Glenn A Doyle

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression
    Glenn A Doyle
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e23373. 2011
  2. doi Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains
    Glenn A Doyle
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:2801-9. 2008
  3. ncbi Confirmation of a major QTL influencing oral morphine intake in C57 and DBA mice using reciprocal congenic strains
    Thomas N Ferraro
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104 6140, USA
    Neuropsychopharmacology 30:742-6. 2005
  4. ncbi Identification and functional significance of polymorphisms in the mu-opioid receptor gene (Oprm) promoter of C57BL/6 and DBA/2 mice
    Glenn A Doyle
    The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Neurosci Res 55:244-54. 2006
  5. pmc Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon
    Glenn A Doyle
    The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    Gene 395:98-107. 2007
  6. ncbi No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) and bipolar I disorder
    Falk W Lohoff
    School of Medicine Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Clinical Research Building, Room 135a, 415 Curie Boulevard, Philadelphia, PA 19104 6140, USA
    Psychiatry Res 135:171-7. 2005
  7. ncbi A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
  8. pmc Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurosci Lett 440:280-3. 2008
  9. pmc Case-control association study of WLS variants in opioid and cocaine addicted populations
    Richard C Crist
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA
    Psychiatry Res 208:62-6. 2013
  10. ncbi Identification of three mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon
    Glenn A Doyle
    The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    Gene 388:135-47. 2007

Collaborators

Detail Information

Publications15

  1. pmc In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression
    Glenn A Doyle
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e23373. 2011
    ..We conclude that CHRNA5 promoter variants may affect relative risk for NA in some heterozygous individuals...
  2. doi Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains
    Glenn A Doyle
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:2801-9. 2008
    ..10 (which harbors Oprm1) between the acromere and Stxbp5, as well as on distal Chr. 6 between marker D6Mit10 and the telomere...
  3. ncbi Confirmation of a major QTL influencing oral morphine intake in C57 and DBA mice using reciprocal congenic strains
    Thomas N Ferraro
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104 6140, USA
    Neuropsychopharmacology 30:742-6. 2005
    ..B6-Mop2 mice. Overall, these data confirm the existence of a gene(s) on chromosome 10 proximal to D10Mit124 that has a strong influence on the difference in morphine drinking behavior between B6 and D2 mice...
  4. ncbi Identification and functional significance of polymorphisms in the mu-opioid receptor gene (Oprm) promoter of C57BL/6 and DBA/2 mice
    Glenn A Doyle
    The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Neurosci Res 55:244-54. 2006
    ..No significant differences in construct activity were found between untreated and morphine-treated BE(2)-C or Neuro-2a cells, suggesting that morphine does not regulate transcription of Oprm...
  5. pmc Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon
    Glenn A Doyle
    The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    Gene 395:98-107. 2007
    ..These exon 19-containing splice variants add to the growing complexity of the mouse Oprm1 gene...
  6. ncbi No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) and bipolar I disorder
    Falk W Lohoff
    School of Medicine Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Clinical Research Building, Room 135a, 415 Curie Boulevard, Philadelphia, PA 19104 6140, USA
    Psychiatry Res 135:171-7. 2005
    ..Our results suggest that common variations in the CHRNA2 gene are unlikely to confer susceptibility to BPD in this sample. Further studies are required to elucidate the susceptibility locus for BPD on chromosome 8p21-22...
  7. ncbi A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
    ..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls...
  8. pmc Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurosci Lett 440:280-3. 2008
    ....
  9. pmc Case-control association study of WLS variants in opioid and cocaine addicted populations
    Richard C Crist
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA
    Psychiatry Res 208:62-6. 2013
    ..However, this study does not exclude the possibilities that rare variants in WLS may affect susceptibility to drug addiction, or that common variants with small effect size may fall below the detection level of our analysis...
  10. ncbi Identification of three mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon
    Glenn A Doyle
    The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    Gene 388:135-47. 2007
    ..In summary, we have identified three brain expressed, alternatively spliced mouse MOR splice variants containing a novel exon and encoding new putative MOR isoforms, MOR-1V and MOR-1W...
  11. doi Re-sequencing of ankyrin 3 exon 48 and case-control association analysis of rare variants in bipolar disorder type I
    Glenn A Doyle
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Bipolar Disord 14:809-21. 2012
    ..Because the GWAS suggested multiple common haplotypes associated with BPD-I (with odds ratio ~1.3), we hypothesized that rare variants within these common haplotypes might increase risk for BPD-I...
  12. ncbi Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Psychiatr Res 39:475-9. 2005
    ..The results of this study suggest that polymorphisms in the CRHR 1 gene are not major risk factors for the development of alcohol dependence in persons of European ancestry...
  13. doi Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychobiology 57:55-60. 2008
    ..Further studies are necessary to confirm this effect, and to elucidate the role of VMAT1 in central nervous system physiology and possible involvement in the genetic origins of SZ...
  14. doi Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder
    Paul J Bloch
    Psychiatric Pharmacogenetics Laboratory, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:1515-9. 2010
    ....
  15. ncbi Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence
    Rachel J Smith
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005
    ..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1...