Wesley Dunnick

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Germline transcription and switch recombination of a transgene containing the entire H chain constant region locus: effect of a mutation in a STAT6 binding site in the gamma 1 promoter
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 173:5531-9. 2004
  2. pmc Transgenes of the mouse immunoglobulin heavy chain locus, lacking distal elements in the 3' regulatory region, are impaired for class switch recombination
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    PLoS ONE 8:e55842. 2013
  3. pmc The 3' end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 201:1459-66. 2005
  4. pmc The role of germline promoters and I exons in cytokine-induced gene-specific class switch recombination
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 186:350-8. 2011
  5. pmc Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 187:4733-43. 2011
  6. ncbi request reprint NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand
    Michael T Berton
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Int Immunol 16:1741-9. 2004
  7. ncbi request reprint Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma
    John T Collins
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    J Immunol 177:5414-9. 2006
  8. pmc Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48103, USA
    J Exp Med 206:2613-23. 2009
  9. ncbi request reprint Receptors and counterreceptors involved in NK-B cell interactions
    Ning Gao
    Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 174:4113-9. 2005

Research Grants

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Germline transcription and switch recombination of a transgene containing the entire H chain constant region locus: effect of a mutation in a STAT6 binding site in the gamma 1 promoter
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 173:5531-9. 2004
    ..We infer that the physiologic level of germline transcription of the gamma1 gene is in excess over the amount required for efficient S recombination...
  2. pmc Transgenes of the mouse immunoglobulin heavy chain locus, lacking distal elements in the 3' regulatory region, are impaired for class switch recombination
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    PLoS ONE 8:e55842. 2013
    ....
  3. pmc The 3' end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 201:1459-66. 2005
    ..Finally, switch recombination to gamma1 is undetectable in the transgenes lacking the 3' elements, as measured by digestion circularization-polymerase chain reaction or by the expression of VDJCgamma1 transcripts...
  4. pmc The role of germline promoters and I exons in cytokine-induced gene-specific class switch recombination
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 186:350-8. 2011
    ..Nevertheless, the small amount of recombination to the chimeric γ1 gene is induced by IFN-γ. These results suggest that cytokine regulation of CSR, but not the magnitude of CSR, is regulated by the promoter/I exons...
  5. pmc Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 187:4733-43. 2011
    ..Thus, we find that the dramatic induction of class-switch recombination during Ag-driven differentiation is the result of an interaction among four separated regulatory elements...
  6. ncbi request reprint NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand
    Michael T Berton
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Int Immunol 16:1741-9. 2004
    ..We conclude that the three proximal NF-kappaB sites are dispensable for expression of gamma1 germline transcripts under most conditions. However, cis-acting elements distal to -150 must be critical to this transcription...
  7. ncbi request reprint Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma
    John T Collins
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    J Immunol 177:5414-9. 2006
    ..These results suggest that some immune responses to infectious agents can result in large amounts of IgG2a expression through ligation of CD40, without the expression of IFN-gamma by Th1 or other cells...
  8. pmc Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region
    Wesley A Dunnick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48103, USA
    J Exp Med 206:2613-23. 2009
    ..Finally, we find that in B cells with a transgene lacking the 3' enhancers, interchromosomal recombination between the transgenic VDJ exon and the endogenous heavy chain C genes is more easily detected than CSR within the transgene...
  9. ncbi request reprint Receptors and counterreceptors involved in NK-B cell interactions
    Ning Gao
    Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 174:4113-9. 2005
    ....

Research Grants29

  1. DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH
    Wesley Dunnick; Fiscal Year: 2001
    ..He will also study the transcriptional regulation of the g2a gene, emphasizing both cis-acting elements in the g2a gene and in the heavy chain 3 regulatory region. ..
  2. DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH
    Wesley Dunnick; Fiscal Year: 2006
    ..We will examine the role of the orientation of switch sequences, and hence the role of the unusual complexes between germline transcripts and switch region DNA, in Aim 4. ..
  3. Normal and aberrant switch recombination to the murine alpha heavy chain gene
    Wesley Dunnick; Fiscal Year: 2007
    ..The information is also likely to be relevant to normal switch recombination, with implications for better vaccine design. ..
  4. DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH
    Wesley Dunnick; Fiscal Year: 2007
    ..Almost alll allergies are caused by the expression of one type of antibody. The understanding to be gained from the proposed experiments may improve approaches toward vaccine development and toward treatment of allergy. ..
  5. DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH
    Wesley Dunnick; Fiscal Year: 2009
    ..Almost alll allergies are caused by the expression of one type of antibody. The understanding to be gained from the proposed experiments may improve approaches toward vaccine development and toward treatment of allergy. ..
  6. DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH
    Wesley Dunnick; Fiscal Year: 1993
    ..We will study two murine heavy chain genes, gamma1 and gamma2a, and two inducers of switch recombination, IL4 for gamma1 and interferon-gamma for gamma2a...
  7. DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH
    Wesley Dunnick; Fiscal Year: 1991
    ..So that we might understand the DNA sequence recognition, specificity, and genetics of switch recombinases we propose to select a cell line that constitutively produces these enzymes...
  8. DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH
    Wesley A Dunnick; Fiscal Year: 2010
    ..Almost alll allergies are caused by the expression of one type of antibody. The understanding to be gained from the proposed experiments may improve approaches toward vaccine development and toward treatment of allergy. ..