Turgut Durduran

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients
    Turgut Durduran
    Departments of Radiology, University of Pennsylvania, PA, USA
    Opt Express 17:3884-902. 2009
  2. pmc Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects
    Turgut Durduran
    ICFO Institut de Ciencies Fotoniques, Av Canal Olimpic s n, Castelldefels 08860, Spain
    J Biomed Opt 15:037004. 2010
  3. pmc Blood flow and oxygenation changes due to low-frequency repetitive transcranial magnetic stimulation of the cerebral cortex
    Rickson C Mesquita
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 18:067006. 2013
  4. pmc Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography
    Regine Choe
    University of Pennsylvania, Department of Physics, 209 S 33rd Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 14:024020. 2009
  5. pmc Direct measurement of tissue blood flow and metabolism with diffuse optics
    Rickson C Mesquita
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Philos Trans A Math Phys Eng Sci 369:4390-406. 2011
  6. ncbi request reprint Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies
    Guoqiang Yu
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 10:024027. 2005
  7. pmc Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults
    Meeri N Kim
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, USA
    Neurocrit Care 12:173-80. 2010
  8. pmc Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury
    Chao Zhou
    University of Pennsylvania, Department of Physics, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 14:034015. 2009
  9. ncbi request reprint Diffuse optical measurement of blood flow in breast tumors
    Turgut Durduran
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Opt Lett 30:2915-7. 2005
  10. pmc Diffuse optical characterization of an exercising patient group with peripheral artery disease
    Rickson C Mesquita
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, PA 19104, USA
    J Biomed Opt 18:57007. 2013

Collaborators

Detail Information

Publications36

  1. pmc Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients
    Turgut Durduran
    Departments of Radiology, University of Pennsylvania, PA, USA
    Opt Express 17:3884-902. 2009
    ..Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere...
  2. pmc Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects
    Turgut Durduran
    ICFO Institut de Ciencies Fotoniques, Av Canal Olimpic s n, Castelldefels 08860, Spain
    J Biomed Opt 15:037004. 2010
    ..7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population...
  3. pmc Blood flow and oxygenation changes due to low-frequency repetitive transcranial magnetic stimulation of the cerebral cortex
    Rickson C Mesquita
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 18:067006. 2013
    ..29). In total, these findings provide new information about hemodynamic/metabolic responses to low-frequency rTMS and, importantly, demonstrate the feasibility of DCS/DOS for noninvasive monitoring of TMS-induced physiologic effects...
  4. pmc Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography
    Regine Choe
    University of Pennsylvania, Department of Physics, 209 S 33rd Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 14:024020. 2009
    ..90 to 0.99, suggesting good discriminatory power. The data demonstrate that benign and malignant lesions can be distinguished by quantitative three-dimensional DOT...
  5. pmc Direct measurement of tissue blood flow and metabolism with diffuse optics
    Rickson C Mesquita
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Philos Trans A Math Phys Eng Sci 369:4390-406. 2011
    ....
  6. ncbi request reprint Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies
    Guoqiang Yu
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 10:024027. 2005
    ..The instrument thus provides a method for evaluation of microcirculation and muscle metabolism in patients with vascular diseases...
  7. pmc Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults
    Meeri N Kim
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, USA
    Neurocrit Care 12:173-80. 2010
    ....
  8. pmc Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury
    Chao Zhou
    University of Pennsylvania, Department of Physics, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 14:034015. 2009
    ..In total, the investigation corraborates potential of the optical methods for bedside monitoring of pediatric and adult human patients in the neurointensive care unit...
  9. ncbi request reprint Diffuse optical measurement of blood flow in breast tumors
    Turgut Durduran
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Opt Lett 30:2915-7. 2005
    ..Increased blood flow was observed in tumor regions relative to healthy tissue, and control subjects did not exhibit significant blood flow heterogeneity. The measurements introduce a new optical contrast for diffuse optical mammography...
  10. pmc Diffuse optical characterization of an exercising patient group with peripheral artery disease
    Rickson C Mesquita
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, PA 19104, USA
    J Biomed Opt 18:57007. 2013
    ..041), even after adjustment for ankle brachial index. This suggests a physiologic connection between rBF and oxygenation that can be measured using diffuse optics, and potentially employed as an evaluative tool in further studies...
  11. pmc Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging
    Erin M Buckley
    University of Pennsylvania, Department of Physics and Astronomy, 3231 Walnut Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 17:037007. 2012
    ..77, slope=0.99±0.12, p<0.001. The relationship between VENC MRI in the aorta and DCS, a negative control, was weakly correlated, R=0.46, slope=1.77±0.45, p<0.001...
  12. ncbi request reprint Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI
    Regine Choe
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104 6396, USA
    Med Phys 32:1128-39. 2005
    ..A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy...
  13. pmc Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, B13 Anatomy and Chemistry, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Photochem Photobiol Sci 8:1683-93. 2009
    ..This research suggests that the benefits of low-fluence-rate PDT are mediated in part by a reduction in intratumor heterogeneity in hypoxic, vascular and cytotoxic responses...
  14. pmc Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound
    Erin M Buckley
    Department of Physics and Astronomy, University of Pennsylvania, 209 S 33rd St, Philadelphia, PA 19104, USA
    Opt Express 17:12571-81. 2009
    ....
  15. ncbi request reprint Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation
    Turgut Durduran
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Opt Lett 29:1766-8. 2004
    ..The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored...
  16. ncbi request reprint Diffuse optical tomography with spectral constraints and wavelength optimization
    Alper Corlu
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Appl Opt 44:2082-93. 2005
    ..Here the technique is described and tested in detail, and optimum wavelength sets for a broad range of chromophore combinations are discovered and analyzed...
  17. ncbi request reprint Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy
    Chao Zhou
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 12:051903. 2007
    ..The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms...
  18. pmc Early postoperative changes in cerebral oxygen metabolism following neonatal cardiac surgery: effects of surgical duration
    Erin M Buckley
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Thorac Cardiovasc Surg 145:196-203, 205.e1; discussion 203-5. 2013
    ....
  19. doi request reprint The effects of healthy aging on cerebral hemodynamic responses to posture change
    Brian L Edlow
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Physiol Meas 31:477-95. 2010
    ..23) and was associated with a smaller magnitude of decline in HbO(2) (p < 0.05) during supine-to-standing posture change. We conclude that healthy aging does not alter postural changes in frontal cortical perfusion...
  20. ncbi request reprint Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry
    Turgut Durduran
    Departments of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cereb Blood Flow Metab 24:518-25. 2004
    ....
  21. pmc Acute functional recovery of cerebral blood flow after forebrain ischemia in rat
    Chao Zhou
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 28:1275-84. 2008
    ..4+/-0.2 secs before ischemia to 3.6+/-0.1 secs at 20 mins into reperfusion (P<0.001); the delay was reduced gradually to 2.9+/-0.2 secs after 3 h, which was still significantly greater than that observed before the insult (P=0.04)...
  22. pmc Neurovascular coupling varies with level of global cerebral ischemia in a rat model
    Wesley B Baker
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cereb Blood Flow Metab 33:97-105. 2013
    ....
  23. ncbi request reprint Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study
    Ulas Sunar
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6396, USA
    J Biomed Opt 11:064021. 2006
    ..0+/-8.1) [microM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise...
  24. pmc Computer aided automatic detection of malignant lesions in diffuse optical mammography
    David R Busch
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Med Phys 37:1840-9. 2010
    ..The methodology is tested in a population of 35 biopsy-confirmed malignant lesions...
  25. pmc Continuous Optical Monitoring of Cerebral Hemodynamics During Head-of-Bed Manipulation in Brain-Injured Adults
    Meeri N Kim
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA, 19104, USA
    Neurocrit Care 20:443-53. 2014
    ....
  26. ncbi request reprint Real-time in situ monitoring of human prostate photodynamic therapy with diffuse light
    Guoqiang Yu
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA
    Photochem Photobiol 82:1279-84. 2006
    ....
  27. ncbi request reprint Characterization of periinfarct flow transients with laser speckle and Doppler after middle cerebral artery occlusion in the rat
    Janos Luckl
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6063, USA
    J Neurosci Res 87:1219-29. 2009
    ..Laser Doppler in itself can be a reliable method for counting/detecting PIFTs, but laser speckle is capable of monitoring the dynamic changes in PIFT morphology over the penumbral and periischemic cortex...
  28. doi request reprint Blood flow reduction in breast tissue due to mammographic compression
    David R Busch
    Division of Neurology, Children s Hospital of Philadelphia, Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, 19104 Electronic address
    Acad Radiol 21:151-61. 2014
    ..Because many breast-imaging technologies derive contrast from the deformed breast, these load-dependent vascular responses affect contrast agent-enhanced and hemoglobin-based breast imaging...
  29. ncbi request reprint Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy
    Guoqiang Yu
    Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 11:3543-52. 2005
    ..To monitor tumor blood flow noninvasively during photodynamic therapy (PDT) and to correlate flow responses with therapeutic efficacy...
  30. ncbi request reprint Pulsatile and steady-state hemodynamics of the human patella bone by diffuse optical spectroscopy
    Parisa Farzam
    ICFO Institut de Ciencies Fotoniques, Mediterranean Technology Park, 08860, Castelldefels Barcelona, Spain
    Physiol Meas 34:839-57. 2013
    ..Moreover, we have investigated the optical and physiological properties of the patella bone and their changes in response to arterial cuff occlusion. ..
  31. pmc Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in utero
    Regine Choe
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 100:12950-4. 2003
    ..Fetal hypoxia was detected. Good agreement was found between fetal blood saturation determined by the transabdominal NIR method and arterial and venous fetal blood saturation quantified from fetal blood samples by using a hemoximeter...
  32. ncbi request reprint Frequency-domain multiplexing system for in vivo diffuse light measurements of rapid cerebral hemodynamics
    Guoqiang Yu
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Appl Opt 42:2931-9. 2003
    ..We evaluate the performance of the instrument with tissue phantoms, and then employ the system to measure in vivo cerebral blood oxygenation during forepaw stimulation of a rat's brain...
  33. ncbi request reprint Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography
    Alper Corlu
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Opt Lett 28:2339-41. 2003
    ..Application of these concepts should significantly improve the fidelity of continuous-wave diffuse near-infrared optical tomography in tissues...
  34. ncbi request reprint Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest
    Joseph P Culver
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 510:293-7. 2003
    ..The new instrument and concept may also be applicable to human studies especially in infants and neonates permitting noninvasive monitoring of cerebral hemodynamics and oxygen (see [4] and [2] for examples of NIR spectroscopy)...
  35. doi request reprint Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke
    Peyman Zirak
    ICFO Institut de Ciencies Fotoniques, Mediterranean Technology Park, 08860 Castelldefels, Barcelona, Spain
    J Biomed Opt 19:18002. 2014
    ..This study suggests that upon further investigation, diffuse optics might have a potential for bed-side acute stroke monitoring and therapy guidance by providing hemodynamics information at the microvascular level...
  36. ncbi request reprint Noninvasive characterization of the healthy human manubrium using diffuse optical spectroscopies
    Parisa Farzam
    ICFO Institut de Ciencies Fotoniques, Mediterranean Technology Park, 08860 Castelldefels Barcelona, Spain
    Physiol Meas 35:1469-91. 2014
    ....