C Duan

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop
    Hongxia Ren
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 182:979-91. 2008
  2. pmc Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development
    Shuming Zou
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA
    PLoS ONE 4:e7026. 2009
  3. pmc Duplication and diversification of the hypoxia-inducible IGFBP-1 gene in zebrafish
    Hiroyasu Kamei
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
    PLoS ONE 3:e3091. 2008
  4. pmc Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence
    Jianfeng Zhou
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e3926. 2008
  5. pmc Comparative endocrinology of aging and longevity regulation
    John B Allard
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan Ann Arbor, MI, USA
    Front Endocrinol (Lausanne) 2:75. 2011
  6. pmc Structural and functional analysis of amphioxus HIFα reveals ancient features of the HIFα family
    Shan Gao
    3Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Bldg, Ann Arbor, MI 48109 1048, USA
    FASEB J 28:1880-90. 2014
  7. pmc Structural and functional analysis of the amphioxus IGFBP gene uncovers ancient origin of IGF-independent functions
    Jianfeng Zhou
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, Michigan 48109 1048
    Endocrinology 154:3753-63. 2013
  8. doi request reprint Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3α
    Peng Zhang
    Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, China
    Am J Physiol Regul Integr Comp Physiol 303:R1165-74. 2012
  9. doi request reprint Duplicated Kiss1 receptor genes in zebrafish: distinct gene expression patterns, different ligand selectivity, and a novel nuclear isoform with transactivating activity
    Takeshi A Onuma
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    FASEB J 26:2941-50. 2012
  10. doi request reprint The conserved clusterin gene is expressed in the developing choroid plexus under the regulation of notch but not IGF signaling in zebrafish
    Shuang Jiao
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Endocrinology 152:1860-71. 2011

Collaborators

Detail Information

Publications42

  1. pmc IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop
    Hongxia Ren
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 182:979-91. 2008
    ..These findings suggest that IGFBP-5 promotes muscle cell differentiation by binding to and switching on the IGF-II auto-regulation loop...
  2. pmc Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development
    Shuming Zou
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA
    PLoS ONE 4:e7026. 2009
    ..These results not only provide new insights into the functional conservation and divergence of the multiple igf genes but also reveal a novel role of IGF signaling in midline formation and notochord development in a vertebrate model...
  3. pmc Duplication and diversification of the hypoxia-inducible IGFBP-1 gene in zebrafish
    Hiroyasu Kamei
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
    PLoS ONE 3:e3091. 2008
    ..The zebrafish is uniquely positioned to provide insight into the process of functional gene evolution due to its amenability to genetic and experimental manipulation and because it possess a large number of duplicated genes...
  4. pmc Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence
    Jianfeng Zhou
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e3926. 2008
    ..Elevated expression of IGFBP-2 is often associated with progression of many types of cancers...
  5. pmc Comparative endocrinology of aging and longevity regulation
    John B Allard
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan Ann Arbor, MI, USA
    Front Endocrinol (Lausanne) 2:75. 2011
    ..Because of the value of comparative studies, it is suggested that the aging field could benefit from adoption of additional model organisms...
  6. pmc Structural and functional analysis of amphioxus HIFα reveals ancient features of the HIFα family
    Shan Gao
    3Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Bldg, Ann Arbor, MI 48109 1048, USA
    FASEB J 28:1880-90. 2014
    ..These findings reveal many ancient features of the HIFα family and provide novel insights into the evolution of the HIFα family...
  7. pmc Structural and functional analysis of the amphioxus IGFBP gene uncovers ancient origin of IGF-independent functions
    Jianfeng Zhou
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, Michigan 48109 1048
    Endocrinology 154:3753-63. 2013
    ....
  8. doi request reprint Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3α
    Peng Zhang
    Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, China
    Am J Physiol Regul Integr Comp Physiol 303:R1165-74. 2012
    ..These results provide new information about the structural and functional conservation, spatial and temporal expression, and physiological regulation of hif-3α in a teleost model organism...
  9. doi request reprint Duplicated Kiss1 receptor genes in zebrafish: distinct gene expression patterns, different ligand selectivity, and a novel nuclear isoform with transactivating activity
    Takeshi A Onuma
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    FASEB J 26:2941-50. 2012
    ..These findings highlight how the duplication of Kiss1r genes may facilitate their adaptation of specialized functions. The discovery of a nuclear Kiss1r isoform raises the possibility of novel function of Kiss1r in the nucleus...
  10. doi request reprint The conserved clusterin gene is expressed in the developing choroid plexus under the regulation of notch but not IGF signaling in zebrafish
    Shuang Jiao
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Endocrinology 152:1860-71. 2011
    ..These results suggest that clusterin is a marker of choroid plexus in zebrafish, and its expression in the developing choroid plexus is under the regulation of Notch but not IGF signaling...
  11. ncbi request reprint The chemotactic and mitogenic responses of vascular smooth muscle cells to insulin-like growth factor-I require the activation of ERK1/2
    Cunming Duan
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
    Mol Cell Endocrinol 206:75-83. 2003
    ..These results suggest that the chemotactic and mitogenic responses of VSMCs to IGF-I require the activation of ERK1 and 2...
  12. ncbi request reprint Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions
    Cunming Duan
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Gen Comp Endocrinol 142:44-52. 2005
    ..In this article, we provide a brief overview of our current understanding of the IGF signaling system with particular reference to IGFBPs...
  13. ncbi request reprint Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: roles in skeletal muscle growth and differentiation
    Cunming Duan
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Gen Comp Endocrinol 167:344-51. 2010
    ..In this article, we provide a brief review of our current understanding of the IGF signaling system and discuss recent findings on how local oxygen availability and IGFBPs act to specify IGF actions in muscle cells...
  14. ncbi request reprint Differential expression and biological effects of insulin-like growth factor-binding protein-4 and -5 in vascular smooth muscle cells
    C Duan
    Department of Biology, University of Michigan, Natural Science Building, Ann Arbor, Michigan 48109 1048, USA
    J Biol Chem 273:16836-42. 1998
    ..Therefore, IGFBP-4 and IGFBP-5 appear to be differentially regulated by autocrine/paracrine IGF-I through distinct mechanisms. These two proteins, in turn, play opposing roles in modulating IGF-I action in stimulating VSMC proliferation...
  15. ncbi request reprint Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the phosphatidylinositol 3-kinase, protein kinase B/Akt, and p70 S6 kinase signaling pathway
    C Duan
    Department of Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    J Biol Chem 274:37147-53. 1999
    ..These results suggest that the action of IGF-I on IGFBP-5 gene expression requires the activation of the PI 3-kinase-PKB/Akt-p70(s6k) pathway but not the MAPK pathway in vascular smooth muscle cells...
  16. pmc Insulin-like growth factor binding protein 2 is a growth inhibitory protein conserved in zebrafish
    C Duan
    Department of Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 96:15274-9. 1999
    ..These results indicate that zebrafish IGFBP-2 is a negative growth regulator acting downstream in the growth hormone-IGF-I axis...
  17. ncbi request reprint Phosphatidylinositol 3-kinase is required for insulin-like growth factor-I-induced vascular smooth muscle cell proliferation and migration
    C Duan
    Department of Biology, University of Michigan, Ann Arbor, Mich 48109 1048, USA
    Circ Res 86:15-23. 2000
    ..These results indicate that activation of PI3 kinase is required for both IGF-I-induced VSMC proliferation and migration...
  18. ncbi request reprint Specifying the cellular responses to IGF signals: roles of IGF-binding proteins
    C Duan
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, Michigan 48109 1048, USA
    J Endocrinol 175:41-54. 2002
    ..A conceptual model of the molecular mechanisms by which IGFBPs act to determine the specific physiological outcomes of IGF stimulation is proposed and discussed...
  19. ncbi request reprint Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression
    P J Schlueter
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Death Differ 14:1095-105. 2007
    ....
  20. ncbi request reprint IGFs stimulate zebrafish cell proliferation by activating MAP kinase and PI3-kinase-signaling pathways
    K C Pozios
    University of Michigan, Department of Biology, Natural Science Building, Ann Arbor, MI 48109, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1230-9. 2001
    ....
  21. ncbi request reprint Insulin-like growth factor signaling in fish
    Antony W Wood
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan Ann Arbor, Ann Arbor, Michigan 48109, USA
    Int Rev Cytol 243:215-85. 2005
    ..This review is intended as a summary of our understanding of IGF signaling, as revealed through research into the expression, function, and evolution of IGF ligands, receptors, and binding proteins in fish...
  22. ncbi request reprint Biochemical and functional analysis of a conserved IGF-binding protein isolated from rainbow trout (Oncorhynchus mykiss) hepatoma cells
    J R Bauchat
    Department of Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Endocrinol 170:619-28. 2001
    ..These results indicate that the IGFBP molecule is structurally and functionally conserved in evolutionarily ancient vertebrate species such as bony fish...
  23. doi request reprint Patterned delivery and expression of gene constructs into zebrafish embryos using microfabricated interfaces
    Tushar Bansal
    Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA
    Biomed Microdevices 11:633-41. 2009
    ..3% and 89%, and a delivery efficiency of 38% and 50% for GFP-DNA and GFP-mRNA respectively. Lastly, we demonstrate the simultaneous delivery of different compounds into the developing embryo...
  24. ncbi request reprint Regulation of vascular smooth muscle cell responses to insulin-like growth factor (IGF)-I by local IGF-binding proteins
    Tzefu Hsieh
    Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 278:42886-92. 2003
    ..IGFBP-5 not only modulates IGF-I actions, but it also stimulates cell migration by interacting with cell-surface heparan sulfate proteoglycans...
  25. ncbi request reprint Structural, biochemical, and expression analysis of two distinct insulin-like growth factor I receptors and their ligands in zebrafish
    Travis Maures
    Department of Molecular, Cellular and Developmental Biology, Natural Science Building, University of Michigan, Ann Arbor, MI 48109, USA
    Endocrinology 143:1858-71. 2002
    ..The differential expression pattern of IGF-IRa and IGF-IRb suggest that they may play distinct roles in regulating the growth and development of zebrafish...
  26. ncbi request reprint Paradoxical actions of endogenous and exogenous insulin-like growth factor-binding protein-5 revealed by RNA interference analysis
    Ping Yin
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 48109, USA
    J Biol Chem 279:32660-6. 2004
    ..These results indicate that endogenous and exogenous IGFBP-5 exhibits opposing biological actions on cell survival and underscore the necessity and utility of studying IGFBP functions through loss-of-function approaches...
  27. ncbi request reprint Targeted knockdown of insulin-like growth factor binding protein-2 disrupts cardiovascular development in zebrafish embryos
    Antony W Wood
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, Michigan 48109, USA
    Mol Endocrinol 19:1024-34. 2005
    ..These findings suggest that IGFBP-2 is required for general embryonic development and growth and plays a local role in regulating vascular development in a model vertebrate organism...
  28. ncbi request reprint Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation
    Yun Li
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:3613-20. 2005
    ..These findings suggest that IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish...
  29. pmc Understanding hypoxia-induced gene expression in early development: in vitro and in vivo analysis of hypoxia-inducible factor 1-regulated zebra fish insulin-like growth factor binding protein 1 gene expression
    Shingo Kajimura
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Cell Biol 26:1142-55. 2006
    ..These results suggest that HIF-1 mediates hypoxia-induced IGFBP-1 gene expression in early development by selectively interacting with the -1090/-1086 HRE and its adjacent HAS...
  30. ncbi request reprint Structure, developmental expression, and physiological regulation of zebrafish IGF binding protein-1
    Travis J Maures
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor 48109, USA
    Endocrinology 143:2722-31. 2002
    ....
  31. pmc Inducible transgenic expression in the short-lived fish Nothobranchius furzeri
    J B Allard
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, 830 N University Avenue, Ann Arbor, MI 48109 1048, USA
    J Fish Biol 82:1733-8. 2013
    ..The availability of this inducible transgenic expression system will make the study of ageing-related antagonistically pleiotropic genes possible using this unique vertebrate model organism...
  32. ncbi request reprint Evidence that IGF binding protein-5 functions as a ligand-independent transcriptional regulator in vascular smooth muscle cells
    Qijin Xu
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor 48109 1048, USA
    Circ Res 94:E46-54. 2004
    ..These results suggest that IGFBP-5 is localized in VSMC nucleus and possesses transcription-regulatory activity that is IGF independent...
  33. pmc Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways
    Hongxia Ren
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:5857-62. 2010
    ....
  34. pmc Duplicated zebrafish insulin-like growth factor binding protein-5 genes with split functional domains: evidence for evolutionarily conserved IGF binding, nuclear localization, and transactivation activity
    Wei Dai
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    FASEB J 24:2020-9. 2010
    ....
  35. ncbi request reprint Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors
    Peter J Schlueter
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Kraus Natural Science Bldg, Ann Arbor, MI 48109, USA
    FASEB J 20:1230-2. 2006
    ....
  36. pmc Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival
    Peter J Schlueter
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 305:377-87. 2007
    ..Collectively, these data suggest a novel role for IGF signaling in early germline development, potentially via cross-talk with chemokine signaling pathways...
  37. ncbi request reprint Fibronectin binds insulin-like growth factor-binding protein 5 and abolishes Its ligand-dependent action on cell migration
    Qijin Xu
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    J Biol Chem 279:4269-77. 2004
    ..These results suggest that FN and IGFBP-5 bind to each other, and this binding negatively regulates the ligand-dependent action of IGFBP-5 by triggering IGFBP-5 proteolysis...
  38. pmc Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation
    Shingo Kajimura
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:1240-5. 2005
    ..The induction of IGFBP-1 expression may be a conserved physiological mechanism to restrict the IGF-stimulated growth and developmental process under hypoxic stress...
  39. ncbi request reprint Structural, gene expression, and functional analysis of the fugu (Takifugu rubripes) insulin-like growth factor binding protein-4 gene
    Mingyu Li
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Physiol Regul Integr Comp Physiol 296:R558-66. 2009
    ..These results provide new information about the structural and functional conservation, expression patterns, and physiological regulation of the IGFBP-4 gene in a teleost fish...
  40. ncbi request reprint Corticotropin-releasing factor receptor subtype 1 and somatostatin modulating hypoxia-caused downregulated mRNA of pituitary growth hormone and upregulated mRNA of hepatic insulin-like growth factor-I of rats
    Xue Qun Chen
    Division of Neurobiology and Physiology, College of Life Sciences, Zhejiang University Yuquan Campus, Hangzhou 310027, China
    Mol Cell Endocrinol 242:50-8. 2005
    ..The pituitary GH/GH mRNA and hepatic IGF-I/IGF-I mRNA, and plasma IGF-I are modified by hypoxia through SS and CRFR1 mediation...
  41. ncbi request reprint Intermittent hypoxia causes a suppressed pituitary growth hormone through somatostatin
    Ning yi Xu
    Division of Neurobiology and Physiology, College of Life Sciences, Zhejiang University Yuquan Campus, Hangzhou 310027, China
    Neuro Endocrinol Lett 25:361-7. 2004
    ..The aim of this study was to investigate the response of the growth hormone (GH) in rat anterior pituitary to intermittent hypoxia (IH) and its modulation by hypothalamic somatostatin (SS)...
  42. ncbi request reprint Several acidic amino acids in the N-domain of insulin-like growth factor-binding protein-5 are important for its transactivation activity
    Yang Zhao
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:14184-91. 2006
    ..Taken together, our results indicate that there are several conserved residues in the IGFBP-5 N-terminal region that are critical for transactivation and that IGFBP-2 and -3 also have strong transactivation activity in their N-domains...

Research Grants7