I M Dozmorov

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. pmc Bladder inflammatory transcriptome in response to tachykinins: neurokinin 1 receptor-dependent genes and transcription regulatory elements
    Ricardo Saban
    Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BMC Urol 7:7. 2007
  2. pmc Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation
    Ricardo Saban
    Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BMC Physiol 7:4. 2007
  3. pmc Regulatory network of inflammation downstream of proteinase-activated receptors
    Ricardo Saban
    Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BMC Physiol 7:3. 2007
  4. pmc Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha
    Marcia R Saban
    College of Medicine, Department of Physiology, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    BMC Immunol 9:4. 2008
  5. pmc Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation
    Ricardo Saban
    Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BMC Immunol 8:17. 2007
  6. pmc Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells
    Mikhail G Dozmorov
    Department of Urology, Oklahoma University Health Sciences Centre, Oklahoma City, OK 73104, USA
    BMC Cancer 6:12. 2006
  7. pmc Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis
    James N Jarvis
    Department of Pediatrics, University of Oklahoma College of Medicine, 940 Stanton L, Young Blvd, Oklahoma City, OK 73104, USA
    Arthritis Res Ther 8:R154. 2006
  8. pmc Hypervariable genes--experimental error or hidden dynamics
    Igor Dozmorov
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Nucleic Acids Res 32:e147. 2004
  9. ncbi request reprint Mobile classification in microarray experiments
    I M Dozmorov
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Scand J Immunol 62:84-91. 2005
  10. ncbi request reprint An associative analysis of gene expression array data
    Igor Dozmorov
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73105, USA
    Bioinformatics 19:204-11. 2003

Collaborators

Detail Information

Publications24

  1. pmc Bladder inflammatory transcriptome in response to tachykinins: neurokinin 1 receptor-dependent genes and transcription regulatory elements
    Ricardo Saban
    Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BMC Urol 7:7. 2007
    ..First, NK1R-dependent transcripts were determined and used to query known databases for their respective transcription regulatory elements (TREs)...
  2. pmc Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation
    Ricardo Saban
    Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BMC Physiol 7:4. 2007
    ..We hypothesize that PARs may link mast cell-derived proteases to bladder inflammation and, therefore, play a fundamental role in the pathogenesis of cystitis...
  3. pmc Regulatory network of inflammation downstream of proteinase-activated receptors
    Ricardo Saban
    Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BMC Physiol 7:3. 2007
    ..coli lipopolysaccharide (LPS), substance P (SP), and antigen was strongly attenuated by PAR1- and to a lesser extent by PAR2-deficiency...
  4. pmc Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha
    Marcia R Saban
    College of Medicine, Department of Physiology, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    BMC Immunol 9:4. 2008
    ..In addition, the transcriptome was precipitated with an antibody against RNA polymerase II and real-time polymerase chain reaction assay (Q-PCR) was used to confirm some of the BCG-specific transcripts...
  5. pmc Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation
    Ricardo Saban
    Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BMC Immunol 8:17. 2007
    ..In order to search for therapeutic targets other than the receptors themselves, we set forth to determine TFs downstream of PAR activation in the C57BL/6 urinary bladders...
  6. pmc Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells
    Mikhail G Dozmorov
    Department of Urology, Oklahoma University Health Sciences Centre, Oklahoma City, OK 73104, USA
    BMC Cancer 6:12. 2006
    ..Understanding how the extracellular matrix affects the phenotype of bladder cancer cells may provide important clues to identify new markers or targets for therapy...
  7. pmc Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis
    James N Jarvis
    Department of Pediatrics, University of Oklahoma College of Medicine, 940 Stanton L, Young Blvd, Oklahoma City, OK 73104, USA
    Arthritis Res Ther 8:R154. 2006
    ..Our data are consistent with the hypothesis that neutrophils play an essential role in the pathogenesis of polyarticular JRA...
  8. pmc Hypervariable genes--experimental error or hidden dynamics
    Igor Dozmorov
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Nucleic Acids Res 32:e147. 2004
    ..F-means clustering establishes, for the first time, groups of co-expressed HV genes and is illustrated with microarray data from patients with juvenile rheumatoid arthritis and healthy controls...
  9. ncbi request reprint Mobile classification in microarray experiments
    I M Dozmorov
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Scand J Immunol 62:84-91. 2005
    ..Stability of these combinations implies a strongly compensatory relationship that may divulge functional interconnections...
  10. ncbi request reprint An associative analysis of gene expression array data
    Igor Dozmorov
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73105, USA
    Bioinformatics 19:204-11. 2003
    ....
  11. ncbi request reprint Protection against hydrogen peroxide-induced cell death in cultured human retinal pigment epithelial cells by 17beta-estradiol: a differential gene expression profile
    Xiaorui Yu
    Department of Ophthalmology, University of Oklahoma Health Science Center, Dean A McGee Eye Institute, 608 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Mech Ageing Dev 126:1135-45. 2005
    ....
  12. ncbi request reprint Gene expression profile of long-lived snell dwarf mice
    Igor Dozmorov
    Department of Pathology, University of Michigan, Ann Arbor 48109 0940, USA
    J Gerontol A Biol Sci Med Sci 57:B99-108. 2002
    ....
  13. ncbi request reprint Identification of mouse retinal genes differentially regulated by dim and bright cyclic light rearing
    Hu Huang
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    Exp Eye Res 80:727-39. 2005
    ..Those that directly affect cell processes such as survival, apoptosis, and transcription are likely play a pivotal role in the regulation of retinal neuroprotection against light-induced photoreceptor apoptosis...
  14. ncbi request reprint Neurokinin 1 receptors and neprilysin modulation of mouse bladder gene regulation
    Igor Dozmorov
    Oklahoma Medical Research Foundation, Microarray Research Facility, Oklahoma City, USA
    Physiol Genomics 12:239-50. 2003
    ....
  15. ncbi request reprint Connective molecular pathways of experimental bladder inflammation
    Igor Dozmorov
    Oklahoma Medical Research Foundation, Arthritis and Immunology Research Program, Microarray Core Facility, The University Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Physiol Genomics 15:209-22. 2003
    ..The significance of these processes was tested from both biological and statistical viewpoints. We propose that connective mosaic may represent the necessary simplification step to visualize cDNA array results...
  16. ncbi request reprint Gene expression arrays reveal a rapid return to normal homeostasis in immunologically-challenged trophoblast-like JAR cells
    James N Jarvis
    Department of Pediatrics, Pediatric Rheumatology Research, Basic Sciences Ed Building 235A, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA
    J Reprod Immunol 61:99-113. 2004
    ..Immunologic/inflammatory challenge at the maternal-fetal interface is compensated by cellular mechanisms that work to reduce inflammation and rapidly restore immunologic balance...
  17. pmc Statistical monitoring of weak spots for improvement of normalization and ratio estimates in microarrays
    Igor Dozmorov
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    BMC Bioinformatics 5:53. 2004
    ..Unfortunately, no accurate method for differentiating additive noise from genes expressed at low levels is currently available...
  18. ncbi request reprint Partitioning of 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol activated pathways for stimulating human prostate cancer LNCaP cell proliferation
    Eva H Nunlist
    Department of Urology, University of Oklahoma Health Sciences Center, 920 Stanton L Young Blvd, WP3150, Oklahoma City, OK 73104, USA
    J Steroid Biochem Mol Biol 91:157-70. 2004
    ..Accordingly, 3alpha-diol might activate cell proliferation cascades independent of AR pathway in the prostate...
  19. ncbi request reprint Global gene expression analysis of human bronchial epithelial cells treated with tobacco condensates
    Ellen D Jorgensen
    Vector Research Ltd, New York, New York 10019, USA
    Cell Cycle 3:1154-68. 2004
    ..Finally, the finding that S9 affects the expression of a number of genes may have implications for various toxicogenetic assays currently used by regulatory agencies to evaluate harmful effects in exposed humans...
  20. pmc From microarray to biology: an integrated experimental, statistical and in silico analysis of how the extracellular matrix modulates the phenotype of cancer cells
    Mikhail G Dozmorov
    Department of Urology, Oklahoma University Health Sciences Centre, Oklahoma City, OK 73104, USA
    BMC Bioinformatics 9:S4. 2008
    ..The resulting model was confirmed by comparing the predicted pattern of TREs with experimental determination of active transcription factors...
  21. ncbi request reprint Multiplex cytokine profiling of initial therapeutic response in patients with chronic hepatitis C virus infection
    Harlan Wright
    Nazhi Zuhdi Transplant Institute, Integris Baptist Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Dig Dis Sci 50:1793-803. 2005
    ..In conclusion, these data raise the possibility that characteristic changes in host response modulate the therapeutic response, demonstrating the prognostic power of serum cytokine profiling in chronic HCV...
  22. ncbi request reprint Distinct profiles of Sjögren's syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF
    Peter Szodoray
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Clin Immunol 117:168-76. 2005
    ..The variables identified by DFA are interdependent and are often of mechanistic significance to the pathologic states they distinguish, suggesting that these factors modulate SS pathology and SSGC formation in a synergistic manner...
  23. ncbi request reprint Decreased glycogen synthase kinase 3-beta levels and related physiological changes in Bacillus anthracis lethal toxin-treated macrophages
    Amy E Tucker
    Department of Botany and Microbiology, The University of Oklahoma, Norman 73019, USA
    Cell Microbiol 5:523-32. 2003
    ..These data provide new information on LeTx's overall influence on macrophage physiology and suggest loss of GSK-3beta contributes to cytotoxicity...
  24. ncbi request reprint A distinct multicytokine profile is associated with anti-cyclical citrullinated peptide antibodies in patients with early untreated inflammatory arthritis
    Carol A Hitchon
    Arthritis Centre, University of Manitoba, 800 Sherbrook Street, Winnipeg, Manitoba R3A 1M4, Canada
    J Rheumatol 31:2336-46. 2004
    ....