Jacque L Duncan

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi High-resolution imaging with adaptive optics in patients with inherited retinal degeneration
    Jacque L Duncan
    Department of Ophthalmology, University of California, San Francisco School of Medicine, San Francisco, California 94143 0730, USA
    Invest Ophthalmol Vis Sci 48:3283-91. 2007
  2. pmc Abnormal cone structure in foveal schisis cavities in X-linked retinoschisis from mutations in exon 6 of the RS1 gene
    Jacque L Duncan
    Department of Ophthalmology, University of California at San Francisco, San Francisco, California 94143, USA
    Invest Ophthalmol Vis Sci 52:9614-23. 2011
  3. pmc Cone structure in retinal degeneration associated with mutations in the peripherin/RDS gene
    Jacque L Duncan
    Department of Ophthalmology, UCSF School of Medicine, 10 Koret Way, Room K 129, San Francisco, CA 94143 0730, USA
    Invest Ophthalmol Vis Sci 52:1557-66. 2011
  4. ncbi Neurotrophic factors minimize the retinal toxicity of verteporfin photodynamic therapy
    Daniel M Paskowitz
    Department of Ophthalmology, University of California, San Francisco, California 94143, USA
    Invest Ophthalmol Vis Sci 48:430-7. 2007
  5. ncbi Retinal damage caused by photodynamic therapy can be reduced using BDNF
    Jacque L Duncan
    University of California, San Francisco, California 94143, USA
    Adv Exp Med Biol 572:297-302. 2006
  6. ncbi Inherited retinal dystrophy in Mer knockout mice
    Jacque L Duncan
    University of California, San Francisco, CA 94143, USA
    Adv Exp Med Biol 533:165-72. 2003
  7. ncbi High-resolution in vivo imaging of the RPE mosaic in eyes with retinal disease
    Austin Roorda
    UC Berkeley School of Optometry, University of California, Berkeley, Berkeley, California 94720 2020, USA
    Invest Ophthalmol Vis Sci 48:2297-303. 2007
  8. pmc Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations
    Matthew M Lavail
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Comp Neurol 511:724-35. 2008
  9. pmc High-resolution images of retinal structure in patients with choroideremia
    Reema Syed
    Department of Ophthalmology, University of California, San Francisco, USA
    Invest Ophthalmol Vis Sci 54:950-61. 2013
  10. ncbi Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa
    Kun Do Rhee
    Jules Stein Eye Institute, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 48:1389-400. 2007

Collaborators

Detail Information

Publications34

  1. ncbi High-resolution imaging with adaptive optics in patients with inherited retinal degeneration
    Jacque L Duncan
    Department of Ophthalmology, University of California, San Francisco School of Medicine, San Francisco, California 94143 0730, USA
    Invest Ophthalmol Vis Sci 48:3283-91. 2007
    ..To investigate macular photoreceptor structure in patients with inherited retinal degeneration using high-resolution images and to correlate the findings with clinical phenotypes and genetic mutations...
  2. pmc Abnormal cone structure in foveal schisis cavities in X-linked retinoschisis from mutations in exon 6 of the RS1 gene
    Jacque L Duncan
    Department of Ophthalmology, University of California at San Francisco, San Francisco, California 94143, USA
    Invest Ophthalmol Vis Sci 52:9614-23. 2011
    ..To evaluate macular cone structure in patients with X-linked retinoschisis (XLRS) caused by mutations in exon 6 of the RS1 gene...
  3. pmc Cone structure in retinal degeneration associated with mutations in the peripherin/RDS gene
    Jacque L Duncan
    Department of Ophthalmology, UCSF School of Medicine, 10 Koret Way, Room K 129, San Francisco, CA 94143 0730, USA
    Invest Ophthalmol Vis Sci 52:1557-66. 2011
    ..To study cone photoreceptor structure and function associated with mutations in the second intradiscal loop region of peripherin/RDS...
  4. ncbi Neurotrophic factors minimize the retinal toxicity of verteporfin photodynamic therapy
    Daniel M Paskowitz
    Department of Ophthalmology, University of California, San Francisco, California 94143, USA
    Invest Ophthalmol Vis Sci 48:430-7. 2007
    ..Also investigated was whether protection would be observed after a second round of PDT with adjunctive BDNF treatment...
  5. ncbi Retinal damage caused by photodynamic therapy can be reduced using BDNF
    Jacque L Duncan
    University of California, San Francisco, California 94143, USA
    Adv Exp Med Biol 572:297-302. 2006
  6. ncbi Inherited retinal dystrophy in Mer knockout mice
    Jacque L Duncan
    University of California, San Francisco, CA 94143, USA
    Adv Exp Med Biol 533:165-72. 2003
  7. ncbi High-resolution in vivo imaging of the RPE mosaic in eyes with retinal disease
    Austin Roorda
    UC Berkeley School of Optometry, University of California, Berkeley, Berkeley, California 94720 2020, USA
    Invest Ophthalmol Vis Sci 48:2297-303. 2007
    ..To use high-resolution and contrast imaging techniques to reveal microscopic retinal structures, including individual retinal pigment epithelial (RPE) cells, in human eyes with inherited retinal disease...
  8. pmc Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations
    Matthew M Lavail
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Comp Neurol 511:724-35. 2008
    ..Thus, specificity of the neuroprotective effect of NT-3 is clearly demonstrated, and different molecular mechanisms are inferred to mediate the protective effect in light-induced and inherited RDs...
  9. pmc High-resolution images of retinal structure in patients with choroideremia
    Reema Syed
    Department of Ophthalmology, University of California, San Francisco, USA
    Invest Ophthalmol Vis Sci 54:950-61. 2013
    ..To study retinal structure in choroideremia patients and carriers using high-resolution imaging techniques...
  10. ncbi Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa
    Kun Do Rhee
    Jules Stein Eye Institute, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 48:1389-400. 2007
    ..To characterize molecular and cellular changes induced by sustained expression of ciliary neurotrophic factor (CNTF) in the rds mutant mouse retina...
  11. doi Adaptive optics scanning laser ophthalmoscopy images in a family with the mitochondrial DNA T8993C mutation
    Michael K Yoon
    Department of Ophthalmology, University of California, San Francisco, California 94143 0730, USA
    Invest Ophthalmol Vis Sci 50:1838-47. 2009
    ..This study was designed to assess the effect of mitochondrial DNA (mtDNA) mutation T8993C on cone structure in a family expressing neurogenic muscle weakness, ataxia, and retinitis pigmentosa (NARP) syndrome...
  12. pmc Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment
    Katherine E Talcott
    Department of Ophthalmology, Division of Preventive Medicine and Public Health, University of California at San Francisco, CA, USA
    Invest Ophthalmol Vis Sci 52:2219-26. 2011
    ..To study cone photoreceptor structure and function in patients with inherited retinal degenerations treated with sustained-release ciliary neurotrophic factor (CNTF)...
  13. ncbi An RCS-like retinal dystrophy phenotype in mer knockout mice
    Jacque L Duncan
    Department of Ophthalmology, Beckman Vision Center, University of California, San Francisco, California 94143, USA
    Invest Ophthalmol Vis Sci 44:826-38. 2003
    ..To determine whether mice that are homozygous for a targeted disruption of the Mer receptor tyrosine kinase gene (mer(kd)) manifest a retinal dystrophy phenotype similar to RCS rats, which carry a mutation in the orthologous gene MERTK:..
  14. pmc Retinal TrkB receptors regulate neural development in the inner, but not outer, retina
    Ruslan N Grishanin
    Neuroscience Program, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Mol Cell Neurosci 38:431-43. 2008
    ..We conclude that retinal BDNF/TrkB signaling has its primary role in the development of inner retinal neuronal circuits, and that this action is not a secondary effect due to the loss of visual signaling in the outer retina...
  15. ncbi Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium
    Daniel M Paskowitz
    Beckman Vision Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Hum Gene Ther 18:871-80. 2007
    ..Viral delivery of RNAi constructs offers a powerful and versatile approach for both gene therapy and the analysis of fundamental questions in retinal biology...
  16. pmc Relationship between foveal cone structure and clinical measures of visual function in patients with inherited retinal degenerations
    Kavitha Ratnam
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California
    Invest Ophthalmol Vis Sci 54:5836-47. 2013
    ..To study the relationship between cone spacing and density and clinical measures of visual function near the fovea...
  17. ncbi Cone structure in patients with usher syndrome type III and mutations in the Clarin 1 gene
    Kavitha Ratnam
    Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143 0730, USA
    JAMA Ophthalmol 131:67-74. 2013
    ..To study macular structure and function in patients with Usher syndrome type III (USH3) caused by mutations in the Clarin 1 gene (CLRN1)...
  18. pmc Heterogeneous patterns of tissue injury in NARP syndrome
    Jeffrey M Gelfand
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    J Neurol 258:440-8. 2011
    ..High-resolution retinal and brain imaging in NARP syndrome revealed analogous patterns of tissue injury characterized by heterogeneous areas of neuronal loss...
  19. ncbi BDNF reduces the retinal toxicity of verteporfin photodynamic therapy
    Daniel M Paskowitz
    Department of Ophthalmology, University of California, San Francisco, 94143 0730, USA
    Invest Ophthalmol Vis Sci 45:4190-6. 2004
    ..In the current study, it was found that the neuroprotective agent brain-derived neurotrophic factor (BDNF) reduces this retinal damage...
  20. ncbi Acute zonal occult outer retinopathy in a patient with graft-versus-host disease
    Marsha C Cheung
    Department of Ophthalmology, University of California, San Francisco, CA, USA
    Am J Ophthalmol 138:1058-60. 2004
    ..To investigate the mechanism of bilateral central vision loss in a patient with graft-versus-host disease...
  21. pmc Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions
    Juliette Johnson
    Department of Ophthalmology, University of California School of Medicine, San Francisco, California 94143, USA
    J Neurosci 27:7245-55. 2007
    ..Furthermore, melanopsin and VGLUT2 expression in a subset of RGCs immediately after birth strongly supports the idea that intrinsic vision can function well before rod- and cone-mediated signaling has matured...
  22. pmc Cone structure imaged with adaptive optics scanning laser ophthalmoscopy in eyes with nonneovascular age-related macular degeneration
    Shiri Zayit-Soudry
    Department of Ophthalmology, University of California at San Francisco, San Francisco, California
    Invest Ophthalmol Vis Sci 54:7498-509. 2013
    ..To evaluate cone spacing using adaptive optics scanning laser ophthalmoscopy (AOSLO) in eyes with nonneovascular AMD, and to correlate progression of AOSLO-derived cone measures with standard measures of macular structure...
  23. pmc Discordant anatomical, electrophysiological, and visual behavioral profiles of retinal degeneration in rat models of retinal degenerative disease
    Trevor J McGill
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 53:6232-44. 2012
    ....
  24. ncbi Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation
    Dean Bok
    Department of Neurobiology, University of California, Los Angeles, CA 90095, USA
    Exp Eye Res 74:719-35. 2002
    ..The mechanisms for these side effects and proper doses of CNTF administration should be determined before human clinical trials are considered for the amelioration of inherited retinal degenerations with CNTF...
  25. ncbi Detection of localized retinal dysfunction in a choroideremia carrier
    Marsha C Cheung
    University of California School of Medicine, San Francisco, California 94143 0730, USA
    Am J Ophthalmol 137:189-91. 2004
    ..To investigate severe unilateral vision loss in a choroideremia carrier...
  26. pmc Adaptive optics retinal imaging: emerging clinical applications
    Pooja Godara
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Optom Vis Sci 87:930-41. 2010
    ..Here, we review some of the advances that were made possible with AO imaging of the human retina and discuss applications and future prospects for clinical imaging...
  27. pmc Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia
    Yien Ming Kuo
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Hum Mol Genet 14:49-57. 2005
    ..Immunohistochemistry shows staining consistent with localization of Pank2 to the mitochondria in both the retina and the spermatozoa...
  28. pmc Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusion
    Jacque L Duncan
    Department of Ophthalmology, University of California San Francisco School of Medicine, San Francisco, California 94143 0730, USA
    J Neurosci 26:7201-11. 2006
    ..These results suggest that PMCA2-mediated Ca2+ extrusion modulates the amplitude and timing of the high-sensitivity rod pathway to a much greater extent than that of the cone pathway...
  29. pmc Visual field loss in patients with cytomegalovirus retinitis
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 118:895-901. 2011
    ..To describe visual field (VF) loss among patients with cytomegalovirus (CMV) retinitis and the risk factors for such loss...
  30. ncbi Macular schisis detachment associated with angle-closure glaucoma
    David A Hollander
    University of California, San Francisco, Department of Ophthalmology, 94143, USA
    Arch Ophthalmol 123:270-2. 2005
  31. ncbi Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration
    Hilary L Wilson
    Department of Ophthalmology, UCSF School of Medicine, San Francisco, CA 94143, USA
    Am J Ophthalmol 137:615-24. 2004
    ..To investigate the relationship between statin and aspirin use and the risk of choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD)...
  32. ncbi Diagnosis and complementary examinations
    Moreno Menghini
    Department of Ophthalmology, University of California, San Francisco, Calif, USA
    Dev Ophthalmol 53:53-69. 2014
    ..Resolution of all images of retinal structure can be improved using adaptive optics, which permits visualization of individual photoreceptors and retinal pigment epithelial cells in the macula. © 2014 S. Karger AG, Basel. ..
  33. ncbi Macular pigment and lutein supplementation in choroideremia
    Jacque L Duncan
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Eye Res 74:371-81. 2002
    ..There was no short-term change in the central vision of the patients on the supplement, but long-term influences of lutein supplementation on disease natural history warrant further study...
  34. ncbi Intraocular CNTF reduces vision in normal rats in a dose-dependent manner
    Trevor J McGill
    Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada
    Invest Ophthalmol Vis Sci 48:5756-66. 2007
    ..CNTF is a neuroprotective agent for retinal degenerations that can cause reduced electroretinogram (ERG) amplitudes. The goal of the present study was to determine the effects of intraocular delivery of CNTF on normal rat visual function...