and variable-angle spectroscopic ellipsometry revealed two competing adsorption mechanisms depending on the molecular properties of the polymer...
  20. doi request reprint Layer-by-Layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network
    Sundar P Authimoolam
    Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, Kentucky, 40506, USA
    Macromol Biosci 16:242-54. 2016
    ..These biomimetic coatings can be utilized as a delivery system, providing a tunable drug release for oral applications. ..
  21. doi request reprint The role of ROS generation from magnetic nanoparticles in an alternating magnetic field on cytotoxicity
    Robert J Wydra
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA
    Acta Biomater 25:284-90. 2015
    ....
  22. doi request reprint Quercetin conjugated poly(β-amino esters) nanogels for the treatment of cellular oxidative stress
    Prachi Gupta
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506 0046, USA
    Acta Biomater 27:194-204. 2015
    ..Uniform release of quercetin over 45-48h was observed upon PβAE ester hydrolysis under physiological conditions with its retained antioxidant activity over the extended times...
  23. ncbi request reprint Temporal separation in the release of bioactive molecules from a moldable calcium sulfate bone graft substitute
    Matt E Brown
    522A Robotics and Manufacturing Building, Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506 0108, USA
    Curr Drug Deliv 11:605-12. 2014
    ....
  24. pmc Affinity based multilayered polymeric self-assemblies for oral wound applications
    Sundar P Authimoolam
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA
    Adv Healthc Mater 2:983-92. 2013
    ..Thus, the proposed affinity based LBLs with their excellent barrier properties offer a modular treatment approach in oral mucosal injuries. ..
  25. pmc Development of imiquimod-loaded mucoadhesive films for oral dysplasia
    Sandeep K Ramineni
    Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506, USA
    J Pharm Sci 102:593-603. 2013
    ..In summary, a noninvasive and local approach with the potential to treat precancerous lesions may be achieved by this described mucoadhesive drug delivery system...
  26. doi request reprint Effects of composition and setting environment on mechanical properties of a composite bone filler
    Matthew E Brown
    Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506, USA
    J Biomed Mater Res A 101:973-80. 2013
    ..With these desirable properties for a bone graft substitute and the potential to be loaded with bioactive drugs, this composite material merits further investigation for the future treatment of bony defects...
  27. ncbi request reprint Polymer nanocarriers protecting active enzyme cargo against proteolysis
    Thomas D Dziubla
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 1 John Morgan 6068, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    J Control Release 102:427-39. 2005
    ..Delivery and protection of catalase from lysosomal degradation afforded by PNC nanotechnology may advance effectiveness and duration of treatment of diverse disease conditions associated with vascular oxidative stress...
  28. pmc Modulation of persistent organic pollutant toxicity through nutritional intervention: emerging opportunities in biomedicine and environmental remediation
    Michael C Petriello
    Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Sci Total Environ 491:11-6. 2014
    ....
  29. pmc Binding, transcytosis and biodistribution of anti-PECAM-1 iron oxide nanoparticles for brain-targeted delivery
    Mo Dan
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, United States of America Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 8:e81051. 2013
    ..Characterize the flux of platelet-endothelial cell adhesion molecule (PECAM-1) antibody-coated superparamagnetic iron oxide nanoparticles (IONPs) across the blood-brain barrier (BBB) and its biodistribution in vitro and in vivo...
  30. pmc The effect of plasticizers on the erosion and mechanical properties of polymeric films
    Cheryl L Rabek
    1Center for Biomedical Engineering, University of Kentucky, Lexington, KY, USA
    J Biomater Appl 28:779-89. 2014
    ..The mechanical properties of cellulose acetate phthalate-Pluronic films can be adjusted by the type and amount of plasticizer added to the system and therefore can be tailored for different drug delivery applications. ..
  31. doi request reprint Physicochemical characterization of nanotemplate engineered solid lipid nanoparticles
    Melissa D Howard
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S Limestone, Lexington, Kentucky 40536 0596, United States
    Langmuir 27:1964-71. 2011
    ..However, it is expected that with appropriate formulation modifications nanotemplate engineered SLNs will possess the properties necessary for a successful drug delivery system...