Research Topics
| Turgut DurduranSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patientsTurgut Durduran
Departments of Radiology, University of Pennsylvania, PA, USA
Opt Express 17:3884-902. 2009..Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere...- Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defectsTurgut Durduran
ICFO Institut de Ciencies Fotoniques, Av Canal Olimpic s n, Castelldefels 08860, Spain
J Biomed Opt 15:037004. 2010..7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population... - Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomographyRegine Choe
University of Pennsylvania, Department of Physics, 209 S 33rd Street, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 14:024020. 2009..90 to 0.99, suggesting good discriminatory power. The data demonstrate that benign and malignant lesions can be distinguished by quantitative three-dimensional DOT... - Direct measurement of tissue blood flow and metabolism with diffuse opticsRickson C Mesquita
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
Philos Trans A Math Phys Eng Sci 369:4390-406. 2011.... 
Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopiesGuoqiang Yu
University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 10:024027. 2005..The instrument thus provides a method for evaluation of microcirculation and muscle metabolism in patients with vascular diseases...- Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adultsMeeri N Kim
Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, USA
Neurocrit Care 12:173-80. 2010.... - Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injuryChao Zhou
University of Pennsylvania, Department of Physics, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 14:034015. 2009..In total, the investigation corraborates potential of the optical methods for bedside monitoring of pediatric and adult human patients in the neurointensive care unit... - Diffuse optical measurement of blood flow in breast tumorsTurgut Durduran
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Opt Lett 30:2915-7. 2005..Increased blood flow was observed in tumor regions relative to healthy tissue, and control subjects did not exhibit significant blood flow heterogeneity. The measurements introduce a new optical contrast for diffuse optical mammography... - Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imagingErin M Buckley
University of Pennsylvania, Department of Physics and Astronomy, 3231 Walnut Street, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 17:037007. 2012..77, slope=0.99±0.12, p<0.001. The relationship between VENC MRI in the aorta and DCS, a negative control, was weakly correlated, R=0.46, slope=1.77±0.45, p<0.001... - Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRIRegine Choe
Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104 6396, USA
Med Phys 32:1128-39. 2005..A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy... - Diffuse optical tomography with spectral constraints and wavelength optimizationAlper Corlu
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Appl Opt 44:2082-93. 2005..Here the technique is described and tested in detail, and optimum wavelength sets for a broad range of chromophore combinations are discovered and analyzed... - Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activationTurgut Durduran
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Opt Lett 29:1766-8. 2004..The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored... - Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasoundErin M Buckley
Department of Physics and Astronomy, University of Pennsylvania, 209 S 33rd St, Philadelphia, PA 19104, USA
Opt Express 17:12571-81. 2009.... - Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapyChao Zhou
University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 12:051903. 2007..The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms... - Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapyTheresa M Busch
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, B13 Anatomy and Chemistry, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
Photochem Photobiol Sci 8:1683-93. 2009..This research suggests that the benefits of low-fluence-rate PDT are mediated in part by a reduction in intratumor heterogeneity in hypoxic, vascular and cytotoxic responses... 
Early postoperative changes in cerebral oxygen metabolism following neonatal cardiac surgery: effects of surgical durationErin M Buckley
Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
J Thorac Cardiovasc Surg 145:196-203, 205.e1; discussion 203-5. 2013....- Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetryTurgut Durduran
Departments of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
J Cereb Blood Flow Metab 24:518-25. 2004.... - The effects of healthy aging on cerebral hemodynamic responses to posture changeBrian L Edlow
Department of Neurology, University of Pennsylvania, Philadelphia, USA
Physiol Meas 31:477-95. 2010..23) and was associated with a smaller magnitude of decline in HbO(2) (p < 0.05) during supine-to-standing posture change. We conclude that healthy aging does not alter postural changes in frontal cortical perfusion... - Neurovascular coupling varies with level of global cerebral ischemia in a rat modelWesley B Baker
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
J Cereb Blood Flow Metab 33:97-105. 2013.... - Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot studyUlas Sunar
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6396, USA
J Biomed Opt 11:064021. 2006..0+/-8.1) [microM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise... - Computer aided automatic detection of malignant lesions in diffuse optical mammographyDavid R Busch
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Med Phys 37:1840-9. 2010..The methodology is tested in a population of 35 biopsy-confirmed malignant lesions... - Characterization of periinfarct flow transients with laser speckle and Doppler after middle cerebral artery occlusion in the ratJanos Luckl
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6063, USA
J Neurosci Res 87:1219-29. 2009..Laser Doppler in itself can be a reliable method for counting/detecting PIFTs, but laser speckle is capable of monitoring the dynamic changes in PIFT morphology over the penumbral and periischemic cortex... - Acute functional recovery of cerebral blood flow after forebrain ischemia in ratChao Zhou
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Cereb Blood Flow Metab 28:1275-84. 2008..4+/-0.2 secs before ischemia to 3.6+/-0.1 secs at 20 mins into reperfusion (P<0.001); the delay was reduced gradually to 2.9+/-0.2 secs after 3 h, which was still significantly greater than that observed before the insult (P=0.04)... - Real-time in situ monitoring of human prostate photodynamic therapy with diffuse lightGuoqiang Yu
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA
Photochem Photobiol 82:1279-84. 2006.... - Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacyGuoqiang Yu
Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Clin Cancer Res 11:3543-52. 2005..To monitor tumor blood flow noninvasively during photodynamic therapy (PDT) and to correlate flow responses with therapeutic efficacy... - Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in uteroRegine Choe
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 100:12950-4. 2003..Fetal hypoxia was detected. Good agreement was found between fetal blood saturation determined by the transabdominal NIR method and arterial and venous fetal blood saturation quantified from fetal blood samples by using a hemoximeter... - Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomographyAlper Corlu
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Opt Lett 28:2339-41. 2003..Application of these concepts should significantly improve the fidelity of continuous-wave diffuse near-infrared optical tomography in tissues... - Frequency-domain multiplexing system for in vivo diffuse light measurements of rapid cerebral hemodynamicsGuoqiang Yu
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Appl Opt 42:2931-9. 2003..We evaluate the performance of the instrument with tissue phantoms, and then employ the system to measure in vivo cerebral blood oxygenation during forepaw stimulation of a rat's brain... - Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrestJoseph P Culver
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
Adv Exp Med Biol 510:293-7. 2003..The new instrument and concept may also be applicable to human studies especially in infants and neonates permitting noninvasive monitoring of cerebral hemodynamics and oxygen (see [4] and [2] for examples of NIR spectroscopy)...