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Genomes and Genes | Jacque L DuncanSummaryAffiliation: University of California Country: USA Publications
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Publications
High-resolution imaging with adaptive optics in patients with inherited retinal degenerationJacque L Duncan
Department of Ophthalmology, University of California, San Francisco School of Medicine, San Francisco, California 94143 0730, USA
Invest Ophthalmol Vis Sci 48:3283-91. 2007..To investigate macular photoreceptor structure in patients with inherited retinal degeneration using high-resolution images and to correlate the findings with clinical phenotypes and genetic mutations...
Abnormal cone structure in foveal schisis cavities in X-linked retinoschisis from mutations in exon 6 of the RS1 geneJacque L Duncan
Department of Ophthalmology, University of California at San Francisco, San Francisco, California 94143, USA
Invest Ophthalmol Vis Sci 52:9614-23. 2011..To evaluate macular cone structure in patients with X-linked retinoschisis (XLRS) caused by mutations in exon 6 of the RS1 gene...- Cone structure in retinal degeneration associated with mutations in the peripherin/RDS geneJacque L Duncan
Department of Ophthalmology, UCSF School of Medicine, 10 Koret Way, Room K 129, San Francisco, CA 94143 0730, USA
Invest Ophthalmol Vis Sci 52:1557-66. 2011..To study cone photoreceptor structure and function associated with mutations in the second intradiscal loop region of peripherin/RDS... - Neurotrophic factors minimize the retinal toxicity of verteporfin photodynamic therapyDaniel M Paskowitz
Department of Ophthalmology, University of California, San Francisco, California 94143, USA
Invest Ophthalmol Vis Sci 48:430-7. 2007..Also investigated was whether protection would be observed after a second round of PDT with adjunctive BDNF treatment... - Retinal damage caused by photodynamic therapy can be reduced using BDNFJacque L Duncan
University of California, San Francisco, California 94143, USA
Adv Exp Med Biol 572:297-302. 2006 - Inherited retinal dystrophy in Mer knockout miceJacque L Duncan
University of California, San Francisco, CA 94143, USA
Adv Exp Med Biol 533:165-72. 2003 - High-resolution in vivo imaging of the RPE mosaic in eyes with retinal diseaseAustin Roorda
UC Berkeley School of Optometry, University of California, Berkeley, Berkeley, California 94720 2020, USA
Invest Ophthalmol Vis Sci 48:2297-303. 2007..To use high-resolution and contrast imaging techniques to reveal microscopic retinal structures, including individual retinal pigment epithelial (RPE) cells, in human eyes with inherited retinal disease... - Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerationsMatthew M Lavail
Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
J Comp Neurol 511:724-35. 2008..Thus, specificity of the neuroprotective effect of NT-3 is clearly demonstrated, and different molecular mechanisms are inferred to mediate the protective effect in light-induced and inherited RDs... - High-resolution images of retinal structure in patients with choroideremiaReema Syed
Department of Ophthalmology, University of California, San Francisco, USA
Invest Ophthalmol Vis Sci 54:950-61. 2013..To study retinal structure in choroideremia patients and carriers using high-resolution imaging techniques... - Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosaKun Do Rhee
Jules Stein Eye Institute, University of California, Los Angeles, California, USA
Invest Ophthalmol Vis Sci 48:1389-400. 2007..To characterize molecular and cellular changes induced by sustained expression of ciliary neurotrophic factor (CNTF) in the rds mutant mouse retina... 
Adaptive optics scanning laser ophthalmoscopy images in a family with the mitochondrial DNA T8993C mutationMichael K Yoon
Department of Ophthalmology, University of California, San Francisco, California 94143 0730, USA
Invest Ophthalmol Vis Sci 50:1838-47. 2009..This study was designed to assess the effect of mitochondrial DNA (mtDNA) mutation T8993C on cone structure in a family expressing neurogenic muscle weakness, ataxia, and retinitis pigmentosa (NARP) syndrome...- Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatmentKatherine E Talcott
Department of Ophthalmology, Division of Preventive Medicine and Public Health, University of California at San Francisco, CA, USA
Invest Ophthalmol Vis Sci 52:2219-26. 2011..To study cone photoreceptor structure and function in patients with inherited retinal degenerations treated with sustained-release ciliary neurotrophic factor (CNTF)... - Retinal TrkB receptors regulate neural development in the inner, but not outer, retinaRuslan N Grishanin
Neuroscience Program, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
Mol Cell Neurosci 38:431-43. 2008..We conclude that retinal BDNF/TrkB signaling has its primary role in the development of inner retinal neuronal circuits, and that this action is not a secondary effect due to the loss of visual signaling in the outer retina... - An RCS-like retinal dystrophy phenotype in mer knockout miceJacque L Duncan
Department of Ophthalmology, Beckman Vision Center, University of California, San Francisco, California 94143, USA
Invest Ophthalmol Vis Sci 44:826-38. 2003..To determine whether mice that are homozygous for a targeted disruption of the Mer receptor tyrosine kinase gene (mer(kd)) manifest a retinal dystrophy phenotype similar to RCS rats, which carry a mutation in the orthologous gene MERTK:.. - Rapid and stable knockdown of an endogenous gene in retinal pigment epitheliumDaniel M Paskowitz
Beckman Vision Center, University of California, San Francisco, San Francisco, CA 94143, USA
Hum Gene Ther 18:871-80. 2007..Viral delivery of RNAi constructs offers a powerful and versatile approach for both gene therapy and the analysis of fundamental questions in retinal biology... - Cone structure in patients with usher syndrome type III and mutations in the Clarin 1 geneKavitha Ratnam
Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143 0730, USA
JAMA Ophthalmol 131:67-74. 2013..To study macular structure and function in patients with Usher syndrome type III (USH3) caused by mutations in the Clarin 1 gene (CLRN1)... - Heterogeneous patterns of tissue injury in NARP syndromeJeffrey M Gelfand
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
J Neurol 258:440-8. 2011..High-resolution retinal and brain imaging in NARP syndrome revealed analogous patterns of tissue injury characterized by heterogeneous areas of neuronal loss... - BDNF reduces the retinal toxicity of verteporfin photodynamic therapyDaniel M Paskowitz
Department of Ophthalmology, University of California, San Francisco, 94143-0730, USA
Invest Ophthalmol Vis Sci 45:4190-6. 2004..CONCLUSIONS: These results suggest that adjunctive neuroprotective therapy may reduce collateral damage to photoreceptors and improve visual outcome after PDT... - Acute zonal occult outer retinopathy in a patient with graft-versus-host diseaseMarsha C Cheung
Department of Ophthalmology, University of California, San Francisco, CA, USA
Am J Ophthalmol 138:1058-60. 2004..The patient continued to have asymmetric progressive vision loss that stabilized over the next 6 months. CONCLUSIONS: Graft-versus-host disease should be included in the autoimmune conditions associated with AZOOR... - Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functionsJuliette Johnson
Department of Ophthalmology, University of California School of Medicine, San Francisco, California 94143, USA
J Neurosci 27:7245-55. 2007..Furthermore, melanopsin and VGLUT2 expression in a subset of RGCs immediately after birth strongly supports the idea that intrinsic vision can function well before rod- and cone-mediated signaling has matured... - Discordant anatomical, electrophysiological, and visual behavioral profiles of retinal degeneration in rat models of retinal degenerative diseaseTrevor J McGill
Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
Invest Ophthalmol Vis Sci 53:6232-44. 2012.... - Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutationDean Bok
Department of Neurobiology, University of California, Los Angeles, CA 90095, USA
Exp Eye Res 74:719-35. 2002..The mechanisms for these side effects and proper doses of CNTF administration should be determined before human clinical trials are considered for the amelioration of inherited retinal degenerations with CNTF... - Detection of localized retinal dysfunction in a choroideremia carrierMarsha C Cheung
University of California School of Medicine, San Francisco, California 94143-0730, USA
Am J Ophthalmol 137:189-91. 2004..Mosaic inactivation of the normal gene may cause expression of the mutation with severe vision loss in choroideremia carriers... - Adaptive optics retinal imaging: emerging clinical applicationsPooja Godara
Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Optom Vis Sci 87:930-41. 2010..Here, we review some of the advances that were made possible with AO imaging of the human retina and discuss applications and future prospects for clinical imaging... - Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermiaYien Ming Kuo
Department of Medicine, University of California, San Francisco, CA 94143, USA
Hum Mol Genet 14:49-57. 2005..Immunohistochemistry shows staining consistent with localization of Pank2 to the mitochondria in both the retina and the spermatozoa... - Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusionJacque L Duncan
Department of Ophthalmology, University of California San Francisco School of Medicine, San Francisco, California 94143 0730, USA
J Neurosci 26:7201-11. 2006..These results suggest that PMCA2-mediated Ca2+ extrusion modulates the amplitude and timing of the high-sensitivity rod pathway to a much greater extent than that of the cone pathway... - Visual field loss in patients with cytomegalovirus retinitisJennifer E Thorne
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ophthalmology 118:895-901. 2011..To describe visual field (VF) loss among patients with cytomegalovirus (CMV) retinitis and the risk factors for such loss... - Macular schisis detachment associated with angle-closure glaucomaDavid A Hollander
University of California, San Francisco, Department of Ophthalmology, 94143, USA
Arch Ophthalmol 123:270-2. 2005 - Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degenerationHilary L Wilson
Department of Ophthalmology, UCSF School of Medicine, San Francisco, CA 94143, USA
Am J Ophthalmol 137:615-24. 2004..98, P =.04). CONCLUSIONS: Therapy with statins or aspirin is associated with decreased rates of CNV among AMD patients. Additional study with a prospective and/or randomized trial of statin and aspirin use in AMD patients is warranted... - Macular pigment and lutein supplementation in choroideremiaJacque L Duncan
Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Exp Eye Res 74:371-81. 2002..There was no short-term change in the central vision of the patients on the supplement, but long-term influences of lutein supplementation on disease natural history warrant further study... - Intraocular CNTF reduces vision in normal rats in a dose-dependent mannerTrevor J McGill
Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada
Invest Ophthalmol Vis Sci 48:5756-66. 2007..CNTF is a neuroprotective agent for retinal degenerations that can cause reduced electroretinogram (ERG) amplitudes. The goal of the present study was to determine the effects of intraocular delivery of CNTF on normal rat visual function...