Research Topics
| W C DrevetsSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Prefrontal cortical-amygdalar metabolism in major depressionW C Drevets
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
Ann N Y Acad Sci 877:614-37. 1999..Antidepressant drugs may compensate for this dysfunction by inhibiting pathological limbic activity...- Serotonin type-1A receptor imaging in depressionW C Drevets
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Nucl Med Biol 27:499-507. 2000.... - Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depressionW C Drevets
Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
Prog Brain Res 126:413-31. 2000..These areas of 'deactivation' during the depressed state may reflect neurophysiological interactions between cognitive and emotional processing, and may relate to the subtle cognitive impairments associated with MDE... - PET imaging of serotonin 1A receptor binding in depressionW C Drevets
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
Biol Psychiatry 46:1375-87. 1999..PET imaging using the 5HT1A receptor radioligand, [11C]WAY-100635, may clarify the clinical conditions under which 5HT1A receptor binding potential (BP) is abnormal in depression... - Gender-specific aging effects on the serotonin 1A receptorC Cidis Meltzer
Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15231, USA
Brain Res 895:9-17. 2001..Gender-specific effects of age on central serotonergic function may relate to differences between men and women in behavior, mood, and susceptibility to neuropsychiatric disease across the adult lifespan... 
A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorderM L Phillips
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Mol Psychiatry 13:829, 833-57. 2008....- Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635Ursula F Bailer
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 62:1032-41. 2005..These psychobiological alterations may be trait related and may contribute to the pathogenesis of AN... - Serotonin-1A receptor imaging in recurrent depression: replication and literature reviewWayne C Drevets
Mood and Anxiety Disorders Program, MINH Molecular Imaging Branch, Bethesda, MD 20892, USA
Nucl Med Biol 34:865-77. 2007..In the current study, we attempted to replicate our previous findings in an independent sample of subjects selected according to the criteria for primary recurrent depression applied in our prior study... - Reduced muscarinic type 2 receptor binding in subjects with bipolar disorderDara M Cannon
Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
Arch Gen Psychiatry 63:741-7. 2006.... - Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controlsAlexander Neumeister
Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
Arch Gen Psychiatry 63:978-86. 2006.... - Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635Eydie L Moses-Kolko
Departments of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Synapse 61:523-30. 2007..To assess effects of chronic antidepressant drug treatment on serotonin type-1A receptor (5-HT(1A)R) binding potential (BP) in major depressive disorder... - Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography studyEydie L Moses-Kolko
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Fertil Steril 89:685-92. 2008..To measure brain serotonin-1A (5HT1A) receptor binding potential (BP) in healthy and depressed postpartum women... 
Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomographyGregor Hasler
Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
Arch Gen Psychiatry 65:1166-75. 2008..However, the results of previous neuroimaging studies are in disagreement, possibly because of experimental design limitations related to sample size, matching between patients and controls, and confounding medication effects...- Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorderDara M Cannon
Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 62:870-7. 2007.... - Neurophysiological responses to traumatic reminders in the acute aftermath of serious motor vehicle collisions using [15O]-H2O positron emission tomographyElizabeth A Osuch
Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Biol Psychiatry 64:327-35. 2008..However, neural responses arising in the early aftermath of a traumatic event have not been studied... - Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry studyDaniel P Dickstein
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 62:734-41. 2005..While numerous magnetic resonance imaging (MRI) studies have evaluated adults with bipolar disorder (BPD), few have examined MRI changes in children with BPD... - Widespread increases of cortical serotonin type 2A receptor availability after hormone therapy in euthymic postmenopausal womenEydie L Moses-Kolko
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Fertil Steril 80:554-9. 2003..To use statistical parametric mapping to determine the extent of previously reported serotonin type 2A (5HT(2A)) receptor binding potential (BP) increases in postmenopausal women following hormone therapy... - Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography studyJulie C Price
PET Facility, Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop St, Rm B938, Pittsburgh, PA 15213, USA
Brain Res 927:97-103. 2002..02). These findings support previous studies that suggest serotonergic underpinnings to the neurobiology of diabetes and have shown diabetes-induced neurological changes in hippocampus... - Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolismWayne C Drevets
Neuroimaging in Mood and Anxiety Disorders Section, National Institutes of Health, NIMH MIB, Bethesda, MD 20892, USA
Eur Neuropsychopharmacol 12:527-44. 2002.... - No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorderOmer Bonne
Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
Am J Psychiatry 162:383-5. 2005..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)... - Estradiol effects on the postmenopausal brainEydie L Moses-Kolko
Am J Psychiatry 161:2136; author reply 2136. 2004 - Sequential H(2)(15)O PET studies in baboons: before and after amphetamineJulie C Price
Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
J Nucl Med 43:1090-100. 2002..A common assumption in bolus injection PET studies of this type is that cerebral blood flow (CBF) does not vary during the scan. The goal of this work was to examine the effect of AMPH administration on sequential PET measures of CBF... - Reduced serotonin type 1A receptor binding in panic disorderAlexander Neumeister
National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
J Neurosci 24:589-91. 2004..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD... - New insights into the role of cortisol and the glucocorticoid receptor in severe depressionPhilip W Gold
National Institutes of Health, National Institute of Mental Health, Clinical Neuroendocrinology Branch, Intramural Research Program, 20852, Bethesda, MD, USA
Biol Psychiatry 52:381-5. 2002 - Distinct profiles of neurocognitive function in unmedicated unipolar depression and bipolar II depressionJoana V Taylor Tavares
Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, United Kingdom
Biol Psychiatry 62:917-24. 2007..In this study, we compared the performance of unmedicated currently depressed MDD and BD groups on a battery of neuropsychological tests that included measures of risk taking and reflection impulsivity... - Orbitofrontal cortex function and structure in depressionWayne C Drevets
Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
Ann N Y Acad Sci 1121:499-527. 2007.... - The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteersJonathan P Roiser
Department of Imaging Neuroscience, Institute of Neurology, London, UK
Neuropsychopharmacology 33:1992-2006. 2008..These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals... - Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometryAllison C Nugent
Section on Neuroimaging in Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
Neuroimage 30:485-97. 2006.... - Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjectsGregor Hasler
Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
Arch Gen Psychiatry 65:521-31. 2008..An instructive paradigm for more directly investigating the relationship between catecholaminergic function and depression has involved the mood response to experimental catecholamine depletion (CD)... - Reduced posterior hippocampal volume in posttraumatic stress disorderOmer Bonne
Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
J Clin Psychiatry 69:1087-91. 2008..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure... - Cerebral blood flow in immediate and sustained anxietyGregor Hasler
Psychiatric University Hospital, 8091 Zurich, Switzerland
J Neurosci 27:6313-9. 2007..This study showed distinct neuronal networks involved in cued fear and contextual anxiety underlying the importance of this distinction for studies on the pathophysiology of anxiety disorders... - Neuroimaging abnormalities in the amygdala in mood disordersWayne C Drevets
Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
Ann N Y Acad Sci 985:420-44. 2003.... - Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjectsAlexander Neumeister
Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
Biol Psychiatry 57:935-7. 2005..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls... - Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigationMichael P Milham
Beckman Institute, University of Illinois, Urbana, Illinois, USA
Biol Psychiatry 57:961-6. 2005..We examine the neural correlates of pediatric anxiety disorders, to consider the validity of the categorization scheme used in recent treatment studies... - Hippocampus, VI. Depression and the HippocampusAlexander Neumeister
UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390-9070, USA
Am J Psychiatry 162:1057. 2005 - Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopyGregor Hasler
Mood and Anxiety Disorders Program, Section on Experimental Therapeutics, National Institutes of Health, Bethesda, MD 20892 2670, USA
Biol Psychiatry 58:969-73. 2005..As a result, the current study investigates whether GABA levels in the prefrontal cortex differ between unmedicated subjects with remitted major depressive disorder (rMDD) and healthy control subjects... - Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controlsAlexander Neumeister
Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
Arch Gen Psychiatry 61:765-73. 2004.... - Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depressionAlexander Neumeister
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Neuropsychopharmacology 31:1750-6. 2006..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD... - Discovering endophenotypes for major depressionGregor Hasler
Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
Neuropsychopharmacology 29:1765-81. 2004.... - Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomographyDara M Cannon
Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
Biol Psychiatry 60:207-17. 2006..This study used PET and [(11)C]DASB, a radioligand that afforded higher sensitivity and specificity for the 5-HTT than previously available radioligands, to compare 5-HTT binding between BD and control subjects... - Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trialMaura L Furey
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 63:1121-9. 2006..002). Subsequently a clinical trial was designed to assess more specifically the antidepressant efficacy of scopolamine... - Regional cerebral glucose metabolic abnormalities in bipolar II depressionLinda Mah
Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 61:765-75. 2007..This study investigated whether cerebral metabolic abnormalities previously reported in unmedicated BD subjects are evident in depressed bipolar disorder type II (BD II) subjects receiving lithium or divalproex... - Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid AMitchel A Kling
Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
Biol Psychiatry 62:309-13. 2007..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients... - 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depressionGregor Hasler
Department of Psychiatry, University Hospital, Culmannstrasse 8, Zurich, Switzerland
Biol Psychiatry 62:1258-64. 2007..For the first time, 5-HT(1A) receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews...