John E Dueber

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Synthetic protein scaffolds provide modular control over metabolic flux
    John E Dueber
    California Institute of Quantitative Biomedical Research QB3, University of California, Berkeley, California, USA
    Nat Biotechnol 27:753-9. 2009
  2. pmc Engineering robust control of two-component system phosphotransfer using modular scaffolds
    Weston R Whitaker
    The University of California, Berkeley and University of California, San Francisco Graduate Program in Bioengineering, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 109:18090-5. 2012
  3. pmc BglBricks: A flexible standard for biological part assembly
    J Christopher Anderson
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    J Biol Eng 4:1. 2010
  4. ncbi request reprint Reprogramming control of an allosteric signaling switch through modular recombination
    John E Dueber
    Program in Biological Sciences, University of California, San Francisco, CA 94143 2240, USA
    Science 301:1904-8. 2003
  5. ncbi request reprint Engineering synthetic signaling proteins with ultrasensitive input/output control
    John E Dueber
    Program in Biological Sciences, University of California, San Francisco, California 94158 2517, USA
    Nat Biotechnol 25:660-2. 2007
  6. pmc The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency
    Nathan A Sallee
    Graduate Program in Chemistry and Chemical Biology, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA
    Nature 454:1005-8. 2008

Collaborators

  • Jay Keasling
  • Weston R Whitaker
  • Adam P Arkin
  • J Christopher Anderson
  • Nathan A Sallee
  • Stephanie A Davis
  • Gabriel C Wu
  • Jonathan A Goler
  • Mariana Leguia
  • Gonzalo M Rivera
  • Bruce J Mayer
  • R Dyche Mullins
  • Wendell A Lim
  • Dan Vasilescu

Detail Information

Publications6

  1. doi request reprint Synthetic protein scaffolds provide modular control over metabolic flux
    John E Dueber
    California Institute of Quantitative Biomedical Research QB3, University of California, Berkeley, California, USA
    Nat Biotechnol 27:753-9. 2009
    ..5 g/l) without the synthetic complex. These strategies should prove generalizeable to other metabolic pathways and programmable for fine-tuning pathway flux...
  2. pmc Engineering robust control of two-component system phosphotransfer using modular scaffolds
    Weston R Whitaker
    The University of California, Berkeley and University of California, San Francisco Graduate Program in Bioengineering, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 109:18090-5. 2012
    ..Thus, we demonstrate that design principles inspired by the complex signal-transduction pathways of eukaryotes may be generalized, abstracted, and applied to prokaryotes using well-characterized parts...
  3. pmc BglBricks: A flexible standard for biological part assembly
    J Christopher Anderson
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    J Biol Eng 4:1. 2010
    ..These tools will provide a foundation from which to transform genetic engineering from a technically intensive art into a purely design-based discipline...
  4. ncbi request reprint Reprogramming control of an allosteric signaling switch through modular recombination
    John E Dueber
    Program in Biological Sciences, University of California, San Francisco, CA 94143 2240, USA
    Science 301:1904-8. 2003
    ..Synthetic switch proteins were created with diverse gating behaviors in response to nonphysiological inputs. Thus, this type of modular framework can facilitate the evolution or engineering of cellular signaling circuits...
  5. ncbi request reprint Engineering synthetic signaling proteins with ultrasensitive input/output control
    John E Dueber
    Program in Biological Sciences, University of California, San Francisco, California 94158 2517, USA
    Nat Biotechnol 25:660-2. 2007
    ..By systematically altering the number and affinity of modular autoinhibitory interactions, we show that we can predictably convert a simple linear signaling protein into an ultrasensitive switch...
  6. pmc The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency
    Nathan A Sallee
    Graduate Program in Chemistry and Chemical Biology, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA
    Nature 454:1005-8. 2008
    ..Thus, this pathogen has used a simple autoinhibitory fragment as a component to build a highly effective actin polymerization machine...