Research Topics
| Kenneth J DrobatzSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Measures of accuracy and performance of diagnostic testsKenneth J Drobatz
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104 6010, USA
J Vet Cardiol 11:S33-40. 2009..This manuscript describes the diagnostic test properties including sensitivity, specificity, predictive value, likelihood ratio, receiver operating characteristic curve...
Association of holidays, full moon, Friday the 13th, day of week, time of day, day of week, and time of year on case distribution in an urban referral small animal emergency clinicKenneth J Drobatz
Department Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
J Vet Emerg Crit Care (San Antonio) 19:479-83. 2009..To interrogate the association of variables: day of week, time of day, day of the year (major holidays, Friday the 13th, and the full moon), and month of year with the caseload of an urban academic emergency service...
Primary bacterial peritonitis in dogs and cats: 24 cases (1990-2006)William T N Culp
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 234:906-13. 2009....
Outcome of dogs with diabetic ketoacidosis: 127 dogs (1993-2003)Daniel Z Hume
Department of Clinical Studies, Matthew J Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
J Vet Intern Med 20:547-55. 2006..Concurrent conditions and electrolyte abnormalities are common in DKA and are associated with length of hospitalization. Survival was correlated to degree of anemia, hypocalcemia, and acidosis...
Renal transplantation in cats with calcium oxalate urolithiasis: 19 cases (1997-2004)Lillian R Aronson
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA
J Am Vet Med Assoc 228:743-9. 2006..In addition to reported complications in renal transplant recipients, formation of calculi within the allograft may also occur...
Incidence of and risk factors for postoperative pneumonia in dogs anesthetized for diagnosis or treatment of intervertebral disk diseaseMelissa A Java
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 235:281-7. 2009..To determine incidence of and risk factors for postoperative pneumonia in dogs anesthetized for diagnosis or treatment of intervertebral disk disease (IVDD)...
Accuracy of a continuous glucose monitoring system in dogs and cats with diabetic ketoacidosisErica L Reineke
Department of Clinical Studies, Matthew J Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Vet Emerg Crit Care (San Antonio) 20:303-12. 2010..2) To determine the effect of perfusion, hydration, body condition score, severity of ketosis, and frequency of calibration on the accuracy of the CGMS...
Spontaneous hemoperitoneum in cats: 65 cases (1994-2006)William T N Culp
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 236:978-82. 2010..To describe the clinical signs, physical examination findings, clinical laboratory abnormalities, etiology, and outcome in cats with spontaneous hemoperitoneum...
Abnormalities of serum electrolyte concentrations in dogs with hypoadrenocorticismJennifer A Adler
Department of Clinical Studies, Matthew J Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA
J Vet Intern Med 21:1168-73. 2007..Additionally, abnormalities in plasma ionized calcium (iCa2+) and ionized magnesium (iMg2+) concentrations and venous pH of dogs with HA are incompletely documented...
The effects of surgery and anesthesia on blood magnesium and calcium concentrations in canine and feline patientsBenjamin M Brainard
Section of Critical Care, Department of Clinical Studies, Matthew J Ryan Hospital of the Veterinary School, University of Pennsylvania, Pennsylvania, PA, USA
Vet Anaesth Analg 34:89-98. 2007..To demonstrate the effect of anesthesia and surgery on serum ionized magnesium and ionized calcium concentrations in clinical canine and feline patients...
Use of lispro insulin for treatment of diabetic ketoacidosis in dogsKirk W Sears
Matthew J Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
J Vet Emerg Crit Care (San Antonio) 22:211-8. 2012....
Suppurative, nonseptic polyarthropathy in dogsMark P Rondeau
Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
J Vet Intern Med 19:654-62. 2005..While seropositivity against the causative agent of Lyme disease was common and possibly a cause of polyarthritis in some dogs of our study, evidence of other vector-borne infection was not identified...
Community-acquired infectious pneumonia in puppies: 65 cases (1993-2002)Anant Radhakrishnan
Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 230:1493-7. 2007..To identify causative organisms, treatment, outcome, and prognosis for dogs < 1 year old with community-acquired infectious pneumonia...
Association of periodontal disease, oral procedures, and other clinical findings with bacterial endocarditis in dogsGordon D Peddle
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 234:100-7. 2009..To identify risk factors potentially associated with the development of bacterial endocarditis in dogs and determine whether periodontal disease and surgical procedures (oral and nonoral) were associated with bacterial endocarditis...
Signalment, history, and outcome of cats with gastrointestinal tract intussusception: 20 cases (1986-2000)Jamie M Burkitt
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 234:771-6. 2009..To determine signalment, history, and outcome of cats with gastrointestinal tract intussusception and to identify physical examination, diagnostic imaging, surgical, histologic, and necropsy findings in affected cats...
Case-control study to evaluate risk factors for the development of sepsis (neutropenia and fever) in dogs receiving chemotherapyKarin U Sorenmo
Department of Clinical Studies, School of Veterinary Medicine, Philadelphia, PA 19104, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 236:650-6. 2010..These results may lead to the implementation of prophylactic measures, especially when doxorubicin or vincristine is used in the induction phase in small dogs with lymphoma...
Signs of neurologic dysfunction in dogs with central versus peripheral vestibular diseaseMark T Troxel
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 227:570-4. 2005..Although neither the degree of head tilt nor the number of beats of postrotatory nystagmus could be used to distinguish CVD from PVD, rate of resting nystagmus may be useful in distinguishing the 2 conditions...
Survival times in dogs with right atrial hemangiosarcoma treated by means of surgical resection with or without adjuvant chemotherapy: 23 cases (1986-2000)Chick Weisse
Section of Small Animal Surgery, Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA
J Am Vet Med Assoc 226:575-9. 2005..In addition, use of adjuvant chemotherapy following resection was associated with significantly longer survival times, compared with resection alone...
Variables associated with outcome in dogs undergoing extrahepatic biliary surgery: 60 cases (1988-2002)Stephen J Mehler
Department of Clinical Studies, Matthew J Ryan Veterinary Hospital of the University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104 6010, USA
Vet Surg 33:644-9. 2004..To report clinical findings and define clinical variables associated with outcome in dogs undergoing extrahepatic biliary surgery...
Indications for and outcome of positive-pressure ventilation in cats: 53 cases (1993-2002)Justine A Lee
Section of Critical Care, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA
J Am Vet Med Assoc 226:924-31. 2005..Death was attributable to progressive respiratory failure, non-responsive hypotension, kidney failure, or neurologic impairment...
Pneumatosis in canine gastric dilatation-volvulus syndromeAnthony J Fischetti
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey St, Philadelphia, PA 19104, USA
Vet Radiol Ultrasound 45:205-9. 2004..The significance of pneumatosis should be taken into consideration with previous treatments for gastric decompression, as percutaneous gastric trocharization or orogastric intubation may increase the number of false-positive results...
Liver function in cats with hyperthyroidism before and after 131I therapyAllyson C Berent
Department of Clinical Studies Small Animal Internal Medicinel Interventional Radiology, University of Pennsylvania, Mathew J Ryan Veterinary Teaching Hospital, Philadelphia, PA, USA
J Vet Intern Med 21:1217-23. 2007..The clinical significance of high serum concentration or activity of markers of liver damage in cats with hyperthyroidism is unknown...
The association of blood lactate concentration with outcome in dogs with idiopathic immune-mediated hemolytic anemia: 173 cases (2003-2006)Melissa L Holahan
Section of Critical Care, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Vet Emerg Crit Care (San Antonio) 20:413-20. 2010..To determine the association of blood lactate with outcome and response to transfusion therapy in dogs with idiopathic immune-mediated hemolytic anemia (IMHA)...
Vascular endothelial growth factor concentrations in body cavity effusions in dogsCraig A Clifford
Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Veterinary Teaching Hospital, 19104 6010, USA
J Vet Intern Med 16:164-8. 2002..05). There was no marked difference demonstrated between effusions associated with malignant and nonmalignant diseases. Further studies are necessary to elucidate the role of VEGF in body cavity effusion formation in dogs...
Effect of cyclosporine, dexamethasone, and human CTLA4-Ig on production of cytokines in lymphocytes of clinically normal cats and cats undergoing renal transplantationLillian R Aronson
Departments of Clinical Studies Philadelphia, PA, USA
Am J Vet Res 72:541-9. 2011....
Underlying cause, pathophysiologic abnormalities, and response to treatment in cats with septic peritonitis: 51 cases (1990-2001)Merilee F Costello
Section of Critical Care, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA
J Am Vet Med Assoc 225:897-902. 2004..However, certain features may be unique, including an absence of signs of pain during abdominal palpation, relative bradycardia, and apparent spontaneous peritonitis in some cats...
Evaluation of risk factors for bite wounds inflicted on caregivers by dogs and cats in a veterinary teaching hospitalKenneth J Drobatz
Section of Critical Care, Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19101, USA
J Am Vet Med Assoc 223:312-6. 2003..Dogs and cats considered to have the propensity to bite frequently do bite, and precautions, such as muzzling, should be taken if the medical condition or conformation of the dog or cat is amenable to this type of restraint...
Magnetic resonance imaging of focal splenic and hepatic lesions in the dogCraig A Clifford
University of Pennsylvania School of Veterinary Medicine, Matthew J Ryan Veterinary Hospital, Philadelphia, PA, USA
J Vet Intern Med 18:330-8. 2004..These results suggest that MRI is a useful modality for abdominal imaging in veterinary patients, and MRI accurately differentiated benign from malignant focal hepatic and splenic lesions in this sample of patients...
Evaluation of erythropoiesis and changes in serum erythropoietin concentration in cats after renal transplantationLillian R Aronson
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA
Am J Vet Res 64:1248-54. 2003..A delay in resolution of anemia in cats may indicate poor graft function and inadequate iron stores, suggesting the need for further evaluation for concurrent illness...
Expression of inhibitory G proteins in adenomatous thyroid glands obtained from hyperthyroid catsCynthia R Ward
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA
Am J Vet Res 66:1478-82. 2005..Decreased G(i2) expression may explain excessive growth and function of the thyroid gland in cats with hyperthyroidism...
Zinc intoxication in dogs: 19 cases (1991-2003)Carolyn M Gurnee
Matthew J Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 5438, USA
J Am Vet Med Assoc 230:1174-9. 2007..To determine physical examination findings, clinicopathologic changes, and prognosis in dogs with zinc toxicosis...
Deployment morbidity among search-and-rescue dogs used after the September 11, 2001, terrorist attacksKimberly A Slensky
Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA
J Am Vet Med Assoc 225:868-73. 2004..6 times more likely to have combined morbidity, compared with dogs at the Pentagon. CONCLUSIONS AND CLINICAL RELEVANCE: Injury and illnesses occurred in most dogs and affected several organ systems, but all were minor...
Evaluation of plasma-ionized magnesium concentration in 122 dogs with diabetes mellitus: a retrospective studySuzanne C Fincham
Department of Clinical Studies, Matthew J. Ryan School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA
J Vet Intern Med 18:612-7. 2004..We conclude that dogs with naturally occurring diabetes mellitus do not have marked hypomagnesemia on initial examination at a tertiary care center...
Effects of CD28 blockade on subsets of naïve T cells in catsLillian R Aronson
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA
Am J Vet Res 66:483-92. 2005..The specificity of its mechanism of action suggests that (hu)CTLA4-Ig may prevent allograft rejection but leave memory responses to previously encountered antigens intact...
Measurements of microvascular perfusion in healthy anesthetized dogs using orthogonal polarization spectral imagingDeborah C Silverstein
Department of Clinical Studies, Matthew J Ryan Veterinary Hospital, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
J Vet Emerg Crit Care (San Antonio) 19:579-87. 2009..To determine normal microvascular assessment parameters for healthy, anesthetized dogs...
Postoperative hypoxemia and hypercarbia in healthy dogs undergoing routine ovariohysterectomy or castration and receiving butorphanol or hydromorphone for analgesiaVicki L Campbell
Section of Anesthesia and Critical Care, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 222:330-6. 2003..However, increases in PaCO2 and decreases in PaO2 were mild, and mean PaCO2 and PaO2 remained within reference limits...
Risk factors, prognostic indicators, and outcome of pyothorax in cats: 80 cases (1986-1999)Lori S Waddell
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA
J Am Vet Med Assoc 221:819-24. 2002..Hypersalivation and low heart rate were associated with worse clinical outcome. Cats with pyothorax were likely to come from multi-cat households...
Use of the vertebral heart scale for differentiation of cardiac and noncardiac causes of respiratory distress in cats: 67 cases (2002-2003)Meg M Sleeper
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 242:366-71. 2013..To assess the effectiveness of the vertebral heart scale (VHS) system to differentiate congestive heart failure from other causes of dyspnea in cats...
Effectiveness of intravenous fluid resuscitation in the emergency room for treatment of hypotension in dogs: 35 cases (2000-2010)Deborah C Silverstein
Matthew J Ryan Veterinary Hospital, Department of Clinical Studies Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
J Vet Emerg Crit Care (San Antonio) 22:666-73. 2012..To assess the effectiveness of fluid resuscitation for the treatment of hypotensive dogs presented to the emergency room...
Effective gene therapy for an inherited CNS disease in a large animal modelCharles H Vite
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Ann Neurol 57:355-64. 2005....
Clinical differentiation of acute necrotizing from chronic nonsuppurative pancreatitis in cats: 63 cases (1996-2001)Jean A Ferreri
Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 223:469-74. 2003....
Cerebrospinal fluid glutamine, tryptophan, and tryptophan metabolite concentrations in dogs with portosystemic shuntsDavid E Holt
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
Am J Vet Res 63:1167-71. 2002..High concentrations of QUIN and other TRP metabolites in the CNS may contribute to neurologic abnormalities found in dogs with PSS and hepatic encephalopathy...
Response to Malassezia pachydermatis by peripheral blood mononuclear cells from clinically normal and atopic dogsDaniel O Morris
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
Am J Vet Res 63:358-62. 2002..Modification of the dysregulated immune response toward M pachydermatis may assist in the reduction of pathologic changes associated with an atopic dermatitis phenotype in dogs...
Cardiac troponin I in feline hypertrophic cardiomyopathyWilliam E Herndon
Veterinary Hospital, University of Pennsylvania, Philadelphia 19104 6010, USA
J Vet Intern Med 16:558-64. 2002..These data indicate that cats with HCM have ongoing myocardial damage. Although the origin of this damage is unknown, it most likely explains the replacement fibrosis that is consistently identified in cats with moderate to severe HCM...
Feline epitheliotropic intestinal malignant lymphoma: 10 cases (1997-2000)Janet K Carreras
Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Veterinary Teaching Hospital, Philadelphia, PA, USA
J Vet Intern Med 17:326-31. 2003..The median survival time was 11 months. Additional studies are warranted to better characterize EIL and its relationship to IBD in cats and non-EIL and to identify optimal treatment strategies for this disease...
