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Genomes and GenesSpecies | Ronald DubnerSummaryAffiliation: University of Maryland Country: USA Publications
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The neurobiology of persistent pain and its clinical implicationsRonald Dubner
Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, MD 21201 1586, USA
Suppl Clin Neurophysiol 57:3-7. 2004..These findings demonstrate activity-dependent plasticity in brain stem circuits that includes changes in excitatory amino acid receptor activation and sensitivity and a phenotypic switch of some RVM neurons...- Endogenous mechanisms of sensory modulationR Dubner
Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
Pain . 1999..These parallel brain mechanisms emphasize the saliency of pain experience as an important learned behavior for the survival of the organism, similar to sequential goal-directed behaviors in an operant task... - Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesiaWei Guo
Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
J Neurosci 24:9161-73. 2004..The group ImGluR-NMDAR coupling cascade leads to phosphorylation of the NMDAR and appears necessary for the initiation of spinal dorsal horn sensitization and behavioral hyperalgesia after inflammation... 
Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitorsKohei Shimizu
Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
Mol Pain 5:75. 2009....- Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent painFeng Wei
Department of Neural and Pain Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
J Neurosci 30:8624-36. 2010..These results indicate that the descending 5-HT from the RVM is an important contributor to pain facilitation during the development of persistent pain, and may not mediate opioid-induced descending inhibition in acute pain... - Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascadeMing Gu
Department of Neural and Pain Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
J Neurosci 31:12823-36. 2011..New pain therapies should focus on prime targets of descending facilitation-induced glial involvement, and in particular the blocking of intercellular signaling transduction between neuron and glia... - Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial painWei Guo
Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
Mol Pain 6:40. 2010..Here we report a model of constant myogenic orofacial pain that lasts for months... - Changes in AMPA receptor phosphorylation in the rostral ventromedial medulla after inflammatory hyperalgesia in ratsYun Guan
Department of Biomedical Sciences, Dental School and Program in Neuroscience University of Maryland, Rm. 5A12, 666 W. Baltimore Street, Baltimore, MD 21201, USA
Neurosci Lett 366:201-5. 2004..These findings provide new evidence linking in vivo AMPA receptor phosphorylation in the RVM pain modulatory circuitry to the enhanced descending pain modulation after inflammation... - Supraspinal glial-neuronal interactions contribute to descending pain facilitationFeng Wei
Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
J Neurosci 28:10482-95. 2008..These studies have addressed a novel contribution of supraspinal astrocytes and associated cytokines as well as central glial-neuronal interactions to the enhancement of descending facilitation of neuropathic pain... - Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zoneHu Wang
Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201-1586, USA
J Comp Neurol 498:390-402. 2006..These findings provide further evidence to support a role of the trigeminal transition zone in response to orofacial deep injury... - Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injuryBryan Chai
Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA
Mol Pain 8:78. 2012..Here we investigated the involvement of the RVM-Vi/Vc circuitry in mediating contralateral orofacial hyperalgesia after an injection of CFA into the masseter muscle... - Glial-cytokine-neuronal interactions underlying the mechanisms of persistent painWei Guo
Department of Biomedical Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
J Neurosci 27:6006-18. 2007..These findings provide evidence of astroglial activation by tissue injury, concomitant IL-1beta induction, and the coupling of NMDA receptor phosphorylation through IL-1 receptor signaling... - Trigeminal transition zone/rostral ventromedial medulla connections and facilitation of orofacial hyperalgesia after masseter inflammation in ratsShinichi Sugiyo
Department of Biomedical Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201-1586, USA
J Comp Neurol 493:510-23. 2005..The Vi/Vc-RVM pathway is activated after orofacial deep tissue injury and plays a critical role in facilitating orofacial hyperalgesia... - The role of trigeminal interpolaris-caudalis transition zone in persistent orofacial painKe Ren
Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, MD 21201 1586, USA
Int Rev Neurobiol 97:207-25. 2011..The Vi/Vc transition zone accesses rostral brain regions that are important for descending pain modulation, and somatovisceral and somatoautonomic processing and plays a unique role in coordinating trigeminal nocifensive responses... - Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitationWei Guo
Department of Biomedical Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
J Neurosci 26:126-37. 2006..Our findings also caution that application of BDNF for recovery from CNS disorders could lead to undesirable central pain... - Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: role of BDNF-TrkB signaling and NMDA receptorsKe Ren
Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, 650 W Baltimore St, Baltimore, MD 21201 1586, USA
Mol Neurobiol 35:224-35. 2007..Further studies will elucidate cellular and molecular mechanisms of pain sensitization and further our understanding of principles of central nervous system plasticity and responsiveness to environmental challenge... 
Chemokine signaling involving chemokine (C-C motif) ligand 2 plays a role in descending pain facilitationWei Guo
Department of Neural and Pain Sciences, School of Dentistry and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
Neurosci Bull 28:193-207. 2012....- Brainstem mechanisms of persistent pain following injuryRonald Dubner
Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201, USA
J Orofac Pain 18:299-305. 2004..The findings support our overall hypothesis that the ventral pole of Vi/Vc is involved in the coordination of bilateral sensorimotor functions of the trigeminal system associated with the response to deep tissue injury... - Differential rostral projections of caudal brainstem neurons receiving trigeminal input after masseter inflammationTetsuya Ikeda
Department of Oral and Craniofacial Biological Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201-1586, USA
J Comp Neurol 465:220-33. 2003..The activation of Vi/Vc neurons and associated ascending pathways may facilitate somatoautonomic and somatovisceral integration and descending pain modulation after orofacial deep tissue injury... - Inflammation-induced upregulation of AMPA receptor subunit expression in brain stem pain modulatory circuitryYun Guan
Program in Neuroscience, University of Maryland, Baltimore, MD 21201 1586, USA
Pain 104:401-13. 2003.... - Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesiaWei Guo
Department of Oral and Craniofacial Biological Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201-1586, USA
J Neurosci 22:6208-17. 2002.... - Bone marrow stromal cells produce long-term pain relief in rat models of persistent painWei Guo
Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, Maryland 21201 1586, USA
Stem Cells 29:1294-303. 2011..The findings prompt studies to elucidate the cellular mechanisms of the BMSC-induced pain relieving effect and translate these observations into clinical settings... - Activation of group I mGlu receptors contributes to facilitation of NMDA receptor membrane current in spinal dorsal horn neurons after hind paw inflammation in ratsKun Yang
Department of Neural and Pain Sciences, School of Dentistry and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
Eur J Pharmacol 670:509-18. 2011..These findings support the hypothesis that signal transduction coupling between group I mGlu receptors and NMDA receptors underlies the activation of NMDA receptors in spinal hyperexcitability and hyperalgesia... - Neuron-glia crosstalk gets serious: role in pain hypersensitivityKe Ren
Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
Curr Opin Anaesthesiol 21:570-9. 2008..The subsequent neuron-glia interactions contribute to pain hypersensitivity. This review will briefly discuss novel findings that have shed light on the cellular mechanisms of neuron-glia interactions in persistent pain... - Interactions between the immune and nervous systems in painKe Ren
Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland, USA
Nat Med 16:1267-76. 2010..A greater understanding of the role of the immune system in pain processing and modulation reveals potential targets for analgesic drug development and new therapeutic opportunities for managing chronic pain... - Neonatal local noxious insult affects gene expression in the spinal dorsal horn of adult ratsKe Ren
Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA
Mol Pain 1:27. 2005..These findings suggest that changes in gene expression may be involved in the long-term nociceptive effects of neonatal noxious insult at the spinal level... - Antibody array analysis of peripheral and blood cytokine levels in rats after masseter inflammationMineo Watanabe
Department of Biomedical Sciences, Dental School, and Program in Neuroscience, University of Maryland, Rm. 5A12, 666W. Baltimore Street, Baltimore, MD 21201, USA
Neurosci Lett 382:128-33. 2005..The findings provide specific targets for further studying the involvement of cytokines in orofacial inflammation and hyperalgesia... - Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesiaGuang Bai
Department of Neural and Pain Sciences, University of Maryland, Baltimore, Maryland 21117, USA
Mol Pain 6:51. 2010.... - Demonstration of a trigeminothalamic pathway to the oval paracentral intralaminar thalamic nucleus and its involvement in the processing of noxious orofacial deep inputsShinichi Sugiyo
Department of Biomedical Sciences, Dental School; and Program in Neuroscience, University of Maryland, Rm. 5A26, 666 W. Baltimore Street, Baltimore, MD 21201, USA
Brain Res 1097:116-22. 2006..The present findings indicate a trigeminothalamic pathway to the OPC intralaminar nucleus involved in central processing of orofacial deep noxious input... - Transition to persistent orofacial pain after nerve injury involves supraspinal serotonin mechanismsMasamichi Okubo
Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
J Neurosci 33:5152-61. 2013.... - Descending modulation in persistent pain: an updateKe Ren
Department of Oral and Craniofacial Biological Sciences, Program in Neuroscience, University of Maryland Dental School, 666 West Baltimore Street, Room 5A12, Baltimore, MD 21201, USA
Pain 100:1-6. 2002 - Age-dependency of analgesia elicited by intraoral sucrose in acute and persistent pain modelsVanessa C Z Anseloni
Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore 21201, USA
Pain 97:93-103. 2002.... - Plasticity in excitatory amino acid receptor-mediated descending pain modulation after inflammationYun Guan
Department of Oral and Craniofacial Biological Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
J Pharmacol Exp Ther 300:513-20. 2002..There is a time-dependent increase in EAA neurotransmission in the RVM after inflammation and NMDA receptors play an important role in AMPA-produced inhibition... - Pain sensitivity risk factors for chronic TMD: descriptive data and empirically identified domains from the OPPERA case control studyJoel D Greenspan
Department of Neural and Pain Sciences, and Brotman Facial Pain Center, University of Maryland Dental School, Baltimore, Maryland 21201, USA
J Pain 12:T61-74. 2011..Variability in the magnitude and consistency of case-control differences highlight the need to consider multiple testing measures to adequately assess pain processing alterations in chronic pain conditions... - Neurons involved in the exteroceptive function of painDonald D Price
Departments of Oral Surgery and Neuroscience, University of Florida, Gainesville, FL 32610, USA
Pain 106:215-9. 2003 - What can be learned by assessing funding patterns for pain research? A commentary on National Institutes of Health grant awards for pain, nausea, and dyspnea researchRonald Dubner
J Pain 6:275-6. 2005 - Attenuation of pain in a randomized trial by suppression of peripheral nociceptive activity in the immediate postoperative periodSharon M Gordon
National Institute of Dental and Craniofacial Research/NIH, 19 Center Drive, Room 1N-117, Bethesda, MD 20892, USA
Anesth Analg 95:1351-7, table of contents. 2002..These findings suggest that pain after minor surgery can be prevented by blocking the development of pain processes that amplify pain for days after surgery...