Antoni Duleba

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of Akt/PKB signaling pathway
    Israel Ortega
    Department of Obstetrics and Gynecology, University of California, Davis, 4860 Y Street, Sacramento, California 95817, USA
    Endocrinology 153:4019-29. 2012
  2. pmc Medical management of metabolic dysfunction in PCOS
    Antoni J Duleba
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California Davis, 4869 Y Street, Suite 2550 ACC, Sacramento, CA 95817, USA
    Steroids 77:306-11. 2012
  3. pmc Is PCOS an inflammatory process?
    Antoni J Duleba
    Department of Obstetrics and Gynecology, University of California Davis, Sacramento, California 95817, USA
    Fertil Steril 97:7-12. 2012
  4. pmc Effects of triclocarban on intact immature male rat: augmentation of androgen action
    Antoni J Duleba
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Davis, CA 95817, USA
    Reprod Sci 18:119-27. 2011
  5. pmc Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment
    Beata Banaszewska
    Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics, and Gynecological Oncology, Poznan University of Medical Sciences, 60 535 Poznan, Poland
    J Clin Endocrinol Metab 96:3493-501. 2011
  6. pmc Predictors of urinary albumin excretion in women with polycystic ovary syndrome
    Antoni J Duleba
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Davis, California, USA
    Fertil Steril 93:2285-90. 2010
  7. pmc Determinants of impaired fasting glucose versus glucose intolerance in polycystic ovary syndrome
    SIDIKA E KARAKAS
    Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition and Vascular Medicine, University of California, Davis, Davis, California, USA
    Diabetes Care 33:887-93. 2010
  8. ncbi request reprint Success of laparoscopic ovarian wedge resection is related to obesity, lipid profile, and insulin levels
    Antoni J Duleba
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Fertil Steril 79:1008-14. 2003
  9. ncbi request reprint Testosterone levels in pregnant women correlate with the insulin response during the glucose tolerance test
    Anuja Dokras
    Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, USA
    Fertil Steril 79:492-7. 2003
  10. pmc Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability
    Anna Sokalska
    Department of Obstetrics and Gynecology, University of California Davis, 4860 Y Street, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 95:5390-4. 2010

Research Grants

Collaborators

Detail Information

Publications17

  1. pmc Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of Akt/PKB signaling pathway
    Israel Ortega
    Department of Obstetrics and Gynecology, University of California, Davis, 4860 Y Street, Sacramento, California 95817, USA
    Endocrinology 153:4019-29. 2012
    ..These findings may be of clinical relevance to conditions associated with excessive production of androgens by theca cells, such as polycystic ovary syndrome...
  2. pmc Medical management of metabolic dysfunction in PCOS
    Antoni J Duleba
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California Davis, 4869 Y Street, Suite 2550 ACC, Sacramento, CA 95817, USA
    Steroids 77:306-11. 2012
    ..In women with PCOS, statins reduce hyperandrogenism, improve lipid profile and reduce systemic inflammation while the effects on insulin sensitivity are variable. Use of statins is contraindicated in pregnancy...
  3. pmc Is PCOS an inflammatory process?
    Antoni J Duleba
    Department of Obstetrics and Gynecology, University of California Davis, Sacramento, California 95817, USA
    Fertil Steril 97:7-12. 2012
    ....
  4. pmc Effects of triclocarban on intact immature male rat: augmentation of androgen action
    Antoni J Duleba
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Davis, CA 95817, USA
    Reprod Sci 18:119-27. 2011
    ..In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in prostate cancer cells...
  5. pmc Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment
    Beata Banaszewska
    Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics, and Gynecological Oncology, Poznan University of Medical Sciences, 60 535 Poznan, Poland
    J Clin Endocrinol Metab 96:3493-501. 2011
    ..A randomized trial on women with polycystic ovary syndrome (PCOS) compared simvastatin, metformin, and a combination of these drugs...
  6. pmc Predictors of urinary albumin excretion in women with polycystic ovary syndrome
    Antoni J Duleba
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Davis, California, USA
    Fertil Steril 93:2285-90. 2010
    ..To evaluate urinary albumin excretion (UAE) in normotensive and nondiabetic women with polycystic ovary syndrome (PCOS) in relation to their clinical, endocrine, and metabolic profiles...
  7. pmc Determinants of impaired fasting glucose versus glucose intolerance in polycystic ovary syndrome
    SIDIKA E KARAKAS
    Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition and Vascular Medicine, University of California, Davis, Davis, California, USA
    Diabetes Care 33:887-93. 2010
    ..To determine insulin resistance and response in patients with polycystic ovary syndrome (PCOS) and normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance, and combined glucose intolerance (CGI)...
  8. ncbi request reprint Success of laparoscopic ovarian wedge resection is related to obesity, lipid profile, and insulin levels
    Antoni J Duleba
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Fertil Steril 79:1008-14. 2003
    ..To evaluate the effects of laparoscopic ovarian wedge resection on hormonal and metabolic parameters of polycystic ovary syndrome (PCOS) and to compare profiles of women who achieved pregnancy with those who did not...
  9. ncbi request reprint Testosterone levels in pregnant women correlate with the insulin response during the glucose tolerance test
    Anuja Dokras
    Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, USA
    Fertil Steril 79:492-7. 2003
    ..To evaluate the association between insulin/insulin-like growth factor I (IGF-I) systems and androgen levels in pregnancy...
  10. pmc Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability
    Anna Sokalska
    Department of Obstetrics and Gynecology, University of California Davis, 4860 Y Street, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 95:5390-4. 2010
    ..Recent clinical trials have demonstrated that statins, 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors, decrease androgen levels in women with PCOS...
  11. ncbi request reprint Lower levels of urinary 2-hydroxyestrogens in polycystic ovary syndrome
    Sana Salih
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555 0587, USA
    J Clin Endocrinol Metab 92:3285-91. 2007
    ..The substrate (2-hydroxyestrogen) and product (2-methoxyestrogen) of catechol-O-methyl transferase (COMT) have been shown to modulate proliferation and angiogenesis of granulosa cells...
  12. ncbi request reprint Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway
    Jakub Kwintkiewicz
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Fertil Steril 86:1053-8. 2006
    ..To evaluate mechanisms involved in mevastatin-induced inhibition of proliferation of ovarian theca-interstitial cells...
  13. ncbi request reprint Simvastatin improves biochemical parameters in women with polycystic ovary syndrome: results of a prospective, randomized trial
    Antoni J Duleba
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 85:996-1001. 2006
    ..To test the hypothesis that statins improve hyperandrogenemia in women with polycystic ovary syndrome (PCOS)...
  14. ncbi request reprint Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways
    Jakub Kwintkiewicz
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Biol Reprod 74:1034-40. 2006
    ..These findings indicate that actions of insulin and oxidative stress converge on MAPK3/1 and RPS6KB1. Furthermore, we speculate that activation of RPS6KB1 may be in part induced via the MAPK3/1 pathway...
  15. ncbi request reprint Treatment of PCOS with metformin and other insulin-sensitizing agents
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8063, USA
    Curr Diab Rep 4:69-75. 2004
    ..Other insulin-sensitizing agents studied in women with PCOS include troglitazone, rosiglitazone, pioglitazone, and D-chiro-inositol...
  16. ncbi request reprint Should patients with polycystic ovarian syndrome be treated with metformin?
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8063, USA
    Hum Reprod 17:2230-6. 2002
    ..The highly promising therapeutic profile of metformin is related to the role of this agent in controlling an important aetiologic factor in the pathogenesis of PCOS: hyperinsulinaemia...
  17. ncbi request reprint Optimizing ovulation induction in women with polycystic ovary syndrome
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Obstet Gynecol 14:245-54. 2002
    ..In clomiphene-resistant subjects, one can consider laparoscopic ovarian drilling and other forms of partial ovarian resection or destruction...

Research Grants7

  1. Role of Antioxidants in Ovarian Thecal Hyperplasiar
    Antoni Duleba; Fiscal Year: 2005
    ..abstract_text> ..
  2. Mevalonate pathway and thecal-interstitial function
    Antoni J Duleba; Fiscal Year: 2010
    ..Ultimately, the proposed research may shed new light on the pathophysiology of PCOS and provide an impetus towards the development of new therapeutic approaches, such as clinical use of statins. ..