Cheng Du

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Beta-catenin phosphorylated at threonine 120 antagonizes generation of active beta-catenin by spatial localization in trans-Golgi network
    Cheng Du
    Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e33830. 2012
  2. doi request reprint Protein kinase D1-mediated phosphorylation and subcellular localization of beta-catenin
    Cheng Du
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusett 01655, USA
    Cancer Res 69:1117-24. 2009
  3. doi request reprint Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail
    Cheng Du
    Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cancer Res 70:7810-9. 2010
  4. pmc Protein kinase D1 inhibits cell proliferation through matrix metalloproteinase-2 and matrix metalloproteinase-9 secretion in prostate cancer
    M Helal Uddin Biswas
    Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 70:2095-104. 2010
  5. pmc Beta-catenin mediates alteration in cell proliferation, motility and invasion of prostate cancer cells by differential expression of E-cadherin and protein kinase D1
    Viqar Syed
    Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 104:82-95. 2008
  6. ncbi request reprint Metallothioneins and resistance to cisplatin and radiation in prostate cancer
    David J Smith
    Department of Surgery, Division of Urology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Urology 67:1341-7. 2006

Collaborators

Detail Information

Publications6

  1. pmc Beta-catenin phosphorylated at threonine 120 antagonizes generation of active beta-catenin by spatial localization in trans-Golgi network
    Cheng Du
    Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e33830. 2012
    ..Our results support the view that β-catenin signaling activity is regulated by spatial compartmentation and post-translational modifications and protein level of β-catenin alone is insufficient to count signaling activity...
  2. doi request reprint Protein kinase D1-mediated phosphorylation and subcellular localization of beta-catenin
    Cheng Du
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusett 01655, USA
    Cancer Res 69:1117-24. 2009
    ..Understanding the molecular basis of PKD1-beta-catenin interaction provides a novel strategy to target beta-catenin function in cells including prostate cancer...
  3. doi request reprint Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail
    Cheng Du
    Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cancer Res 70:7810-9. 2010
    ..Together, our results suggest that PKD1 functions as a tumor and metastasis suppressor, at least partly by regulating Snail-mediated EMT, and that loss of PKD1 may contribute to acquisition of an aggressive malignant phenotype...
  4. pmc Protein kinase D1 inhibits cell proliferation through matrix metalloproteinase-2 and matrix metalloproteinase-9 secretion in prostate cancer
    M Helal Uddin Biswas
    Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 70:2095-104. 2010
    ..The study shows a novel mechanism for antiproliferative effects of PKD1, a protein of emerging translational interest in several human cancers, through increased production of MMP-2 and MMP-9 in cancer cells...
  5. pmc Beta-catenin mediates alteration in cell proliferation, motility and invasion of prostate cancer cells by differential expression of E-cadherin and protein kinase D1
    Viqar Syed
    Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 104:82-95. 2008
    ..This study establishes the functional significance of combined dysregulation of PKD1 and E-cadherin in PC and that their effect on cell growth is mediated by beta-catenin...
  6. ncbi request reprint Metallothioneins and resistance to cisplatin and radiation in prostate cancer
    David J Smith
    Department of Surgery, Division of Urology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Urology 67:1341-7. 2006
    ..Because prostatic tissue has the greatest concentration of zinc in the human body, in this study we analyzed the effect of MT induction by zinc in prostate cancer (PCa)...