Affiliation: University of Michigan
Bradford S, Ranghini E, Grimley E, Lee P, Dressler G. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds. J Biol Chem. 2019;294:3125-3136 pubmed publisher
..Our results underscore the feasibility of utilizing HTS to identify compounds that mimic key downstream events of BMP signaling in renal cells and have yielded a lead BMP agonist. ..
Higashi A, Aronow B, Dressler G. Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis. J Am Soc Nephrol. 2019;30:80-94 pubmed publisher
..In chronic models, however, activated fibroblasts are resistant to the antifibrotic effects of PGE2 due to suppression of a subset of PGE receptors. ..
Grimley E, Dressler G. Are Pax proteins potential therapeutic targets in kidney disease and cancer?. Kidney Int. 2018;94:259-267 pubmed publisher
..Given the paucity of effective treatments for renal cancer and cystic disease, the Pax family of proteins represents new pharmaceutical targets that merit exploration and further development. ..
Dressler G, Woolf A. Pax2 in development and renal disease. Int J Dev Biol. 1999;43:463-8 pubmed
..Thus, Pax2 misexpresssion may be a key determinant in the initiation and progression of renal diseases marked by increased or deregulated cell proliferation. ..
Dressler G, Patel S. Epigenetics in kidney development and renal disease. Transl Res. 2015;165:166-76 pubmed publisher
..Thus, the state of the epigenome in adult cells must be considered when attempting to alleviate or alter gene expression patterns in disease. ..
Dressler G. The cellular basis of kidney development. Annu Rev Cell Dev Biol. 2006;22:509-29 pubmed
..Despite the kidney's architectural complexity, with the advent of genomics and expression arrays, it is becoming one of the best-characterized organ systems in developmental biology. ..
Dressler G. Advances in early kidney specification, development and patterning. Development. 2009;136:3863-74 pubmed publisher
..How these developments influence and advance our understanding of kidney development is discussed. ..
Dressler G. Turning the page on epigenetic bookmarks. Dev Cell. 2010;18:4-5 pubmed publisher
Soofi A, Wolf K, Ranghini E, Amin M, Dressler G. The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice. Am J Physiol Gastrointest Liver Physiol. 2016;311:G587-G598 pubmed publisher
..These data demonstrate that shifting the TGF-? signaling paradigm with the secreted regulatory protein KCP can significantly alter the liver pathology in aging mice and in diet-induced NAFLD. ..