TERRY DU CLOS

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. ncbi Function of C-reactive protein
    T W Du Clos
    The VA Medical Center and the University of New Mexico School of Medicine, Department of Medicine, Albuquerque, USA
    Ann Med 32:274-8. 2000
  2. pmc Pentraxins (CRP, SAP) in the process of complement activation and clearance of apoptotic bodies through Fcγ receptors
    Terry W Du Clos
    Department of Veterans Affairs Medical Center and the University of New Mexico School of Medicine, Albuquerque, New Mexico 87108, USA
    Curr Opin Organ Transplant 16:15-20. 2011
  3. ncbi C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity
    Terry W Du Clos
    Department of Veterans Affairs Medical Center Research Service 151, 1501 San Pedro S E, Albuquerque, NM 87108, USA
    Immunol Res 30:261-77. 2004
  4. ncbi The role of C-reactive protein in the resolution of bacterial infection
    T W Du Clos
    Department of Veterans Affairs Medical Center, University of New Mexico, Albuquerque, New Mexico 87108, USA
    Curr Opin Infect Dis 14:289-93. 2001
  5. pmc Chromatin clearance in C57Bl/10 mice: interaction with heparan sulphate proteoglycans and receptors on Kupffer cells
    T W Du Clos
    Department of Veterans Affairs Medical Center, Albuquerque, NM 87108, USA
    Clin Exp Immunol 117:403-11. 1999
  6. ncbi Limited Wegener's granulomatosis presenting with complete heart block
    N O Ghaussy
    Division of Rheumatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Veterans Administration Hospital, Albuquerque, NM 87131, USA
    Scand J Rheumatol 33:115-8. 2004
  7. ncbi Serum amyloid P component and C-reactive protein mediate phagocytosis through murine Fc gamma Rs
    C Mold
    Department of Molecular Genetics and Microbiology, Veterans Affairs Medical Center, and Department of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
    J Immunol 166:1200-5. 2001
  8. ncbi Regulation of complement activation by C-reactive protein
    C Mold
    Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque 87131, USA
    Immunopharmacology 42:23-30. 1999
  9. ncbi Definition of a C-reactive protein binding determinant on histones
    T W Du Clos
    Veterans Administration Medical Center, Albuquerque, New Mexico 87108
    J Biol Chem 266:2167-71. 1991
  10. pmc C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific
    M P Stein
    Department of Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87108, USA
    J Clin Invest 105:369-76. 2000

Research Grants

Collaborators

Detail Information

Publications14

  1. ncbi Function of C-reactive protein
    T W Du Clos
    The VA Medical Center and the University of New Mexico School of Medicine, Department of Medicine, Albuquerque, USA
    Ann Med 32:274-8. 2000
    ..Thus, CRP is though to act as a surveillance molecule for altered self and certain pathogens. This recognition provides early defense and leads to a proinflammatory signal and activation of the humoural, adaptive immune system...
  2. pmc Pentraxins (CRP, SAP) in the process of complement activation and clearance of apoptotic bodies through Fcγ receptors
    Terry W Du Clos
    Department of Veterans Affairs Medical Center and the University of New Mexico School of Medicine, Albuquerque, New Mexico 87108, USA
    Curr Opin Organ Transplant 16:15-20. 2011
    ..Understanding the role of pentraxins in inflammation has been advanced by the recent identification and structural analysis of their receptor interactions...
  3. ncbi C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity
    Terry W Du Clos
    Department of Veterans Affairs Medical Center Research Service 151, 1501 San Pedro S E, Albuquerque, NM 87108, USA
    Immunol Res 30:261-77. 2004
    ..A general description of the proposed function of CRP is provided as a framework for future investigation...
  4. ncbi The role of C-reactive protein in the resolution of bacterial infection
    T W Du Clos
    Department of Veterans Affairs Medical Center, University of New Mexico, Albuquerque, New Mexico 87108, USA
    Curr Opin Infect Dis 14:289-93. 2001
    ..The recent identification of the interaction of C-reactive protein with Fc gamma receptors will lead to an enhanced understanding of C-reactive protein and its role in both the innate and acquired immune systems...
  5. pmc Chromatin clearance in C57Bl/10 mice: interaction with heparan sulphate proteoglycans and receptors on Kupffer cells
    T W Du Clos
    Department of Veterans Affairs Medical Center, Albuquerque, NM 87108, USA
    Clin Exp Immunol 117:403-11. 1999
    ..These data suggest that chromatin clearance is mediated by charge interactions with cell surface HSPG and by DNA receptors. Clearance and degradation of chromatin require functional macrophages in the liver and spleen...
  6. ncbi Limited Wegener's granulomatosis presenting with complete heart block
    N O Ghaussy
    Division of Rheumatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Veterans Administration Hospital, Albuquerque, NM 87131, USA
    Scand J Rheumatol 33:115-8. 2004
    ..In addition, a gallium-scan fused with a myocardial perfusion scan and cardiac magnetic resonance imaging (MRI) suggested focal inflammation near the atrioventricular (AV) node...
  7. ncbi Serum amyloid P component and C-reactive protein mediate phagocytosis through murine Fc gamma Rs
    C Mold
    Department of Molecular Genetics and Microbiology, Veterans Affairs Medical Center, and Department of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
    J Immunol 166:1200-5. 2001
    ..The use of FcgammaR by the pentraxins links innate and adaptive immunity and may have important consequences for processing, presentation, and clearance of the self-Ags to which these proteins bind...
  8. ncbi Regulation of complement activation by C-reactive protein
    C Mold
    Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque 87131, USA
    Immunopharmacology 42:23-30. 1999
    ..Complement activation by CRP may help limit the inflammatory response by providing opsonization with minimal generation of C5a and C5b-9...
  9. ncbi Definition of a C-reactive protein binding determinant on histones
    T W Du Clos
    Veterans Administration Medical Center, Albuquerque, New Mexico 87108
    J Biol Chem 266:2167-71. 1991
    ..Thus we have defined the first reported CRP binding determinant on a protein...
  10. pmc C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific
    M P Stein
    Department of Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87108, USA
    J Clin Invest 105:369-76. 2000
    ..This counterbalance may affect the contribution of FcgammaRIIA alleles to host defense and autoimmunity...
  11. ncbi C-reactive protein binding to murine leukocytes requires Fc gamma receptors
    M P Stein
    Veterans Affairs Medical Center, Albuquerque, NM 87108, USA
    J Immunol 164:1514-20. 2000
    ..These findings may have important implications in understanding the physiological function of CRP...
  12. ncbi C-reactive protein reacts with the U1 small nuclear ribonucleoprotein
    T W Du Clos
    Department of Medicine, VA Medical Center, Albuquerque, New Mexico 87108
    J Immunol 143:2553-9. 1989
    ..Considering the ability of CRP to inhibit antibody responses to its ligands and its ability to activate C and promote phagocytosis it is suggested that CRP may play a role in the regulation of autoantibody responses to nuclear Ag...

Research Grants9

  1. C-REACTIVE PROTEIN--RECETORS, LIGANDS AND AUTOIMMUNITY
    TERRY DU CLOS; Fiscal Year: 1999
    ..Functional studies will delineate the ability of CRP to stimulate signal transduction and opsonic activities through each of the two receptors. ..