Research Topics
Genomes and Genes
| C DuanSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Detail Information
Publications
Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3αPeng Zhang
Dept of Molecular, Cellular, and Developmental Biology, Univ of Michigan, Ann Arbor, MI 48109
Am J Physiol Regul Integr Comp Physiol 303:R1165-74. 2012..These results provide new information about the structural and functional conservation, spatial and temporal expression, and physiological regulation of hif-3α in a teleost model organism...- Duplicated Kiss1 receptor genes in zebrafish: distinct gene expression patterns, different ligand selectivity, and a novel nuclear isoform with transactivating activityTakeshi A Onuma
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
FASEB J 26:2941-50. 2012..These findings highlight how the duplication of Kiss1r genes may facilitate their adaptation of specialized functions. The discovery of a nuclear Kiss1r isoform raises the possibility of novel function of Kiss1r in the nucleus... - The conserved clusterin gene is expressed in the developing choroid plexus under the regulation of notch but not IGF signaling in zebrafishShuang Jiao
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Endocrinology 152:1860-71. 2011..These results suggest that clusterin is a marker of choroid plexus in zebrafish, and its expression in the developing choroid plexus is under the regulation of Notch but not IGF signaling... - Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: roles in skeletal muscle growth and differentiationCunming Duan
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Gen Comp Endocrinol 167:344-51. 2010..In this article, we provide a brief review of our current understanding of the IGF signaling system and discuss recent findings on how local oxygen availability and IGFBPs act to specify IGF actions in muscle cells... 
Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actionsCunming Duan
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Gen Comp Endocrinol 142:44-52. 2005..In this article, we provide a brief overview of our current understanding of the IGF signaling system with particular reference to IGFBPs...- The chemotactic and mitogenic responses of vascular smooth muscle cells to insulin-like growth factor-I require the activation of ERK1/2Cunming Duan
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
Mol Cell Endocrinol 206:75-83. 2003..These results suggest that the chemotactic and mitogenic responses of VSMCs to IGF-I require the activation of ERK1 and 2... - Specifying the cellular responses to IGF signals: roles of IGF-binding proteinsC Duan
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, Michigan 48109 1048, USA
J Endocrinol 175:41-54. 2002..A conceptual model of the molecular mechanisms by which IGFBPs act to determine the specific physiological outcomes of IGF stimulation is proposed and discussed... - Differential expression and biological effects of insulin-like growth factor-binding protein-4 and -5 in vascular smooth muscle cellsC Duan
Department of Biology, University of Michigan, Natural Science Building, Ann Arbor, Michigan 48109 1048, USA
J Biol Chem 273:16836-42. 1998..Therefore, IGFBP-4 and IGFBP-5 appear to be differentially regulated by autocrine/paracrine IGF-I through distinct mechanisms. These two proteins, in turn, play opposing roles in modulating IGF-I action in stimulating VSMC proliferation... - Phosphatidylinositol 3-kinase is required for insulin-like growth factor-I-induced vascular smooth muscle cell proliferation and migrationC Duan
Department of Biology, University of Michigan, Ann Arbor, Mich 48109 1048, USA
Circ Res 86:15-23. 2000..These results indicate that activation of PI3 kinase is required for both IGF-I-induced VSMC proliferation and migration... 
Insulin-like growth factor binding protein 2 is a growth inhibitory protein conserved in zebrafishC Duan
Department of Biology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 96:15274-9. 1999..These results indicate that zebrafish IGFBP-2 is a negative growth regulator acting downstream in the growth hormone-IGF-I axis...- Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the phosphatidylinositol 3-kinase, protein kinase B/Akt, and p70 S6 kinase signaling pathwayC Duan
Department of Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
J Biol Chem 274:37147-53. 1999..These results suggest that the action of IGF-I on IGFBP-5 gene expression requires the activation of the PI 3-kinase-PKB/Akt-p70(s6k) pathway but not the MAPK pathway in vascular smooth muscle cells... - IGFs stimulate zebrafish cell proliferation by activating MAP kinase and PI3-kinase-signaling pathwaysK C Pozios
University of Michigan, Department of Biology, Natural Science Building, Ann Arbor, MI 48109, USA
Am J Physiol Regul Integr Comp Physiol 280:R1230-9. 2001.... - Insulin-like growth factor signaling in fishAntony W Wood
Department of Molecular, Cellular, and Developmental Biology, University of Michigan Ann Arbor, Ann Arbor, Michigan 48109, USA
Int Rev Cytol 243:215-85. 2005..This review is intended as a summary of our understanding of IGF signaling, as revealed through research into the expression, function, and evolution of IGF ligands, receptors, and binding proteins in fish... - Biochemical and functional analysis of a conserved IGF-binding protein isolated from rainbow trout (Oncorhynchus mykiss) hepatoma cellsJ R Bauchat
Department of Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Endocrinol 170:619-28. 2001..These results indicate that the IGFBP molecule is structurally and functionally conserved in evolutionarily ancient vertebrate species such as bony fish... - Patterned delivery and expression of gene constructs into zebrafish embryos using microfabricated interfacesTushar Bansal
Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA
Biomed Microdevices 11:633-41. 2009..3% and 89%, and a delivery efficiency of 38% and 50% for GFP-DNA and GFP-mRNA respectively. Lastly, we demonstrate the simultaneous delivery of different compounds into the developing embryo... - Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergenceJianfeng Zhou
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 3:e3926. 2008..Elevated expression of IGFBP-2 is often associated with progression of many types of cancers... - Regulation of vascular smooth muscle cell responses to insulin-like growth factor (IGF)-I by local IGF-binding proteinsTzefu Hsieh
Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 278:42886-92. 2003..IGFBP-5 not only modulates IGF-I actions, but it also stimulates cell migration by interacting with cell-surface heparan sulfate proteoglycans... - Structural, biochemical, and expression analysis of two distinct insulin-like growth factor I receptors and their ligands in zebrafishTravis Maures
Department of Molecular, Cellular and Developmental Biology, Natural Science Building, University of Michigan, Ann Arbor, MI 48109, USA
Endocrinology 143:1858-71. 2002..The differential expression pattern of IGF-IRa and IGF-IRb suggest that they may play distinct roles in regulating the growth and development of zebrafish... - Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progressionP J Schlueter
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Cell Death Differ 14:1095-105. 2007.... - Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord developmentShuming Zou
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA
PLoS ONE 4:e7026. 2009..These results not only provide new insights into the functional conservation and divergence of the multiple igf genes but also reveal a novel role of IGF signaling in midline formation and notochord development in a vertebrate model... - Structure, developmental expression, and physiological regulation of zebrafish IGF binding protein-1Travis J Maures
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor 48109, USA
Endocrinology 143:2722-31. 2002.... - Understanding hypoxia-induced gene expression in early development: in vitro and in vivo analysis of hypoxia-inducible factor 1-regulated zebra fish insulin-like growth factor binding protein 1 gene expressionShingo Kajimura
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Mol Cell Biol 26:1142-55. 2006..These results suggest that HIF-1 mediates hypoxia-induced IGFBP-1 gene expression in early development by selectively interacting with the -1090/-1086 HRE and its adjacent HAS... - Paradoxical actions of endogenous and exogenous insulin-like growth factor-binding protein-5 revealed by RNA interference analysisPing Yin
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 48109, USA
J Biol Chem 279:32660-6. 2004..These results indicate that endogenous and exogenous IGFBP-5 exhibits opposing biological actions on cell survival and underscore the necessity and utility of studying IGFBP functions through loss-of-function approaches... - Targeted knockdown of insulin-like growth factor binding protein-2 disrupts cardiovascular development in zebrafish embryosAntony W Wood
Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, Michigan 48109, USA
Mol Endocrinol 19:1024-34. 2005..These findings suggest that IGFBP-2 is required for general embryonic development and growth and plays a local role in regulating vascular development in a model vertebrate organism... - Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiationYun Li
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 280:3613-20. 2005..These findings suggest that IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish... - Evidence that IGF binding protein-5 functions as a ligand-independent transcriptional regulator in vascular smooth muscle cellsQijin Xu
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor 48109 1048, USA
Circ Res 94:E46-54. 2004..These results suggest that IGFBP-5 is localized in VSMC nucleus and possesses transcription-regulatory activity that is IGF independent... - Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptorsPeter J Schlueter
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Kraus Natural Science Bldg, Ann Arbor, MI 48109, USA
FASEB J 20:1230-2. 2006.... - Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survivalPeter J Schlueter
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Dev Biol 305:377-87. 2007..Collectively, these data suggest a novel role for IGF signaling in early germline development, potentially via cross-talk with chemokine signaling pathways... - IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loopHongxia Ren
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
J Cell Biol 182:979-91. 2008..These findings suggest that IGFBP-5 promotes muscle cell differentiation by binding to and switching on the IGF-II auto-regulation loop... - Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathwaysHongxia Ren
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 107:5857-62. 2010.... - Duplicated zebrafish insulin-like growth factor binding protein-5 genes with split functional domains: evidence for evolutionarily conserved IGF binding, nuclear localization, and transactivation activityWei Dai
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
FASEB J 24:2020-9. 2010.... - Fibronectin binds insulin-like growth factor-binding protein 5 and abolishes Its ligand-dependent action on cell migrationQijin Xu
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
J Biol Chem 279:4269-77. 2004..These results suggest that FN and IGFBP-5 bind to each other, and this binding negatively regulates the ligand-dependent action of IGFBP-5 by triggering IGFBP-5 proteolysis... - Structural, gene expression, and functional analysis of the fugu (Takifugu rubripes) insulin-like growth factor binding protein-4 geneMingyu Li
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Am J Physiol Regul Integr Comp Physiol 296:R558-66. 2009..These results provide new information about the structural and functional conservation, expression patterns, and physiological regulation of the IGFBP-4 gene in a teleost fish... - Duplication and diversification of the hypoxia-inducible IGFBP-1 gene in zebrafishHiroyasu Kamei
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
PLoS ONE 3:e3091. 2008..The zebrafish is uniquely positioned to provide insight into the process of functional gene evolution due to its amenability to genetic and experimental manipulation and because it possess a large number of duplicated genes... - Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardationShingo Kajimura
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 102:1240-5. 2005..The induction of IGFBP-1 expression may be a conserved physiological mechanism to restrict the IGF-stimulated growth and developmental process under hypoxic stress... - Corticotropin-releasing factor receptor subtype 1 and somatostatin modulating hypoxia-caused downregulated mRNA of pituitary growth hormone and upregulated mRNA of hepatic insulin-like growth factor-I of ratsXue Qun Chen
Division of Neurobiology and Physiology, College of Life Sciences, Zhejiang University Yuquan Campus, Hangzhou 310027, China
Mol Cell Endocrinol 242:50-8. 2005..The pituitary GH/GH mRNA and hepatic IGF-I/IGF-I mRNA, and plasma IGF-I are modified by hypoxia through SS and CRFR1 mediation... - Intermittent hypoxia causes a suppressed pituitary growth hormone through somatostatinNing-Yi Xu
Division of Neurobiology and Physiology, College of Life Sciences, Zhejiang University (Yuquan Campus, Hangzhou 310027, China
Neuro Endocrinol Lett 25:361-7. 2004..This suppression may be due to a modulation of hypoxia-activated SS... - Several acidic amino acids in the N-domain of insulin-like growth factor-binding protein-5 are important for its transactivation activityYang Zhao
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 281:14184-91. 2006..Taken together, our results indicate that there are several conserved residues in the IGFBP-5 N-terminal region that are critical for transactivation and that IGFBP-2 and -3 also have strong transactivation activity in their N-domains...
Research Grants
- IGF-I AND PROTEINS IN VASCULAR SMOOTH MUSCLE CELLSCunming Duan; Fiscal Year: 2003....
- IGF-I and its binding proteins in vascular smooth muscle cellsCunming Duan; Fiscal Year: 2007....