B Draznin

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action
    Boris Draznin
    Division of Endocrinology, Diabetes and Metabolism, University of Colorado School of Medicine, Aurora, Colorado, USA
    Diabetes Care 36:1807-14. 2013
  2. doi request reprint Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle
    B Draznin
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Denver, School of Medicine, Aurora CO 80045, USA
    Horm Metab Res 44:650-5. 2012
  3. doi request reprint Subcutaneous administration of glargine to diabetic patients receiving insulin infusion prevents rebound hyperglycemia
    Elisa Hsia
    Division of Endocrinology, University of Colorado School of Medicine, Denver, Colorado 80045, USA
    J Clin Endocrinol Metab 97:3132-7. 2012
  4. pmc Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding
    Rebecca L Adochio
    Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Nutr Metab (Lond) 6:37. 2009
  5. doi request reprint Comparison of 70/30 biphasic insulin with glargine/lispro regimen in non-critically ill diabetic patients on continuous enteral nutrition therapy
    Elisa Hsia
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver, 12801 E 17th Ave, Aurora, CO 80045, USA
    Nutr Clin Pract 26:714-7. 2011
  6. pmc Mechanism of the mitogenic influence of hyperinsulinemia
    Boris Draznin
    Division of Endocrinology, Department of Medicine, University of Colorado, Denver, USA
    Diabetol Metab Syndr 3:10. 2011
  7. doi request reprint Mitogenic action of insulin: friend, foe or 'frenemy'?
    B Draznin
    Adult Diabetes Program, University of Colorado Denver, Mail Stop 8106, 12631 E 17th Ave, Aurora, CO 80045, USA
    Diabetologia 53:229-33. 2010
  8. ncbi request reprint Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals
    M L Goalstone
    Medical Research Service and Department of Medicine, Veterans Affairs Medical Center and the University of Colorado Health Sciences Center, Denver, USA
    Diabetologia 42:310-6. 1999
  9. doi request reprint In vivo knockdown of p85alpha with an antisense oligonucleotide improves insulin sensitivity in Lep(ob/ob) and diet-induced obese mice
    M W Moriarty
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Horm Metab Res 41:757-61. 2009
  10. ncbi request reprint Insulin signals to prenyltransferases via the Shc branch of intracellular signaling
    M L Goalstone
    Veterans Affairs Medical Center Research Service and the Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    J Biol Chem 276:12805-12. 2001

Collaborators

Detail Information

Publications18

  1. pmc Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action
    Boris Draznin
    Division of Endocrinology, Diabetes and Metabolism, University of Colorado School of Medicine, Aurora, Colorado, USA
    Diabetes Care 36:1807-14. 2013
    ....
  2. doi request reprint Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle
    B Draznin
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Denver, School of Medicine, Aurora CO 80045, USA
    Horm Metab Res 44:650-5. 2012
    ....
  3. doi request reprint Subcutaneous administration of glargine to diabetic patients receiving insulin infusion prevents rebound hyperglycemia
    Elisa Hsia
    Division of Endocrinology, University of Colorado School of Medicine, Denver, Colorado 80045, USA
    J Clin Endocrinol Metab 97:3132-7. 2012
    ..Transition of diabetic patients from iv insulin infusion to s.c. insulin frequently results in rebound hyperglycemia...
  4. pmc Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding
    Rebecca L Adochio
    Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Nutr Metab (Lond) 6:37. 2009
    ..abstract:..
  5. doi request reprint Comparison of 70/30 biphasic insulin with glargine/lispro regimen in non-critically ill diabetic patients on continuous enteral nutrition therapy
    Elisa Hsia
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver, 12801 E 17th Ave, Aurora, CO 80045, USA
    Nutr Clin Pract 26:714-7. 2011
    ..Administration of 70/30 biphasic insulin 3 times daily is a safe therapeutic regimen in diabetic patients on continuous EN as it maintains glycemia in the target range and might produce fewer episodes of hypoglycemia...
  6. pmc Mechanism of the mitogenic influence of hyperinsulinemia
    Boris Draznin
    Division of Endocrinology, Department of Medicine, University of Colorado, Denver, USA
    Diabetol Metab Syndr 3:10. 2011
    ..Stimulatory effect of hyperinsulinemia on farnesyltransferase in the presence of insulin resistance represents one potential mechanism responsible for mitogenicity and atherogenicity of insulin...
  7. doi request reprint Mitogenic action of insulin: friend, foe or 'frenemy'?
    B Draznin
    Adult Diabetes Program, University of Colorado Denver, Mail Stop 8106, 12631 E 17th Ave, Aurora, CO 80045, USA
    Diabetologia 53:229-33. 2010
    ..The stimulatory effect of hyperinsulinaemia on farnesyltransferase in the presence of insulin resistance represents one potential mechanism responsible for mitogenicity and atherogenicity of insulin...
  8. ncbi request reprint Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals
    M L Goalstone
    Medical Research Service and Department of Medicine, Veterans Affairs Medical Center and the University of Colorado Health Sciences Center, Denver, USA
    Diabetologia 42:310-6. 1999
    ..In summary, these data confirm increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals...
  9. doi request reprint In vivo knockdown of p85alpha with an antisense oligonucleotide improves insulin sensitivity in Lep(ob/ob) and diet-induced obese mice
    M W Moriarty
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Horm Metab Res 41:757-61. 2009
    ..This was associated with increased phosphoinositide 3-kinase activity and improved insulin sensitivity in diet-induced obese and Lep (ob/ob) mice. Thus, p85alpha could be an important therapeutic target to ameliorate insulin resistance...
  10. ncbi request reprint Insulin signals to prenyltransferases via the Shc branch of intracellular signaling
    M L Goalstone
    Veterans Affairs Medical Center Research Service and the Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    J Biol Chem 276:12805-12. 2001
    ..An additional pathway involving the Shc SH2 domain may be necessary to mediate the insulin effect on FTase and GGTase I...
  11. ncbi request reprint Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues
    E Stephens
    Veterans Affairs Research Service, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    Am J Physiol Endocrinol Metab 281:E217-23. 2001
    ....
  12. ncbi request reprint Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation
    D J Klemm
    Research Service, Veterans Affairs Medical Center and Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    J Biol Chem 276:28430-5. 2001
    ..It appears that insulin-stimulated prenylation of the Ras family GTPases assures normal phosphorylation and activation of CREB that, in turn, triggers the intrinsic cascade of adipogenesis...
  13. ncbi request reprint Cytosolic calcium and insulin resistance in elderly patients with essential hypertension
    R L Byyny
    Department of Medicine, University of Colorado Health Sciences Center, Denver
    Am J Hypertens 5:459-64. 1992
    ..In summary, older hypertensive, and particularly older obese hypertensive, patients manifest significant insulin resistance accompanied by elevated levels of [Ca2+]i in their adipocytes...
  14. ncbi request reprint Effect of insulin on cell cycle progression in MCF-7 breast cancer cells. Direct and potentiating influence
    J Chappell
    Research Service of the Department of Veterans Affairs, Denver, Colorado 80220, USA
    J Biol Chem 276:38023-8. 2001
    ....
  15. ncbi request reprint Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia
    B Draznin
    Denver Veterans Affairs Medical Center, Department of Medicine, University of Colorado Health Sciences Center, 80220, USA
    Endocrinology 141:1310-6. 2000
    ..This aspect of insulin action may represent one facet of the molecular mechanism of the potentially detrimental influence of hyperinsulinemia...
  16. ncbi request reprint Nutritional upregulation of p85alpha expression is an early molecular manifestation of insulin resistance
    M A Cornier
    Research Service, Department of Veterans Affairs, Denver, CO, USA
    Diabetologia 49:748-54. 2006
    ..We sought to define early molecular alterations associated with nutritionally induced insulin resistance in humans...
  17. ncbi request reprint Discordance between intramuscular triglyceride and insulin sensitivity in skeletal muscle of Zucker diabetic rats after treatment with fenofibrate and rosiglitazone
    K J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA
    Diabetes Obes Metab 9:714-23. 2007
    ..PPAR agonists may also affect IMTG via changes in insulin sensitivity, SREBP-1 or other factors...
  18. ncbi request reprint Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes
    M L Goalstone
    Medical Research Service and the Department of Medicine, Veterans Affairs Medical Center and the University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    J Biol Chem 271:27585-9. 1996
    ....