Gideon Dreyfuss

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc snRNAs contain specific SMN-binding domains that are essential for snRNP assembly
    Jeongsik Yong
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    Mol Cell Biol 24:2747-56. 2004
  2. pmc A functional interaction between the survival motor neuron complex and RNA polymerase II
    L Pellizzoni
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 152:75-85. 2001
  3. pmc Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems
    B Charroux
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Cell Biol 147:1181-94. 1999
  4. pmc Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli
    B Charroux
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Cell Biol 148:1177-86. 2000
  5. ncbi request reprint Messenger-RNA-binding proteins and the messages they carry
    Gideon Dreyfuss
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    Nat Rev Mol Cell Biol 3:195-205. 2002
  6. ncbi request reprint Why do cells need an assembly machine for RNA-protein complexes?
    Jeongsik Yong
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    Trends Cell Biol 14:226-32. 2004
  7. ncbi request reprint Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex
    Jennifer Baccon
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Biol Chem 277:31957-62. 2002
  8. ncbi request reprint Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component
    Livio Pellizzoni
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    J Biol Chem 277:7540-5. 2002
  9. ncbi request reprint The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure
    Yingli Ma
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Structure 13:883-92. 2005
  10. pmc miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    Zissimos Mourelatos
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    Genes Dev 16:720-8. 2002

Research Grants

Collaborators

Detail Information

Publications49

  1. pmc snRNAs contain specific SMN-binding domains that are essential for snRNP assembly
    Jeongsik Yong
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    Mol Cell Biol 24:2747-56. 2004
    ..It is likely that this surveillance capacity of the SMN complex ensures assembly of Sm cores on the correct RNAs only and prevents illicit, potentially deleterious, assembly of Sm cores on random RNAs...
  2. pmc A functional interaction between the survival motor neuron complex and RNA polymerase II
    L Pellizzoni
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 152:75-85. 2001
    ..These findings indicate a functional as well as physical association of the SMN complex with pol II and suggest a role for the SMN complex in the assembly of the pol II transcription/processing machinery...
  3. pmc Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems
    B Charroux
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Cell Biol 147:1181-94. 1999
    ..The presence of a DEAD box motif in Gemin3 suggests that it may provide the catalytic activity that plays a critical role in the function of the SMN complex on RNPs...
  4. pmc Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli
    B Charroux
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Cell Biol 148:1177-86. 2000
    ..Interestingly, Gemin4 is also detected in the nucleoli, suggesting that the SMN complex may also function in preribosomal RNA processing or ribosome assembly...
  5. ncbi request reprint Messenger-RNA-binding proteins and the messages they carry
    Gideon Dreyfuss
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    Nat Rev Mol Cell Biol 3:195-205. 2002
    ..These proteins communicate crucial information to the translation machinery for the surveillance of nonsense mutations and for mRNA localization and translation...
  6. ncbi request reprint Why do cells need an assembly machine for RNA-protein complexes?
    Jeongsik Yong
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    Trends Cell Biol 14:226-32. 2004
    ..We discuss how this surveillance capacity of the SMN complex might ensure assembly of Sm cores only on the correct RNAs and prevent illicit, potentially deleterious assembly of Sm cores on random RNAs...
  7. ncbi request reprint Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex
    Jennifer Baccon
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Biol Chem 277:31957-62. 2002
    ..With the identification of Gemin7, the inventory of the core components of the SMN complex appears essentially complete...
  8. ncbi request reprint Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component
    Livio Pellizzoni
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    J Biol Chem 277:7540-5. 2002
    ..Co-immunoprecipitation, immunolocalization, and in vitro binding experiments demonstrate that Gemin6 is a component of the SMN complex that localizes to gems and interacts with several Sm proteins of the spliceosomal snRNPs...
  9. ncbi request reprint The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure
    Yingli Ma
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Structure 13:883-92. 2005
    ....
  10. pmc miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    Zissimos Mourelatos
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    Genes Dev 16:720-8. 2002
    ..The genomic sequences predict that miRNAs are likely to be derived from larger precursors that have the capacity to form stem-loop structures...
  11. pmc The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway
    Séverine Massenet
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104 6148, USA
    Mol Cell Biol 22:6533-41. 2002
    ..Thus, the SMN complex is associated with snRNPs during the entire process of their biogenesis in the cytoplasm and may have multiple functions throughout this process...
  12. pmc The survival of motor neurons protein determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy
    Lili Wan
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    Mol Cell Biol 25:5543-51. 2005
    ..Thus, SMN determines the capacity for snRNP biogenesis, and our findings provide evidence for a measurable deficiency in a biochemical activity in cells from patients with spinal muscular atrophy...
  13. ncbi request reprint A novel WD repeat protein component of the methylosome binds Sm proteins
    Westley J Friesen
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Biol Chem 277:8243-7. 2002
    ....
  14. pmc Lymphotropic Herpesvirus saimiri uses the SMN complex to assemble Sm cores on its small RNAs
    Tracey J Golembe
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    Mol Cell Biol 25:602-11. 2005
    ....
  15. ncbi request reprint Essential role for the SMN complex in the specificity of snRNP assembly
    Livio Pellizzoni
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    Science 298:1775-9. 2002
    ..Thus, the SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, nonspecific binding of Sm proteins to RNAs...
  16. pmc SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing
    Zhenxi Zhang
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    Cell 133:585-600. 2008
    ..These findings reveal a key role for the SMN complex in RNA metabolism and in splicing regulation and indicate that SMA is a general splicing disease that is not restricted to motor neurons...
  17. ncbi request reprint The Gemin5 protein of the SMN complex identifies snRNAs
    Daniel J Battle
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell 23:273-9. 2006
    ..Gemin5 therefore functions as the factor that allows the SMN complex to distinguish snRNAs from other cellular RNAs for snRNP biogenesis...
  18. ncbi request reprint Gemins modulate the expression and activity of the SMN complex
    Wenqin Feng
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    Hum Mol Genet 14:1605-11. 2005
    ....
  19. pmc eIF4A3 is a novel component of the exon junction complex
    Chia C Chan
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    RNA 10:200-9. 2004
    ..Using monoclonal antibodies, we show that eIF4A3 is found in the nucleus whereas eIF4A1 and eIF4A2 are found in the cytoplasm. Thus, eIF4A3 likely provides a splicing-dependent influence on the translation of mRNAs...
  20. ncbi request reprint The SMN complex, an assemblyosome of ribonucleoproteins
    Sergey Paushkin
    Howard Hughes Medical Institute, and the Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    Curr Opin Cell Biol 14:305-12. 2002
    ..This forms symmetrical dimethylarginines within the RG-rich domains of the substrates, thereby converting them to high-affinity binders of the SMN complex, and most likely providing regulation of the ribonucleoprotein assembly processes...
  21. ncbi request reprint PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs
    Michael D Diem
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    Nat Struct Mol Biol 14:1173-9. 2007
    ..We suggest that PYM functions as a bridge between EJC-bearing spliced mRNAs and the translation machinery to enhance translation of the mRNAs...
  22. pmc A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis
    Michael G Berg
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 32:1271-83. 2012
    ..EJIPT provides a platform for characterization and discovery of splicing and EJC modulators...
  23. ncbi request reprint Molecular functions of the SMN complex
    Stephen J Kolb
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Child Neurol 22:990-4. 2007
    ..This review focuses on the current understanding of the mechanism of the role of the SMN complex in small nuclear ribonucleoprotein assembly and considers the relationship of this function to spinal muscular atrophy...
  24. ncbi request reprint SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate
    Daniel J Battle
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Biol Chem 282:27953-9. 2007
    ..These findings demonstrate a modular nature of the SMN complex and identify a new intermediate in the snRNP assembly process...
  25. doi request reprint Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains
    Chi Kong Lau
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, USA
    Nat Struct Mol Biol 16:486-91. 2009
    ..The WD repeat domain is thus a previously undescribed RNA binding domain, and we suggest that the presence of WD repeats should be considered as predictive of potential function in RNA binding...
  26. pmc Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
    Jeongsik Yong
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    Mol Cell 38:551-62. 2010
    ..We propose a stepwise pathway of SMN complex formation and snRNP biogenesis, highlighting Gemin5's function in delivering pre-snRNAs as substrates for Sm core assembly and processing...
  27. ncbi request reprint The SMN complex
    Amelie K Gubitz
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    Exp Cell Res 296:51-6. 2004
    ..A detailed understanding of the cellular roles of the SMN complex may help the development of therapeutic strategies for this neurodegenerative disease...
  28. pmc Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs
    Tracey J Golembe
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Mol Cell Biol 25:10989-1004. 2005
    ..These findings demonstrate that the SMN complex is the identifier, as well as assembler, of the abundant class of snRNAs in cells because it is able to recognize an snRNP code that they contain...
  29. pmc Ars2 promotes proper replication-dependent histone mRNA 3' end formation
    Joshua J Gruber
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell 45:87-98. 2012
    ..Together, the data demonstrate that Ars2 contributes to histone mRNA 3' end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA...
  30. pmc Inactivation of the SMN complex by oxidative stress
    Lili Wan
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    Mol Cell 31:244-54. 2008
    ..Thus, the SMN complex is a redox-sensitive assemblyosome and an ROS target, suggesting that it may play a role in oxidative stress pathophysiology, which is associated with many degenerative diseases...
  31. pmc Numerous microRNPs in neuronal cells containing novel microRNAs
    Josee Dostie
    Howard Hughes Medical Institute, and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    RNA 9:180-6. 2003
    ..These subfamilies comprise multiple copies of miRNAs on different chromosomes, suggesting an important function in the regulation of gene expression...
  32. pmc A novel cell immunoassay to measure survival of motor neurons protein in blood cells
    Stephen J Kolb
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    BMC Neurol 6:6. 2006
    ..A major goal of current therapeutic approaches is to increase SMN levels in SMA patients. The purpose of this study was to develop a reliable assay to measure SMN protein levels from peripheral blood samples...
  33. pmc Sequence-specific interaction of U1 snRNA with the SMN complex
    Jeongsik Yong
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    EMBO J 21:1188-96. 2002
    ..These findings indicate that SMN complex interaction with SL1 is sequence-specific and critical for U1 snRNP biogenesis, further supporting the direct role of the SMN complex in RNP biogenesis...
  34. pmc tRNA binds to cytochrome c and inhibits caspase activation
    Yide Mei
    Department of Cancer Biology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cell 37:668-78. 2010
    ..These findings suggest that tRNA, in addition to its well-established role in gene expression, may determine cellular responsiveness to apoptotic stimuli...
  35. pmc U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
    Daisuke Kaida
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    Nature 468:664-8. 2010
    ..These findings reveal a critical splicing-independent function for U1 snRNP in protecting the transcriptome, which we propose explains its overabundance...
  36. pmc Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly
    Rundong Zhang
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, USA
    Cell 146:384-95. 2011
    ..These findings provide insight into SMN complex assembly and specificity, linking snRNP biogenesis and SMA pathogenesis...
  37. pmc Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing
    Ihab Younis
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    Mol Cell Biol 30:1718-28. 2010
    ..Our findings reveal unexpected activities of clinically used drugs in splicing and uncover differential regulation of constitutively spliced introns...
  38. ncbi request reprint Structure of the Y14-Magoh core of the exon junction complex
    Chi Kong Lau
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Curr Biol 13:933-41. 2003
    ..This tenacious, persistent, splicing-dependent, yet RNA sequence-independent, association suggests an important signaling function and must require distinct structural features for these proteins...
  39. ncbi request reprint Translation is required to remove Y14 from mRNAs in the cytoplasm
    Josee Dostie
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Curr Biol 12:1060-7. 2002
    ..How Y14 and other components of the EJC are removed from mRNAs into the cytoplasm has not been determined...
  40. pmc Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation
    Joshua J Gruber
    Abramson Family Cancer Research Institute and Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell 138:328-39. 2009
    ..These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation...
  41. pmc Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA
    Ihab Younis
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, United States
    elife 2:e00780. 2013
    ..DOI:http://dx.doi.org/10.7554/eLife.00780.001. ..
  42. pmc A degron created by SMN2 exon 7 skipping is a principal contributor to spinal muscular atrophy severity
    Sungchan Cho
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 24:438-42. 2010
    ..These findings explain a key aspect of the SMA disease mechanism, and suggest new treatment approaches based on interference with SMNDelta7-DEG activity...
  43. pmc RNA-binding proteins and post-transcriptional gene regulation
    Tina Glisovic
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6148, United States
    FEBS Lett 582:1977-86. 2008
    ..In this short review, we focus on the RBPs that interact with pre-mRNAs and mRNAs and discuss their roles in the regulation of post-transcriptional gene expression...
  44. ncbi request reprint Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins
    Amelie K Gubitz
    Howard Hughes Medical Institute, Department of Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Biol Chem 277:5631-6. 2002
    ..The presence of 13 WD repeat domains in the amino-terminal half of Gemin5 and a coiled-coil motif near its carboxyl terminus indicate that it may form a large heteromeric complex and engage in multiple interactions...
  45. ncbi request reprint A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex
    Naoyuki Kataoka
    Institute for Virus Research, Kyoto University, Kyoto 606, Japan
    J Biol Chem 279:7009-13. 2004
    ..These findings indicate that EJC formation is an ordered pathway that involves stepwise association of components and is coupled to specific intermediates of the splicing reaction...
  46. ncbi request reprint Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration
    Manuela Neumann
    Center for Neuropathology and Prion Research, Ludwig Maximilians University, Feodor Lynen Str 23, 81377 Munich, Germany
    Acta Neuropathol 113:543-8. 2007
    ..These results argue against a role of these binding partners in the pathogenesis of FTLD-U and emphasize the specificity of TDP-43 as marker for FTLD-U pathology...
  47. pmc Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
    Isao Kashima
    Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    Genes Dev 20:355-67. 2006
    ..Thus, the SMG-1-mediated phosphorylation of Upf1 occurs on the association of SURF with EJC, which provides the link between the EJC and recognition of PTCs and triggers NMD...
  48. ncbi request reprint Ce-Y14 and MAG-1, components of the exon-exon junction complex, are required for embryogenesis and germline sexual switching in Caenorhabditis elegans
    Taizo Kawano
    Department of Life Science, Graduate School of Science and Technology, Kobe University, 1 1 Rokkodaicho, Nadaku, Kobe 657 8501, Japan
    Mech Dev 121:27-35. 2004
    ..Our results demonstrate that the evolutionarily conserved interaction between two EJC components, Ce-Y14 and MAG-1, has critical developmental roles in C. elegans...
  49. pmc Where in the cell is the minor spliceosome?
    Joan A Steitz
    Yale University and Howard Hughes Medical Institute, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 105:8485-6. 2008

Research Grants3

  1. FUNCTIONS OF SMN - THE SPINAL MUSCULAR ATROPHY PROTEIN
    Gideon Dreyfuss; Fiscal Year: 2002
    ..Studies will be carried out to understand in details the molecular functions and interactions of the SMN protein and of the SMN complex. From these studies approaches to therapy of SMA are likely to emerge. ..