F Dudek

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Recording EEG in immature rats with a novel miniature telemetry system
    A Zayachkivsky
    Dept of Physiology, Univ of Utah School of Medicine, Salt Lake City, UT 84108 6500, USA
    J Neurophysiol 109:900-11. 2013
  2. doi request reprint The time course of acquired epilepsy: implications for therapeutic intervention to suppress epileptogenesis
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, 420 Chipeta Way, Suite 1700, Salt Lake City, UT 84108, United States
    Neurosci Lett 497:240-6. 2011
  3. pmc The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Epilepsia 51:126-30. 2010
  4. ncbi request reprint Epileptogenesis in the dentate gyrus: a critical perspective
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Prog Brain Res 163:755-73. 2007
  5. doi request reprint Commentary: a skeptical view of experimental gene therapy to block epileptogenesis
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Neurotherapeutics 6:319-22. 2009
  6. doi request reprint Seizure probability in animal models of acquired epilepsy: a perspective on the concept of the preictal state
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, 420 Chipeta Way, Suite 1700, Salt Lake City, UT 84108, United States
    Epilepsy Res 97:324-31. 2011
  7. ncbi request reprint Epilepsy and reproductive disorders: the role of the gonadotropin-releasing hormone network
    Jessica A Fawley
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Epilepsy Behav 8:477-82. 2006
  8. doi request reprint Circadian difference in firing rate of isolated rat suprachiasmatic nucleus neurons
    Nikolai I Kononenko
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Neurosci Lett 436:314-6. 2008
  9. pmc Repetitive perforant-path stimulation induces epileptiform bursts in minislices of dentate gyrus from rats with kainate-induced epilepsy
    Li Rong Shao
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
    J Neurophysiol 105:522-7. 2011
  10. pmc Both synaptic and intrinsic mechanisms underlie the different properties of population bursts in the hippocampal CA3 area of immature versus adult rats
    Li Rong Shao
    Department of Biomedical Sciences, Anatomy and Neurobiology, Colorado State University, Fort Collins, CO 80523, USA
    J Physiol 587:5907-23. 2009

Research Grants

  1. LOCAL INTERACTIONS BETWEEN HIPPOCAMPAL NEURONS
    F Edward Dudek; Fiscal Year: 2004
  2. Pharmacoresistance in rats with kainate-induced epilepsy
    F Dudek; Fiscal Year: 2005
  3. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2006
  4. LOCAL INTERACTIONS BETWEEN HIPPOCAMPAL NEURONS
    F Edward Dudek; Fiscal Year: 2006
  5. LOCAL INTERACTIONS BETWEEN HIPPOCAMPAL NEURONS
    F Edward Dudek; Fiscal Year: 2002
  6. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2003
  7. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2007

Collaborators

Detail Information

Publications37

  1. pmc Recording EEG in immature rats with a novel miniature telemetry system
    A Zayachkivsky
    Dept of Physiology, Univ of Utah School of Medicine, Salt Lake City, UT 84108 6500, USA
    J Neurophysiol 109:900-11. 2013
    ..This new technical approach should improve animal models of human conditions that rely on EEG monitoring for diagnosis and therapy...
  2. doi request reprint The time course of acquired epilepsy: implications for therapeutic intervention to suppress epileptogenesis
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, 420 Chipeta Way, Suite 1700, Salt Lake City, UT 84108, United States
    Neurosci Lett 497:240-6. 2011
    ....
  3. pmc The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Epilepsia 51:126-30. 2010
    ..We discuss several potential explanations for the differences in the effects of SR141716 in the adult-rat, kainate versus immature-rat, hyperthermia models...
  4. ncbi request reprint Epileptogenesis in the dentate gyrus: a critical perspective
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Prog Brain Res 163:755-73. 2007
    ..Finally, in addition to its unique features and potential importance in epileptogenesis, the dentate gyrus may also serve as a model for other cortical structures in acquired epilepsy...
  5. doi request reprint Commentary: a skeptical view of experimental gene therapy to block epileptogenesis
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Neurotherapeutics 6:319-22. 2009
    ....
  6. doi request reprint Seizure probability in animal models of acquired epilepsy: a perspective on the concept of the preictal state
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, 420 Chipeta Way, Suite 1700, Salt Lake City, UT 84108, United States
    Epilepsy Res 97:324-31. 2011
    ....
  7. ncbi request reprint Epilepsy and reproductive disorders: the role of the gonadotropin-releasing hormone network
    Jessica A Fawley
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Epilepsy Behav 8:477-82. 2006
    ..This review provides a brief overview of evidence from experimental animal and clinical studies exploring the basis for epilepsy-associated reproductive abnormalities...
  8. doi request reprint Circadian difference in firing rate of isolated rat suprachiasmatic nucleus neurons
    Nikolai I Kononenko
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Neurosci Lett 436:314-6. 2008
    ..These data suggest that populations of isolated SCN neurons with no synaptic interactions contain a functioning circadian clock, and are particularly amenable to biophysical experiments...
  9. pmc Repetitive perforant-path stimulation induces epileptiform bursts in minislices of dentate gyrus from rats with kainate-induced epilepsy
    Li Rong Shao
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
    J Neurophysiol 105:522-7. 2011
    ..e., 5-10 hz)...
  10. pmc Both synaptic and intrinsic mechanisms underlie the different properties of population bursts in the hippocampal CA3 area of immature versus adult rats
    Li Rong Shao
    Department of Biomedical Sciences, Anatomy and Neurobiology, Colorado State University, Fort Collins, CO 80523, USA
    J Physiol 587:5907-23. 2009
    ....
  11. doi request reprint On the role of calcium and potassium currents in circadian modulation of firing rate in rat suprachiasmatic nucleus neurons: multielectrode dish analysis
    Nikolai I Kononenko
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurosci Res 62:51-7. 2008
    ..These data indicate that neither nifedipine-sensitive Ca(2+) current(s) nor 4-AP-sensitive K(+) current(s) are key membrane targets for circadian modulation of electrical firing rate in SCN neurons...
  12. ncbi request reprint Neuropathogical features of a rat model for perinatal hypoxic-ischemic encephalopathy with associated epilepsy
    Shilpa D Kadam
    Department of Biomedical Sciences, Neurosciences Division, Colorado State University, Fort Collins, Colorado 80523, USA
    J Comp Neurol 505:716-37. 2007
    ..The occurrence of cortical abnormalities that are associated with epilepsy in humans correlates with the consequent detection of spontaneous recurrent seizures...
  13. ncbi request reprint Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system
    Thomas P Sutula
    Department of Neurology H6 570 CSC, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    Prog Brain Res 163:541-63. 2007
    ....
  14. ncbi request reprint Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols
    Heidi L Grabenstatter
    Department of Biomedical Sciences, Anatomy and Neurobiology Section, Colorado State University, Fort Collins, Colorado 80523, USA
    Epilepsia 48:2287-95. 2007
    ..The purpose was to develop a convenient drug-in-food approach for continuous, long-term administration of potential antiepileptic drugs (AEDs)...
  15. ncbi request reprint The use of radiotelemetry to evaluate electrographic seizures in rats with kainate-induced epilepsy
    Philip Williams
    Department of Biomedical Sciences, Anatomy and Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
    J Neurosci Methods 155:39-48. 2006
    ....
  16. ncbi request reprint Do interictal spikes drive epileptogenesis?
    Kevin Staley
    Departments of Pediatrics and Neurology, University of Colorado, School of Medicine, Denver, CO 80262, USA
    Neuroscientist 11:272-6. 2005
    ..Thus, spikes may guide the development of the neuronal circuits that initiate spontaneous seizures. If so, then attempts to prevent or cure epilepsy may best be directed at spikes rather than seizures...
  17. ncbi request reprint Detection of increased local excitatory circuits in the hippocampus during epileptogenesis using focal flash photolysis of caged glutamate
    Li Rong Shao
    Department of Biomedical Sciences Anatomy and Neurobiology Section, Colorado State University, Fort Collins, Colorado 80523, USA
    Epilepsia 46:100-6. 2005
    ..The present study tested whether local excitatory circuits in the hippocampus are increased in an animal model of temporal lobe epilepsy, and thus may contribute to epileptic seizures...
  18. ncbi request reprint GABA receptor-mediated inhibition of neuronal activity in rat SCN in vitro: pharmacology and influence of circadian phase
    Valentin K Gribkoff
    Neuroscience Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA
    J Neurophysiol 90:1438-48. 2003
    ....
  19. ncbi request reprint Mechanism of irregular firing of suprachiasmatic nucleus neurons in rat hypothalamic slices
    Nikolai I Kononenko
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurophysiol 91:267-73. 2004
    ..Thus GABAA receptor-mediated IPSPs appear responsible for irregular firing of SCN neurons in hypothalamic slices...
  20. ncbi request reprint Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy
    Heidi L Grabenstatter
    Department of Biomedical Sciences, Anatomy and Neurobiology Section, Colorado State University, Fort Collins, Colorado 80523, USA
    Epilepsia 46:8-14. 2005
    ..As a proof-of-principle test, the present experiments used spontaneous epileptic seizures in kainate-treated rats to examine the efficacy of topiramate (TPM) with a repeated-measures, crossover protocol...
  21. ncbi request reprint The search for animal models of epileptogenesis and pharmacoresistance: are there biologic barriers to simple validation strategies?
    F Edward Dudek
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Epilepsia 43:1275-7. 2002
  22. ncbi request reprint Epilepsy and synaptic reorganization in a perinatal rat model of hypoxia-ischemia
    Philip A Williams
    Department of Biomedical Sciences, Section of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523, USA
    Epilepsia 45:1210-8. 2004
    ..We tested the hypothesis that perinatal H-I will induce spontaneous motor seizures, hippocampal lesions, and synaptic reorganization in the dentate gyrus...
  23. ncbi request reprint Effects of fluoxetine and TFMPP on spontaneous seizures in rats with pilocarpine-induced epilepsy
    Eric J Hernandez
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523, USA
    Epilepsia 43:1337-45. 2002
    ..We tested the hypothesis that fluoxetine and trifluoromethylphenylpiperazine (TFMPP, a nonselective 5-HT-receptor agonist) reduce the frequency of spontaneous motor seizures in pilocarpine-treated rats...
  24. ncbi request reprint Reassessment of the effects of cycloheximide on mossy fiber sprouting and epileptogenesis in the pilocarpine model of temporal lobe epilepsy
    Philip A Williams
    Department of Biomedical Sciences, Anatomy and Neurobiology Section, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurophysiol 88:2075-87. 2002
    ..However, the develoment of spontaneous motor seizures, in a small number of rats, could occur without detectable hippocampal neuron loss or mossy fiber sprouting, as assessed by the Timm stain method...
  25. ncbi request reprint The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus
    F Edward Dudek
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, CO 80523, USA
    Prog Brain Res 135:53-65. 2002
    ....
  26. ncbi request reprint Episodic bursting activity and response to excitatory amino acids in acutely dissociated gonadotropin-releasing hormone neurons genetically targeted with green fluorescent protein
    M Cathleen Kuehl-Kovarik
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523 1670, USA
    J Neurosci 22:2313-22. 2002
    ....
  27. ncbi request reprint Network interactions mediated by new excitatory connections between CA1 pyramidal cells in rats with kainate-induced epilepsy
    Bret N Smith
    Department of Anatomy and Neurobiology, Program in Molecular, Cellular, and Integrative Neuroscience, Colorado State University, Fort Collins, CO 80523, USA
    J Neurophysiol 87:1655-8. 2002
    ..These data further support the hypothesis that excitatory connections between CA1 pyramidal cells increase after kainate-induced status epilepticus...
  28. ncbi request reprint Noise of the slowly inactivating Na current in suprachiasmatic nucleus neurons
    Nikolai I Kononenko
    Department of Biomedical Sciences, Anatomy and Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
    Neuroreport 16:981-5. 2005
    ..The data suggest that single-channel noise is due to the opening of channels mediating INa,S with a conductance of about 3.4 pS...
  29. doi request reprint Chemoconvulsant model of chronic spontaneous seizures
    Jennifer L Hellier
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    Curr Protoc Neurosci . 2005
    ..This modified chemoconvulsant treatment protocol (i.e., multiple low doses) is efficient and relatively simple, and the properties of the chronic epileptic state appear similar to those of severe human TLE...
  30. ncbi request reprint Riluzole-sensitive slowly inactivating sodium current in rat suprachiasmatic nucleus neurons
    Nikolai I Kononenko
    Department of Biomedical Sciences, Anatomy and Neurobiology Section, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurophysiol 91:710-8. 2004
    ..We concluded that I(Na,S) is ubiquitously expressed by all SCN neurons and that this current is a necessary but not sufficient depolarizing component of the mechanism for spontaneous firing...
  31. ncbi request reprint Development of spontaneous seizures after experimental status epilepticus: implications for understanding epileptogenesis
    Philip A Williams
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
    Epilepsia 48:157-63. 2007
    ..Experimental analyses of the time course of occurrence of spontaneous seizures are interpreted in terms of possible cellular mechanisms underlying epileptogenesis...
  32. ncbi request reprint Increased excitatory synaptic activity and local connectivity of hippocampal CA1 pyramidal cells in rats with kainate-induced epilepsy
    Li Rong Shao
    Dept of Biomedical Sciences, Anatomy and Neurobiology Section, 1617 Campus Delivery, Colorado State University, Fort Collins, CO 80523, USA
    J Neurophysiol 92:1366-73. 2004
    ..These data provide new electrophysiological evidence for the formation of recurrent excitatory circuits in the CA1 area of rats with kainate-induced epilepsy...
  33. ncbi request reprint Update on connexins and gap junctions in neurons and glia in the mammalian nervous system
    James I Nagy
    Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Avenue Winnipeg, Manitoba, Canada R3E 3J7
    Brain Res Brain Res Rev 47:191-215. 2004
    ....
  34. ncbi request reprint Electrophysiological evidence using focal flash photolysis of caged glutamate that CA1 pyramidal cells receive excitatory synaptic input from the subiculum
    Li Rong Shao
    Department of Biomedical Sciences, Anatomy and Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
    J Neurophysiol 93:3007-11. 2005
    ..Thus a reciprocal excitatory synaptic circuit connects the subiculum and the CA1 area in the normal adult rat...
  35. ncbi request reprint 5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus
    Jayne R Bramley
    Dept of Biomedical Sciences, Anatomy and Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
    J Neurophysiol 93:3157-64. 2005
    ....
  36. ncbi request reprint Changes in mIPSCs and sIPSCs after kainate treatment: evidence for loss of inhibitory input to dentate granule cells and possible compensatory responses
    Li Rong Shao
    Department of Biomedical Sciences, Anatomy and Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
    J Neurophysiol 94:952-60. 2005
    ....
  37. ncbi request reprint Absence of temporal lobe epilepsy pathology in dogs with medically intractable epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University School of Medicine, CA 94305 5330, USA
    J Vet Intern Med 16:95-9. 2002
    ..These findings demonstrate a lack of hilar neuron loss and granule cell axon reorganization, suggesting that temporal lobe epilepsy is not a common cause of medically intractable epilepsy in dogs...

Research Grants20

  1. LOCAL INTERACTIONS BETWEEN HIPPOCAMPAL NEURONS
    F Edward Dudek; Fiscal Year: 2004
    ....
  2. Pharmacoresistance in rats with kainate-induced epilepsy
    F Dudek; Fiscal Year: 2005
    ..abstract_text> ..
  3. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2006
    ..abstract_text> ..
  4. LOCAL INTERACTIONS BETWEEN HIPPOCAMPAL NEURONS
    F Edward Dudek; Fiscal Year: 2006
    ....
  5. LOCAL INTERACTIONS BETWEEN HIPPOCAMPAL NEURONS
    F Edward Dudek; Fiscal Year: 2002
    ....
  6. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2003
    ..abstract_text> ..
  7. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2007
    ..abstract_text> ..