Michael P Dube

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Relationship of body composition, metabolic status, antiretroviral use, and HIV disease factors to endothelial dysfunction in HIV-infected subjects
    Michael P Dube
    Department of Medicine and the Divisions of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA
    AIDS Res Hum Retroviruses 26:847-54. 2010
  2. doi request reprint Lipid metabolism in treated HIV Infection
    Michael P Dube
    The Division of Infectious Diseases and the Department of Medicine, University of Southern California, Keck School of Medicine, 5P21 Rand Schrader Health and Research Clinic, Los Angeles, CA 90033, USA
    Best Pract Res Clin Endocrinol Metab 25:429-42. 2011
  3. ncbi request reprint Long-term body fat outcomes in antiretroviral-naive participants randomized to nelfinavir or efavirenz or both plus dual nucleosides. Dual X-ray absorptiometry results from A5005s, a substudy of Adult Clinical Trials Group 384
    Michael P Dube
    Division of Infectious Diseases, Indiana University, Indianapolis, USA
    J Acquir Immune Defic Syndr 45:508-14. 2007
  4. ncbi request reprint Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapy
    Erika M Young
    Department of Medicine and Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202 2879, USA
    Cardiovasc Toxicol 4:179-86. 2004
  5. ncbi request reprint Effects of potent antiretroviral therapy on free testosterone levels and fat-free mass in men in a prospective, randomized trial: A5005s, a substudy of AIDS Clinical Trials Group Study 384
    Michael P Dube
    Division of Infectious Diseases, Indiana University, Indianapolis, USA
    Clin Infect Dis 45:120-6. 2007
  6. pmc No impairment of endothelial function or insulin sensitivity with 4 weeks of the HIV protease inhibitors atazanavir or lopinavir-ritonavir in healthy subjects without HIV infection: a placebo-controlled trial
    Michael P Dube
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Clin Infect Dis 47:567-74. 2008
  7. pmc Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Infect Dis 204:1946-50. 2011
  8. pmc Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study
    Samir K Gupta
    Department of Medicine, Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, USA
    AIDS 24:1377-80. 2010
  9. pmc Worsening endothelial function with efavirenz compared to protease inhibitors: a 12-month prospective study
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    PLoS ONE 7:e45716. 2012
  10. pmc Pentoxifylline, inflammation, and endothelial function in HIV-infected persons: a randomized, placebo-controlled trial
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 8:e60852. 2013

Collaborators

Detail Information

Publications22

  1. pmc Relationship of body composition, metabolic status, antiretroviral use, and HIV disease factors to endothelial dysfunction in HIV-infected subjects
    Michael P Dube
    Department of Medicine and the Divisions of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA
    AIDS Res Hum Retroviruses 26:847-54. 2010
    ..A definitive association with measures of adiposity was not detected in multivariate analysis, suggesting that lipoatrophy may not be an important contributor to endothelial dysfunction in HIV-infected individuals on ART...
  2. doi request reprint Lipid metabolism in treated HIV Infection
    Michael P Dube
    The Division of Infectious Diseases and the Department of Medicine, University of Southern California, Keck School of Medicine, 5P21 Rand Schrader Health and Research Clinic, Los Angeles, CA 90033, USA
    Best Pract Res Clin Endocrinol Metab 25:429-42. 2011
    ..In this review, we summarize what is known about the relative tendency of different antiretroviral drugs to alter lipid levels, and suggest an approach to intervention for dyslipidemia in this population...
  3. ncbi request reprint Long-term body fat outcomes in antiretroviral-naive participants randomized to nelfinavir or efavirenz or both plus dual nucleosides. Dual X-ray absorptiometry results from A5005s, a substudy of Adult Clinical Trials Group 384
    Michael P Dube
    Division of Infectious Diseases, Indiana University, Indianapolis, USA
    J Acquir Immune Defic Syndr 45:508-14. 2007
    ..Long-term regional body fat outcomes have not been well described in randomized antiretroviral drug trials...
  4. ncbi request reprint Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapy
    Erika M Young
    Department of Medicine and Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202 2879, USA
    Cardiovasc Toxicol 4:179-86. 2004
    ..This improvement occurred independent of development of insulin resistance, which occurred only with indinavir...
  5. ncbi request reprint Effects of potent antiretroviral therapy on free testosterone levels and fat-free mass in men in a prospective, randomized trial: A5005s, a substudy of AIDS Clinical Trials Group Study 384
    Michael P Dube
    Division of Infectious Diseases, Indiana University, Indianapolis, USA
    Clin Infect Dis 45:120-6. 2007
    ..The effects of initiation of different antiretroviral regimens on testosterone levels and changes in fat-free mass have not been reported...
  6. pmc No impairment of endothelial function or insulin sensitivity with 4 weeks of the HIV protease inhibitors atazanavir or lopinavir-ritonavir in healthy subjects without HIV infection: a placebo-controlled trial
    Michael P Dube
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Clin Infect Dis 47:567-74. 2008
    ..Some PIs, such as indinavir, directly induce endothelial dysfunction, an effect that may mediate that portion of the increase in cardiovascular events that is not attributable to dyslipidemia...
  7. pmc Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Infect Dis 204:1946-50. 2011
    ..None of the renal markers, modeled as either continuous or categorical variables, correlated with FMD. Contrary to expectations, endothelial dysfunction may not be the link between nephropathy and CVD in HIV...
  8. pmc Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study
    Samir K Gupta
    Department of Medicine, Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, USA
    AIDS 24:1377-80. 2010
    ..Pentoxifylline may reverse HIV-related endothelial dysfunction by directly inhibiting the endothelial leukocyte adhesion pathway...
  9. pmc Worsening endothelial function with efavirenz compared to protease inhibitors: a 12-month prospective study
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    PLoS ONE 7:e45716. 2012
    ....
  10. pmc Pentoxifylline, inflammation, and endothelial function in HIV-infected persons: a randomized, placebo-controlled trial
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 8:e60852. 2013
    ..Our preliminary in vitro and in vivo research suggests that pentoxifylline (PTX) reduces vascular inflammation and improves endothelial function in HIV-infected persons not requiring antiretroviral therapy...
  11. ncbi request reprint Glucose metabolism, lipid, and body fat changes in antiretroviral-naive subjects randomized to nelfinavir or efavirenz plus dual nucleosides
    Michael P Dube
    Division of Infectious Diseases, Indiana University, Indianapolis, Indiana, USA
    AIDS 19:1807-18. 2005
    ..To determine if particular components of antiretroviral drug regimens are associated with greater insulin resistance, dyslipidemia, and peripheral lipoatrophy...
  12. pmc Severe impairment of endothelial function with the HIV-1 protease inhibitor indinavir is not mediated by insulin resistance in healthy subjects
    Michael P Dube
    Department of Medicine and the Division of Infectious Diseases, Indiana University School of Medicine, Wishard Memorial Hospital, 1001 W 10th Street, Suite OPW 430, Indianapolis, IN 46202, USA
    Cardiovasc Toxicol 8:15-22. 2008
    ..This suggests that indinavir's effects on glucose metabolism are not directly related to indinavir-associated endothelial dysfunction. Studies of the vascular effects of newer protease inhibitors are needed...
  13. ncbi request reprint Indinavir impairs endothelial function in healthy HIV-negative men
    Sudha S Shankar
    Division of Endocrinology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am Heart J 150:933. 2005
    ..Potent antiretroviral treatment has drastically reduced mortality in HIV-infected patients but may accelerate atherosclerotic disease, which could be partially mediated via endothelial dysfunction...
  14. doi request reprint Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study
    Samir K Gupta
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    AIDS 22:653-5. 2008
    ..However, hepatotoxicity occurred frequently. Research using alternative agents is warranted to examine the role of inflammation in HIV-related cardiovascular disease...
  15. pmc Safety and efficacy of extended-release niacin for the treatment of dyslipidaemia in patients with HIV infection: AIDS Clinical Trials Group Study A5148
    Michael P Dube
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Antivir Ther 11:1081-9. 2006
    ..Dyslipidaemia is very common in patients with HIV infection, but current therapies are often suboptimal. Since niacin may cause insulin resistance and hepatotoxicity, it has generally been avoided in this setting...
  16. ncbi request reprint Clinical aspects of endothelial dysfunction associated with human immunodeficiency virus infection and antiretroviral agents
    Sudha S Shankar
    Department of Medicine and Divisions of Endocrinology, Indiana University School of Medicine, Indianapolis, IN, USA
    Cardiovasc Toxicol 4:261-9. 2004
    ....
  17. ncbi request reprint Metabolic effects of nandrolone decanoate and resistance training in men with HIV
    Fred R Sattler
    Departments of Medicine, Biokinesiology and Physical Therapy, and of Biometry, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Am J Physiol Endocrinol Metab 283:E1214-22. 2002
    ..05). These metabolic effects were favorable (other than for HDL), but changes were generally transient (except for HDL in group 2), with measurements returning to baseline 2 mo after the interventions were completed...
  18. pmc The effects of highly active antiretroviral therapy on albuminuria in HIV-infected persons: results from a randomized trial
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Wishard Hospital, OPW 430, 1001 W 10th Street, Indianapolis, IN 46202, USA
    Nephrol Dial Transplant 20:2237-42. 2005
    ..Alternatively, albuminuria may improve with HAART as a result of treating renal parenchymal HIV infection. Longitudinal studies have not been performed previously addressing the effects of HAART on albuminuria...
  19. ncbi request reprint The effect of long-term storage on measured plasma lactate concentrations and prospective lactate results from a multicenter trial of antiretroviral therapy
    Michael P Dube
    Department of Medicine and Division of Infectious Diseases, Indiana University School of Medicine, Wishard Memorial Hospital, 1001 W 10th Street, Suite OPW 430, Indianapolis, IN 46202, USA
    Clin Chem Lab Med 43:947-52. 2005
    ..001 from baseline; p=0.04 for difference between groups over time). When performed as in this study, frozen storage with central batch lactate analysis is appropriate for prospectively collected samples in multicenter trials...
  20. ncbi request reprint Guidelines for the evaluation and management of dyslipidemia in human immunodeficiency virus (HIV)-infected adults receiving antiretroviral therapy: recommendations of the HIV Medical Association of the Infectious Disease Society of America and the Adult
    Michael P Dube
    Indiana University, Indianapolis, USA
    Clin Infect Dis 37:613-27. 2003
  21. ncbi request reprint Exogenous cushing syndrome mimicking human immunodeficiency virus lipodystrophy
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis, IN, 46202, USA
    Clin Infect Dis 35:E69-71. 2002
    ..Clinicians should be aware that clinical clues may indicate conditions other than lipodystrophy that may cause abnormal fat accumulation and that fluticasone should be cautiously administered to patients who are receiving ritonavir...
  22. ncbi request reprint Prospective, intensive study of metabolic changes associated with 48 weeks of amprenavir-based antiretroviral therapy
    Michael P Dube
    Department of Medicine, Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
    Clin Infect Dis 35:475-81. 2002
    ..A trend toward insulin resistance appeared late in the study following weight gain, particularly of trunk fat, but without loss of limb fat...