Ronald Dubner

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint The neurobiology of persistent pain and its clinical implications
    Ronald Dubner
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, MD 21201 1586, USA
    Suppl Clin Neurophysiol 57:3-7. 2004
  2. ncbi request reprint Endogenous mechanisms of sensory modulation
    R Dubner
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Pain . 1999
  3. ncbi request reprint Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia
    Wei Guo
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 24:9161-73. 2004
  4. pmc Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors
    Kohei Shimizu
    Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 5:75. 2009
  5. pmc Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade
    Ming Gu
    Department of Neural and Pain Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 31:12823-36. 2011
  6. pmc Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain
    Feng Wei
    Department of Neural and Pain Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 30:8624-36. 2010
  7. ncbi request reprint Changes in AMPA receptor phosphorylation in the rostral ventromedial medulla after inflammatory hyperalgesia in rats
    Yun Guan
    Department of Biomedical Sciences, Dental School and Program in Neuroscience University of Maryland, Rm 5A12, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Neurosci Lett 366:201-5. 2004
  8. pmc Supraspinal glial-neuronal interactions contribute to descending pain facilitation
    Feng Wei
    Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 28:10482-95. 2008
  9. pmc Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain
    Wei Guo
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 6:40. 2010
  10. ncbi request reprint Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zone
    Hu Wang
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Comp Neurol 498:390-402. 2006

Detail Information

Publications40

  1. ncbi request reprint The neurobiology of persistent pain and its clinical implications
    Ronald Dubner
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, MD 21201 1586, USA
    Suppl Clin Neurophysiol 57:3-7. 2004
    ..These findings demonstrate activity-dependent plasticity in brain stem circuits that includes changes in excitatory amino acid receptor activation and sensitivity and a phenotypic switch of some RVM neurons...
  2. ncbi request reprint Endogenous mechanisms of sensory modulation
    R Dubner
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Pain . 1999
    ..These parallel brain mechanisms emphasize the saliency of pain experience as an important learned behavior for the survival of the organism, similar to sequential goal-directed behaviors in an operant task...
  3. ncbi request reprint Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia
    Wei Guo
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 24:9161-73. 2004
    ..The group ImGluR-NMDAR coupling cascade leads to phosphorylation of the NMDAR and appears necessary for the initiation of spinal dorsal horn sensitization and behavioral hyperalgesia after inflammation...
  4. pmc Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors
    Kohei Shimizu
    Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 5:75. 2009
    ....
  5. pmc Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade
    Ming Gu
    Department of Neural and Pain Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 31:12823-36. 2011
    ..New pain therapies should focus on prime targets of descending facilitation-induced glial involvement, and in particular the blocking of intercellular signaling transduction between neuron and glia...
  6. pmc Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain
    Feng Wei
    Department of Neural and Pain Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 30:8624-36. 2010
    ..These results indicate that the descending 5-HT from the RVM is an important contributor to pain facilitation during the development of persistent pain, and may not mediate opioid-induced descending inhibition in acute pain...
  7. ncbi request reprint Changes in AMPA receptor phosphorylation in the rostral ventromedial medulla after inflammatory hyperalgesia in rats
    Yun Guan
    Department of Biomedical Sciences, Dental School and Program in Neuroscience University of Maryland, Rm 5A12, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Neurosci Lett 366:201-5. 2004
    ..These findings provide new evidence linking in vivo AMPA receptor phosphorylation in the RVM pain modulatory circuitry to the enhanced descending pain modulation after inflammation...
  8. pmc Supraspinal glial-neuronal interactions contribute to descending pain facilitation
    Feng Wei
    Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 28:10482-95. 2008
    ..These studies have addressed a novel contribution of supraspinal astrocytes and associated cytokines as well as central glial-neuronal interactions to the enhancement of descending facilitation of neuropathic pain...
  9. pmc Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain
    Wei Guo
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 6:40. 2010
    ..Here we report a model of constant myogenic orofacial pain that lasts for months...
  10. ncbi request reprint Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zone
    Hu Wang
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Comp Neurol 498:390-402. 2006
    ..These findings provide further evidence to support a role of the trigeminal transition zone in response to orofacial deep injury...
  11. pmc Transition to persistent orofacial pain after nerve injury involves supraspinal serotonin mechanisms
    Masamichi Okubo
    Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    J Neurosci 33:5152-61. 2013
    ....
  12. pmc Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury
    Bryan Chai
    Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 8:78. 2012
    ..Here we investigated the involvement of the RVM-Vi/Vc circuitry in mediating contralateral orofacial hyperalgesia after an injection of CFA into the masseter muscle...
  13. pmc Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain
    Wei Guo
    Department of Biomedical Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 27:6006-18. 2007
    ..These findings provide evidence of astroglial activation by tissue injury, concomitant IL-1beta induction, and the coupling of NMDA receptor phosphorylation through IL-1 receptor signaling...
  14. ncbi request reprint Trigeminal transition zone/rostral ventromedial medulla connections and facilitation of orofacial hyperalgesia after masseter inflammation in rats
    Shinichi Sugiyo
    Department of Biomedical Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Comp Neurol 493:510-23. 2005
    ..The Vi/Vc-RVM pathway is activated after orofacial deep tissue injury and plays a critical role in facilitating orofacial hyperalgesia...
  15. pmc The role of trigeminal interpolaris-caudalis transition zone in persistent orofacial pain
    Ke Ren
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, MD 21201 1586, USA
    Int Rev Neurobiol 97:207-25. 2011
    ..The Vi/Vc transition zone accesses rostral brain regions that are important for descending pain modulation, and somatovisceral and somatoautonomic processing and plays a unique role in coordinating trigeminal nocifensive responses...
  16. ncbi request reprint Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: role of BDNF-TrkB signaling and NMDA receptors
    Ke Ren
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, 650 W Baltimore St, Baltimore, MD 21201 1586, USA
    Mol Neurobiol 35:224-35. 2007
    ..Further studies will elucidate cellular and molecular mechanisms of pain sensitization and further our understanding of principles of central nervous system plasticity and responsiveness to environmental challenge...
  17. ncbi request reprint Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation
    Wei Guo
    Department of Biomedical Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 26:126-37. 2006
    ..Our findings also caution that application of BDNF for recovery from CNS disorders could lead to undesirable central pain...
  18. pmc Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade
    Wei Guo
    Department of Neural and Pain Sciences, Dental School Program in Neuroscience, University of Maryland, 650 W, Baltimore St, Baltimore, Maryland 21201, USA
    Mol Pain 10:35. 2014
    ..However, the mechanisms underlying the activation of the 5-HT3 receptor and its contribution to facilitation of pain remain unclear...
  19. pmc Chemokine signaling involving chemokine (C-C motif) ligand 2 plays a role in descending pain facilitation
    Wei Guo
    Department of Neural and Pain Sciences, School of Dentistry and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    Neurosci Bull 28:193-207. 2012
    ....
  20. ncbi request reprint Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia
    Wei Guo
    Department of Oral and Craniofacial Biological Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Neurosci 22:6208-17. 2002
    ....
  21. ncbi request reprint Brainstem mechanisms of persistent pain following injury
    Ronald Dubner
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201, USA
    J Orofac Pain 18:299-305. 2004
    ..The findings support our overall hypothesis that the ventral pole of Vi/Vc is involved in the coordination of bilateral sensorimotor functions of the trigeminal system associated with the response to deep tissue injury...
  22. pmc Bone marrow stromal cells produce long-term pain relief in rat models of persistent pain
    Wei Guo
    Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, Maryland 21201 1586, USA
    Stem Cells 29:1294-303. 2011
    ..The findings prompt studies to elucidate the cellular mechanisms of the BMSC-induced pain relieving effect and translate these observations into clinical settings...
  23. ncbi request reprint Differential rostral projections of caudal brainstem neurons receiving trigeminal input after masseter inflammation
    Tetsuya Ikeda
    Department of Oral and Craniofacial Biological Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Comp Neurol 465:220-33. 2003
    ..The activation of Vi/Vc neurons and associated ascending pathways may facilitate somatoautonomic and somatovisceral integration and descending pain modulation after orofacial deep tissue injury...
  24. ncbi request reprint Inflammation-induced upregulation of AMPA receptor subunit expression in brain stem pain modulatory circuitry
    Yun Guan
    Program in Neuroscience, University of Maryland, Baltimore, MD 21201 1586, USA
    Pain 104:401-13. 2003
    ....
  25. pmc Activation of group I mGlu receptors contributes to facilitation of NMDA receptor membrane current in spinal dorsal horn neurons after hind paw inflammation in rats
    Kun Yang
    Department of Neural and Pain Sciences, School of Dentistry and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Eur J Pharmacol 670:509-18. 2011
    ..These findings support the hypothesis that signal transduction coupling between group I mGlu receptors and NMDA receptors underlies the activation of NMDA receptors in spinal hyperexcitability and hyperalgesia...
  26. pmc Interactions between the immune and nervous systems in pain
    Ke Ren
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland, USA
    Nat Med 16:1267-76. 2010
    ..A greater understanding of the role of the immune system in pain processing and modulation reveals potential targets for analgesic drug development and new therapeutic opportunities for managing chronic pain...
  27. pmc Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia
    Guang Bai
    Department of Neural and Pain Sciences, University of Maryland, Baltimore, Maryland 21117, USA
    Mol Pain 6:51. 2010
    ....
  28. ncbi request reprint Antibody array analysis of peripheral and blood cytokine levels in rats after masseter inflammation
    Mineo Watanabe
    Department of Biomedical Sciences, Dental School, and Program in Neuroscience, University of Maryland, Rm 5A12, 666W Baltimore Street, Baltimore, MD 21201, USA
    Neurosci Lett 382:128-33. 2005
    ..The findings provide specific targets for further studying the involvement of cytokines in orofacial inflammation and hyperalgesia...
  29. pmc Neuron-glia crosstalk gets serious: role in pain hypersensitivity
    Ke Ren
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    Curr Opin Anaesthesiol 21:570-9. 2008
    ..The subsequent neuron-glia interactions contribute to pain hypersensitivity. This review will briefly discuss novel findings that have shed light on the cellular mechanisms of neuron-glia interactions in persistent pain...
  30. pmc Neonatal local noxious insult affects gene expression in the spinal dorsal horn of adult rats
    Ke Ren
    Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 1:27. 2005
    ..These findings suggest that changes in gene expression may be involved in the long-term nociceptive effects of neonatal noxious insult at the spinal level...
  31. ncbi request reprint Demonstration of a trigeminothalamic pathway to the oval paracentral intralaminar thalamic nucleus and its involvement in the processing of noxious orofacial deep inputs
    Shinichi Sugiyo
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Rm 5A26, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Brain Res 1097:116-22. 2006
    ..The present findings indicate a trigeminothalamic pathway to the OPC intralaminar nucleus involved in central processing of orofacial deep noxious input...
  32. ncbi request reprint Descending modulation in persistent pain: an update
    Ke Ren
    Department of Oral and Craniofacial Biological Sciences, Program in Neuroscience, University of Maryland Dental School, 666 West Baltimore Street, Room 5A12, Baltimore, MD 21201, USA
    Pain 100:1-6. 2002
  33. pmc Central Terminal Sensitization of TRPV1 by Descending Serotonergic Facilitation Modulates Chronic Pain
    Yu Shin Kim
    Department of Neuroscience, Center of Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 81:873-87. 2014
    ..Our results reveal central mechanisms facilitating central terminal sensitization underlying chronic pain. ..
  34. ncbi request reprint Plasticity in excitatory amino acid receptor-mediated descending pain modulation after inflammation
    Yun Guan
    Department of Oral and Craniofacial Biological Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Pharmacol Exp Ther 300:513-20. 2002
    ..There is a time-dependent increase in EAA neurotransmission in the RVM after inflammation and NMDA receptors play an important role in AMPA-produced inhibition...
  35. ncbi request reprint Age-dependency of analgesia elicited by intraoral sucrose in acute and persistent pain models
    Vanessa C Z Anseloni
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore 21201, USA
    Pain 97:93-103. 2002
    ....
  36. doi request reprint Multipotent stromal cells for arthritic joint pain therapy and beyond
    Wei Guo
    Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA
    Pain Manag 4:153-62. 2014
    ..It is hypothesized that MSCs interact with the host immune cells and the relayed signal helps to produce and maintain a long-lasting therapeutic effect including pain relief...
  37. pmc Pain sensitivity risk factors for chronic TMD: descriptive data and empirically identified domains from the OPPERA case control study
    Joel D Greenspan
    Department of Neural and Pain Sciences, and Brotman Facial Pain Center, University of Maryland Dental School, Baltimore, Maryland 21201, USA
    J Pain 12:T61-74. 2011
    ....
  38. ncbi request reprint Neurons involved in the exteroceptive function of pain
    Donald D Price
    Departments of Oral Surgery and Neuroscience, University of Florida, Gainesville, FL 32610, USA
    Pain 106:215-9. 2003
  39. ncbi request reprint What can be learned by assessing funding patterns for pain research? A commentary on National Institutes of Health grant awards for pain, nausea, and dyspnea research
    Ronald Dubner
    J Pain 6:275-6. 2005
  40. ncbi request reprint Attenuation of pain in a randomized trial by suppression of peripheral nociceptive activity in the immediate postoperative period
    Sharon M Gordon
    National Institute of Dental and Craniofacial Research NIH, 19 Center Drive, Room 1N 117, Bethesda, MD 20892, USA
    Anesth Analg 95:1351-7, table of contents. 2002
    ..In contrast, blocking the intraoperative nociceptive barrage does not appear to contribute significantly to the subsequent reduction in pain...