Esther E Dupont-Versteegden

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Identification of cold-shock protein RBM3 as a possible regulator of skeletal muscle size through expression profiling
    Esther E Dupont-Versteegden
    Department of Rehabilitation Sciences, Division of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1263-73. 2008
  2. ncbi Apoptosis in skeletal muscle and its relevance to atrophy
    Esther E Dupont-Versteegden
    University of Arkansas for Medical Sciences, Department of Geriatrics, Little Rock, AR 72205, United States
    World J Gastroenterol 12:7463-6. 2006
  3. ncbi Effect of flywheel-based resistance exercise on processes contributing to muscle atrophy during unloading in adult rats
    Esther E Dupont-Versteegden
    Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 West Markham 807, Little Rock, Arkansas 72205, USA
    J Appl Physiol (1985) 101:202-12. 2006
  4. pmc Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy
    Christopher S Fry
    1900 S Limestone, CTW 105, University of Kentucky, Lexington, KY 40536, USA
    FASEB J 28:1654-65. 2014
  5. ncbi Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonuclei
    Esther E Dupont-Versteegden
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1730-40. 2006
  6. ncbi Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway
    Esther E Dupont-Versteegden
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Am J Physiol Cell Physiol 282:C1387-95. 2002
  7. ncbi Insulin facilitation of muscle protein synthesis following resistance exercise in hindlimb-suspended rats is independent of a rapamycin-sensitive pathway
    James D Fluckey
    Nutrition, Metabolism and Exercise Laboratory, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 806, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 287:E1070-5. 2004
  8. pmc Cell death-resistance of differentiated myotubes is associated with enhanced anti-apoptotic mechanisms compared to myoblasts
    Rijin Xiao
    Division of Physical Therapy, Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, 900 S Limestone, Lexington, KY 40536 0200, USA
    Apoptosis 16:221-34. 2011
  9. pmc Evidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophy
    John J McCarthy
    Department of Physiology, College Health Sciences, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Physiol Genomics 39:219-26. 2009
  10. ncbi Exercise-induced gene expression in soleus muscle is dependent on time after spinal cord injury in rats
    Esther E Dupont-Versteegden
    Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, Arkansas 72205, USA
    Muscle Nerve 29:73-81. 2004

Research Grants

  1. Impaired Regulation of Muscle size with Aging
    ESTHER DUPONT VERSTEEGDEN; Fiscal Year: 2002
  2. INTEGRATED STUDY OF MUSCULOSKELETAL LOSS AND RESTORATION
    ESTHER DUPONT VERSTEEGDEN; Fiscal Year: 2006
  3. INTEGRATED STUDY OF MUSCULOSKELETAL LOSS AND RESTORATION
    ESTHER DUPONT VERSTEEGDEN; Fiscal Year: 2007
  4. INTEGRATED STUDY OF MUSCULOSKELETAL LOSS AND RESTORATION
    ESTHER DUPONT VERSTEEGDEN; Fiscal Year: 2009
  5. INTEGRATED STUDY OF MUSCULOSKELETAL LOSS AND RESTORATION
    Esther E Dupont Versteegden; Fiscal Year: 2010

Collaborators

Detail Information

Publications21

  1. pmc Identification of cold-shock protein RBM3 as a possible regulator of skeletal muscle size through expression profiling
    Esther E Dupont-Versteegden
    Department of Rehabilitation Sciences, Division of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1263-73. 2008
    ..We conclude that a cold-shock response may be part of a compensatory mechanism in muscles undergoing atrophy to preserve remaining muscle mass and that RBM3 may be a therapeutic target to prevent muscle loss...
  2. ncbi Apoptosis in skeletal muscle and its relevance to atrophy
    Esther E Dupont-Versteegden
    University of Arkansas for Medical Sciences, Department of Geriatrics, Little Rock, AR 72205, United States
    World J Gastroenterol 12:7463-6. 2006
    ..It remains to be determined whether a decrease in apoptosis will alleviate atrophy and distinct research strategies may be required for different causes of skeletal muscle loss...
  3. ncbi Effect of flywheel-based resistance exercise on processes contributing to muscle atrophy during unloading in adult rats
    Esther E Dupont-Versteegden
    Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 West Markham 807, Little Rock, Arkansas 72205, USA
    J Appl Physiol (1985) 101:202-12. 2006
    ..Identifying specific exercise parameters that affect these latter processes may be useful in designing effective exercise strategies in the elderly or during spaceflight...
  4. pmc Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy
    Christopher S Fry
    1900 S Limestone, CTW 105, University of Kentucky, Lexington, KY 40536, USA
    FASEB J 28:1654-65. 2014
    ..These results provide evidence that satellite cells regulate the muscle environment during growth...
  5. ncbi Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonuclei
    Esther E Dupont-Versteegden
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1730-40. 2006
    ....
  6. ncbi Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway
    Esther E Dupont-Versteegden
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Am J Physiol Cell Physiol 282:C1387-95. 2002
    ..Therefore, results suggest that calcineurin may be playing opposing roles during skeletal muscle atrophy and under muscle mass-maintaining conditions...
  7. ncbi Insulin facilitation of muscle protein synthesis following resistance exercise in hindlimb-suspended rats is independent of a rapamycin-sensitive pathway
    James D Fluckey
    Nutrition, Metabolism and Exercise Laboratory, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 806, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 287:E1070-5. 2004
    ..These results demonstrate that the capacity for an augmented anabolic response to resistance exercise is maintained after 4 days of HS and is independent of a rapamycin-sensitive pathway...
  8. pmc Cell death-resistance of differentiated myotubes is associated with enhanced anti-apoptotic mechanisms compared to myoblasts
    Rijin Xiao
    Division of Physical Therapy, Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, 900 S Limestone, Lexington, KY 40536 0200, USA
    Apoptosis 16:221-34. 2011
    ..These results show that resistance to apoptosis in myotubes is increased despite high levels of pro-apoptotic signaling mechanisms, and we suggest that this protective effect is mediated by enhanced anti-caspase mechanisms...
  9. pmc Evidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophy
    John J McCarthy
    Department of Physiology, College Health Sciences, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Physiol Genomics 39:219-26. 2009
    ..These results further expand the role of miRs in adult skeletal muscle and are consistent with a model in which the MyomiR network regulates slow myosin expression during muscle atrophy...
  10. ncbi Exercise-induced gene expression in soleus muscle is dependent on time after spinal cord injury in rats
    Esther E Dupont-Versteegden
    Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, Arkansas 72205, USA
    Muscle Nerve 29:73-81. 2004
    ..Furthermore, the data suggest that the lumbar spinal cord undergoes time-dependent changes that temporarily impede the ability of the muscle to respond to exercise...
  11. ncbi Apoptosis in muscle atrophy: relevance to sarcopenia
    Esther E Dupont-Versteegden
    Department of Geriatrics, Institute on Aging, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Exp Gerontol 40:473-81. 2005
    ..The functional relevance of the increase in apoptosis with respect to the loss of muscle fibers and muscle cross-sectional area with aging remains to be determined and interventions to decrease apoptosis in muscle need to be evaluated...
  12. pmc Enhanced survival of skeletal muscle myoblasts in response to overexpression of cold shock protein RBM3
    Amy L Ferry
    Department of Rehabilitation Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Am J Physiol Cell Physiol 301:C392-402. 2011
    ....
  13. pmc Satellite cell depletion does not inhibit adult skeletal muscle regrowth following unloading-induced atrophy
    Janna R Jackson
    Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, Lexington, 40536 0200, USA
    Am J Physiol Cell Physiol 303:C854-61. 2012
    ..These results provide convincing evidence that satellite cells are not required for muscle regrowth following atrophy and that, instead, the myonuclear domain size changes as myofibers adapt...
  14. ncbi Hindlimb unloading in adult rats using an alternative tail harness design
    Micheal Knox
    University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Aviat Space Environ Med 75:692-6. 2004
    ..However, using current methodologies, maintenance of adult rats in hindlimb unloading for long periods is challenging. Therefore, our goal was to develop a technique allowing long-term hindlimb unloading in adult rats...
  15. ncbi Satellite cell regulation of muscle mass is altered at old age
    Jason C Gallegly
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Appl Physiol 97:1082-90. 2004
    ..These data indicate that altered satellite cell function with age contributes to the impaired response of soleus muscle to an intervention that attenuates muscle atrophy in young animals during imposed disuse...
  16. pmc Age-related changes of cell death pathways in rat extraocular muscle
    Colleen A McMullen
    Department of Physiology, University of Kentucky, 800 Rose St, MS508, Lexington, KY 40536 0298, USA
    Exp Gerontol 44:420-5. 2009
    ..Based on these data, we suggest that the decrease in autophagy with age leads to the accumulation of damaged organelles, particularly mitochondria, which results in the decrease in function observed in EOM with age...
  17. ncbi Aging alters the skeletal response to disuse in the rat
    Daniel S Perrien
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham St, Slot 505, Little Rock, AR 72205, USA
    Am J Physiol Regul Integr Comp Physiol 292:R988-96. 2007
    ....
  18. pmc Effective fiber hypertrophy in satellite cell-depleted skeletal muscle
    John J McCarthy
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Development 138:3657-66. 2011
    ..These results provide convincing evidence that skeletal muscle fibers are capable of mounting a robust hypertrophic response to mechanical overload that is not dependent on satellite cells...
  19. ncbi Age-related differences in apoptosis with disuse atrophy in soleus muscle
    Christiaan Leeuwenburgh
    Biochemistry of Aging Laboratory and Department of Aging and Geriatric Research, University of Florida, Gainesville, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1288-96. 2005
    ..Apoptosis in skeletal muscle is partly mediated by the subsarcolemmal mitochondria through EndoG translocation to the nucleus in response to HS...
  20. ncbi Insulin-facilitated increase of muscle protein synthesis after resistance exercise involves a MAP kinase pathway
    James D Fluckey
    Muscle Biology Laboratory, Dept of Health and Kinesiology, Mail Stop 4243, Texas A and M University, College Station, TX 77845, USA
    Am J Physiol Endocrinol Metab 290:E1205-11. 2006
    ..Together, these results suggest that the insulin-facilitated increase of muscle protein synthesis after resistance exercise requires multiple signaling pathways...
  21. ncbi Altered activity of signaling pathways in diaphragm and tibialis anterior muscle of dystrophic mice
    Joshua M Lang
    Muscle Biology Laboratory, School of Kinesiology, University of Illinois, Chicago, Illinois 60608, USA
    Exp Biol Med (Maywood) 229:503-11. 2004
    ..The specificity of these responses, particularly in the diaphragm, provides insight for potential targets for blunting the progression of the muscular dystrophy phenotype...

Research Grants6

  1. Impaired Regulation of Muscle size with Aging
    ESTHER DUPONT VERSTEEGDEN; Fiscal Year: 2002
    ..Also, potential regulatory pathways and molecules involved in control of muscle size will be determined. ..
  2. INTEGRATED STUDY OF MUSCULOSKELETAL LOSS AND RESTORATION
    ESTHER DUPONT VERSTEEGDEN; Fiscal Year: 2006
    ..Identifying these common pathways influencing muscle and bone integrity could lead to putative targets for pharmacologic or therapeutic interventions. ..
  3. INTEGRATED STUDY OF MUSCULOSKELETAL LOSS AND RESTORATION
    ESTHER DUPONT VERSTEEGDEN; Fiscal Year: 2007
    ..Identifying these common pathways influencing muscle and bone integrity could lead to putative targets for pharmacologic or therapeutic interventions. ..
  4. INTEGRATED STUDY OF MUSCULOSKELETAL LOSS AND RESTORATION
    ESTHER DUPONT VERSTEEGDEN; Fiscal Year: 2009
    ..Identifying these common pathways influencing muscle and bone integrity could lead to putative targets for pharmacologic or therapeutic interventions. ..
  5. INTEGRATED STUDY OF MUSCULOSKELETAL LOSS AND RESTORATION
    Esther E Dupont Versteegden; Fiscal Year: 2010
    ..Identifying these common pathways influencing muscle and bone integrity could lead to putative targets for pharmacologic or therapeutic interventions. ..