IAN DAVID DUNCAN

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint His36Pro point-mutated proteolipid protein retained in the endoplasmic reticulum of oligodendrocytes in the shaking pup
    Jonathan Song
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Glia 53:257-65. 2006
  2. pmc Schwann cell invasion of the central nervous system of the myelin mutants
    I D Duncan
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
    J Anat 190:35-49. 1997
  3. pmc Extensive remyelination of the CNS leads to functional recovery
    I D Duncan
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:6832-6. 2009
  4. ncbi request reprint Replacing cells in multiple sclerosis
    Ian D Duncan
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    J Neurol Sci 265:89-92. 2008
  5. pmc The myelin mutants as models to study myelin repair in the leukodystrophies
    Ian D Duncan
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Neurotherapeutics 8:607-24. 2011
  6. ncbi request reprint The PLP mutants from mouse to man
    Ian D Duncan
    Department of Neuroscience, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    J Neurol Sci 228:204-5. 2005
  7. ncbi request reprint Suppression of activated microglia promotes survival and function of transplanted oligodendroglial progenitors
    Su Chun Zhang
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Glia 41:191-8. 2003
  8. doi request reprint Selective reduction in microglia density and function in the white matter of colony-stimulating factor-1-deficient mice
    Yoichi Kondo
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Neurosci Res 87:2686-95. 2009
  9. ncbi request reprint Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII
    Maria Nikodemova
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:15208-16. 2007
  10. ncbi request reprint Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microglia
    Maria Nikodemova
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurochem 96:314-23. 2006

Detail Information

Publications27

  1. ncbi request reprint His36Pro point-mutated proteolipid protein retained in the endoplasmic reticulum of oligodendrocytes in the shaking pup
    Jonathan Song
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Glia 53:257-65. 2006
    ..These results suggest that mutated PLP/DM20 in the shp could be selectively retained in RER, causing disruption of their translocation to the periphery to myelinate axons...
  2. pmc Schwann cell invasion of the central nervous system of the myelin mutants
    I D Duncan
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
    J Anat 190:35-49. 1997
    ..Extensive Schwann cell CNS myelination may have therapeutic significance in human myelin disease...
  3. pmc Extensive remyelination of the CNS leads to functional recovery
    I D Duncan
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:6832-6. 2009
    ..Most importantly, it confirms the clinical relevance of remyelination and its ability to restore function...
  4. ncbi request reprint Replacing cells in multiple sclerosis
    Ian D Duncan
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    J Neurol Sci 265:89-92. 2008
    ..Focal repair of strategic lesions followed by more disseminated delivery of exogenous cells will be the short and long-term goals...
  5. pmc The myelin mutants as models to study myelin repair in the leukodystrophies
    Ian D Duncan
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Neurotherapeutics 8:607-24. 2011
    ..We discuss how grafts are identified and functional outcomes are measured. Finally, we briefly discuss the cells that have been successfully transplanted, which may be used in future clinical trials...
  6. ncbi request reprint The PLP mutants from mouse to man
    Ian D Duncan
    Department of Neuroscience, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    J Neurol Sci 228:204-5. 2005
  7. ncbi request reprint Suppression of activated microglia promotes survival and function of transplanted oligodendroglial progenitors
    Su Chun Zhang
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Glia 41:191-8. 2003
    ..Hence, minocycline likely modulates the function of reactive glia in vivo to promote the survival and myelination of transplanted oligodendroglial progenitors...
  8. doi request reprint Selective reduction in microglia density and function in the white matter of colony-stimulating factor-1-deficient mice
    Yoichi Kondo
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Neurosci Res 87:2686-95. 2009
    ..These findings demonstrate that this mutant is a valuable model in which to study roles of microglia/macrophages in the pathophysiology of myelin disorders...
  9. ncbi request reprint Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII
    Maria Nikodemova
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:15208-16. 2007
    ..Such a fundamental mechanism may underlie the pleiotropic effects of minocycline in CNS inflammatory disorders...
  10. ncbi request reprint Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microglia
    Maria Nikodemova
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurochem 96:314-23. 2006
    ..In addition, minocycline attenuated lipopolysaccharide-stimulated degradation of IkappaBalpha implying a possible inhibitory role on NF-kappaB transcriptional activity...
  11. ncbi request reprint Canine spongiform leukoencephalomyelopathy is associated with a missense mutation in cytochrome b
    Fang Yuan Li
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Neurobiol Dis 21:35-42. 2006
    ..Western blot analysis showed increased levels of core I and core II but decreased level of cytochrome c1 of the complex III and cytochrome c oxidase of the complex IV of the respiratory chain...
  12. pmc Galactocerebrosidase-deficient oligodendrocytes maintain stable central myelin by exogenous replacement of the missing enzyme in mice
    Yoichi Kondo
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:18670-5. 2005
    ..These findings suggest that the mutant OLs can internalize exogenous GALC and maintain stable myelin, demonstrating that exogenous enzyme replacement will be a key strategy in the therapy of GLD...
  13. ncbi request reprint Mapping of taiep rat phenotype to rat Chromosome 9
    Fang Yuan Li
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison Madison, Wisconsin 53706, USA
    Mamm Genome 14:703-5. 2003
    ..This information may also be a key to the complete understanding of the mechanism of microtubule assembly/disassembly in many cell types...
  14. ncbi request reprint RNA transport in oligodendrocytes from the taiep mutant rat
    Jonathan Song
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Mol Cell Neurosci 24:926-38. 2003
    ..Altered orientation of microtubules in oligodendrocyte fine processes and a physical barrier created by densely packed microtubules may also contribute to the inhibition of RNA trafficking in taiep oligodendrocytes...
  15. pmc 11C-(R)-PK11195 PET imaging of microglial activation and response to minocycline in zymosan-treated rats
    Alexander K Converse
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Nucl Med 52:257-62. 2011
    ..A reproducible focal white matter lesion was used to reliably compare treatment conditions...
  16. doi request reprint Minocycline attenuates experimental autoimmune encephalomyelitis in rats by reducing T cell infiltration into the spinal cord
    Maria Nikodemova
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53705, USA
    J Neuroimmunol 219:33-7. 2010
    ..Our results indicate that minocycline regulates T cell infiltration into the CNS without modifying the dominant cytokine production...
  17. doi request reprint Quantification of myelin and axon pathology during relapsing progressive experimental autoimmune encephalomyelitis in the Biozzi ABH mouse
    Samuel J Jackson
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA
    J Neuropathol Exp Neurol 68:616-25. 2009
    ....
  18. ncbi request reprint Myelin water fraction in human cervical spinal cord in vivo
    Yijing Wu
    Department of Medical Physics, University of Wisconsin Medical School, Madison, WI 53792 3252, USA
    J Comput Assist Tomogr 30:304-6. 2006
    ..This technical note reports the test-retest reproducibility of a short T2-based estimate of myelin content in human spinal cord in vivo...
  19. doi request reprint Slowly progressive axonal degeneration in a rat model of chronic, nonimmune-mediated demyelination
    Alastair Wilkins
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neuropathol Exp Neurol 69:1256-69. 2010
    ....
  20. ncbi request reprint Inhibition of autoimmune encephalomyelitis by a tetracycline
    Natalija Popovic
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Ann Neurol 51:215-23. 2002
    ..As an established antiinflammatory drug with neuroprotective properties, minocycline may provide a novel therapeutic agent for relapsing-remitting multiple sclerosis...
  21. doi request reprint Transplantation of oligodendrocyte progenitor cells in animal models of leukodystrophies
    Yoichi Kondo
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA
    Methods Mol Biol 549:175-85. 2009
    ....
  22. doi request reprint Generation of cultured oligodendrocyte progenitor cells from rat neonatal brains
    Eric C Larsen
    Department of Medical Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
    Curr Protoc Stem Cell Biol . 2008
    ..Prior to clinical trials, such approaches can be tested in animal models. Here, we describe the isolation of rat OPCs in culture conditions that provide large numbers of purified populations of cells...
  23. pmc Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia
    Julia M Edgar
    Applied Neurobiology Group, Institute of Comparative Medicine, University of Glasgow, Scotland, UK
    J Cell Biol 166:121-31. 2004
    ..Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis...
  24. ncbi request reprint Mutations in the rat myelin basic protein gene are associated with specific alterations in other myelin gene expression
    Jean Luc Carre
    Service de Biochimie et Biologie Mol├ęculaire, Faculte de Medecine, 22 avenue C Desmoulins, 29200 Brest, France
    Neurosci Lett 330:17-20. 2002
    ..Quantitation of mRNA levels indicated that decreases in PLP and DM20 were a result of changes in mRNA levels but detected no change in other myelin gene transcripts...
  25. ncbi request reprint Magnetically labeled glial cells as cellular MR contrast agents
    Jeff W M Bulte
    Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD, USA
    Acad Radiol 9:S148-50. 2002
  26. ncbi request reprint High b-value q-space diffusion MRI in myelin-deficient rat spinal cords
    Inbal E Biton
    School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Magn Reson Imaging 24:161-6. 2006
    ..Myelin was found to have a pronounced effect on the diffusion characteristics of water in WM but less so on the diffusion anisotropy observed at the diffusion time used in the present study...
  27. ncbi request reprint In vivo magnetic resonance tracking of magnetically labeled cells after transplantation
    Jeff W M Bulte
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Cereb Blood Flow Metab 22:899-907. 2002
    ..Now that MR tracking of magnetically labeled cells appears feasible, it is anticipated that this technique may ultimately become an important tool for monitoring the efficacy of clinical (stem) cell transplantation protocols...

Research Grants13

  1. MICROTUBULES AND MYELINATION IN A MUTANT RAT
    Ian Duncan; Fiscal Year: 2002
    ..Similar experiments will be performed on normal oligodendrocyte in which the cytoskeleton has been pharmacologically manipulated. ..
  2. The role of microglia/macrophages and their therapeutic use in Krabbe's disease
    Ian Duncan; Fiscal Year: 2007
    ..These combined data will provide the foundation required to devise therapeutic approaches to treating patients at all stages of the disease. ..
  3. The role of microglia/macrophages and their therapeutic use in Krabbe's disease
    IAN DAVID DUNCAN; Fiscal Year: 2010
    ..These combined data will provide the foundation required to devise therapeutic approaches to treating patients at all stages of the disease. ..