Shao Jun Du

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. doi request reprint skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization
    Huiqing Li
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt St, Baltimore, MD 21202, USA
    FASEB J 23:1988-2000. 2009
  2. pmc Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos
    Marta Codina
    Center of Marine Biotechnology, Biotechnology Institute, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 5:e8416. 2010
  3. ncbi request reprint Gli2 mediation of hedgehog signals in slow muscle induction in zebrafish
    S J Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 710 E Pratt St, Baltimore, MD 21202, USA
    Differentiation 67:84-91. 2001
  4. pmc Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos
    Shao Jun Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 105:554-9. 2008
  5. ncbi request reprint Muscle-specific expression of the smyd1 gene is controlled by its 5.3-kb promoter and 5'-flanking sequence in zebrafish embryos
    Shao Jun Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    Dev Dyn 235:3306-15. 2006
  6. ncbi request reprint Muscle-specific expression of myogenin in zebrafish embryos is controlled by multiple regulatory elements in the promoter
    Shao Jun Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt Street, Baltimore, MD 21202, USA
    Comp Biochem Physiol B Biochem Mol Biol 134:123-34. 2003
  7. ncbi request reprint Visualizing normal and defective bone development in zebrafish embryos using the fluorescent chromophore calcein
    S J Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    Dev Biol 238:239-46. 2001
  8. ncbi request reprint Zebrafish tiggy-winkle hedgehog promoter directs notochord and floor plate green fluorescence protein expression in transgenic zebrafish embryos
    S J Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore 21202, USA
    Dev Dyn 222:655-66. 2001
  9. pmc Smyd1b is required for skeletal and cardiac muscle function in zebrafish
    Huiqing Li
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21202 Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201 Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 Department of Bioengineering and Environmental Science, Changsha University, Hunan 410003, China
    Mol Biol Cell 24:3511-21. 2013
  10. pmc SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos
    Xungang Tan
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 103:2713-8. 2006

Collaborators

Detail Information

Publications20

  1. doi request reprint skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization
    Huiqing Li
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt St, Baltimore, MD 21202, USA
    FASEB J 23:1988-2000. 2009
    ..Western blot analysis revealed that myosin protein levels were significantly reduced. Collectively, these results demonstrate that skNAC plays a vital role in myofibril assembly and function during muscle cell differentiation...
  2. pmc Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos
    Marta Codina
    Center of Marine Biotechnology, Biotechnology Institute, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 5:e8416. 2010
    ..It is not clear whether the disorganization of these sarcomeric structures is due to a direct effect from loss of Hsp90alpha1 function or indirectly through the disorganization of myosin thick filaments...
  3. ncbi request reprint Gli2 mediation of hedgehog signals in slow muscle induction in zebrafish
    S J Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 710 E Pratt St, Baltimore, MD 21202, USA
    Differentiation 67:84-91. 2001
    ....
  4. pmc Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos
    Shao Jun Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 105:554-9. 2008
    ..These results indicate that Hsp90alpha1 plays an important role in muscle development, likely through facilitating myosin folding and assembly into organized myofibril filaments...
  5. ncbi request reprint Muscle-specific expression of the smyd1 gene is controlled by its 5.3-kb promoter and 5'-flanking sequence in zebrafish embryos
    Shao Jun Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    Dev Dyn 235:3306-15. 2006
    ..Together, these data indicate that smyd1 is specifically expressed in most, if not all, striated muscles, and the muscle specificity is controlled by the 5.3-kb promoter and flanking sequences...
  6. ncbi request reprint Muscle-specific expression of myogenin in zebrafish embryos is controlled by multiple regulatory elements in the promoter
    Shao Jun Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt Street, Baltimore, MD 21202, USA
    Comp Biochem Physiol B Biochem Mol Biol 134:123-34. 2003
    ..In addition, because these regulatory elements control myogenin expression in mouse and human embryos, these data suggest that the regulatory mechanism controlling myogenin expression might be conserved during evolution...
  7. ncbi request reprint Visualizing normal and defective bone development in zebrafish embryos using the fluorescent chromophore calcein
    S J Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    Dev Biol 238:239-46. 2001
    ..Together, these results clearly demonstrated the sensitivity of calcein staining for visualizing bone structures in developing zebrafish embryos and its effectiveness for screening for mutants that have bone structure defects...
  8. ncbi request reprint Zebrafish tiggy-winkle hedgehog promoter directs notochord and floor plate green fluorescence protein expression in transgenic zebrafish embryos
    S J Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore 21202, USA
    Dev Dyn 222:655-66. 2001
    ..Together, these data indicated that the 5.2-kb twhh promoter contains regulatory elements for tissue-specific expression of twhh in the floor plate, pectoral fin bud, branchial arches, retina, and Kupffer's vesicle...
  9. pmc Smyd1b is required for skeletal and cardiac muscle function in zebrafish
    Huiqing Li
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21202 Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201 Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 Department of Bioengineering and Environmental Science, Changsha University, Hunan 410003, China
    Mol Biol Cell 24:3511-21. 2013
    ..Together these data support the idea that Smyd1b may work together with myosin chaperones to control myosin folding, degradation, and assembly into sarcomeres during myofibrillogenesis. ..
  10. pmc SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos
    Xungang Tan
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 103:2713-8. 2006
    ..Together, these data indicate that SmyD1a and SmyD1b are histone methyltransferases and play a critical role in myofibril organization during myofiber maturation...
  11. ncbi request reprint Analysis of myostatin gene structure, expression and function in zebrafish
    Cheng Xu
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    J Exp Biol 206:4067-79. 2003
    ..Together, these data demonstrate that Myostatin plays an inhibitory role in hyperplastic muscle growth in zebrafish...
  12. pmc Functional analysis of slow myosin heavy chain 1 and myomesin-3 in sarcomere organization in zebrafish embryonic slow muscles
    Jin Xu
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    J Genet Genomics 39:69-80. 2012
    ..Together, these studies indicate that myosin thick filaments are required for M-line organization and M-line localization of myomesin-3. In contrast, myomesin-3 is dispensable for sarcomere organization in slow muscles...
  13. pmc Smyd1b_tv1, a key regulator of sarcomere assembly, is localized on the M-line of skeletal muscle fibers
    Huiqing Li
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e28524. 2011
    ..Smyd1b encodes two alternatively spliced isoforms, smyd1b_tv1 and smyd1b_tv2, that are expressed in skeletal and cardiac muscles and play a vital role in myofibrillogenesis in skeletal muscles of zebrafish embryos...
  14. doi request reprint Development of a transgenic zebrafish model expressing GFP in the notochord, somite and liver directed by the hfe2 gene promoter
    Yue Hong Bian
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 701 East Pratt Street, Baltimore, MD 21202, USA
    Transgenic Res 20:787-98. 2011
    ..Moreover, the Tg(hfe2:gfp) transgenic zebrafish line provides a useful model system for analyzing liver development in zebrafish...
  15. doi request reprint Analyzing notochord segmentation and intervertebral disc formation using the twhh:gfp transgenic zebrafish model
    Yutaka Haga
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Transgenic Res 18:669-83. 2009
    ..These studies demonstrate that the twhh:gfp transgenic zebrafish is a useful model for studying vertebral segmentation and disc formation, and moreover, that RA signaling may play a role in this process...
  16. pmc Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear
    Josep Rotllant
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Matrix Biol 27:561-72. 2008
    ..A comparison of the phenotypes of Sparc knockdown and known zebrafish mutants with similar defects places Sparc downstream of sox9 in the genetic network that regulates development of the pharyngeal skeleton and inner ear of vertebrates...
  17. ncbi request reprint Differential expression of two MyoD genes in fast and slow muscles of gilthead seabream ( Sparus aurata)
    Xungang Tan
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt Street, Baltimore, MD 21202, USA
    Dev Genes Evol 212:207-17. 2002
    ..Hedgehog signaling is required for induction of MyoDexpression in adaxial cells...
  18. pmc Expression and functional characterization of Smyd1a in myofibril organization of skeletal muscles
    Jie Gao
    Institute of Marine and Environmental Technology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangdong, China
    PLoS ONE 9:e86808. 2014
    ..Although Smyd1b function is well characterized in skeletal and cardiac muscles, the function of Smyd1a is, however, unknown...
  19. ncbi request reprint Early development of forebrain gonadotrophin-releasing hormone (GnRH) neurones and the role of GnRH as an autocrine migration factor
    E Abraham
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD, USA
    J Neuroendocrinol 20:394-405. 2008
    ..Moreover we show, in vivo, that GnRH3 is an important factor regulating GnRH3 fibre pathfinding and neurone localisation in an autocrine fashion...
  20. ncbi request reprint Cloning and characterization of myogenin from seabream (Sparus aurata) and analysis of promoter muscle specificity
    Marta Codina
    Department of Physiology, Faculty of Biology, University of Barcelona, Spain Center of Marine Biotechnology, University of Maryland Biotechnology Institute, USA
    Comp Biochem Physiol Part D Genomics Proteomics 3:128-39. 2008
    ..Deletion analysis demonstrated that this muscle-specific activity depends on the presence of a MEF2 and a MEF3 binding site within the 550 bp myogenin promoter sequence...

Research Grants4

  1. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2003
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  2. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2000
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  3. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2001
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  4. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2002
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..