Research Topics
| IAN DAVID DUNCANSummaryAffiliation: University of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
His36Pro point-mutated proteolipid protein retained in the endoplasmic reticulum of oligodendrocytes in the shaking pupJonathan Song
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
Glia 53:257-65. 2006..These results suggest that mutated PLP/DM20 in the shp could be selectively retained in RER, causing disruption of their translocation to the periphery to myelinate axons...
Schwann cell invasion of the central nervous system of the myelin mutantsI D Duncan
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
J Anat 190:35-49. 1997..Extensive Schwann cell CNS myelination may have therapeutic significance in human myelin disease...- Extensive remyelination of the CNS leads to functional recoveryI D Duncan
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 106:6832-6. 2009..Most importantly, it confirms the clinical relevance of remyelination and its ability to restore function... - Replacing cells in multiple sclerosisIan D Duncan
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
J Neurol Sci 265:89-92. 2008..Focal repair of strategic lesions followed by more disseminated delivery of exogenous cells will be the short and long-term goals... - The myelin mutants as models to study myelin repair in the leukodystrophiesIan D Duncan
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Neurotherapeutics 8:607-24. 2011..We discuss how grafts are identified and functional outcomes are measured. Finally, we briefly discuss the cells that have been successfully transplanted, which may be used in future clinical trials... - The PLP mutants from mouse to manIan D Duncan
Department of Neuroscience, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA
J Neurol Sci 228:204-5. 2005 - Suppression of activated microglia promotes survival and function of transplanted oligodendroglial progenitorsSu-Chun Zhang
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
Glia 41:191-8. 2003..Hence, minocycline likely modulates the function of reactive glia in vivo to promote the survival and myelination of transplanted oligodendroglial progenitors... 
Selective reduction in microglia density and function in the white matter of colony-stimulating factor-1-deficient miceYoichi Kondo
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
J Neurosci Res 87:2686-95. 2009..These findings demonstrate that this mutant is a valuable model in which to study roles of microglia/macrophages in the pathophysiology of myelin disorders...- Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaIIMaria Nikodemova
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
J Biol Chem 282:15208-16. 2007..Such a fundamental mechanism may underlie the pleiotropic effects of minocycline in CNS inflammatory disorders... - Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microgliaMaria Nikodemova
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
J Neurochem 96:314-23. 2006..In addition, minocycline attenuated lipopolysaccharide-stimulated degradation of IkappaBalpha implying a possible inhibitory role on NF-kappaB transcriptional activity... - Canine spongiform leukoencephalomyelopathy is associated with a missense mutation in cytochrome bFang Yuan Li
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
Neurobiol Dis 21:35-42. 2006..Western blot analysis showed increased levels of core I and core II but decreased level of cytochrome c1 of the complex III and cytochrome c oxidase of the complex IV of the respiratory chain... - Galactocerebrosidase-deficient oligodendrocytes maintain stable central myelin by exogenous replacement of the missing enzyme in miceYoichi Kondo
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 102:18670-5. 2005..These findings suggest that the mutant OLs can internalize exogenous GALC and maintain stable myelin, demonstrating that exogenous enzyme replacement will be a key strategy in the therapy of GLD... - Mapping of taiep rat phenotype to rat Chromosome 9Fang Yuan Li
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison Madison, Wisconsin 53706, USA
Mamm Genome 14:703-5. 2003..This information may also be a key to the complete understanding of the mechanism of microtubule assembly/disassembly in many cell types... - RNA transport in oligodendrocytes from the taiep mutant ratJonathan Song
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
Mol Cell Neurosci 24:926-38. 2003..Altered orientation of microtubules in oligodendrocyte fine processes and a physical barrier created by densely packed microtubules may also contribute to the inhibition of RNA trafficking in taiep oligodendrocytes... - 11C-(R)-PK11195 PET imaging of microglial activation and response to minocycline in zymosan-treated ratsAlexander K Converse
Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
J Nucl Med 52:257-62. 2011..A reproducible focal white matter lesion was used to reliably compare treatment conditions... - Minocycline attenuates experimental autoimmune encephalomyelitis in rats by reducing T cell infiltration into the spinal cordMaria Nikodemova
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53705, USA
J Neuroimmunol 219:33-7. 2010..Our results indicate that minocycline regulates T cell infiltration into the CNS without modifying the dominant cytokine production... - Quantification of myelin and axon pathology during relapsing progressive experimental autoimmune encephalomyelitis in the Biozzi ABH mouseSamuel J Jackson
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA
J Neuropathol Exp Neurol 68:616-25. 2009.... - Myelin water fraction in human cervical spinal cord in vivoYijing Wu
Department of Medical Physics, University of Wisconsin Medical School, Madison, WI 53792-3252, USA
J Comput Assist Tomogr 30:304-6. 2006..This technical note reports the test-retest reproducibility of a short T2-based estimate of myelin content in human spinal cord in vivo... - Slowly progressive axonal degeneration in a rat model of chronic, nonimmune-mediated demyelinationAlastair Wilkins
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
J Neuropathol Exp Neurol 69:1256-69. 2010.... - Inhibition of autoimmune encephalomyelitis by a tetracyclineNatalija Popovic
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
Ann Neurol 51:215-23. 2002..As an established antiinflammatory drug with neuroprotective properties, minocycline may provide a novel therapeutic agent for relapsing-remitting multiple sclerosis... - Transplantation of oligodendrocyte progenitor cells in animal models of leukodystrophiesYoichi Kondo
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA
Methods Mol Biol 549:175-85. 2009.... - Generation of cultured oligodendrocyte progenitor cells from rat neonatal brainsEric C Larsen
Department of Medical Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
Curr Protoc Stem Cell Biol . 2008..Prior to clinical trials, such approaches can be tested in animal models. Here, we describe the isolation of rat OPCs in culture conditions that provide large numbers of purified populations of cells... 
Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegiaJulia M Edgar
Applied Neurobiology Group, Institute of Comparative Medicine, University of Glasgow, Scotland, UK
J Cell Biol 166:121-31. 2004..Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis...- Mutations in the rat myelin basic protein gene are associated with specific alterations in other myelin gene expressionJean Luc Carre
Service de Biochimie et Biologie Moléculaire, Faculte de Medecine, 22 avenue C Desmoulins, 29200 Brest, France
Neurosci Lett 330:17-20. 2002..Quantitation of mRNA levels indicated that decreases in PLP and DM20 were a result of changes in mRNA levels but detected no change in other myelin gene transcripts... - Magnetically labeled glial cells as cellular MR contrast agentsJeff W M Bulte
Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD, USA
Acad Radiol 9:S148-50. 2002 - High b-value q-space diffusion MRI in myelin-deficient rat spinal cordsInbal E Biton
School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
Magn Reson Imaging 24:161-6. 2006..Myelin was found to have a pronounced effect on the diffusion characteristics of water in WM but less so on the diffusion anisotropy observed at the diffusion time used in the present study... - In vivo magnetic resonance tracking of magnetically labeled cells after transplantationJeff W M Bulte
Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
J Cereb Blood Flow Metab 22:899-907. 2002..Now that MR tracking of magnetically labeled cells appears feasible, it is anticipated that this technique may ultimately become an important tool for monitoring the efficacy of clinical (stem) cell transplantation protocols...
Research Grants
- MICROTUBULES AND MYELINATION IN A MUTANT RATIan Duncan; Fiscal Year: 2002..Similar experiments will be performed on normal oligodendrocyte in which the cytoskeleton has been pharmacologically manipulated. ..
- The role of microglia/macrophages and their therapeutic use in Krabbe's diseaseIan Duncan; Fiscal Year: 2007..These combined data will provide the foundation required to devise therapeutic approaches to treating patients at all stages of the disease. ..
- The role of microglia/macrophages and their therapeutic use in Krabbe's diseaseIAN DAVID DUNCAN; Fiscal Year: 2010..These combined data will provide the foundation required to devise therapeutic approaches to treating patients at all stages of the disease. ..