Andrew W Duncan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Frequent aneuploidy among normal human hepatocytes
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon, USA
    Gastroenterology 142:25-8. 2012
  2. pmc Aneuploidy as a mechanism for stress-induced liver adaptation
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Portland, OR, USA
    J Clin Invest 122:3307-15. 2012
  3. doi request reprint Aneuploidy, polyploidy and ploidy reversal in the liver
    Andrew W Duncan
    Department of Pathology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh, PA 15219, United States
    Semin Cell Dev Biol 24:347-56. 2013
  4. pmc The ploidy conveyor of mature hepatocytes as a source of genetic variation
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nature 467:707-10. 2010
  5. pmc Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice
    Craig Dorrell
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, USA
    Genes Dev 25:1193-203. 2011
  6. pmc Ploidy reductions in murine fusion-derived hepatocytes
    Andrew W Duncan
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Genet 5:e1000385. 2009
  7. pmc Liver repopulation and regeneration: new approaches to old questions
    Andrew W Duncan
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Opin Organ Transplant 18:197-202. 2013
  8. pmc Stem cells and liver regeneration
    Andrew W Duncan
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Gastroenterology 137:466-81. 2009
  9. pmc Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol
    Qing Shuo Zhang
    Oregon Stem Cell Center, Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    Blood 116:5140-8. 2010

Detail Information

Publications9

  1. pmc Frequent aneuploidy among normal human hepatocytes
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon, USA
    Gastroenterology 142:25-8. 2012
    ..Aneuploidy therefore does not necessarily predispose liver cells to transformation but might promote genetic diversity among hepatocytes...
  2. pmc Aneuploidy as a mechanism for stress-induced liver adaptation
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Portland, OR, USA
    J Clin Invest 122:3307-15. 2012
    ..This result indicates that selection of a specific aneuploid karyotype can result in the adaptation of hepatocytes to chronic liver injury. The extent to which aneuploidy promotes hepatic adaptation in humans remains under investigation...
  3. doi request reprint Aneuploidy, polyploidy and ploidy reversal in the liver
    Andrew W Duncan
    Department of Pathology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh, PA 15219, United States
    Semin Cell Dev Biol 24:347-56. 2013
    ..Future work is required to elucidate the mechanisms regulating dynamic chromosome changes in the liver and to understand how these processes impact normal and abnormal liver function...
  4. pmc The ploidy conveyor of mature hepatocytes as a source of genetic variation
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nature 467:707-10. 2010
    ..We propose that this mechanism evolved to generate genetic diversity and permits adaptation of hepatocytes to xenobiotic or nutritional injury...
  5. pmc Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice
    Craig Dorrell
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, USA
    Genes Dev 25:1193-203. 2011
    ....
  6. pmc Ploidy reductions in murine fusion-derived hepatocytes
    Andrew W Duncan
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Genet 5:e1000385. 2009
    ..The generation of such daughter cells increases liver diversity, which may increase the likelihood of oncogenesis...
  7. pmc Liver repopulation and regeneration: new approaches to old questions
    Andrew W Duncan
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Opin Organ Transplant 18:197-202. 2013
    ....
  8. pmc Stem cells and liver regeneration
    Andrew W Duncan
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Gastroenterology 137:466-81. 2009
    ..This review will consider liver stem cells in the context of each definition...
  9. pmc Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol
    Qing Shuo Zhang
    Oregon Stem Cell Center, Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    Blood 116:5140-8. 2010
    ..We conclude that Fancd2(-/-) mice have readily quantifiable hematopoietic defects, and that this model is well suited for pharmacologic screening studies...