Timothy C Durazzo

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc History of cigarette smoking in cognitively-normal elders is associated with elevated cerebrospinal fluid biomarkers of oxidative stress
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA Electronic address
    Drug Alcohol Depend 142:262-8. 2014
  2. pmc Smoking and increased Alzheimer's disease risk: a review of potential mechanisms
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA Electronic address
    Alzheimers Dement 10:S122-45. 2014
  3. pmc Associations of Cigarette Smoking and Polymorphisms in Brain-Derived Neurotrophic Factor and Catechol-O-Methyltransferase with Neurocognition in Alcohol Dependent Individuals during Early Abstinence
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
    Front Pharmacol 3:178. 2012
  4. pmc Interactive effects of chronic cigarette smoking and age on hippocampal volumes
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA Electronic address
    Drug Alcohol Depend 133:704-11. 2013
  5. ncbi request reprint Chronic cigarette smoking in alcohol dependence: associations with cortical thickness and N-acetylaspartate levels in the extended brain reward system
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Addict Biol 18:379-91. 2013
  6. pmc The influence of chronic cigarette smoking on neurocognitive recovery after mild traumatic brain injury
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, California 94121, USA
    J Neurotrauma 30:1013-22. 2013
  7. pmc Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking
    Timothy C Durazzo
    San Francisco VA Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Alzheimers Dement 8:513-9. 2012
  8. pmc A comprehensive assessment of neurocognition in middle-aged chronic cigarette smokers
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Drug Alcohol Depend 122:105-11. 2012
  9. ncbi request reprint Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism
    Timothy C Durazzo
    Center for Neuroimaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Front Biosci 12:4079-100. 2007
  10. pmc Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence
    Timothy C Durazzo
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94121, USA
    Alcohol Clin Exp Res 35:1187-200. 2011

Detail Information

Publications46

  1. pmc History of cigarette smoking in cognitively-normal elders is associated with elevated cerebrospinal fluid biomarkers of oxidative stress
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA Electronic address
    Drug Alcohol Depend 142:262-8. 2014
    ..The goal of this study was to compare cognitively-normal elders on cerebrospinal fluid (CSF) levels of F2-isoprostane biomarkers of OxS...
  2. pmc Smoking and increased Alzheimer's disease risk: a review of potential mechanisms
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA Electronic address
    Alzheimers Dement 10:S122-45. 2014
    ..Cigarette smoking has been linked with both increased and decreased risk for Alzheimer's disease (AD). This is relevant for the US military because the prevalence of smoking in the military is approximately 11% higher than in civilians...
  3. pmc Associations of Cigarette Smoking and Polymorphisms in Brain-Derived Neurotrophic Factor and Catechol-O-Methyltransferase with Neurocognition in Alcohol Dependent Individuals during Early Abstinence
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
    Front Pharmacol 3:178. 2012
    ..Overall, the findings lend support to the expanding clinical movement to make smoking cessation programs available to smokers at the inception of treatment for alcohol/substance use disorders...
  4. pmc Interactive effects of chronic cigarette smoking and age on hippocampal volumes
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA Electronic address
    Drug Alcohol Depend 133:704-11. 2013
    ....
  5. ncbi request reprint Chronic cigarette smoking in alcohol dependence: associations with cortical thickness and N-acetylaspartate levels in the extended brain reward system
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Addict Biol 18:379-91. 2013
    ....
  6. pmc The influence of chronic cigarette smoking on neurocognitive recovery after mild traumatic brain injury
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, California 94121, USA
    J Neurotrauma 30:1013-22. 2013
    ..Results suggest consideration of the effects of chronic cigarette smoking is necessary to understand the potential factors influencing neurocognitive recovery after MTBI...
  7. pmc Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking
    Timothy C Durazzo
    San Francisco VA Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Alzheimers Dement 8:513-9. 2012
    ....
  8. pmc A comprehensive assessment of neurocognition in middle-aged chronic cigarette smokers
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Drug Alcohol Depend 122:105-11. 2012
    ..Therefore, the scope of neurocognitive dysfunction associated with chronic cigarette smoking in middle age (i.e., 30-60 age range) has not been fully delineated...
  9. ncbi request reprint Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism
    Timothy C Durazzo
    Center for Neuroimaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Front Biosci 12:4079-100. 2007
    ..Consideration of the potential separate and interactive effects of chronic smoking and alcohol use disorders may have significant implications for pharmacological and behavioral treatment interventions...
  10. pmc Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence
    Timothy C Durazzo
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94121, USA
    Alcohol Clin Exp Res 35:1187-200. 2011
    ..This study compared thickness, surface area, and volume in neocortical components of the BRS among nonsmoking light-drinking controls (controls), individuals who remained abstinent and those who relapsed after treatment...
  11. pmc Chronic cigarette smoking: implications for neurocognition and brain neurobiology
    Timothy C Durazzo
    Department of Radiology and Biomedical Imaging, University of California, 505 Parnassus Avenue, M 391, San Francisco, CA 94143, USA
    Int J Environ Res Public Health 7:3760-91. 2010
    ..Longitudinal studies are needed to determine if the smoking-related neurobiological and neurocognitive abnormalities increase over time and/or show recovery with sustained smoking cessation...
  12. pmc Cortical perfusion in alcohol-dependent individuals during short-term abstinence: relationships to resumption of hazardous drinking after treatment
    Timothy C Durazzo
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 94121, USA
    Alcohol 44:201-10. 2010
    ..The significantly decreased frontal GM perfusion in resumers compared with both abstainers and nsLD across the assessment interval suggests premorbid and/or acquired neurobiological abnormalities of the frontal GM in resumers...
  13. pmc Metabolite levels in the brain reward pathway discriminate those who remain abstinent from those who resume hazardous alcohol consumption after treatment for alcohol dependence
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases 114M, San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA
    J Stud Alcohol Drugs 71:278-89. 2010
    ..This study compared baseline metabolite levels in components of the brain reward system among individuals who remained abstinent and those who resumed hazardous alcohol consumption after treatment for alcohol dependence...
  14. ncbi request reprint A comparison of neurocognitive function in nonsmoking and chronically smoking short-term abstinent alcoholics
    Timothy C Durazzo
    San Francisco Veterans Administration Medical Center, Center for Imaging of Neurodegenerative Disease, San Francisco, CA 94116, USA
    Alcohol 39:1-11. 2006
    ....
  15. pmc Measures of learning, memory and processing speed accurately predict smoking status in short-term abstinent treatment-seeking alcohol-dependent individuals
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA, USA
    Alcohol Alcohol 45:507-13. 2010
    ..The primary goal of this study was to identify which measures commonly used to assess neurocognition in AUDs accurately predict smoking status of individuals seeking treatment of alcohol dependence...
  16. pmc Combined neuroimaging, neurocognitive and psychiatric factors to predict alcohol consumption following treatment for alcohol dependence
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Disease 114M, San Francisco Veterans Administration Medical Center, and Department of Radiology, University of California, 4150 Clement St, San Francisco CA 94121, USA
    Alcohol Alcohol 43:683-91. 2008
    ..This study examined the ability of multimodality magnetic resonance, neurocognitive, psychiatric and demographic, to predict alcohol consumption after treatment for AUD...
  17. pmc The relationships of sociodemographic factors, medical, psychiatric, and substance-misuse co-morbidities to neurocognition in short-term abstinent alcohol-dependent individuals
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Alcohol 42:439-49. 2008
    ..The study of participants who demonstrate common co-morbidities observed in AUD is necessary to fully understand how AUD, as a clinical syndrome, affects neurocognition, brain neurobiology, and their changes with extended abstinence...
  18. ncbi request reprint The neurobiological and neurocognitive consequences of chronic cigarette smoking in alcohol use disorders
    Timothy C Durazzo
    Department of Veterans Administration Medical Center, Center for Imaging of Neurodegenerative Disease, CA 94121, USA
    Alcohol Alcohol 42:174-85. 2007
    ....
  19. pmc Chronic cigarette smoking and heavy drinking in human immunodeficiency virus: consequences for neurocognition and brain morphology
    Timothy C Durazzo
    Center for Neuroimaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, USA
    Alcohol 41:489-501. 2007
    ..Overall, the findings suggested that the direct and/or indirect effects of chronic cigarette smoking created an additional burden on the integrity of brain neurobiology and neurocognition in this cohort of HIV-positive heavy drinkers...
  20. ncbi request reprint Chronic smoking is associated with differential neurocognitive recovery in abstinent alcoholic patients: a preliminary investigation
    Timothy C Durazzo
    San Francisco Veterans Administration Medical Center, San Francisco, CA 94121, USA
    Alcohol Clin Exp Res 31:1114-27. 2007
    ..However, previous studies investigating neurocognitive recovery in abstinent alcoholic patients did not specifically consider the potential effects of chronic cigarette smoking...
  21. pmc Non-treatment-seeking heavy drinkers: effects of chronic cigarette smoking on brain structure
    Timothy C Durazzo
    Center for Neuroimaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Drug Alcohol Depend 87:76-82. 2007
    ....
  22. pmc Interactive effects of chronic cigarette smoking and age on brain volumes in controls and alcohol-dependent individuals in early abstinence
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Addict Biol 19:132-43. 2014
    ..The findings indicate that consideration of smoking status is necessary for a better understanding of the factors contributing to regional brain atrophy in AUD. ..
  23. ncbi request reprint Brain metabolite concentrations and neurocognition during short-term recovery from alcohol dependence: Preliminary evidence of the effects of concurrent chronic cigarette smoking
    Timothy C Durazzo
    San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA
    Alcohol Clin Exp Res 30:539-51. 2006
    ..However, the potential effects of chronic cigarette smoking on the recovery of alcohol-induced brain injury have not been studied...
  24. pmc Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics
    Stefan Gazdzinski
    Magnetic Resonance Unit, San Francisco Veterans Administration Medical Center, San Francisco, CA 94121, United States
    Psychiatry Res 162:133-45. 2008
    ..These data may also have implications for other conditions with established MTL involvement and significant smoking co-morbidity, such as schizophrenia-spectrum and mood disorders...
  25. pmc Glutamate, GABA, and other cortical metabolite concentrations during early abstinence from alcohol and their associations with neurocognitive changes
    Anderson Mon
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Drug Alcohol Depend 125:27-36. 2012
    ..We used proton magnetic resonance spectroscopy (MRS) to study cross-sectionally and longitudinally the concentrations of these in alcohol dependent individuals (ALC) during early abstinence from alcohol...
  26. pmc Neurocognition in 1-month-abstinent treatment-seeking alcohol-dependent individuals: interactive effects of age and chronic cigarette smoking
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, California Department of Radiology and Biomedical Imaging, University of California, San Francisco, California
    Alcohol Clin Exp Res 37:1794-803. 2013
    ..However, the potential interactive effects of age and cigarette smoking on neurocognition in early abstinent alcohol-dependent individuals (ALC) have not investigated...
  27. pmc The effects of chronic cigarette smoking on cognitive recovery during early abstinence from alcohol
    David L Pennington
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Alcohol Clin Exp Res 37:1220-7. 2013
    ..We evaluated whether cigarette smoking interferes with cognitive improvement during early abstinence from alcohol, a period thought important for maintaining long-term sobriety...
  28. pmc Body mass index is associated with brain metabolite levels in alcohol dependence--a multimodal magnetic resonance study
    Stefan Gazdzinski
    Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, San Francisco, California, USA
    Alcohol Clin Exp Res 34:2089-96. 2010
    ..Here, we evaluated whether BMI in alcohol-dependent individuals was independently associated with regional measures of brain structure, metabolite concentrations, and neocortical blood flow...
  29. pmc The impact of chronic cigarette smoking on recovery from cortical gray matter perfusion deficits in alcohol dependence: longitudinal arterial spin labeling MRI
    Anderson Mon
    Department of Radiology, Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, University of California, San Francisco, California 94121, USA
    Alcohol Clin Exp Res 33:1314-21. 2009
    ..However, no longitudinal magnetic resonance imaging (MRI) studies of cerebral perfusion changes during abstinence from alcohol have been reported...
  30. pmc Tract-Based Spatial Statistics (TBSS) of diffusion tensor imaging data in alcohol dependence: abnormalities of the motivational neurocircuitry
    Ping Hong Yeh
    Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, San Francisco, CA 94121, USA
    Psychiatry Res 173:22-30. 2009
    ..These abnormalities in fiber connections could be partially responsible for deficiencies in executive functions, behavioral regulation, and impulse control commonly described in alcohol dependence...
  31. pmc Brain morphology at entry into treatment for alcohol dependence is related to relapse propensity
    Valerie A Cardenas
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94121, USA
    Biol Psychiatry 70:561-7. 2011
    ..We examined whether any differences in brain volumes at entry into alcohol dependence treatment differentiate subsequent Abstainers from Relapsers...
  32. pmc Metabolic abnormalities in lobar and subcortical brain regions of abstinent polysubstance users: magnetic resonance spectroscopic imaging
    Christoph Abé
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Alcohol Alcohol 48:543-51. 2013
    ..The aim of the study was to explore neurometabolic and associated cognitive characteristics of patients with polysubstance use (PSU) in comparison with patients with predominant alcohol use using proton magnetic resonance spectroscopy...
  33. pmc Cerebral white matter recovery in abstinent alcoholics--a multimodality magnetic resonance study
    Stefan Gazdzinski
    Centre for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Centre, San Francisco, USA
    Brain 133:1043-53. 2010
    ....
  34. ncbi request reprint Temporal dynamics and determinants of whole brain tissue volume changes during recovery from alcohol dependence
    Stefan Gazdzinski
    Department of Veterans Affairs Medical Center San Francisco, San Francisco, CA 94121, USA
    Drug Alcohol Depend 78:263-73. 2005
    ..Previous quantitative measurements of brain volumes in alcohol dependent individuals performed after several weeks of abstinence likely underestimated the full extent of chronic alcohol-associated brain shrinkage...
  35. pmc Are treated alcoholics representative of the entire population with alcohol use disorders? A magnetic resonance study of brain injury
    Stefan Gazdzinski
    Center for Imaging of Neurodegenerative Diseases CIND, Veterans Administration Medical Center, San Francisco, CA 94121, USA
    Alcohol 42:67-76. 2008
    ....
  36. pmc BMI and neuronal integrity in healthy, cognitively normal elderly: a proton magnetic resonance spectroscopy study
    Stefan Gazdzinski
    Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, San Francisco, California, USA
    Obesity (Silver Spring) 18:743-8. 2010
    ..Future studies need to evaluate whether these metabolite abnormalities are involved in the development and maintenance of weight problems...
  37. ncbi request reprint Hierarchical linear modeling (HLM) of longitudinal brain structural and cognitive changes in alcohol-dependent individuals during sobriety
    Ping Hong Yeh
    Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, United States Northern California Institute for Research and Education, USA
    Drug Alcohol Depend 91:195-204. 2007
    ....
  38. pmc Deformation-based morphometry of brain changes in alcohol dependence and abstinence
    Valerie A Cardenas
    Center for the Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, Department of Radiology, University of California, San Francisco, NCIRE, CA 94121, USA
    Neuroimage 34:879-87. 2007
    ..Abstinence-associated tissue volume gains are significant in focal parts of the fronto-ponto-cerebellar circuit that is adversely affected by heavy drinking...
  39. ncbi request reprint Smoking comorbidity in alcoholism: neurobiological and neurocognitive consequences
    Dieter J Meyerhoff
    Department of Radiology, University of California at San Francisco, San Francisco, California, USA
    Alcohol Clin Exp Res 30:253-64. 2006
    ....
  40. pmc Effects of fat on MR-measured metabolite signal strengths: implications for in vivo MRS studies of the human brain
    Anderson Mon
    Department of Radiology and Biomedical Imaging, University of California, San Francisco Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, CA, USA Department of Biomedical Engineering, All Nations University College, Koforidua, Ghana
    NMR Biomed 26:1768-74. 2013
    ....
  41. doi request reprint Chronic alcohol consumption, abstinence and relapse: brain proton magnetic resonance spectroscopy studies in animals and humans
    Dieter J Meyerhoff
    Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA
    Curr Top Behav Neurosci 13:511-40. 2013
    ....
  42. ncbi request reprint Cigarette smoking exacerbates chronic alcohol-induced brain damage: a preliminary metabolite imaging study
    Timothy C Durazzo
    San Francisco Veterans Administration Medical Center, MRS Unit 114M, 4150 Clement St, San Francisco, CA 94121, USA
    Alcohol Clin Exp Res 28:1849-60. 2004
    ..Nevertheless, previous research has typically not accounted for the potential independent or compounding effects of cigarette smoking on alcohol-induced brain injury and neurocognition...
  43. pmc Polysubstance and alcohol dependence: unique abnormalities of magnetic resonance-derived brain metabolite levels
    Christoph Abé
    Department of Radiology and Biomedical Imaging, University of California, San Francisco and Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center San Francisco, CA 94121, USA
    Drug Alcohol Depend 130:30-7. 2013
    ..The concurrent misuse of several substances may have unique and different effects on brain biology and function compared to any mono-substance misuse...
  44. pmc A mathematical formula for prediction of gray and white matter volume recovery in abstinent alcohol dependent individuals
    Anderson Mon
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Psychiatry Res 194:198-204. 2011
    ....
  45. pmc Postural stability in cigarette smokers and during abstinence from alcohol
    Thomas P Schmidt
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, California Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California
    Alcohol Clin Exp Res 38:1753-60. 2014
    ..However, little is known about the effects of chronic cigarette smoking on postural stability and its changes during abstinence from alcohol...
  46. pmc Proton magnetic resonance spectroscopy in alcohol use disorders: a potential new endophenotype?
    Dieter J Meyerhoff
    University of California San Francisco, VA Medical Center San Francisco, Center for Imaging of Neurodegenerative Diseases, San Francisco, California 94121, USA
    Alcohol Clin Exp Res 32:1146-58. 2008
    ..Current effort is directed at defining new classification schemes for alcohol use disorders (AUD) based on genetic/biological, physiological, and behavioral endophenotypes...