Genomes and Genes
Deborah L Drazen
Affiliation: University of Cincinnati
- Differential effects of adrenalectomy on melanin-concentrating hormone and orexin ADeborah L Drazen
Department of Psychiatry, Genome Research Institute, University of Cincinnati, 2170 East Galbraith Road, Building 43, Third Floor, Cincinnati, Ohio 45237, USA
Endocrinology 145:3404-12. 2004....
- Adrenalectomy alters the sensitivity of the central nervous system melanocortin systemDeborah L Drazen
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
Diabetes 52:2928-34. 2003..We conclude that the potent weight-reducing effects of ADX likely involve heightened responsiveness to melanocortin receptor stimulation...
- Peripheral signals in the control of satiety and hungerDeborah L Drazen
Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, MSB G059, Cincinnati, OH 45267 0559, USA
Curr Opin Clin Nutr Metab Care 6:621-9. 2003....
- Meal-anticipatory glucagon-like peptide-1 secretion in ratsTorsten P Vahl
Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45237, USA
Endocrinology 151:569-75. 2010..These findings document for the first time a cephalic increase of plasma GLP-1 and suggest that it functions to facilitate consumption of a large meal...
- Neuropeptide Y prepares rats for scheduled feedingDeborah L Drazen
Department of Psychiatry, University of Cincinnati, 2170 E Galbraith Rd, Bldg E, Rm 313, Cincinnati, OH 45237, USA
Am J Physiol Regul Integr Comp Physiol 288:R1606-11. 2005..These data suggest that NPY plays a role in mediating conditionable food-anticipatory responses that help to cope with the effects of large caloric loads...
- Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient statusDeborah L Drazen
Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45267, USA
Endocrinology 147:23-30. 2006..Together, these data are consistent with a role for ghrelin in the regulation of anticipatory processes involved in food intake and nutrient disposition...
- The critical role of the melanocortin system in the control of energy balanceRandy J Seeley
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267 0559, USA
Annu Rev Nutr 24:133-49. 2004..Reviewed here is the wide range of evidence that points to the melanocortin system as a critical node in the diverse neurocircuitry that regulates food intake and body weight...
- Role for dopamine-3 receptor in the hyperphagia of an unanticipated high-fat meal in ratsJon F Davis
University of Cincinnati, Department of Psychiatry, Reading, OH 45237, USA
Pharmacol Biochem Behav 85:190-7. 2006..Raclopride was ineffective at disrupting food intake. These results support the hypothesis that the dopamine-3 receptor is involved in the hyperphagia of an unexpected high fat meal...
- Reductions in total body fat decrease humoral immunityGregory E Demas
Department of Biology, Program in Neural Science, and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN 47405, USA
Proc Biol Sci 270:905-11. 2003..There was no significant increase in EWAT in IWATx hamsters compared with sham animals and IgG remained significantly reduced in IWATx hamsters. These results suggest that reductions in energy availability can impair humoral immunity...
- A role for the melanocortin 4 receptor in sexual functionLex H T Van der Ploeg
Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
Proc Natl Acad Sci U S A 99:11381-6. 2002..Our results provide a basis for the existence of MC4R-controlled neuronal pathways that control sexual function...
- Exposure to short days, but not short-term melatonin, enhances humoral immunity of male Syrian hamsters (Mesocricetus auratus)Deborah L Drazen
Department of Psychology, Johns Hopkins University, Baltimore, MD, USA
J Pineal Res 33:118-24. 2002..These results confirm previous findings of photoperiodic changes in immunity in rodents and suggest that changes in humoral immunity are not due to short-term changes in melatonin...
- Short day lengths attenuate the symptoms of infection in Siberian hamstersStaci D Bilbo
Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218 2686, USA
Proc Biol Sci 269:447-54. 2002..Taken together, short day lengths attenuated the symptoms of infection, presumably to optimize energy expenditure and survival outcome...