S Doxsey

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase
    Adam Gromley
    University of Massachusetts Medical School, Department of Molecular Medicine, Worcester, MA 01605, USA
    J Cell Biol 161:535-45. 2003
  2. pmc Multiplying madly: Deacetylases take charge of centrosome duplication and amplification
    Hui Fang Hung
    Program in Molecular Medicine University of Massachusetts Medical School at Worcester Worcester, MA USA
    Cell Cycle 11:4304. 2012
  3. pmc The cilia protein IFT88 is required for spindle orientation in mitosis
    Benedicte Delaval
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Suite 210, Worcester, Massachusetts 01605, USA
    Nat Cell Biol 13:461-8. 2011
  4. pmc Pericentrin in cellular function and disease
    Benedicte Delaval
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 188:181-90. 2010
  5. pmc Polarity sets the stage for cytokinesis
    Heidi Hehnly
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 23:7-11. 2012
  6. doi request reprint Genetics. Dwarfism, where pericentrin gains stature
    Benedicte Delaval
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 319:732-3. 2008
  7. ncbi request reprint Centrosomes in cellular regulation
    Stephen Doxsey
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Annu Rev Cell Dev Biol 21:411-34. 2005
  8. ncbi request reprint Centrosome control of the cell cycle
    Stephen Doxsey
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Trends Cell Biol 15:303-11. 2005
  9. ncbi request reprint Re-evaluating centrosome function
    S Doxsey
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Rev Mol Cell Biol 2:688-98. 2001
  10. pmc The Drosophila kinesin-like protein KLP67A is essential for mitotic and male meiotic spindle assembly
    Rita Gandhi
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Biol Cell 15:121-31. 2004

Research Grants

  1. Centrosome Protein Function
    Stephen Doxsey; Fiscal Year: 2007
  2. Centrosome Protein Function
    Stephen Doxsey; Fiscal Year: 2006
  3. CENTROSOME ASSEMBLY AND FUNCTION
    Stephen Doxsey; Fiscal Year: 2004
  4. Centrosome Protein Function
    Stephen Doxsey; Fiscal Year: 2005
  5. CENTROSOME ASSEMBLY AND FUNCTION
    Stephen Doxsey; Fiscal Year: 2003
  6. CENTROSOME ASSEMBLY AND FUNCTION
    Stephen Doxsey; Fiscal Year: 2002
  7. CENTROSOME ASSEMBLY AND FUNCTION
    Stephen Doxsey; Fiscal Year: 2001
  8. CENTROSOME ASSEMBLY AND FUNCTION
    Stephen Doxsey; Fiscal Year: 2000
  9. CENTROSOME PROTEIN PERICENTRIN
    Stephen Doxsey; Fiscal Year: 1999

Collaborators

  • B Burke
  • Nathan D Lawson
  • P Kaldis
  • D McCollum
  • G J Pazour
  • Benedicte Delaval
  • Heidi Hehnly
  • Keith Mikule
  • Hui Fang Hung
  • Agata Jurczyk
  • Adam Gromley
  • Hana Blazkova
  • Rita Gandhi
  • I Gavanescu
  • Alison Bright
  • Jacqueline Schmuckli-Maurer
  • Agata Jurcyzk
  • Dirk A Dobbelaere
  • Paula C Fernandez
  • Polla Hergert
  • Conrad von Schubert
  • Rebekka Schwab
  • Nico Angliker
  • P Bangs
  • R M Welsh
  • Andrea Pereira
  • Silvia Bonaccorsi
  • Dorien J M Peters
  • Diana Wentworth
  • Sambra Redick
  • Maurizio Gatti
  • E Szomolanyi-Tsuda
  • George Witman
  • Jovenal San Agustin
  • E Halilovic
  • G Pihan
  • James Sillibourne
  • Mette Mogensen
  • Irina Groisman
  • Ensar Halilovic
  • Maureen Blomberg
  • A Purohit
  • C Powers
  • R Craig

Detail Information

Publications17

  1. pmc A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase
    Adam Gromley
    University of Massachusetts Medical School, Department of Molecular Medicine, Worcester, MA 01605, USA
    J Cell Biol 161:535-45. 2003
    ..We conclude that centriolin is required for a late stage of vertebrate cytokinesis, perhaps the final cell cleavage event, and plays a role in progression into S phase...
  2. pmc Multiplying madly: Deacetylases take charge of centrosome duplication and amplification
    Hui Fang Hung
    Program in Molecular Medicine University of Massachusetts Medical School at Worcester Worcester, MA USA
    Cell Cycle 11:4304. 2012
    ..Comment on: Ling H, et al. Cell Cycle 2012; 11:3779-91...
  3. pmc The cilia protein IFT88 is required for spindle orientation in mitosis
    Benedicte Delaval
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Suite 210, Worcester, Massachusetts 01605, USA
    Nat Cell Biol 13:461-8. 2011
    ..This work identifies a mitotic mechanism for a cilia protein in the orientation of cell division and has important implications for the etiology of ciliopathies...
  4. pmc Pericentrin in cellular function and disease
    Benedicte Delaval
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 188:181-90. 2010
    ..In this review, we focus on human conditions associated with loss or elevation of pericentrin and propose cellular and molecular models that might explain them...
  5. pmc Polarity sets the stage for cytokinesis
    Heidi Hehnly
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 23:7-11. 2012
    ..Here we focus on how the canonical pathways for cell polarization and cell migration may play a role in spatiotemporal membrane trafficking events required for the final stages of cytokinesis...
  6. doi request reprint Genetics. Dwarfism, where pericentrin gains stature
    Benedicte Delaval
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 319:732-3. 2008
  7. ncbi request reprint Centrosomes in cellular regulation
    Stephen Doxsey
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Annu Rev Cell Dev Biol 21:411-34. 2005
    ..These new liaisons between MTOCs and cellular regulation are the focus of this review. Elucidation of these and other previously unappreciated centrosome functions promises to yield exciting scientific discovery for some time to come...
  8. ncbi request reprint Centrosome control of the cell cycle
    Stephen Doxsey
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Trends Cell Biol 15:303-11. 2005
    ..In this review (which is part of the Chromosome Segregation and Aneuploidy series), we discuss recent data that provide the most direct links between centrosomes and cell-cycle progression...
  9. ncbi request reprint Re-evaluating centrosome function
    S Doxsey
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Rev Mol Cell Biol 2:688-98. 2001
    ..Molecules that regulate centrosome duplication have been identified, and the expanding list of intriguing centrosome-anchored activities, the functions of which have yet to be determined, promises continued discovery...
  10. pmc The Drosophila kinesin-like protein KLP67A is essential for mitotic and male meiotic spindle assembly
    Rita Gandhi
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Biol Cell 15:121-31. 2004
    ....
  11. pmc Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export
    P Bangs
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biol 143:1801-12. 1998
    ....
  12. ncbi request reprint Duplicating dangerously: linking centrosome duplication and aneuploidy
    Stephen Doxsey
    Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 10:439-40. 2002
    ..Recent evidence indicates that deregulation of centrosome duplication affects centrosome number and promotes aneuploidy, features characteristic of human tumors...
  13. pmc Mycoplasma infection induces a scleroderma-like centrosome autoantibody response in mice
    I Gavanescu
    Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Clin Exp Immunol 137:288-97. 2004
    ..Antibiotic treatment of mice prevents autoantibody development. Centrosome autoantibodies may provide an aetiological link between infection and human autoimmunity and suggest novel therapeutic strategies in these disorders...
  14. ncbi request reprint Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest
    Keith Mikule
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Cell Biol 9:160-70. 2007
    ..This model satisfies the definition of a checkpoint in having three elements: a perturbation that is sensed, a transducer (p53) and a receiver (p21)...
  15. pmc Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly
    Agata Jurczyk
    Department of Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech II, Suite 210, Worcester, MA 01605, USA
    J Cell Biol 166:637-43. 2004
    ..We conclude that Pcnt, IFTs, and PC2 form a complex in vertebrate cells that is required for assembly of primary cilia and possibly motile cilia and flagella...
  16. ncbi request reprint The IKK inhibitor BMS-345541 affects multiple mitotic cell cycle transitions
    Hana Blazkova
    Division of Molecular Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
    Cell Cycle 6:2531-40. 2007
    ....

Research Grants13

  1. Centrosome Protein Function
    Stephen Doxsey; Fiscal Year: 2007
    ..We will determine the mechanism of GI arrest and identify the signal transduction pathway that connects centrosome proteins to cell cycle arrest. ..
  2. Centrosome Protein Function
    Stephen Doxsey; Fiscal Year: 2006
    ..We will determine the mechanism of GI arrest and identify the signal transduction pathway that connects centrosome proteins to cell cycle arrest. ..
  3. CENTROSOME ASSEMBLY AND FUNCTION
    Stephen Doxsey; Fiscal Year: 2004
    ..The third aim is to identify and characterize other pericentrin-interacting proteins and to characterize a novel centriole protein which, like pericentrin, was identified using autoimmune sera. ..
  4. Centrosome Protein Function
    Stephen Doxsey; Fiscal Year: 2005
    ..We will determine the mechanism of GI arrest and identify the signal transduction pathway that connects centrosome proteins to cell cycle arrest. ..
  5. CENTROSOME ASSEMBLY AND FUNCTION
    Stephen Doxsey; Fiscal Year: 2003
    ..The third aim is to identify and characterize other pericentrin-interacting proteins and to characterize a novel centriole protein which, like pericentrin, was identified using autoimmune sera. ..
  6. CENTROSOME ASSEMBLY AND FUNCTION
    Stephen Doxsey; Fiscal Year: 2002
    ..The third aim is to identify and characterize other pericentrin-interacting proteins and to characterize a novel centriole protein which, like pericentrin, was identified using autoimmune sera. ..
  7. CENTROSOME ASSEMBLY AND FUNCTION
    Stephen Doxsey; Fiscal Year: 2001
    ..The third aim is to identify and characterize other pericentrin-interacting proteins and to characterize a novel centriole protein which, like pericentrin, was identified using autoimmune sera. ..
  8. CENTROSOME ASSEMBLY AND FUNCTION
    Stephen Doxsey; Fiscal Year: 2000
    ..The third aim is to identify and characterize other pericentrin-interacting proteins and to characterize a novel centriole protein which, like pericentrin, was identified using autoimmune sera. ..
  9. CENTROSOME PROTEIN PERICENTRIN
    Stephen Doxsey; Fiscal Year: 1999
    ..We are especially excited about the future prospect of realizing our long term goal of reconstituting centrosome function in vitro from individual components. ..