W C Drevets

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Prefrontal cortical-amygdalar metabolism in major depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Ann N Y Acad Sci 877:614-37. 1999
  2. ncbi request reprint Serotonin type-1A receptor imaging in depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nucl Med Biol 27:499-507. 2000
  3. ncbi request reprint Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Prog Brain Res 126:413-31. 2000
  4. ncbi request reprint PET imaging of serotonin 1A receptor binding in depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Biol Psychiatry 46:1375-87. 1999
  5. ncbi request reprint Gender-specific aging effects on the serotonin 1A receptor
    C Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15231, USA
    Brain Res 895:9-17. 2001
  6. pmc A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder
    M L Phillips
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 13:829, 833-57. 2008
  7. ncbi request reprint Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:1032-41. 2005
  8. pmc Serotonin-1A receptor imaging in recurrent depression: replication and literature review
    Wayne C Drevets
    Mood and Anxiety Disorders Program, MINH Molecular Imaging Branch, Bethesda, MD 20892, USA
    Nucl Med Biol 34:865-77. 2007
  9. ncbi request reprint Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 63:741-7. 2006
  10. ncbi request reprint Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Prefrontal cortical-amygdalar metabolism in major depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Ann N Y Acad Sci 877:614-37. 1999
    ..Antidepressant drugs may compensate for this dysfunction by inhibiting pathological limbic activity...
  2. ncbi request reprint Serotonin type-1A receptor imaging in depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nucl Med Biol 27:499-507. 2000
    ....
  3. ncbi request reprint Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Prog Brain Res 126:413-31. 2000
    ..These areas of 'deactivation' during the depressed state may reflect neurophysiological interactions between cognitive and emotional processing, and may relate to the subtle cognitive impairments associated with MDE...
  4. ncbi request reprint PET imaging of serotonin 1A receptor binding in depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Biol Psychiatry 46:1375-87. 1999
    ..PET imaging using the 5HT1A receptor radioligand, [11C]WAY-100635, may clarify the clinical conditions under which 5HT1A receptor binding potential (BP) is abnormal in depression...
  5. ncbi request reprint Gender-specific aging effects on the serotonin 1A receptor
    C Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15231, USA
    Brain Res 895:9-17. 2001
    ..Gender-specific effects of age on central serotonergic function may relate to differences between men and women in behavior, mood, and susceptibility to neuropsychiatric disease across the adult lifespan...
  6. pmc A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder
    M L Phillips
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 13:829, 833-57. 2008
    ....
  7. ncbi request reprint Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:1032-41. 2005
    ..Previous studies have shown that women with anorexia nervosa (AN), when ill and after recovery, have alterations of serotonin (5-HT) neuronal activity and core eating disorder symptoms, such as anxiety...
  8. pmc Serotonin-1A receptor imaging in recurrent depression: replication and literature review
    Wayne C Drevets
    Mood and Anxiety Disorders Program, MINH Molecular Imaging Branch, Bethesda, MD 20892, USA
    Nucl Med Biol 34:865-77. 2007
    ..In the current study, we attempted to replicate our previous findings in an independent sample of subjects selected according to the criteria for primary recurrent depression applied in our prior study...
  9. ncbi request reprint Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 63:741-7. 2006
    ....
  10. ncbi request reprint Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006
    ....
  11. ncbi request reprint Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635
    Eydie L Moses-Kolko
    Departments of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Synapse 61:523-30. 2007
    ..To assess effects of chronic antidepressant drug treatment on serotonin type-1A receptor (5-HT(1A)R) binding potential (BP) in major depressive disorder...
  12. pmc Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study
    Eydie L Moses-Kolko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Fertil Steril 89:685-92. 2008
    ..To measure brain serotonin-1A (5HT1A) receptor binding potential (BP) in healthy and depressed postpartum women...
  13. doi request reprint Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomography
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:1166-75. 2008
    ..However, the results of previous neuroimaging studies are in disagreement, possibly because of experimental design limitations related to sample size, matching between patients and controls, and confounding medication effects...
  14. ncbi request reprint Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder
    Dara M Cannon
    Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 62:870-7. 2007
    ....
  15. pmc Neurophysiological responses to traumatic reminders in the acute aftermath of serious motor vehicle collisions using [15O]-H2O positron emission tomography
    Elizabeth A Osuch
    Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
    Biol Psychiatry 64:327-35. 2008
    ..However, neural responses arising in the early aftermath of a traumatic event have not been studied...
  16. ncbi request reprint Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:734-41. 2005
    ..While numerous magnetic resonance imaging (MRI) studies have evaluated adults with bipolar disorder (BPD), few have examined MRI changes in children with BPD...
  17. ncbi request reprint Widespread increases of cortical serotonin type 2A receptor availability after hormone therapy in euthymic postmenopausal women
    Eydie L Moses-Kolko
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Fertil Steril 80:554-9. 2003
    ..To use statistical parametric mapping to determine the extent of previously reported serotonin type 2A (5HT(2A)) receptor binding potential (BP) increases in postmenopausal women following hormone therapy...
  18. ncbi request reprint Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study
    Julie C Price
    PET Facility, Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop St, Rm B938, Pittsburgh, PA 15213, USA
    Brain Res 927:97-103. 2002
    ..02). These findings support previous studies that suggest serotonergic underpinnings to the neurobiology of diabetes and have shown diabetes-induced neurological changes in hippocampus...
  19. ncbi request reprint Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism
    Wayne C Drevets
    Neuroimaging in Mood and Anxiety Disorders Section, National Institutes of Health, NIMH MIB, Bethesda, MD 20892, USA
    Eur Neuropsychopharmacol 12:527-44. 2002
    ....
  20. ncbi request reprint No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
    Omer Bonne
    Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 162:383-5. 2005
    ..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)...
  21. ncbi request reprint Estradiol effects on the postmenopausal brain
    Eydie L Moses-Kolko
    Am J Psychiatry 161:2136; author reply 2136. 2004
  22. ncbi request reprint Sequential H(2)(15)O PET studies in baboons: before and after amphetamine
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Nucl Med 43:1090-100. 2002
    ..A common assumption in bolus injection PET studies of this type is that cerebral blood flow (CBF) does not vary during the scan. The goal of this work was to examine the effect of AMPH administration on sequential PET measures of CBF...
  23. ncbi request reprint Reduced serotonin type 1A receptor binding in panic disorder
    Alexander Neumeister
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
    J Neurosci 24:589-91. 2004
    ..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD...
  24. ncbi request reprint New insights into the role of cortisol and the glucocorticoid receptor in severe depression
    Philip W Gold
    National Institutes of Health, National Institute of Mental Health, Clinical Neuroendocrinology Branch, Intramural Research Program, 20852, Bethesda, MD, USA
    Biol Psychiatry 52:381-5. 2002
  25. ncbi request reprint Distinct profiles of neurocognitive function in unmedicated unipolar depression and bipolar II depression
    Joana V Taylor Tavares
    Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, United Kingdom
    Biol Psychiatry 62:917-24. 2007
    ..In this study, we compared the performance of unmedicated currently depressed MDD and BD groups on a battery of neuropsychological tests that included measures of risk taking and reflection impulsivity...
  26. ncbi request reprint Orbitofrontal cortex function and structure in depression
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Ann N Y Acad Sci 1121:499-527. 2007
    ....
  27. pmc The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers
    Jonathan P Roiser
    Department of Imaging Neuroscience, Institute of Neurology, London, UK
    Neuropsychopharmacology 33:1992-2006. 2008
    ..These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals...
  28. ncbi request reprint Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neuroimage 30:485-97. 2006
    ....
  29. pmc Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:521-31. 2008
    ..An instructive paradigm for more directly investigating the relationship between catecholaminergic function and depression has involved the mood response to experimental catecholamine depletion (CD)...
  30. pmc Reduced posterior hippocampal volume in posttraumatic stress disorder
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Psychiatry 69:1087-91. 2008
    ..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure...
  31. pmc Cerebral blood flow in immediate and sustained anxiety
    Gregor Hasler
    Psychiatric University Hospital, 8091 Zurich, Switzerland
    J Neurosci 27:6313-9. 2007
    ..This study showed distinct neuronal networks involved in cued fear and contextual anxiety underlying the importance of this distinction for studies on the pathophysiology of anxiety disorders...
  32. ncbi request reprint Neuroimaging abnormalities in the amygdala in mood disorders
    Wayne C Drevets
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Ann N Y Acad Sci 985:420-44. 2003
    ....
  33. ncbi request reprint Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
    Alexander Neumeister
    Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 57:935-7. 2005
    ..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls...
  34. ncbi request reprint Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigation
    Michael P Milham
    Beckman Institute, University of Illinois, Urbana, Illinois, USA
    Biol Psychiatry 57:961-6. 2005
    ..We examine the neural correlates of pediatric anxiety disorders, to consider the validity of the categorization scheme used in recent treatment studies...
  35. ncbi request reprint Hippocampus, VI. Depression and the Hippocampus
    Alexander Neumeister
    UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:1057. 2005
  36. ncbi request reprint Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy
    Gregor Hasler
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Biol Psychiatry 58:969-73. 2005
    ..As a result, the current study investigates whether GABA levels in the prefrontal cortex differ between unmedicated subjects with remitted major depressive disorder (rMDD) and healthy control subjects...
  37. ncbi request reprint Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
    ....
  38. ncbi request reprint Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:1750-6. 2006
    ..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD...
  39. ncbi request reprint Discovering endophenotypes for major depression
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
    Neuropsychopharmacology 29:1765-81. 2004
    ....
  40. ncbi request reprint Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 60:207-17. 2006
    ..This study used PET and [(11)C]DASB, a radioligand that afforded higher sensitivity and specificity for the 5-HTT than previously available radioligands, to compare 5-HTT binding between BD and control subjects...
  41. pmc Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial
    Maura L Furey
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1121-9. 2006
    ..002). Subsequently a clinical trial was designed to assess more specifically the antidepressant efficacy of scopolamine...
  42. ncbi request reprint Regional cerebral glucose metabolic abnormalities in bipolar II depression
    Linda Mah
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 61:765-75. 2007
    ..This study investigated whether cerebral metabolic abnormalities previously reported in unmedicated BD subjects are evident in depressed bipolar disorder type II (BD II) subjects receiving lithium or divalproex...
  43. pmc Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A
    Mitchel A Kling
    Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Biol Psychiatry 62:309-13. 2007
    ..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients...
  44. pmc 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, Zurich, Switzerland
    Biol Psychiatry 62:1258-64. 2007
    ..For the first time, 5-HT(1A) receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews...