Rene J Duquesnoy

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. I. Description of the algorithm
    Rene J Duquesnoy
    CLSI Tissue Typing Laboratory, Department of Pathology, Division of Transplantation Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA, USA
    Hum Immunol 63:339-52. 2002
  2. ncbi request reprint 14th International HLA and Immunogenetics Workshop: report on the structural basis of HLA compatibility
    R J Duquesnoy
    Division of Transplantation Pathology, Thomas E Starzl Transplantation Institute, University of Ptttsburgh Medical Center, Pittsburgh, PA 15261, USA
    Tissue Antigens 69:180-4. 2007
  3. pmc HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. V. Eplet matching for HLA-DR, HLA-DQ, and HLA-DP
    Rene J Duquesnoy
    Division of Transplantation Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Hum Immunol 68:12-25. 2007
  4. ncbi request reprint HLAMatchmaker-based analysis of human monoclonal antibody reactivity demonstrates the importance of an additional contact site for specific recognition of triplet-defined epitopes
    Rene J Duquesnoy
    University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Hum Immunol 66:749-61. 2005
  5. ncbi request reprint HLAMatchmaker-based strategy to identify acceptable HLA class I mismatches for highly sensitized kidney transplant candidates
    Rene J Duquesnoy
    Department of Pathology, Division of Transplantation Pathology, University of Pittsburgh Medical Center, Biomedical Science Tower, Room W1552, Pittsburgh, Pennsylvania 15261, USA
    Transpl Int 17:22-30. 2004
  6. ncbi request reprint HLAmatchmaker: a molecularly based algorithm for histocompatibility determination. IV. An alternative strategy to increase the number of compatible donors for highly sensitized patients
    Rene J Duquesnoy
    University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Transplantation 75:889-97. 2003
  7. ncbi request reprint HLAmatchmaker: a molecularly based algorithm for histocompatibility determination. III. Effect of matching at the HLA-A,B amino acid triplet level on kidney transplant survival
    Rene J Duquesnoy
    University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Transplantation 75:884-9. 2003
  8. ncbi request reprint Multilaboratory evaluation of serum analysis for HLA antibody and crossmatch reactivity by lymphocytotoxicity methods
    Rene J Duquesnoy
    Division of Transplant Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Arch Pathol Lab Med 127:149-56. 2003
  9. ncbi request reprint HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. II. Verification of the algorithm and determination of the relative immunogenicity of amino acid triplet-defined epitopes
    Rene J Duquesnoy
    Department of Pathology, Division of Transplantation Pathology and the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pennsylvania 15261, USA
    Hum Immunol 63:353-63. 2002
  10. doi request reprint Human monoclonal antibody reactivity with human leukocyte antigen class I epitopes defined by pairs of mismatched eplets and self-eplets
    Marilyn Marrari
    Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 90:1468-72. 2010

Collaborators

Detail Information

Publications26

  1. ncbi request reprint HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. I. Description of the algorithm
    Rene J Duquesnoy
    CLSI Tissue Typing Laboratory, Department of Pathology, Division of Transplantation Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA, USA
    Hum Immunol 63:339-52. 2002
    ..This donor selection strategy is suitable especially for allosensitized patients in need of a compatible transplant or platelet transfusion...
  2. ncbi request reprint 14th International HLA and Immunogenetics Workshop: report on the structural basis of HLA compatibility
    R J Duquesnoy
    Division of Transplantation Pathology, Thomas E Starzl Transplantation Institute, University of Ptttsburgh Medical Center, Pittsburgh, PA 15261, USA
    Tissue Antigens 69:180-4. 2007
    ..This progress report describes a preliminary HLAMatchmaker-based data analysis in each project. The findings support the clinical usefulness of structural HLA matching...
  3. pmc HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. V. Eplet matching for HLA-DR, HLA-DQ, and HLA-DP
    Rene J Duquesnoy
    Division of Transplantation Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Hum Immunol 68:12-25. 2007
    ..This computer algorithm can be downloaded from the HLA Matchmaker Webside at http://tpis.upmc.edu...
  4. ncbi request reprint HLAMatchmaker-based analysis of human monoclonal antibody reactivity demonstrates the importance of an additional contact site for specific recognition of triplet-defined epitopes
    Rene J Duquesnoy
    University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Hum Immunol 66:749-61. 2005
    ..An HLAMatchmaker-based analysis of the reactivity of human mAbs will increase our understanding of the structural definition of HLA epitopes and their reactivity with alloantibodies...
  5. ncbi request reprint HLAMatchmaker-based strategy to identify acceptable HLA class I mismatches for highly sensitized kidney transplant candidates
    Rene J Duquesnoy
    Department of Pathology, Division of Transplantation Pathology, University of Pittsburgh Medical Center, Biomedical Science Tower, Room W1552, Pittsburgh, Pennsylvania 15261, USA
    Transpl Int 17:22-30. 2004
    ..HLAMatchmaker offers a useful strategy of identifying more donors with acceptable HLA mismatches and could alleviate the problem of accumulation of highly sensitized patients on the transplant waiting list...
  6. ncbi request reprint HLAmatchmaker: a molecularly based algorithm for histocompatibility determination. IV. An alternative strategy to increase the number of compatible donors for highly sensitized patients
    Rene J Duquesnoy
    University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Transplantation 75:889-97. 2003
    ..This report describes how HLAMatchmaker can be used to identify more compatible donors for highly sensitized patients...
  7. ncbi request reprint HLAmatchmaker: a molecularly based algorithm for histocompatibility determination. III. Effect of matching at the HLA-A,B amino acid triplet level on kidney transplant survival
    Rene J Duquesnoy
    University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Transplantation 75:884-9. 2003
    ..The present study was designed to determine how class I HLA matching at the triplet level affects kidney transplant outcome...
  8. ncbi request reprint Multilaboratory evaluation of serum analysis for HLA antibody and crossmatch reactivity by lymphocytotoxicity methods
    Rene J Duquesnoy
    Division of Transplant Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Arch Pathol Lab Med 127:149-56. 2003
    ....
  9. ncbi request reprint HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. II. Verification of the algorithm and determination of the relative immunogenicity of amino acid triplet-defined epitopes
    Rene J Duquesnoy
    Department of Pathology, Division of Transplantation Pathology and the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pennsylvania 15261, USA
    Hum Immunol 63:353-63. 2002
    ..Mismatching for triplets with low immunogenicity provides further opportunities for identifying donors with acceptable HLA mismatches for highly sensitized patients...
  10. doi request reprint Human monoclonal antibody reactivity with human leukocyte antigen class I epitopes defined by pairs of mismatched eplets and self-eplets
    Marilyn Marrari
    Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 90:1468-72. 2010
    ..This study addressed the question how mismatched HLA antigens induce specific antibodies in context with eplet differences with the antibody producer...
  11. doi request reprint How did a patient who types for HLA-B*4403 develop antibodies that react with HLA-B*4402?
    Jon Lomago
    Tissue Typing Laboratory, Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Hum Immunol 71:176-8. 2010
    ..This finding illustrates the importance of analyzing antibody specificities against HLA epitopes in the determination of mismatch acceptability for sensitized patients...
  12. doi request reprint Structural aspects of human leukocyte antigen class I epitopes detected by human monoclonal antibodies
    Rene J Duquesnoy
    Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Hum Immunol 73:267-77. 2012
    ....
  13. pmc Structurally based epitope analysis of major histocompatibility complex class I-related chain A (MICA) antibody specificity patterns
    Rene J Duquesnoy
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Hum Immunol 69:826-32. 2008
    ..In conclusion, HLAMatchmaker is a useful algorithm to analyze the reactivity patterns of anti-MICA antibodies and the determination of MICA mismatch acceptability at the structural level...
  14. doi request reprint HLAMatchmaker-based definition of structural human leukocyte antigen epitopes detected by alloantibodies
    Rene J Duquesnoy
    Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Curr Opin Organ Transplant 14:403-9. 2009
    ..This review addresses the concept that human leukocyte antigen (HLA) antibody specificity should be determined to HLA epitopes rather than HLA antigens...
  15. doi request reprint Clinical usefulness of HLAMatchmaker in HLA epitope matching for organ transplantation
    Rene J Duquesnoy
    Division of Transplantation Pathology, University of Pittsburgh Medical Center, Thomas E Starzl Biomedical Science Tower, Room W1552, Pittsburgh, PA 15261, United States
    Curr Opin Immunol 20:594-601. 2008
    ..Moreover, HLAMatchmaker is useful in the analysis of serum antibody reactivity and benefits the strategy of identifying acceptable mismatches for highly sensitized patients...
  16. pmc Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR,DQ,DP epitopes
    Rene J Duquesnoy
    Division of Transplantation Pathology and Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Transpl Immunol 18:352-60. 2008
    ..These data demonstrate that HLA class II reactive sera display distinct specificity patterns associated with structurally defined epitopes on different HLA-D alleles...
  17. pmc Why can sensitization by an HLA-DR2 mismatch lead to antibodies that react also with HLA-DR1?
    Marilyn Marrari
    Division of Transplant Pathology and Thomas E Starzl Transplantation Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Hum Immunol 70:403-9. 2009
    ..Immunogenic eplets on DR1 are 12LKF2 (unique for DR1), 14FEH (shared with DR9 and DR10), and 25HRL (shared with DR10)...
  18. doi request reprint Detection of donor-specific HLA antibodies before and after removal of a rejected kidney transplant
    Marilyn Marrari
    Division of Transplant Pathology and Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Thomas E Starzl Biomedical Science Tower, Room W1552, Pittsburgh, PA 15261, United States
    Transpl Immunol 22:105-9. 2010
    ..This understanding seems relevant to the determination of acceptable mismatches for patients considered for retransplantation...
  19. pmc A structurally based approach to determine HLA compatibility at the humoral immune level
    Rene J Duquesnoy
    Division of Transplantation Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Hum Immunol 67:847-62. 2006
    ..The eplet version of HLAMatchmaker represents therefore a more complete repertoire of structurally defined HLA epitopes and provides a more detailed assessment of HLA compatibility...
  20. doi request reprint Detection of antibodies against HLA-C epitopes in patients with rejected kidney transplants
    Rene J Duquesnoy
    Division of Transplantation Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transpl Immunol 24:164-71. 2011
    ..HLA-C displays considerable amino acid polymorphism that can be translated into a structurally defined epitope repertoire...
  21. doi request reprint Human leukocyte antigen epitope analysis to assess complement- and non-complement-binding donor-specific antibody repertoire in a pediatric heart transplant recipient
    Adriana Zeevi
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Hum Immunol 73:48-51. 2012
    ..Our findings illustrate the usefulness of determining antibody specificities against epitopes using various Luminex-based assays...
  22. doi request reprint Structural aspects of HLA class I epitopes reacting with human monoclonal antibodies in Ig-binding, C1q-binding and lymphocytotoxicity assays
    Rene J Duquesnoy
    Division of Transplant Pathology, University of Pittsburgh Medical Center, United States Electronic address
    Hum Immunol 74:1271-9. 2013
    ..Eplet-carrying alleles that lack such configurations may only bind with antibody. This concept is important to our understanding whether or not complement-fixing donor-specific HLA antibodies can initiate antibody-mediated rejection. ..
  23. doi request reprint Brief report: Why did two patients who type for HLA-B13 have antibodies that react with all Bw4 antigens except HLA-B13?
    Marilyn Marrari
    Division of Transplantation Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transpl Immunol 25:217-20. 2011
    ..This finding is consistent with the concept that alloantibody responses originate from B-cells with self-HLA immunoglobulin receptors...
  24. ncbi request reprint HLA mismatching increases the risk of BK virus nephropathy in renal transplant recipients
    Yehia Awadalla
    Departments of Pathology and Biostatistics, University of Pittsburgh, Pittsburgh
    Am J Transplant 4:1691-6. 2004
    ..We propose that HLA mismatching promotes the development of BKV nephropathy through rejection-related inflammatory processes and heavy immunosuppression which cause virus reactivation and injury of the tubular epithelium...
  25. ncbi request reprint Structural epitope matching for HLA-alloimmunized thrombocytopenic patients: a new strategy to provide more effective platelet transfusion support?
    Rene J Duquesnoy
    Division of Transplantation Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Transfusion 48:221-7. 2008
    ..Although many blood banks are using this matching strategy, the general experience is that such matched PLT transfusions are often ineffective...
  26. doi request reprint Human leukocyte antigen class II antibodies and transplant outcome
    Rene J Duquesnoy
    Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Transplantation 86:638-40. 2008