Thomas D Dziubla

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies
    Thomas D Dziubla
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, 1 John Morgan Building, 36th Street and Hamilton Walk, Philadelphia, PA 19104 6068, USA
    Biomaterials 29:215-27. 2008
  2. pmc Loading PEG-catalase into filamentous and spherical polymer nanocarriers
    ERIC A SIMONE
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pharm Res 26:250-60. 2009
  3. pmc Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase
    ERIC A SIMONE
    Department of Bioengineering, Institute for Translational Medicine and Therapeutics, and Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biomacromolecules 10:1324-30. 2009
  4. pmc Polymeric carriers: role of geometry in drug delivery
    ERIC A SIMONE
    University of Pennsylvania, Department of Bioengineering, 3620 Hamilton Walk, 1 John Morgan Building, Philadelphia, PA 19104, USA
    Expert Opin Drug Deliv 5:1283-300. 2008
  5. ncbi request reprint Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers
    ERIC A SIMONE
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biomacromolecules 8:3914-21. 2007
  6. ncbi request reprint Synthetic carriers for vascular delivery of protein therapeutics
    Thomas D Dziubla
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biotechnol Genet Eng Rev 22:267-98. 2006
  7. ncbi request reprint Polymer nanocarriers protecting active enzyme cargo against proteolysis
    Thomas D Dziubla
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 1 John Morgan 6068, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    J Control Release 102:427-39. 2005

Detail Information

Publications7

  1. pmc Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies
    Thomas D Dziubla
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, 1 John Morgan Building, 36th Street and Hamilton Walk, Philadelphia, PA 19104 6068, USA
    Biomaterials 29:215-27. 2008
    ..Vascular targeting of PNC-loaded detoxifying enzymes may find wide medical applications including management of oxidative stress and other toxicities...
  2. pmc Loading PEG-catalase into filamentous and spherical polymer nanocarriers
    ERIC A SIMONE
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pharm Res 26:250-60. 2009
    ..Based on a unique phase alignment that occurs during formulation, we postulated that PEG-ylation of the cargo enzyme would enhance its encapsulation within diblock copolymer nanocarriers and thus resistance to proteases...
  3. pmc Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase
    ERIC A SIMONE
    Department of Bioengineering, Institute for Translational Medicine and Therapeutics, and Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biomacromolecules 10:1324-30. 2009
    ..Thus, we report here for the first time f-PNC that encapsulate an active enzyme with polymer MW-tunable flexibility, offering several potential therapeutic applications...
  4. pmc Polymeric carriers: role of geometry in drug delivery
    ERIC A SIMONE
    University of Pennsylvania, Department of Bioengineering, 3620 Hamilton Walk, 1 John Morgan Building, Philadelphia, PA 19104, USA
    Expert Opin Drug Deliv 5:1283-300. 2008
    ..This article reviews drug delivery aspects of non-spherical drug delivery systems, including material selection and formulation, drug loading and release, biocompatibility, circulation behavior, targeting and subcellular addressing...
  5. ncbi request reprint Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers
    ERIC A SIMONE
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biomacromolecules 8:3914-21. 2007
    ..PNC morphology also greatly influenced its degradation, offering a new means of controlled delivery...
  6. ncbi request reprint Synthetic carriers for vascular delivery of protein therapeutics
    Thomas D Dziubla
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biotechnol Genet Eng Rev 22:267-98. 2006
  7. ncbi request reprint Polymer nanocarriers protecting active enzyme cargo against proteolysis
    Thomas D Dziubla
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 1 John Morgan 6068, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    J Control Release 102:427-39. 2005
    ..Delivery and protection of catalase from lysosomal degradation afforded by PNC nanotechnology may advance effectiveness and duration of treatment of diverse disease conditions associated with vascular oxidative stress...