Gary E Duncan

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, USA
    Brain Res 1443:98-105. 2012
  2. pmc Increased sensitivity to kainic acid in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, USA
    Brain Res 1307:166-76. 2010
  3. pmc Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Res 1265:186-95. 2009
  4. pmc Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl)glycine in a genetic model of NMDA receptor hypofunction
    Gary E Duncan
    Department of Psychiatry, 410 Taylor Hall, CB 7090, University of North Carolina, Chapel Hill, NC 27599, USA
    Brain Res 1221:41-8. 2008
  5. pmc Typical and atypical antipsychotic drug effects on locomotor hyperactivity and deficits in sensorimotor gating in a genetic model of NMDA receptor hypofunction
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    Pharmacol Biochem Behav 85:481-91. 2006
  6. ncbi request reprint Alterations in regional brain metabolism in genetic and pharmacological models of reduced NMDA receptor function
    Gary Duncan
    Department of Psychiatry, CB 7090, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Brain Res 951:166-76. 2002
  7. ncbi request reprint Effects of haloperidol, clozapine, and quetiapine on sensorimotor gating in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, CB 7090, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7090, USA
    Psychopharmacology (Berl) 184:190-200. 2006
  8. ncbi request reprint The novel antiepileptic drug lacosamide blocks behavioral and brain metabolic manifestations of seizure activity in the 6 Hz psychomotor seizure model
    Gary E Duncan
    Department of Psychiatry, School of Medicine, CB 7090, 410 Taylor Hall, University of North Carolina, Chapel Hill, NC 27599 7090, USA
    Epilepsy Res 67:81-7. 2005
  9. ncbi request reprint Chronic administration of haloperidol and olanzapine attenuates ketamine-induced brain metabolic activation
    Gary E Duncan
    Department of Psychiatry, CB 7090, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7250, USA
    J Pharmacol Exp Ther 305:999-1005. 2003
  10. ncbi request reprint Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, University of North Carolina School of Medicine, CB 7090, Chapel Hill, NC 27599 7090, USA
    Behav Brain Res 153:507-19. 2004

Detail Information

Publications17

  1. pmc Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, USA
    Brain Res 1443:98-105. 2012
    ..The results also provide further support for the idea that selective kainate receptor antagonists could be novel therapeutic candidates for schizophrenia...
  2. pmc Increased sensitivity to kainic acid in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, USA
    Brain Res 1307:166-76. 2010
    ..These findings suggest that selective kainate receptor antagonists could be novel therapeutic candidates for schizophrenia...
  3. pmc Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Res 1265:186-95. 2009
    ..The mutant mice also exhibited reduced Fos in response to swim stress in specific brain regions. These data suggest that the NR1 hypomorphic mice have functional activation deficits in response to social challenge and swim stress...
  4. pmc Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl)glycine in a genetic model of NMDA receptor hypofunction
    Gary E Duncan
    Department of Psychiatry, 410 Taylor Hall, CB 7090, University of North Carolina, Chapel Hill, NC 27599, USA
    Brain Res 1221:41-8. 2008
    ..The results suggest that the NMDA receptor hypofunction in the NR1 -/- mice is not global but regionally specific and that subcortical structures are responsible for the seizure-inducing effects of TZG...
  5. pmc Typical and atypical antipsychotic drug effects on locomotor hyperactivity and deficits in sensorimotor gating in a genetic model of NMDA receptor hypofunction
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    Pharmacol Biochem Behav 85:481-91. 2006
    ..Since both haloperidol and the atypical drugs increased PPI, it is likely that D2 dopamine receptor blockade is responsible for the drug effects on sensorimotor gating...
  6. ncbi request reprint Alterations in regional brain metabolism in genetic and pharmacological models of reduced NMDA receptor function
    Gary Duncan
    Department of Psychiatry, CB 7090, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Brain Res 951:166-76. 2002
    ....
  7. ncbi request reprint Effects of haloperidol, clozapine, and quetiapine on sensorimotor gating in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, CB 7090, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7090, USA
    Psychopharmacology (Berl) 184:190-200. 2006
    ..These mice show increased acoustic startle reactivity and deficits in prepulse inhibition (PPI) of acoustic startle...
  8. ncbi request reprint The novel antiepileptic drug lacosamide blocks behavioral and brain metabolic manifestations of seizure activity in the 6 Hz psychomotor seizure model
    Gary E Duncan
    Department of Psychiatry, School of Medicine, CB 7090, 410 Taylor Hall, University of North Carolina, Chapel Hill, NC 27599 7090, USA
    Epilepsy Res 67:81-7. 2005
    ..The data provide evidence that lacosamide antagonizes the neural activation induced by an electrical seizure stimulus, without suppressing normal brain metabolic activity...
  9. ncbi request reprint Chronic administration of haloperidol and olanzapine attenuates ketamine-induced brain metabolic activation
    Gary E Duncan
    Department of Psychiatry, CB 7090, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7250, USA
    J Pharmacol Exp Ther 305:999-1005. 2003
    ....
  10. ncbi request reprint Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, University of North Carolina School of Medicine, CB 7090, Chapel Hill, NC 27599 7090, USA
    Behav Brain Res 153:507-19. 2004
    ..The NR1 hypomorphic mice could represent a model system to explore novel treatment and preventative strategies for certain symptoms of schizophrenia...
  11. pmc Development of a mouse test for repetitive, restricted behaviors: relevance to autism
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 188:178-94. 2008
    ..Further work is required to determine the characteristics of optimal mouse social stimuli in the olfactory hole-board test...
  12. ncbi request reprint Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor function
    Sheryl S Moy
    Department of Psychiatry, and Neurodevelopmental Disorders Research Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Brain Res 1089:186-94. 2006
    ..Overall, these findings suggest that the NR1-/- mouse may provide a model for enhanced sensitivity to dopamine agonist-induced disruption of PPI...
  13. ncbi request reprint Amphetamine-induced Fos is reduced in limbic cortical regions but not in the caudate or accumbens in a genetic model of NMDA receptor hypofunction
    Seiya Miyamoto
    Department of Psychiatry, the Mental Health and Neuroscience Clinical Research Center, USA
    Neuropsychopharmacology 29:2180-8. 2004
    ..The results suggest a neuroanatomically selective activation deficit to amphetamine challenge in the NR1-deficient mice...
  14. doi request reprint Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection
    Jeffrey A Lieberman
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, 1051 Riverside Dr, Unit 4, New York, NY 10032, USA
    Pharmacol Rev 60:358-403. 2008
    ....
  15. ncbi request reprint Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?
    Christine E Marx
    Duke University Medical Center, Durham NC, USA
    Pharmacol Biochem Behav 84:598-608. 2006
    ..987). Olanzapine also elevates pregnenolone levels, but to a lesser degree than clozapine. Pregnenolone induction may contribute to the clinical actions of clozapine and olanzapine...
  16. ncbi request reprint Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27705, USA
    Neuropsychopharmacology 28:1-13. 2003
    ..Alterations in this neuroactive steroid may result in the modulation of GABAergic and dopaminergic neurotransmission, potentially contributing to antipsychotic efficacy...
  17. ncbi request reprint Recent advances in the neurobiology of schizophrenia
    Seiya Miyamoto
    St Marianna University School of Medicine, Kawasaki 216 8511, Japan
    Mol Interv 3:27-39. 2003
    ..Rapidly advancing research into schizophrenia includes diverse etiological hypotheses, and offers directions for future research and treatments...

Research Grants6

  1. Antipsychotic Actions in Models of NMDA Hypofunction
    Gary Duncan; Fiscal Year: 2003
    ....
  2. Antipsychotic Actions in Models of NMDA Hypofunction
    Gary Duncan; Fiscal Year: 2004
    ....
  3. Antipsychotic Actions in Models of NMDA Hypofunction
    Gary Duncan; Fiscal Year: 2005
    ....
  4. Antipsychotic Actions in Models of NMDA Hypofunction
    Gary Duncan; Fiscal Year: 2006
    ....
  5. ELEMENTARY SCHOOL NEUROSCIENCE LITERACY
    Gary Duncan; Fiscal Year: 2006
    ..The proposed work will pilot the program in schools with diverse demographics, to guide the development of resources and materials that will allow dissemination of the Brain Explorers program in a wide range of public school settings. ..
  6. Antipsychotic Actions in Models of NMDA Hypofunction
    Gary Duncan; Fiscal Year: 2007
    ....