Kevin Duff

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..Practice effects have been widely reported in healthy older adults, but these improvements due to repeat exposure to test materials have been more equivocal in individuals with mild cognitive impairment (MCI)...

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..Overall, these results provide additional validation of the mTICS as a valuable screening instrument for cognition in individuals with milder cognitive impairments...

..Psychiatric disturbances are relatively common in manifest Huntington's disease (HD), but less is known about these symptoms in the earliest phase of the illness...

..These propensities must be considered in studies of prodromal HD participants...

..These data might allow clinicians and researchers to better assess laterality effects of brain dysfunction when using the RBANS, although clinical validation is needed...

..In participants manifesting prodromal motor signs and psychiatric symptoms, the TMT primarily measures cognition and is able to discriminate between groups based on health status and estimated time to diagnosis...

..The RBANS provided additional information about other cognitive domains affected (e.g., memory) and may be a useful measure for tracking longitudinal change...

..Participant/companion discrepancies, especially closest to Huntington's disease diagnosis, might suggest early lack of awareness in these individuals...

..This study compares self-paced timing performance (cross-sectionally and longitudinally) between participants with prodromal Huntington's disease (pr-HD) and a comparison group of gene non-expanded participants from affected families (NC)...

..58-.61). Although the utility of this index needs to be investigated in clinical samples, practitioners should use caution when interpreting these types of indicator as pathognomonic for the presence of disease...

..A case example is presented that illustrates how the algorithms can be used clinically...

..Irregular word reading tests appear to decline with HD progression, whereas estimation methods based on demographic factors may be more robust but overestimate premorbid functioning...

..Education about these possible pretransplant sequelae and the potential for rebound may be helpful to patients and families as they prepare for this treatment and the recovery period...

..A case example is presented that utilizes the formulas...

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..These are also important areas for clinical monitoring and treatment planning as up to 65% experienced loss in at least one area prior to diagnosis...

..Additionally, this prognostic index could be used to offer interventions to patients who are in the earliest stages of progressive neurodegenerative disorders...

..A case example is provided that demonstrates the use of the current findings in conjunction with existing change formulas...

..Although additional research is needed, the current study supports the clinical applicability of the RBANS in patients with HD...

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..Although psychiatric symptoms have been reported in individuals with the HD gene expansion prior to clinical diagnosis (pre-HD), little is known about OCS in this phase of disease...

..Line Orientation fell from normal to defective levels; these findings were associated with decline in related standard neuropsychological measures...

..Although the mechanism of poorer cognition and impending death remains unclear, some possibilities are discussed (e.g., brain dysfunction, poor medical compliance, impaired cellular immunity)...

..The objective was to examine cortical volumes in relation to cognitive performance among patients who do not have dementia, but who do have mild cognitive deficits...

..64 and 0.66). Preliminary psychometric analyses support further study of the IFIPT. The measure showed evidence of clinical utility by demonstrating group differences between this sample of healthy adults and those with MCI...

..Secondary analyses using data from a different data collection point and including a diagnosed group showed the highest stress scores in the diagnosed group. Possible explanations and implications are discussed...

..Huntington's disease (HD) is a progressive, neuropsychiatric disorder, and limited reports indicate that risperidone might improve motor and psychiatric functioning for these patients...

..The goal of this study was to examine neurocognitive and daily functioning of elderly patients showing exclusively VS in comparison with patients presenting with VS and dysphoria...

..These findings suggest that donepezil treatment may be associated with a relative maintenance of CBF and improved list-learning...

..Fewer studies have examined other cerebral structures in early HD and potential associations with cognition...

..A case example is presented that illustrates how the algorithms can be used clinically...

..Atomoxetine is a norepinephrine reuptake inhibitor approved for treatment of attention-deficit/hyperactivity disorder...

..Information about cognitive reserve and AN subtype may provide clinicians with valuable prognostic information and help guide treatment...

..96 and 0.98, respectively). Results suggest that RBANS scores yield excellent estimates of diagnostic accuracy and that the RBANS is a useful screening tool in detection of cognitive deficits associated with AD...

..In these older adults, global cognition was related to walking speed...

..We conclude that future clinical trials designed for very early disease will require the development of new and more sensitive measures of real-life function...

..These findings could have clinical implications, as poorer attention, especially in patients with multiple medical problems, could lead to poorer medical compliance and worse outcomes...

..The purpose of this study was to examine the probability of obsessive and compulsive (OC) symptoms across stages of Huntington's disease (HD) with both cross sectional and longitudinal data...

..Although causality cannot be inferred, a clear and robust relationship between executive functioning and memory is evident, and clinicians should consider this overlap when interpreting poor performance among these two domains...

..Practitioners and researchers who elect to use the current normative data are encouraged to consider the similarities and differences between the present sample and their individual patients or research participants...

..Although some SVTs may be better suited to HD, cognitive ability should be considered when evaluating effort in HD...

..The Langbehn et al. model appears accurate enough to have substantial utility in various research contexts. We also emphasize remaining caveats, many of which are relevant for any direct application to genetic counseling...

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..Alternate forms and baseline practice sessions may help control early, rapid improvements in clinical trials...

..It is hoped that the current information will encourage individuals at all levels to become involved in peer-reviewing for neuropsychology journals...

..Studies to determine the factors that connect delerium soon after transplantation to mortality are highly warranted...

..Such research will aid the clinical neuropsychological practitioner in interpreting aberrant performance profiles on the MAS in forensic situations...

..Although preliminary, it is hoped that data presented will offer the practitioner assistance with clinical diagnosis and decision-making in a manner that will help minimize diagnostic errors...

..Recommendations in the application of the OPIE-3 are made and future research is proposed...

..The formulas for estimating premorbid FSIQ were highly significant and accurate in predicting FSIQ scores of participants in the WAIS-III normative sample...

..Differences in estimated VIQ and PIQ scores were evaluated and the OPIE-3 algorithms were found to accurately predict VIQ and PIQ differences within the WAIS-III standardization sample...

..These preliminary data suggest that retention rates of the RBANS memory subtests may add to the clinical utility of this test as a neuropsychological diagnostic and research tool...

..In contrast to previous results, we found no evidence of relative impairments in recognizing disgust or fear, and no evidence to support a link between the striatum and disgust recognition...

..These findings indicate that verbal episodic memory is affected in early pre-diagnostic HD and may decline as striatal volumes decrease and individuals approach the motor diagnostic threshold...

..The differences noted raise the possibility of a clinical subtype of the disease...

..1996). Rey Auditory and Verbal Learning Test: A handbook. Los Angeles, CA: Western Psychological Services] meta-norms found the RAVLT to best distinguish patients suspected of Alzheimer's disease from the psychiatric comparison group...

..The OPIE-3(2ST), OPIE-3MR, and OPIE-3VOC yielded robust estimates of FSIQ across age groups in a neurologically intact sample. Limitations, particularly with individuals aged 16-17 and 85-89 years, are discussed...

..Similarly, these data highlight the mediating effects of the global level of cognitive functioning on discrepancy scores...

..These data may be helpful in clinical practice by assisting the clinician in determining the clinical significance of score changes...

..5%). Olfactory assessment may be of diagnostic utility in the differential diagnosis of AD versus VaD versus MD in elderly patients...

..This study evaluated the results of the UPSIT for 197 community-dwelling adults between the ages of 55 and 75. An item analysis identified six items that had poor hit rates in this sample. Implications of these results are discussed...