Affiliation: University of Arizona
- Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6)Jin Yan
Department of Pharmacology, University of Arizona College of Medicine, 1501 N Campbell Ave, PO Box 245050, Tucson, AZ 85724, USA
Mol Pain 8:6. 2012..Intracranial interleukin-6 (IL-6) levels have been shown to be elevated during migraine attacks, suggesting that this cytokine may facilitate pain signaling from the meninges and contribute to the development of headache...
- Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic painOhannes K Melemedjian
Department of Pharmacology, University of Arizona, N Campbell Ave, Tucson, 85724, USA
Mol Pain 7:70. 2011..Therefore, injury-induced dysregulation of translation control underlies pathology leading to neuropathic pain and reveals AMPK as a novel therapeutic target for the potential treatment of neuropathic pain...
- Cutaneous sensory neurons expressing the Mrgprd receptor sense extracellular ATP and are putative nociceptorsG Dussor
Vollum Institute L474, Oregon Health and Science University, Portland, Oregon, USA
J Neurophysiol 99:1581-9. 2008..These properties, together with selective innervation of the stratum granulosum, indicate that Mrgprd+ neurons are nociceptors in the outer epidermis and may respond indirectly to external stimuli by detecting ATP release in the skin...
- Nucleotide signaling and cutaneous mechanisms of pain transductionG Dussor
Department of Pharmacology, The University of Arizona College of Medicine, Tucson, AZ 85724, USA
Brain Res Rev 60:24-35. 2009..This review discusses recent advances in our understanding of communication mechanisms between cells of the skin and sensory axons in the transduction of sensory input leading to pain...