ADAM DUPUY

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors
    Benjamin T Brett
    Center for Bioinformatics and Computational Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 6:e24668. 2011
  2. pmc Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer
    Laura M Rogers
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Invest Dermatol 133:1863-9. 2013
  3. pmc Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis
    Jesse D Riordan
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Genet 9:e1003441. 2013
  4. pmc A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice
    Adam J Dupuy
    Department of Anatomy and Cell Biology, Center for Bioinformatics, Computational Biology and Biomedical Engineering, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Res 69:8150-6. 2009
  5. pmc Transposon-based screens for cancer gene discovery in mouse models
    Adam J Dupuy
    Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States
    Semin Cancer Biol 20:261-8. 2010

Collaborators

Detail Information

Publications5

  1. pmc Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors
    Benjamin T Brett
    Center for Bioinformatics and Computational Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 6:e24668. 2011
    ..Overall, this method will facilitate ongoing efforts to decipher the genetic complexity of the human cancer genome by providing more accurate comparative information from Sleeping Beauty models of cancer...
  2. pmc Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer
    Laura M Rogers
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Invest Dermatol 133:1863-9. 2013
    ..Finally, we provide evidence that ZMIZ1 is overexpressed in a significant percentage of human breast, ovarian, and colon cancers in addition to human SCCs, suggesting that ZMIZ1 may play a broader role in epithelial cancers...
  3. pmc Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis
    Jesse D Riordan
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Genet 9:e1003441. 2013
    ..In addition to identifying Rtl1 as a novel driver of HCC, our study represents one of the first direct in vivo demonstrations of a role for such a co-opted genetic element in promoting carcinogenesis...
  4. pmc A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice
    Adam J Dupuy
    Department of Anatomy and Cell Biology, Center for Bioinformatics, Computational Biology and Biomedical Engineering, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Res 69:8150-6. 2009
    ..These novel alleles provide additional tools for the SB system and provide some insight into how this mutagenesis system can be manipulated to model cancer in mice...
  5. pmc Transposon-based screens for cancer gene discovery in mouse models
    Adam J Dupuy
    Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States
    Semin Cancer Biol 20:261-8. 2010
    ..This review provides a brief summary of the SB system and its use in modeling cancer in mice...

Research Grants3

  1. Identifying genetic mechanisms in T-ALL with an inducible Sleeping Beauty system
    ADAM DUPUY; Fiscal Year: 2009
    ..Given the importance of this pathway in T-ALL additional studies to understand the genetic mechanisms that synergize with NOTCH1 would be beneficial in designing more effective treatments. ..
  2. Identifying genetic mechanisms in T-ALL with an inducible Sleeping Beauty system
    Adam J Dupuy; Fiscal Year: 2010
    ..Given the importance of this pathway in T-ALL additional studies to understand the genetic mechanisms that synergize with NOTCH1 would be beneficial in designing more effective treatments. ..