Research Topics
Species | Gregory DresslerSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Epigenetics in kidney development and renal diseaseGregory R Dressler
Department of Pathology, University of Michigan, Ann Arbor, Mich Electronic address
Transl Res 165:166-76. 2015..Thus, the state of the epigenome in adult cells must be considered when attempting to alleviate or alter gene expression patterns in disease. ..
Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotypeGaelle M Lefevre
Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS Genet 6:e1001142. 2010..These data demonstrate that alterations or mutations in an epigenetic regulatory pathway can alter the phenotypes of differentiated cells and lead to a chronic disease state...- Patterning and early cell lineage decisions in the developing kidney: the role of Pax genesGregory R Dressler
Department of Pathology, University of Michigan, Ann Arbor, MI, USA
Pediatr Nephrol 26:1387-94. 2011..This epigenetic function may underlie the ability of Pax2 and similar proteins to maintain cell lineages during development... - Turning the page on epigenetic bookmarksGregory R Dressler
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
Dev Cell 18:4-5. 2010.... - Advances in early kidney specification, development and patterningGregory R Dressler
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
Development 136:3863-74. 2009..How these developments influence and advance our understanding of kidney development is discussed... - Epigenetics, development, and the kidneyGregory R Dressler
Department of Pathology, 2049 BSRB 2200, University of Michigan, Ann Arbor, MI 48109, USA
J Am Soc Nephrol 19:2060-7. 2008..The role of epigenetic modifications in development and disease is under intense investigation and has already affected our view of cancer and aging... - Another niche for NotchG R Dressler
Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
Kidney Int 73:1207-9. 2008..In an adult acute tubular necrosis model, Kobayashi et al. now show expression of many Notch components and the activation of Notch target genes, suggesting a critical function for Notch in regenerating proximal tubules... 
Kidney development branches outG R Dressler
Department of Pathology, University of Michigan, Ann Arbor 48109, USA
Dev Genet 24:189-93. 1999..Coincidentally, it has become increasingly clear that progress made in renal development can impact our understanding of the genetic basis of disease...- The cellular basis of kidney developmentGregory R Dressler
Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
Annu Rev Cell Dev Biol 22:509-29. 2006..Despite the kidney's architectural complexity, with the advent of genomics and expression arrays, it is becoming one of the best-characterized organ systems in developmental biology... - Pax2 in development and renal diseaseG R Dressler
Department of Pathology, The University of Michigan Medical Center, Ann Arbor 48109 0650, USA
Int J Dev Biol 43:463-8. 1999..Thus, Pax2 misexpresssion may be a key determinant in the initiation and progression of renal diseases marked by increased or deregulated cell proliferation... - Tubulogenesis in the developing mammalian kidneyGregory Dressler
Dept of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
Trends Cell Biol 12:390-5. 2002..Cell signaling pathways and transcription factors have been defined through genetic and biochemical assays such that a picture of early kidney tubulogenesis is beginning to emerge... - Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathwaysMing Fang
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
Development 136:1929-38. 2009..These data suggest a highly conserved function for ptip in epigenetic control of development and differentiation... - BRCT domain-containing protein PTIP is essential for progression through mitosisEun Ah Cho
Department of Pathology Program in Cell and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Cell Biol 23:1666-73. 2003..Given the role of BRCT domain proteins in DNA repair and cell cycle control, we propose that PTIP is an essential element of the cell proliferation machinery, perhaps by functioning in the DNA repair pathways... - Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epitheliaDoyeob Kim
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
J Am Soc Nephrol 16:3527-34. 2005..These methods may facilitate the large-scale culture of renal epithelial precursor cells for a variety of applications... - A Hox-Eya-Pax complex regulates early kidney developmental gene expressionKe Qin Gong
Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical Center, 109 Zina Pitcher, 3045 BSRB, Ann Arbor, MI 48109 2200, USA
Mol Cell Biol 27:7661-8. 2007..Thus, anterior-posterior-patterning Hox proteins interact with Pax2 and Eya1, factors important for nephrogenic mesoderm specification, to directly regulate the activation of downstream target genes during early kidney development... - The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complexSanjeevkumar R Patel
Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Dev Cell 13:580-92. 2007..Embryonic lethal ptip-null mutants and conditional mutants both show reduced levels of methylated H3K4. Thus, PTIP bridges DNA-binding developmental regulators to histone methyltransferase-dependent epigenetic regulation... - The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factorPatrick D Brophy
Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 278:52401-5. 2003.... - Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosageJason C Clarke
Department of Pediatrics, University of Michigan, Ann Arbor 48109, USA, and Kolling Institute, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia
Hum Mol Genet 15:3420-8. 2006..The effects of reduced Pax2 gene dosage are thus amplified resulting in a haploinsufficient phenotype... - Expression of Pax2 in the intermediate mesoderm is regulated by YY1Sanjeevkumar R Patel
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Dev Biol 267:505-16. 2004..These data point to a novel role for YY1 in the establishment of high level tissue-specific expression within the intermediate mesoderm... - Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylationYi Cai
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
EMBO J 22:5522-9. 2003..These data suggest a new model for Groucho mediated suppression of transcription through the specific inhibition of modifications in the activation domain of a transactivator... - Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cellsXiao Yan Li
Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
J Cell Biol 195:729-38. 2011.... - The role of PTIP in maintaining embryonic stem cell pluripotencyDoyeob Kim
Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
Stem Cells 27:1516-23. 2009..These results suggest that the maintenance of H3K4 methylation is essential and requires PTIP function during the in vitro propagation of pluripotent ES cells... - PTIP regulates 53BP1 and SMC1 at the DNA damage sitesJiaxue Wu
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Biol Chem 284:18078-84. 2009..Taken together, these results suggest that the role of PTIP in the DNA damage response is downstream of RNF8 and upstream of 53BP1. Thus, PTIP regulates 53BP1-dependent signaling pathway following DNA damage... - Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic diseaseJingmei Lin
Department of Pathology, University of Michigan, 1301 Catherine Street, Ann Arbor, Michigan 48109, USA
Nat Med 11:387-93. 2005..The data indicate an important role for KCP in attenuating the pathology of renal fibrotic disease... - PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidneyDoyeob Kim
Department of Pathology, University of Michigan, MSRB1, BSRB 2049, 109 Zina Pitcher Dr, Ann Arbor, MI 48109, USA
Dev Biol 307:290-9. 2007..These data suggest a critical role for the PI3K/PTEN axis in shaping the pattern of epithelial branches in response to RET activation... - Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locusKristopher R Schwab
Department of Pathology, University of Michigan, BSRB 2049, 109 Zina Pitcher Dr, Ann Arbor, MI 48109, USA
Mol Cell Biol 31:1503-11. 2011..We propose a model whereby PTIP stabilizes the Pax5 DNA interactions that promote chromatin looping and regulate transcriptional responses needed for class switch recombination... - BMP7 signaling in renal development and diseaseSanjeevkumar R Patel
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Trends Mol Med 11:512-8. 2005..The activities of these secreted factors are regulated, in part, by extracellular ligand binding proteins which can enhance or suppress receptor ligand interactions... - The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epitheliaJingmei Lin
Department of Pathology, University of Michigan, MSRB1 4510D, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0650, USA
Mol Cell Biol 26:4577-85. 2006.... - Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activationYi Cai
Departments of Pathology and Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 277:1217-22. 2002..The data demonstrate that Pax2 is a new target for the JNK signaling module and point to a novel mechanism for mediating Pax-dependent transcription regulation... - Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinaseMing Jer Tang
Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
Dev Biol 243:128-36. 2002..The data suggest that activation of RET in the ureteric bud epithelium signals through PI3K to control outgrowth and branching morphogenesis... - Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidneyMichelle Self
Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
EMBO J 25:5214-28. 2006..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud... - The development of the bladder trigone, the center of the anti-reflux mechanismRenata Viana
Columbia University, Department of Urology, 650 West 168th Street, New York, NY 10032, USA
Development 134:3763-9. 2007..These studies suggest that urinary tract development occurs differently than previously thought, providing new insights into the mechanisms underlying normal and abnormal development... - PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complexYoung Wook Cho
Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Biol Chem 282:20395-406. 2007..As histone H3 K4 methylation associates with active genes, our study suggests a potential role of PTIP in the regulation of gene expression...
Research Grants
- CELL MIGRATION, CHEMOATTRACTION AND THE RET/GDNF PATHWAYGregory Dressler; Fiscal Year: 2002..In addition to advancing our understanding of basic developmental processes, the mechnisms of migration and invasion by oncogenic RET derived tumor cells will also be illuminated. ..
- Differentiation of ES Cells into Renal EpitheliaGregory Dressler; Fiscal Year: 2006..Since ES cells potentially represent an unlimited supply of renal progenitors, these experiments will lay the foundation for cell based therapies to improve the efficacy of ATN treatment. ..
- Cell Signaling in Developing EpitheliaGregory R Dressler; Fiscal Year: 2010..How these interactions can be manipulated for therapeutic effects needs to be investigated and is the subject of this proposal. ..