Research Topics
Genomes and Genes | Zhijun DuanSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesisMarshall Horwitz
Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA
Curr Opin Hematol 10:49-54. 2003..The authors propose that neutrophil elastase acts as an inhibitor of myelopoiesis, substantiating a chalone hypothesis proposed many years ago...- Gfi-1 oncoproteins in hematopoiesisZhijun Duan
Department of Medicine, University of Washington School of Medicine, Seattle 98195 7720, USA
Hematology 8:339-44. 2003..The ongoing identification of repressed target genes and interacting transcriptional cofactors is helping to unravel the central contributions of these two hematopoietic factors... - Leukemia in severe congenital neutropenia: defective proteolysis suggests new pathways to malignancy and opportunities for therapyMarshall Horwitz
Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, 1705 NE Pacific Street, HSB K236B, Seattle, WA 98195 7720, USA
Cancer Invest 21:579-87. 2003..Continued elucidation of the clinical features, molecular genetics, and biochemistry is likely to provide insight into novel pathways of leukemia induction with attendant prospects for new avenues of therapy... 
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1Zhijun Duan
Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Box 357720, Seattle, WA 98195, USA
Mol Cell Biol 25:10338-51. 2005..Silencing of Gfi1 expression in myeloid cells reverses G9a and HDAC1 recruitment to p21Cip/WAF1 and elevates its expression. These findings highlight the role of epigenetics in the regulation of development and oncogenesis by Gfi1...- Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5Zhijun Duan
Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
Mol Cell Biol 27:6889-902. 2007..In neutropenic patients, we identified PRDM5 protein sequence variants perturbing transcriptional function, suggesting a potentially important role in hematopoiesis... - Hereditary neutropenia: dogs explain human neutrophil elastase mutationsMarshall Horwitz
Division of Medical Genetics Department of Medicine, University of Washington School of Medicine, 1705 NE Pacific Street, HSB K236B, Box 357720 Seattle, WA 98195, USA
Trends Mol Med 10:163-70. 2004.... - A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropeniaZhijun Duan
Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
Mol Cell Biol 24:58-70. 2004.... - Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastaseKathleen F Benson
Division of Medical Genetics/Department of Medicine, University of Washington School of Medicine, Box 357720, 1705 NE Pacific Street, HSB-K236B, Seattle, Washington 98195, USA
Nat Genet 35:90-6. 2003..Most mutations in ELA2 that cause human cyclic hematopoiesis prevent membrane localization of neutrophil elastase, whereas most mutations in ELA2 that cause SCN lead to exclusive membrane localization... - Gfi-1 takes center stage in hematopoietic stem cellsZhijun Duan
Division of Medical Genetics/Department of Medicine, University of Washington School of Medicine, 1705 NE Pacific Street, HSB-K236B, Box 357720, Seattle, WA 98195, USA
Trends Mol Med 11:49-52. 2005.... - Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2Richard E Person
Department of Pathology, University of Washington School of Medicine, Box 357720, Seattle, Washington 98195, USA
Nat Genet 34:308-12. 2003.... - Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cellsCarol B Ware
Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
Cell Stem Cell 4:359-69. 2009..Our results indicate that HDACi can promote ESC self-renewal across species, and demonstrate that ESCs can toggle between alternative states in response to environmental factors... - Neutrophil elastase in cyclic and severe congenital neutropeniaMarshall S Horwitz
Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
Blood 109:1817-24. 2007..Nevertheless, mutations in all 3 genes are capable of causing the mislocalization of NE and may also induce the unfolded protein response, suggesting that there might a convergent pathogenic mechanism focusing on NE... 
The genome in space and time: does form always follow function? How does the spatial and temporal organization of a eukaryotic genome reflect and influence its functions?Zhijun Duan
Division of Hematology, Department of Medicine, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA
Bioessays 34:800-10. 2012..However, the answer as to whether genome architecture is a hallmark of cell identity remains elusive...- Targets of the transcriptional repressor oncoprotein Gfi-1Zhijun Duan
Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, 1705 Northeast Pacific Street, HSB K236B, P O Box 357720, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 100:5932-7. 2003.... - Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cellsLoretta L Doan
Institute for Cellular Therapeutics, University of Louisville, KY, USA
Nucleic Acids Res 32:2508-19. 2004..Moreover, they support a role for auto- and trans-regulation of Gfi1 by GFI1 and GFI1B in maintaining the normal expression patterns of Gfi1, and suggest that GFI1B may indirectly affect T-cell activation through repression of Gfi1...