Gregory Dressler

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype
    Gaelle M Lefevre
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Genet 6:e1001142. 2010
  2. ncbi request reprint Kidney development branches out
    G R Dressler
    Department of Pathology, University of Michigan, Ann Arbor 48109, USA
    Dev Genet 24:189-93. 1999
  3. doi request reprint Another niche for Notch
    G R Dressler
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Kidney Int 73:1207-9. 2008
  4. ncbi request reprint Epigenetics, development, and the kidney
    Gregory R Dressler
    Department of Pathology, 2049 BSRB 2200, University of Michigan, Ann Arbor, MI 48109, USA
    J Am Soc Nephrol 19:2060-7. 2008
  5. ncbi request reprint The cellular basis of kidney development
    Gregory R Dressler
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Annu Rev Cell Dev Biol 22:509-29. 2006
  6. pmc Advances in early kidney specification, development and patterning
    Gregory R Dressler
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 136:3863-74. 2009
  7. doi request reprint Turning the page on epigenetic bookmarks
    Gregory R Dressler
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Cell 18:4-5. 2010
  8. ncbi request reprint Tubulogenesis in the developing mammalian kidney
    Gregory Dressler
    Dept of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Cell Biol 12:390-5. 2002
  9. ncbi request reprint Pax2 in development and renal disease
    G R Dressler
    Department of Pathology, The University of Michigan Medical Center, Ann Arbor 48109 0650, USA
    Int J Dev Biol 43:463-8. 1999
  10. doi request reprint Patterning and early cell lineage decisions in the developing kidney: the role of Pax genes
    Gregory R Dressler
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Pediatr Nephrol 26:1387-94. 2011

Research Grants

  1. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2006
  2. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2009
  3. CELL MIGRATION, CHEMOATTRACTION AND THE RET/GDNF PATHWAY
    Gregory Dressler; Fiscal Year: 1999
  4. Differentiation of ES Cells into Renal Epithelia
    Gregory Dressler; Fiscal Year: 2006
  5. Cell Signaling in Developing Epithelia
    Gregory Dressler; Fiscal Year: 2006
  6. Epigenetic Regulation of Kidney Development
    Gregory Dressler; Fiscal Year: 2006
  7. Epigenetic Regulation of Kidney Development
    Gregory Dressler; Fiscal Year: 2007
  8. Epigenetic Regulation of Kidney Development
    Gregory Dressler; Fiscal Year: 2009
  9. Cell Signaling in Developing Epithelia
    Gregory Dressler; Fiscal Year: 2009
  10. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory R Dressler; Fiscal Year: 2010

Collaborators

Detail Information

Publications32

  1. pmc Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype
    Gaelle M Lefevre
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Genet 6:e1001142. 2010
    ..These data demonstrate that alterations or mutations in an epigenetic regulatory pathway can alter the phenotypes of differentiated cells and lead to a chronic disease state...
  2. ncbi request reprint Kidney development branches out
    G R Dressler
    Department of Pathology, University of Michigan, Ann Arbor 48109, USA
    Dev Genet 24:189-93. 1999
    ..Coincidentally, it has become increasingly clear that progress made in renal development can impact our understanding of the genetic basis of disease...
  3. doi request reprint Another niche for Notch
    G R Dressler
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Kidney Int 73:1207-9. 2008
    ..In an adult acute tubular necrosis model, Kobayashi et al. now show expression of many Notch components and the activation of Notch target genes, suggesting a critical function for Notch in regenerating proximal tubules...
  4. ncbi request reprint Epigenetics, development, and the kidney
    Gregory R Dressler
    Department of Pathology, 2049 BSRB 2200, University of Michigan, Ann Arbor, MI 48109, USA
    J Am Soc Nephrol 19:2060-7. 2008
    ..The role of epigenetic modifications in development and disease is under intense investigation and has already affected our view of cancer and aging...
  5. ncbi request reprint The cellular basis of kidney development
    Gregory R Dressler
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Annu Rev Cell Dev Biol 22:509-29. 2006
    ..Despite the kidney's architectural complexity, with the advent of genomics and expression arrays, it is becoming one of the best-characterized organ systems in developmental biology...
  6. pmc Advances in early kidney specification, development and patterning
    Gregory R Dressler
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 136:3863-74. 2009
    ..How these developments influence and advance our understanding of kidney development is discussed...
  7. doi request reprint Turning the page on epigenetic bookmarks
    Gregory R Dressler
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Cell 18:4-5. 2010
    ....
  8. ncbi request reprint Tubulogenesis in the developing mammalian kidney
    Gregory Dressler
    Dept of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Cell Biol 12:390-5. 2002
    ..Cell signaling pathways and transcription factors have been defined through genetic and biochemical assays such that a picture of early kidney tubulogenesis is beginning to emerge...
  9. ncbi request reprint Pax2 in development and renal disease
    G R Dressler
    Department of Pathology, The University of Michigan Medical Center, Ann Arbor 48109 0650, USA
    Int J Dev Biol 43:463-8. 1999
    ..Thus, Pax2 misexpresssion may be a key determinant in the initiation and progression of renal diseases marked by increased or deregulated cell proliferation...
  10. doi request reprint Patterning and early cell lineage decisions in the developing kidney: the role of Pax genes
    Gregory R Dressler
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Pediatr Nephrol 26:1387-94. 2011
    ..This epigenetic function may underlie the ability of Pax2 and similar proteins to maintain cell lineages during development...
  11. pmc Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways
    Ming Fang
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 136:1929-38. 2009
    ..These data suggest a highly conserved function for ptip in epigenetic control of development and differentiation...
  12. pmc A Hox-Eya-Pax complex regulates early kidney developmental gene expression
    Ke Qin Gong
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical Center, 109 Zina Pitcher, 3045 BSRB, Ann Arbor, MI 48109 2200, USA
    Mol Cell Biol 27:7661-8. 2007
    ..Thus, anterior-posterior-patterning Hox proteins interact with Pax2 and Eya1, factors important for nephrogenic mesoderm specification, to directly regulate the activation of downstream target genes during early kidney development...
  13. ncbi request reprint Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia
    Doyeob Kim
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Am Soc Nephrol 16:3527-34. 2005
    ..These methods may facilitate the large-scale culture of renal epithelial precursor cells for a variety of applications...
  14. pmc BRCT domain-containing protein PTIP is essential for progression through mitosis
    Eun Ah Cho
    Department of Pathology Program in Cell and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Biol 23:1666-73. 2003
    ..Given the role of BRCT domain proteins in DNA repair and cell cycle control, we propose that PTIP is an essential element of the cell proliferation machinery, perhaps by functioning in the DNA repair pathways...
  15. pmc Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation
    Yi Cai
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    EMBO J 22:5522-9. 2003
    ..These data suggest a new model for Groucho mediated suppression of transcription through the specific inhibition of modifications in the activation domain of a transactivator...
  16. ncbi request reprint Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage
    Jason C Clarke
    Department of Pediatrics, University of Michigan, Ann Arbor 48109, USA, and Kolling Institute, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia
    Hum Mol Genet 15:3420-8. 2006
    ..The effects of reduced Pax2 gene dosage are thus amplified resulting in a haploinsufficient phenotype...
  17. ncbi request reprint Expression of Pax2 in the intermediate mesoderm is regulated by YY1
    Sanjeevkumar R Patel
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Dev Biol 267:505-16. 2004
    ..These data point to a novel role for YY1 in the establishment of high level tissue-specific expression within the intermediate mesoderm...
  18. pmc The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex
    Sanjeevkumar R Patel
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Cell 13:580-92. 2007
    ..Embryonic lethal ptip-null mutants and conditional mutants both show reduced levels of methylated H3K4. Thus, PTIP bridges DNA-binding developmental regulators to histone methyltransferase-dependent epigenetic regulation...
  19. ncbi request reprint The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor
    Patrick D Brophy
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 278:52401-5. 2003
    ....
  20. pmc Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells
    Xiao Yan Li
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 195:729-38. 2011
    ....
  21. pmc The role of PTIP in maintaining embryonic stem cell pluripotency
    Doyeob Kim
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Stem Cells 27:1516-23. 2009
    ..These results suggest that the maintenance of H3K4 methylation is essential and requires PTIP function during the in vitro propagation of pluripotent ES cells...
  22. pmc PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney
    Doyeob Kim
    Department of Pathology, University of Michigan, MSRB1, BSRB 2049, 109 Zina Pitcher Dr, Ann Arbor, MI 48109, USA
    Dev Biol 307:290-9. 2007
    ..These data suggest a critical role for the PI3K/PTEN axis in shaping the pattern of epithelial branches in response to RET activation...
  23. pmc PTIP regulates 53BP1 and SMC1 at the DNA damage sites
    Jiaxue Wu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 284:18078-84. 2009
    ..Taken together, these results suggest that the role of PTIP in the DNA damage response is downstream of RNF8 and upstream of 53BP1. Thus, PTIP regulates 53BP1-dependent signaling pathway following DNA damage...
  24. ncbi request reprint Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease
    Jingmei Lin
    Department of Pathology, University of Michigan, 1301 Catherine Street, Ann Arbor, Michigan 48109, USA
    Nat Med 11:387-93. 2005
    ..The data indicate an important role for KCP in attenuating the pathology of renal fibrotic disease...
  25. pmc Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus
    Kristopher R Schwab
    Department of Pathology, University of Michigan, BSRB 2049, 109 Zina Pitcher Dr, Ann Arbor, MI 48109, USA
    Mol Cell Biol 31:1503-11. 2011
    ..We propose a model whereby PTIP stabilizes the Pax5 DNA interactions that promote chromatin looping and regulate transcriptional responses needed for class switch recombination...
  26. ncbi request reprint BMP7 signaling in renal development and disease
    Sanjeevkumar R Patel
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Mol Med 11:512-8. 2005
    ..The activities of these secreted factors are regulated, in part, by extracellular ligand binding proteins which can enhance or suppress receptor ligand interactions...
  27. ncbi request reprint Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation
    Yi Cai
    Departments of Pathology and Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 277:1217-22. 2002
    ..The data demonstrate that Pax2 is a new target for the JNK signaling module and point to a novel mechanism for mediating Pax-dependent transcription regulation...
  28. pmc The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia
    Jingmei Lin
    Department of Pathology, University of Michigan, MSRB1 4510D, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0650, USA
    Mol Cell Biol 26:4577-85. 2006
    ....
  29. ncbi request reprint Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinase
    Ming Jer Tang
    Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
    Dev Biol 243:128-36. 2002
    ..The data suggest that activation of RET in the ureteric bud epithelium signals through PI3K to control outgrowth and branching morphogenesis...
  30. ncbi request reprint The development of the bladder trigone, the center of the anti-reflux mechanism
    Renata Viana
    Columbia University, Department of Urology, 650 West 168th Street, New York, NY 10032, USA
    Development 134:3763-9. 2007
    ..These studies suggest that urinary tract development occurs differently than previously thought, providing new insights into the mechanisms underlying normal and abnormal development...
  31. pmc Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
    Michelle Self
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    EMBO J 25:5214-28. 2006
    ..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
  32. pmc PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
    Young Wook Cho
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 282:20395-406. 2007
    ..As histone H3 K4 methylation associates with active genes, our study suggests a potential role of PTIP in the regulation of gene expression...

Research Grants28

  1. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2006
    ....
  2. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2009
    ....
  3. CELL MIGRATION, CHEMOATTRACTION AND THE RET/GDNF PATHWAY
    Gregory Dressler; Fiscal Year: 1999
    ..In addition to advancing our understanding of basic developmental processes, the mechnisms of migration and invasion by oncogenic RET derived tumor cells will also be illuminated. ..
  4. Differentiation of ES Cells into Renal Epithelia
    Gregory Dressler; Fiscal Year: 2006
    ..Since ES cells potentially represent an unlimited supply of renal progenitors, these experiments will lay the foundation for cell based therapies to improve the efficacy of ATN treatment. ..
  5. Cell Signaling in Developing Epithelia
    Gregory Dressler; Fiscal Year: 2006
    ..abstract_text> ..
  6. Epigenetic Regulation of Kidney Development
    Gregory Dressler; Fiscal Year: 2006
    ..PTIP may be a direct link between developmental regulatory factors such as Pax2 and the mechanism of epigenetic modifications that determine and fix cell lineages. ..
  7. Epigenetic Regulation of Kidney Development
    Gregory Dressler; Fiscal Year: 2007
    ..PTIP may be a direct link between developmental regulatory factors such as Pax2 and the mechanism of epigenetic modifications that determine and fix cell lineages. ..
  8. Epigenetic Regulation of Kidney Development
    Gregory Dressler; Fiscal Year: 2009
    ..PTIP may be a direct link between developmental regulatory factors such as Pax2 and the mechanism of epigenetic modifications that determine and fix cell lineages. ..
  9. Cell Signaling in Developing Epithelia
    Gregory Dressler; Fiscal Year: 2009
    ..How these interactions can be manipulated for therapeutic effects needs to be investigated and is the subject of this proposal. ..
  10. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory R Dressler; Fiscal Year: 2010
    ....
  11. Epigenetic Regulation of Kidney Development
    Gregory R Dressler; Fiscal Year: 2010
    ..PTIP may be a direct link between developmental regulatory factors such as Pax2 and the mechanism of epigenetic modifications that determine and fix cell lineages. ..
  12. Cell Signaling in Developing Epithelia
    Gregory Dressler; Fiscal Year: 2005
    ..abstract_text> ..
  13. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2005
    ....
  14. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 1999
    ..Antibodies will be made, and interaction domains with Pax-2 will be defined as has already been done with PTIP. ..
  15. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2000
    ..Antibodies will be made, and interaction domains with Pax-2 will be defined as has already been done with PTIP. ..
  16. CELL MIGRATION, CHEMOATTRACTION AND THE RET/GDNF PATHWAY
    Gregory Dressler; Fiscal Year: 2000
    ..In addition to advancing our understanding of basic developmental processes, the mechnisms of migration and invasion by oncogenic RET derived tumor cells will also be illuminated. ..
  17. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2001
    ..Antibodies will be made, and interaction domains with Pax-2 will be defined as has already been done with PTIP. ..
  18. CELL MIGRATION, CHEMOATTRACTION AND THE RET/GDNF PATHWAY
    Gregory Dressler; Fiscal Year: 2001
    ..In addition to advancing our understanding of basic developmental processes, the mechnisms of migration and invasion by oncogenic RET derived tumor cells will also be illuminated. ..
  19. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2002
    ..Antibodies will be made, and interaction domains with Pax-2 will be defined as has already been done with PTIP. ..
  20. CELL MIGRATION, CHEMOATTRACTION AND THE RET/GDNF PATHWAY
    Gregory Dressler; Fiscal Year: 2002
    ..In addition to advancing our understanding of basic developmental processes, the mechnisms of migration and invasion by oncogenic RET derived tumor cells will also be illuminated. ..
  21. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2003
    ....
  22. Cell Signaling in Developing Epithelia
    Gregory Dressler; Fiscal Year: 2003
    ..abstract_text> ..
  23. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2004
    ....
  24. Cell Signaling in Developing Epithelia
    Gregory Dressler; Fiscal Year: 2004
    ..abstract_text> ..
  25. Cell Signaling in Developing Epithelia
    Gregory R Dressler; Fiscal Year: 2010
    ..How these interactions can be manipulated for therapeutic effects needs to be investigated and is the subject of this proposal. ..