Katerina Dvorak

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells
    Aaron Goldman
    Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 6:e23835. 2011
  2. pmc Role of interleukin-6 in Barrett's esophagus pathogenesis
    Katerina Dvorak
    Department of Cellular and Moleculart Medicine, The University of Arizona, Tucson, AZ 85724, USA
    World J Gastroenterol 19:2307-12. 2013
  3. doi request reprint Expression of bile acid transporting proteins in Barrett's esophagus and esophageal adenocarcinoma
    Katerina Dvorak
    Department of Cell Biology and Anatomy, The University of Arizona, Tucson, Arizona 85724, USA
    Am J Gastroenterol 104:302-9. 2009
  4. ncbi request reprint Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagus
    Katerina Dvorak
    Department of Cell Biology and Anatomy, College of Medicine, The University of Arizona, Tucson, Arizona 85724, USA
    Clin Cancer Res 13:5305-13. 2007
  5. pmc Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus
    Katerina Dvorak
    Department of Cell Biology and Anatomy, PO Box 245044, University of Arizona, Tucson, AZ 85724, USA
    Gut 56:763-71. 2007
  6. ncbi request reprint Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles
    Harris Bernstein
    Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, Arizona 85724 5044, USA
    Dig Dis Sci 52:628-42. 2007
  7. pmc The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: the role of deoxycholic acid
    Heather B Roesly
    Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 302:G864-72. 2012
  8. pmc Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis
    Ludmila Khailova
    Department of Pediatrics, University of Arizona, Tucson, Arizona 85724 5073, USA
    Am J Physiol Gastrointest Liver Physiol 297:G940-9. 2009
  9. pmc Field defects in progression to gastrointestinal tract cancers
    Carol Bernstein
    Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, and Hematology Oncology Southern Arizona Veterans Affairs Health Care System, Tucson, AZ 85723, USA
    Cancer Lett 260:1-10. 2008
  10. pmc Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis
    Aaron Goldman
    Department of Cell Biology and Anatomy, Univ of Arizona, 1501 N Campbell Ave P O Box 245044, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 300:G292-302. 2011

Collaborators

Detail Information

Publications25

  1. pmc The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells
    Aaron Goldman
    Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 6:e23835. 2011
    ..Cells tolerate acidification but evade DCA-induced apoptosis if NHE is inhibited. Our data suggests that suppression of NHE by endogenous or exogenous inhibitors may lead to apoptosis resistance during GI tumorigenesis...
  2. pmc Role of interleukin-6 in Barrett's esophagus pathogenesis
    Katerina Dvorak
    Department of Cellular and Moleculart Medicine, The University of Arizona, Tucson, AZ 85724, USA
    World J Gastroenterol 19:2307-12. 2013
    ..This review critically appraises the role of IL-6/STAT3 pathway in progression of BE to EAC from the published evidence currently available...
  3. doi request reprint Expression of bile acid transporting proteins in Barrett's esophagus and esophageal adenocarcinoma
    Katerina Dvorak
    Department of Cell Biology and Anatomy, The University of Arizona, Tucson, Arizona 85724, USA
    Am J Gastroenterol 104:302-9. 2009
    ..Our major goal was to evaluate the expression of bile acid transporters in normal squamous epithelium, BE with different grades of dysplasia, and esophageal adenocarcinoma (EAC)...
  4. ncbi request reprint Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagus
    Katerina Dvorak
    Department of Cell Biology and Anatomy, College of Medicine, The University of Arizona, Tucson, Arizona 85724, USA
    Clin Cancer Res 13:5305-13. 2007
    ..Here, we test the hypothesis that bile acids and gastric acids, two components of refluxate associated with gastresophageal reflux disease, activate the IL-6/STAT3 pathway...
  5. pmc Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus
    Katerina Dvorak
    Department of Cell Biology and Anatomy, PO Box 245044, University of Arizona, Tucson, AZ 85724, USA
    Gut 56:763-71. 2007
    ..Barrett's oesophagus is a premalignant condition associated with an increased risk for the development of oesophageal adenocarcinoma (ADCA). Previous studies indicated that oxidative damage contributes to the development of ADCA...
  6. ncbi request reprint Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles
    Harris Bernstein
    Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, Arizona 85724 5044, USA
    Dig Dis Sci 52:628-42. 2007
    ..Overall, our results indicate that NOS2 expression is necessary for the development of deoxycholate-induced colitis in mice, a unique dietary-related model of colitis...
  7. pmc The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: the role of deoxycholic acid
    Heather B Roesly
    Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 302:G864-72. 2012
    ..In summary, these data suggest that autophagy is initially activated in response to bile acids, but chronic exposure to bile acids leads to decreased Beclin-1 expression and autophagy resistance...
  8. pmc Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis
    Ludmila Khailova
    Department of Pediatrics, University of Arizona, Tucson, Arizona 85724 5073, USA
    Am J Physiol Gastrointest Liver Physiol 297:G940-9. 2009
    ..bifidum protects against NEC in the neonatal rat model. This protective effect is associated with reduction of inflammatory reaction in the ileum, regulation of main components of mucus layer, and improvement of intestinal integrity...
  9. pmc Field defects in progression to gastrointestinal tract cancers
    Carol Bernstein
    Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, and Hematology Oncology Southern Arizona Veterans Affairs Health Care System, Tucson, AZ 85723, USA
    Cancer Lett 260:1-10. 2008
    ..These features are often associated with high bile acid exposure and may explain the association of dietary-related factors with cancer progression...
  10. pmc Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis
    Aaron Goldman
    Department of Cell Biology and Anatomy, Univ of Arizona, 1501 N Campbell Ave P O Box 245044, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 300:G292-302. 2011
    ..In summary, our study shows that long-term exposure of squamous cells to BA at acidic pH causes the cells to display the same characteristics and markers as BE...
  11. ncbi request reprint Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment
    Jessica A Clark
    Department of Pediatrics, University of Arizona, Tucson, AZ 85724 5073, USA
    Am J Physiol Gastrointest Liver Physiol 291:G938-49. 2006
    ..EGF treatment maintains intestinal integrity at the site of injury by accelerating goblet cell maturation and mucin production and normalizing expression of TJ proteins, leading to improved intestinal barrier function...
  12. pmc Epidermal growth factor reduces autophagy in intestinal epithelium and in the rat model of necrotizing enterocolitis
    Andrew A Maynard
    Dept of Pediatrics, Univ of Arizona, Tucson, 85724 5073, USA
    Am J Physiol Gastrointest Liver Physiol 299:G614-22. 2010
    ..Supplementation of EGF blocks intestinal autophagy in both in vivo and in vitro conditions. Results from this study indicate that EGF-mediated protection against NEC injury is associated with regulation of intestinal autophagy...
  13. pmc Bile acids induce ileal damage during experimental necrotizing enterocolitis
    Melissa D Halpern
    Department of Pediatrics, Steele Children s Research Center, University of Arizona, Tucson, 85724, USA
    Gastroenterology 130:359-72. 2006
    ..While the effect of bile acids (BAs) on intestinal mucosal injury is known, we investigated the contribution of BAs during the development of NEC in neonatal rats...
  14. pmc A novel mechanism of acid and bile acid-induced DNA damage involving Na+/H+ exchanger: implication for Barrett's oesophagus
    Aaron Goldman
    Arizona Cancer Center, University of Arizona, USA
    Gut 59:1606-16. 2010
    ....
  15. ncbi request reprint A novel dietary-related model of esophagitis and Barrett's esophagus, a premalignant lesion
    Naihsuan C Guy
    Department of Immunobiology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Nutr Cancer 59:217-27. 2007
    ..This mouse model of esophagitis and BE is expected to contribute to a deeper understanding of BE pathogenesis and to strategies for prevention of BE progression to cancer...
  16. ncbi request reprint Unique dietary-related mouse model of colitis
    Harris Bernstein
    Department of Cell Biology and Anatomy, College of Medicine, Tucson, AZ 85724, USA
    Inflamm Bowel Dis 12:278-93. 2006
    ..Deoxycholate (DOC) is increased in the colonic contents in response to a high-fat diet. Thus, an elevated level of DOC in the colonic lumen may play a role in the natural course of development of IBD...
  17. pmc Changes in hepatic cell junctions structure during experimental necrotizing enterocolitis: effect of EGF treatment
    Ludmila Khailova
    Department of Pediatrics, University of Arizona, Tucson, Arizona 85724, USA
    Pediatr Res 66:140-4. 2009
    ..These data show that hepatic cellular junctions are significantly altered during NEC pathogenesis. EGF-mediated reduction of experimental NEC is associated with protection of hepatic integrity and structure...
  18. pmc Abnormal expression of biomarkers in incompletely ablated Barrett's esophagus
    Katerina Dvorak
    Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, AZ, USA
    Ann Surg 244:1031-6. 2006
    ....
  19. ncbi request reprint Crypt-restricted loss and decreased protein expression of cytochrome C oxidase subunit I as potential hypothesis-driven biomarkers of colon cancer risk
    Claire M Payne
    Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, 85724
    Cancer Epidemiol Biomarkers Prev 14:2066-75. 2005
    ..The results suggest, however, that aberrant cytochrome c oxidase subunit I expression may be a better biomarker than loss of apoptosis competence for increased colon cancer risk...
  20. doi request reprint Molecular mechanisms of Barrett's esophagus and adenocarcinoma
    Katerina Dvorak
    Department of Cell Biology and Anatomy, College of Medicine, Tucson, Arizona, USA
    Ann N Y Acad Sci 1232:381-91. 2011
    ....
  21. pmc Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis
    Claire M Payne
    Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, AZ 85724 5044, USA
    J Toxicol 2009:785907. 2009
    ..It was concluded that the activation of autophagy by DOC has important implications for colon carcinogenesis and for the treatment of colon cancer in conjunction with commonly used chemotherapeutic agents...
  22. ncbi request reprint Epidermal growth factor reduces hepatic sequelae in experimental necrotizing enterocolitis
    Melissa D Halpern
    Department of Pediatrics, Steele Children s Research Center, University of Arizona, Tucson, Ariz, USA
    Biol Neonate 89:227-35. 2006
    ..In this study, we examined the effects of EGF on the liver portion of the gut/liver axis in the neonatal rat model of NEC...
  23. pmc Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis
    Claire M Payne
    Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, Arizona, USA
    Clin Exp Gastroenterol 1:19-47. 2008
    ..This review provides a mechanistic explanation for the important link between a Western-style diet and associated increased levels of colon cancer...
  24. pmc Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice
    Lisa D Beilke
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Toxicol Lett 188:38-44. 2009
    ..This study demonstrates that although apoptosis is reduced in hepatoprotected mice pre-treated with CAR and non-CAR activators; hepatoprotection is not directly a result of CAR-induced Mcl-1 expression...
  25. ncbi request reprint Pathogenesis of diarrhea in the adult: diagnostic challenges and life-threatening conditions
    Claire M Payne
    Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, Arizona 85724 5044, USA
    Eur J Gastroenterol Hepatol 18:1047-51. 2006
    ..Determining the etiology of chronic diarrhea in specific cases may be a diagnostic challenge for both gastroenterologists and primary care physicians...