Affiliation: University of Iowa
- A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in miceAdam J Dupuy
Department of Anatomy and Cell Biology, Center for Bioinformatics, Computational Biology and Biomedical Engineering, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Cancer Res 69:8150-6. 2009..These novel alleles provide additional tools for the SB system and provide some insight into how this mutagenesis system can be manipulated to model cancer in mice...
- Transposon-based screens for cancer gene discovery in mouse modelsAdam J Dupuy
Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States
Semin Cancer Biol 20:261-8. 2010..This review provides a brief summary of the SB system and its use in modeling cancer in mice...
- Identifying genetic mechanisms in T-ALL with an inducible Sleeping Beauty systemAdam J Dupuy; Fiscal Year: 2010..Given the importance of this pathway in T-ALL additional studies to understand the genetic mechanisms that synergize with NOTCH1 would be beneficial in designing more effective treatments. ..