A S Dumont

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..Investigations into the nature of the inflammatory response accompanying SAH are needed to elucidate the precise role(s) of inflammatory events in SAH-induced pathologies...

..A modified, right-sided subtemporal transtentorial approach has been adopted in all cases of isolated unruptured BA bifurcation aneurysms. Technical nuances are described...

..Meticulous attention to detail, particularly with respect to reconstruction and closure of the sellar floor, is necessary for its effective application...

..In the present study the authors examined the effects of short-course pravastatin treatment on endothelial function in CAs obtained in control and insulin-resistant rats with fructose-induced hypertension...

..In the present study the authors examined the contribution of the potent vasoconstrictor endothelin-1 (ET-1) to endothelial dysfunction in human SVs...

..We hypothesized that there may be a difference in angiographic and clinical vasospasm, cerebral infarction, and clinical outcome between patients undergoing clipping compared to coiling...

..We describe a staged endovascular treatment entailing stenting using a stent-in-stent technique, as well as planned but delayed embolization as the aneurysm increases in size to allow the introduction of coils...

..The authors discuss their experience and review the contemporary literature concerning meningiomas of the orbit and the care of patients harboring such lesions...

..Indications for surgical intervention include acute and/or serially radiographically documented and relentless visual impairment and significant cosmetic deformity. Individualized management strategies are also discussed...

..In these instances the treating physician must decide which lesions should be managed conservatively, and which should be treated...

..Surgical intervention is discussed, including, the selection of operative candidates, open and endovascular procedures, and potential complications. The evolution of endovascular technology and techniques is highlighted...

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..Further study with long term follow up, however, is still necessary to characterise the efficacy, durability, and cost efficiency of endovascular treatment of UIA...

..Recurrences are common, although in a subset of patients prolonged disease-free survival is demonstrated...

..Therapies directed at many of these mechanisms are currently under investigation and hold significant promise for an ultimate solution to this substantial problem...

..The MR imaging, CT scanning, and fluoroscopic stereotaxy modalities all have unique advantages as well as specific limitations...

..Treatment with E2 holds therapeutic promise in the treatment of cerebral vasospasm following SAH and merits further investigation...

..The purpose of the present study was to examine whether levels of adhesion molecules are altered after treatment with CGS 26303 in this animal model...

..Preliminary studies suggest that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) may decrease the risk of vasospasm, but additional study is required...

..In this paper the authors discuss the historical evolution of treatment for cerebrovascular occlusive disease...

..The purpose of this study was to evaluate the results obtained in patients who underwent anterior stabilization for three-column thoracolumbar fractures...

..The present study investigated the efficacy of ATL-146e in the prevention of leukocyte infiltration and attenuation of posthemorrhagic vasospasm...

..This study was designed to examine the effects of an adenosine A2A receptor agonist, (2(4-[2-carboxyethyl]phenyl)ethylamino)-5'-N-ethylcarboxamidoadenosine (CGS 21680), in the prevention of SAH-induced vasospasm...

..The authors examine the indications for and outcomes following decompressive craniectomy in a single-center pediatric patient population with traumatic brain injury (TBI)...

..The role of E2 in the treatment of cerebral vasospasm after SAH is promising and is worthy of further investigation...

..This paper examines a single-surgeon experience with single-level ACDF without use of plates or hard collars in patients with degenerative spondylosis in whom allograft was used as the fusion material...

..The authors describe their current endoscopic technique and elucidate the advantages and disadvantages of the pure endoscopic adenomectomy compared with the standard microscopic approach...

..These observations provide a possible mechanism for the improvement in diabetic heart function observed after chronic bosentan treatment...

..g. genetically-altered animals and gene expression arrays). This model also represents a replicable and inexpensive approach for screening therapeutic candidates...

..The management strategies and outcomes in pediatric patients with elevated intracranial pressure (ICP) following severe traumatic brain injury (TBI) are examined in this study...

..These data suggest that antagonism of both angiotensin II and endothelin may be important in attenuating saphenous vein arteriosclerosis...

..The authors' present technique for management of lumbar stenosis is also illustrated...

..In the present article the authors review the current management practices of ICH, discuss the controlled trials, and highlight recent trials and future avenues of further study...

..This era's critical innovations and neurosurgical personalities are the topic of this historical overview...

..Understanding preoperative assessment, intraoperative management, potential complications, their management, and strategies for avoidance are fundamental to successful perioperative patient care and avoidance of morbidity and mortality...

..We recommend an ABO-Rh type and antibody screen for aneurysm and arteriovenous malformation surgery and no screen for carotid endarterectomy to efficiently utilize transfusion therapy in cerebrovascular surgery...

..CONCLUSIONS: These findings provide the first evidence that anti-E-selectin antibody was effective in prevention of SAH-induced vasospasm and imply a possible role of E selectin in the pathogenesis of vasospasm after SAH...

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..In this study the investigators compared the commonly used Fisher scale with 2 newer radiographic scales for the prediction of vasospasm, delayed infarction, and poor outcome...

..The optimal transfusion threshold is unknown, but current practice most often uses a liberal approach. We assessed the association between anemia or transfusion and subsequent adverse outcomes...

..Intracranial vascular involvement in these patients may become increasingly common as the management of HIV infection continues to improve and afflicted patients survive for longer periods...

..The aim of this review was to detail the characteristics and management of pediatric cervical spine injury...

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..Recent preclinical and clinical studies are reviewed, as well as clinical trials for other medical indications. Some of the newer endothelin receptor antagonists are also examined...

..These data lend credence to the notion that CRP functions as a proatherosclerotic factor as well as a powerful risk marker...

..A thorough understanding of the potentially serious risks of repetitive injury, however, mandates that only a proper conservative period of observation and evaluation will best serve the competitor...

..In this study the authors evaluate the incidence, temporal course, and predictive factors of perioperative seizures and epilepsy during long-term follow up of patients with SAH who underwent surgical treatment...

..Future cooperative intra- and interinstitutional efforts between scientists and clinicians will hopefully culminate in an improved outlook and eventual cure for patients with gliomas...

..Less invasive methods, such as endoscopic transsphenoidal surgery and stereotactic radiosurgery, have shown promise as primary and adjuvant treatment modalities, respectively...

..These tumors can still be extremely difficult to manage, however, and can cause significant morbidity to the patient, both from tumor mass effect and secondary to hormonal imbalances...

..CONCLUSION: The results of this study suggest that hMSC and BMP-9 ex vivo gene therapy may be useful in inducing spinal fusion as well as other related procedures and certainly warrants further clinical development...

..Less invasive modalities such as endoscopic transsphenoidal surgery, and stereotactic radiosurgery have shown promise as primary and adjuvant treatment modalities, respectively...

..In this article the authors review various cellular and extracellular signaling pathways that may prove promising in the treatment of patients with malignant glioma...

..This review addresses the postoperative management of patients undergoing pituitary surgery with an emphasis on careful screening and recognition of complications...